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  1. Article ; Online: Circumflex to Left Atrial Appendage Fistula Associated With Watchman FLX Closure Device.

    Milutinovic, Stefan / Lopez-Mattei, Juan / Rosen, Jeffrey / Agarwal, Anuj / Escárcega, Ricardo O

    JACC. Case reports

    2024  Volume 29, Issue 4, Page(s) 102202

    Abstract: An 82-year-old man who had undergone Watchman FLX (Boston Scientific) device implantation presented with dyspnea. Multimodality evaluation demonstrated a small fistula from the proximal circumflex artery to the left atrial appendage. Anatomically, the ... ...

    Abstract An 82-year-old man who had undergone Watchman FLX (Boston Scientific) device implantation presented with dyspnea. Multimodality evaluation demonstrated a small fistula from the proximal circumflex artery to the left atrial appendage. Anatomically, the left circumflex artery is close to the atrial appendage; therefore, it is plausible that fistula formation could be a late complication of implantation of the device.
    Language English
    Publishing date 2024-01-04
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2666-0849
    ISSN (online) 2666-0849
    DOI 10.1016/j.jaccas.2023.102202
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Surgical treatment options for congenital pseudarthrosis of tibia in children: cross-union versus other options: a systematic review.

    Rastogi, Anuj / Agarwal, Anil

    Journal of pediatric orthopedics. Part B

    2022  Volume 31, Issue 2, Page(s) 139–149

    Abstract: The systematic review aimed to provide a comprehensive update on various surgical treatment options for congenital pseudarthrosis of tibia (CPT) in children and the outcome achieved in terms of union, union time and complications of non-union and ... ...

    Abstract The systematic review aimed to provide a comprehensive update on various surgical treatment options for congenital pseudarthrosis of tibia (CPT) in children and the outcome achieved in terms of union, union time and complications of non-union and refracture. A literature search was performed in PubMed (including Medline) database for broad keywords: 'Congenital pseudarthrosis of tibia and children'. Studies selected included full-text articles on surgical treatments of CPT following: intra-medullary rod (IMR)/Ilizarov/combined IMR with Ilizarov/vascularized fibular graft (VFG) and cross-union. Out of 719 studies, 57(1227 CPT patients/1235 tibias) were included for review. Cross-union group had 100% union rate with no non-unions, least refracture rate (22.5%) and minimal time to primary union (4.5 months). For IMR, Ilizarov, combined IMR with Ilizarov and VFG, the respective results were as follows: primary union rates - 67.7, 84.2, 83.7 and 65.3%; final union - 76.5, 81.5, 92.4 and 87.1%; primary union time - 12.6, 9.3, 5.3 and 9.5 months; non-union rates - 17.0, 13.6, 6.0 and 7.9%; refracture rates - 48.1, 47.7, 33.7 and 34.6%. The success probability was lowest for IMR (35.2%), 44% for Ilizarov, 55.5% for combined IMR with Ilizarov, 42.7% for VFG and highest 77.5% for cross-union group. Outcomes of the more recent cross-union technique fare better than other surgical methods. However, studies on cross-union are few and longer follow-up is lacking. Combined IMR with Ilizarov and VFG have better results compared to IMR or Ilizarov alone.
    MeSH term(s) Child ; Fibula ; Humans ; Ilizarov Technique ; Pseudarthrosis/surgery ; Tibia/surgery
    Language English
    Publishing date 2022-01-31
    Publishing country United States
    Document type Journal Article ; Systematic Review
    ISSN 1473-5865
    ISSN (online) 1473-5865
    DOI 10.1097/BPB.0000000000000924
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Long-term outcomes of the Ponseti method for treatment of clubfoot: a systematic review.

    Rastogi, Anuj / Agarwal, Anil

    International orthopaedics

    2021  Volume 45, Issue 10, Page(s) 2599–2608

    Abstract: Purpose: The Ponseti method has revolutionized the clubfoot treatment and has been adopted globally in the past couple of decades. However, most reported results of the Ponseti method are either short or midterm. Studies reporting long-term outcomes of ... ...

    Abstract Purpose: The Ponseti method has revolutionized the clubfoot treatment and has been adopted globally in the past couple of decades. However, most reported results of the Ponseti method are either short or midterm. Studies reporting long-term outcomes of the Ponseti method are limited. The following systematic review aimed to provide a comprehensive overview of the published articles on long-term outcomes of the Ponseti method.
    Material and methods: A literature search was performed for articles published in electronic database PubMed (includes Medline) and Cochrane for broad keywords: "Clubfoot"; "Ponseti method/technique"; "long term outcomes/results." Studies selected included full-text articles in English language on children less than one year with primary idiopathic clubfoot treated by the Ponseti method with mean ten year follow-up. Non-idiopathic causes or syndromic clubfoot and case reports/review articles/meta-analyses were excluded. The following parameters were included for analysis: number of patients/clubfeet, male/female, mean age at treatment, mean/range of follow-up, relapses, additional surgery, range of motion, various outcome scores, and radiological variables.
    Results: Fourteen studies with 774 patients/1122 feet were included. The male:female ratio was 2.4:1. Mean follow-up recorded in studies was 14.5 years. Relapses occurred in 47% patients with additional surgery being required in 79% patients with relapses. Of these, 86% of surgery were extra-articular while 14% were intra-articular. Plantigrade foot was achieved in majority patients with mean ankle dorsiflexion of 11 degrees. The outcome scores were in general good in contrast to radiological angles which were mostly outside normal range with talar flattening/navicular wedging/degenerative osteoarthritis changes occurring in 60%, 76%, and 30%, respectively.
    Conclusions: Long-term follow-up of infants with primary idiopathic clubfeet treated by the Ponseti method revealed relatively high relapse and additional surgery rates. Radiologically, the various angles were inconsistent compared to normal ranges and anatomical deformations/degenerative changes were present in treated feet. Moreover, the relapse rates and requirement of additional surgery increased on long-term follow-up. Despite this, majority feet were plantigrade and demonstrated good clinical results as measured by various outcome tools. There should be emphasis on long-term follow-up of children with clubfeet in view of late relapses and secondary late changes.
    MeSH term(s) Casts, Surgical ; Child ; Clubfoot/surgery ; Female ; Follow-Up Studies ; Foot ; Humans ; Infant ; Male ; Manipulation, Orthopedic ; Range of Motion, Articular ; Treatment Outcome
    Language English
    Publishing date 2021-08-20
    Publishing country Germany
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 80384-4
    ISSN 1432-5195 ; 0341-2695
    ISSN (online) 1432-5195
    ISSN 0341-2695
    DOI 10.1007/s00264-021-05189-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A pentavalent approach for the evaluation of traumatic brachial plexopathy on MRI: correlation of macropattern and micropattern.

    Singh, Dharmendra Kumar / Kumar, Nishith / Bhayana, Aanchal / Altamash, Mohd / Sharma, Anuradha / Agarwal, Anuj

    The British journal of radiology

    2023  Volume 96, Issue 1146, Page(s) 20220913

    Abstract: Macropattern analysis of traumatic brachial plexopathy (TBP) by Magnetic Resonance Imaging (MRI) encompasses localization of injured segments and determination of the severity of injury. The micropattern analysis implies the correlation of the MRI ... ...

    Abstract Macropattern analysis of traumatic brachial plexopathy (TBP) by Magnetic Resonance Imaging (MRI) encompasses localization of injured segments and determination of the severity of injury. The micropattern analysis implies the correlation of the MRI features of TBP with Sunderland's grading of the nerve injury, thereby guiding the management protocol. This review article presents a simplified novel pentavalent approach for the radiological anatomy of brachial plexus, MRI acquisition protocol for the evaluation of brachial plexus, cardinal imaging signs of TBP, and their correlation with Sunderland's microanatomical grading.
    MeSH term(s) Humans ; Brachial Plexus Neuropathies/diagnostic imaging ; Brachial Plexus Neuropathies/etiology ; Brachial Plexus/diagnostic imaging ; Magnetic Resonance Imaging/methods ; Radiology
    Language English
    Publishing date 2023-03-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2982-8
    ISSN 1748-880X ; 0007-1285
    ISSN (online) 1748-880X
    ISSN 0007-1285
    DOI 10.1259/bjr.20220913
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Dental Services and their Awareness and Utilization among the Health Care Workers in a South Indian District - A Cross Sectional Study.

    Agarwal, Komal / Kolapally, Swetha / Jha, Kunal / Chaturvedi, Mudita / Maini, Anuj P / Varma Datla, Praveen K / Tiwari, Heena D

    Journal of pharmacy & bioallied sciences

    2024  Volume 16, Issue Suppl 1, Page(s) S212–S214

    Abstract: Aim: The present research was carried out to evaluate the amount of usage of dental care opportunities and also to assess the problems faced by health care workers (HCWs) of a south Indian district in using dental services.: Methodology: This study ... ...

    Abstract Aim: The present research was carried out to evaluate the amount of usage of dental care opportunities and also to assess the problems faced by health care workers (HCWs) of a south Indian district in using dental services.
    Methodology: This study had around 500 participants who belonged from various health care sectors who were selected with the help of multistage sampling. The data obtained from this cross-sectional research was analysed statistically using SPSS 22.0.
    Results: It was noticed that around 35% of participants went for a dentist's appointment in past 1 year where male members predominated (45%). One of the commonest reasons for utilizing dental care services was pain as an dental emergency factor (70%). Other reasons were dental caries (18%) restoration, breakage of tooth (10%) and a host of other factors (11%). Around 350 participants felt that going to the dentist was only necessary when there was an emergency (61%).
    Conclusion: The target population less frequently visited the dentist to maintain their teeth as they believed when you have pain, that is the time you go to a dental specialist.
    Language English
    Publishing date 2024-02-29
    Publishing country India
    Document type Journal Article
    ZDB-ID 2573569-X
    ISSN 0975-7406 ; 0976-4879
    ISSN (online) 0975-7406
    ISSN 0976-4879
    DOI 10.4103/jpbs.jpbs_462_23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Selective REM sleep restriction in mice using a device designed for tunable somatosensory stimulation.

    Huffman, Dillon M / Ajwad, Asma'a A / Agarwal, Anuj / Lhamon, Michael E / Donohue, Kevin / O'Hara, Bruce F / Sunderam, Sridhar

    Journal of neuroscience methods

    2024  Volume 404, Page(s) 110063

    Abstract: Background: Sleep perturbation is widely used to investigate the physiological mechanisms that mediate sleep-wake dynamics, and to isolate the specific roles of sleep in health and disease. However, state-of-the-art methods to accomplish sleep ... ...

    Abstract Background: Sleep perturbation is widely used to investigate the physiological mechanisms that mediate sleep-wake dynamics, and to isolate the specific roles of sleep in health and disease. However, state-of-the-art methods to accomplish sleep perturbation in preclinical models are limited in their throughput, flexibility, and specificity.
    New method: A system was developed to deliver vibro-tactile somatosensory stimulation aimed at controlled, selective sleep perturbation. The frequency and intensity of stimulation can be tuned to target a variety of experimental applications, from sudden arousal to sub-threshold transitions between light and deep stages of NREM sleep. This device was activated in closed-loop to selectively interrupt REM sleep in mice.
    Results: Vibro-tactile stimulation effectively and selectively interrupted REM sleep - significantly reducing the average REM bout duration relative to matched, unstimulated baseline recordings. As REM sleep was repeatedly interrupted, homeostatic mechanisms prompted a progressively quicker return to REM sleep. These effects were dependent on the parameters of stimulation applied.
    Comparison with existing methods: Existing sleep perturbation systems often require moving parts within the cage and/or restrictive housing. The system presented is unique in that it interrupts sleep without invading the animal's space. The ability to vary stimulation parameters is a great advantage over existing methods, as it allows for adaptation in response to habituation and/or circadian/homeostatic changes in arousal threshold.
    Conclusions: The proposed method of stimulation demonstrates feasibility in affecting mouse sleep within a standard home cage environment, thus limiting environmental stress. Furthermore, the ability to tune frequency and intensity of stimulation allows for graded control over the extent of sleep perturbation, which potentially expands the utility of this technology beyond applications related to sleep.
    MeSH term(s) Mice ; Animals ; Sleep, REM/physiology ; Sleep/physiology ; Arousal ; Sleep, Slow-Wave ; Homeostasis ; Electroencephalography
    Language English
    Publishing date 2024-01-30
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 282721-9
    ISSN 1872-678X ; 0165-0270
    ISSN (online) 1872-678X
    ISSN 0165-0270
    DOI 10.1016/j.jneumeth.2024.110063
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: LDRGDb - Legumes disease resistance genes database.

    Saxena, Harshita / Kulshreshtha, Aishani / Agarwal, Avinav / Kumar, Anuj / Singh, Nisha / Jain, Chakresh Kumar

    Frontiers in plant science

    2023  Volume 14, Page(s) 1143111

    Abstract: Legumes comprise one of the world's largest, most diverse, and economically important plant families, known for their nutritional and medicinal benefits. Legumes are susceptible to a wide range of diseases, similar to other agricultural crops. Diseases ... ...

    Abstract Legumes comprise one of the world's largest, most diverse, and economically important plant families, known for their nutritional and medicinal benefits. Legumes are susceptible to a wide range of diseases, similar to other agricultural crops. Diseases have a considerable impact on the production of legume crop species, resulting in large yield losses worldwide. Due to continuous interactions between plants and their pathogens in the environment and the evolution of new pathogens under high selection pressure; disease resistant genes emerge in plant cultivars in the field against those pathogens or disease. Thus, disease resistant genes play critical roles in plant resistance responses, and their discovery and subsequent use in breeding programmes aid in reducing yield loss. The genomic era, with its high-throughput and low-cost genomic tools, has revolutionised our understanding of the complex interactions between legumes and pathogens, resulting in the identification of several critical participants in both the resistant and susceptible relationships. However, a substantial amount of existing information about numerous legume species has been disseminated as text or is preserved across fractions in different databases, posing a challenge for researchers. As a result, the range, scope, and complexity of these resources pose challenges to those who manage and use them. Therefore, there is an urgent need to develop tools and a single conjugate database to manage genetic information for the world's plant genetic resources, allowing for the rapid incorporation of essential resistance genes into breeding strategies. Here, developed the first comprehensive database of disease resistance genes named as LDRGDb - LEGUMES DISEASE RESISTANCE GENES DATABASE comprises 10 legumes [Pigeon pea (
    Language English
    Publishing date 2023-04-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2023.1143111
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Single-triangle technique for congenital ptosis repair with a frontalis sling in blepharophimosis patients.

    Mehta, Anuj / Naik, Mayuresh / Agarwal, Siddharth

    Taiwan journal of ophthalmology

    2021  Volume 12, Issue 1, Page(s) 82–87

    Abstract: The purpose of this study was to describe the single-triangle technique for congenital ptosis repair with a frontalis sling in blepharophimosis patients. The single-triangle technique was used in 40 eyes of 20 patients of blepharophimosis syndrome. The ... ...

    Abstract The purpose of this study was to describe the single-triangle technique for congenital ptosis repair with a frontalis sling in blepharophimosis patients. The single-triangle technique was used in 40 eyes of 20 patients of blepharophimosis syndrome. The center point of the lid is marked. The desired base length is calculated depending on the available horizontal fissure width. Two marks are inked 2 mm above the lid margin, equidistant from the central mark. A single brow mark is placed in such a way that it is directly above the center point of the lid. These are now joined to complete the triangle. In blepharophimosis patients, the mean preoperative margin reflex distance (MRD1) was 1.0 ± 1.1 mm which increased to 4.1 ± 1.6 mm after surgery. The MRD1 increased by 3.1 ± 1.7 mm. Cosmetic outcome was graded with a score of 0, 1, or 2 to indicate poor, good, and excellent results, respectively. Out of the 40 eyes that were operated, 33 eyes had a score of 2, 5 eyes had a score of 1, and 2 eyes were scored 0. The single-triangle technique has several advantages over both the Fox pentagon technique and modified Crawford technique in severe blepharophimosis patients. It is not only a much simpler procedure to perform but also has a better control over the curvature of the lid without any central focal notching, thus providing better cosmesis and esthetic results.
    Language English
    Publishing date 2021-04-17
    Publishing country India
    Document type Journal Article
    ZDB-ID 2652841-1
    ISSN 2211-5072 ; 2211-5072
    ISSN (online) 2211-5072
    ISSN 2211-5072
    DOI 10.4103/tjo.tjo_6_21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Relapses in clubfoot treated with Ponseti technique and standard bracing protocol- a systematic analysis.

    Agarwal, Anil / Rastogi, Anuj / Rastogi, Prateek

    Journal of clinical orthopaedics and trauma

    2021  Volume 18, Page(s) 199–204

    Abstract: Purpose: The analysis determined the relapses in clubfoot children treated with Ponseti technique and standard bracing protocol and their correlation with overall follow up duration using pooled data from various series. It also tested the prescribed ... ...

    Abstract Purpose: The analysis determined the relapses in clubfoot children treated with Ponseti technique and standard bracing protocol and their correlation with overall follow up duration using pooled data from various series. It also tested the prescribed timelines of 5 and 7 years for slow-down/cessation of relapses in clubfoot children.
    Methods: A systematic literature search was performed for articles published in "Pubmed (includes Medline indexed journals)" electronic databases using key words: "Clubfoot or CTEV or congenital talipes equinovarus", "Ponseti" for years 1
    Results: There were total 2206 patients in the included 24 studies. Average follow up was 6 years. The average relapse rates for clubfoot patients in the pooled data stood at 30%. The overall relapse rates increased with a longer follow up and the curve befitted a linear regression equation with weak positive correlation (Pearson correlation coefficient = 0.08). The relapse rates in follow up categories of <5 years (26.6 ± 15.6%), 5-7 years (30.8 ± 16.3%) and >7 years (28.4 ± 6.2%) were similar statistically (Analysis of variance, ANOVA).
    Conclusions: Approximately 1 in 3 clubfoot patients suffer relapse post Ponseti technique and standard bracing protocol. A weak positive correlation was observed for relapses when correlated with increasing follow up years. The relapses however tend to slow down after initial growth years. There is a need to educate the care receivers regarding the possibility of late relapses despite proper Ponseti treatment and accordingly to keep them under supervised follow up for longer periods.
    Language English
    Publishing date 2021-05-02
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 2596956-0
    ISSN 2213-3445 ; 0976-5662
    ISSN (online) 2213-3445
    ISSN 0976-5662
    DOI 10.1016/j.jcot.2021.04.029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Comparison Between a Single Subpedicular Transforaminal Epidural Steroid Injection and Lateral Recess Steroid Injection in Reducing Paracentral Disc Herniation-Related Chronic Neuropathic Leg Pain: A Retrospective Study.

    Jain, Anuj / Agarwal, Amit / Jain, Suruchi / Waindeskar, Vaishali

    World neurosurgery

    2021  Volume 149, Page(s) e392–e399

    Abstract: Background: This retrospective study compares the results of 2 different techniques of transforaminal epidural steroid injection (TFESI)-subpedicular (SP-TFESI) and lateral recess epidural steroid injection (LRSI) in relieving chronic lumbar radicular ... ...

    Abstract Background: This retrospective study compares the results of 2 different techniques of transforaminal epidural steroid injection (TFESI)-subpedicular (SP-TFESI) and lateral recess epidural steroid injection (LRSI) in relieving chronic lumbar radicular pain.
    Methods: Records of 97 patients who had undergone injection for unilateral lumbar radicular pain and had a paracentral disc were analyzed. Numerical rating scale (NRS) and Oswestry Disability Index (ODI) scores were measured at baseline and at 2, 4, 12, and 24 weeks thereafter.
    Results: At 24 weeks, the NRS was significantly lower than the baseline in both groups; NRS in the LRSI group was significantly lower than NRS in the SP-TFESI group at 12 and 24 weeks (P = 0.02 each). ODI score was also significantly lower in the LRSI group through the 12-week time point (P = 0.003 at 2 weeks; P = 0.009 at 4 weeks; P = 0.02 at 12 weeks). At the end of 24 weeks, a significantly greater number of patients in the LRSI group achieved minimal clinically important difference for NRS and ODI (P = 0.008 and 0.016, respectively).
    Conclusions: At the end of 24 weeks, LRSI appears to be a superior technique in relieving unilateral lumbar radicular pain due to a paracentral disc.
    MeSH term(s) Adult ; Chronic Pain/drug therapy ; Chronic Pain/etiology ; Dexamethasone/administration & dosage ; Female ; Glucocorticoids/administration & dosage ; Humans ; Injections, Epidural/methods ; Intervertebral Disc Displacement/complications ; Lumbar Vertebrae ; Male ; Middle Aged ; Neuralgia/drug therapy ; Neuralgia/etiology ; Pain Measurement ; Radiculopathy/drug therapy ; Radiculopathy/etiology ; Retrospective Studies
    Chemical Substances Glucocorticoids ; Dexamethasone (7S5I7G3JQL)
    Language English
    Publishing date 2021-02-09
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2021.02.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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