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  1. Article ; Online: Human-to-Animal Transmission of SARS-CoV-2, South Korea, 2021

    Jinsun Bae / Changseek Ro / Yunhee Kang / Eulhae Ga / Woonsung Na / Daesub Song

    Emerging Infectious Diseases, Vol 29, Iss 5, Pp 1066-

    2023  Volume 1067

    Abstract: To investigate SARS-CoV-2 transmission from humans to animals in Seoul, South Korea, we submitted samples from companion animals owned by persons with confirmed COVID-19. Real-time PCR indicated higher SARS-CoV-2 viral infection rates for dogs and cats ... ...

    Abstract To investigate SARS-CoV-2 transmission from humans to animals in Seoul, South Korea, we submitted samples from companion animals owned by persons with confirmed COVID-19. Real-time PCR indicated higher SARS-CoV-2 viral infection rates for dogs and cats than previously reported from the United States and Europe. Host-specific adaptations could introduce mutant SARS-CoV-2 to humans.
    Keywords COVID-19 ; 2019 novel coronavirus disease ; coronavirus disease ; severe acute respiratory syndrome coronavirus 2 ; SARS-CoV-2 ; viruses ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher Centers for Disease Control and Prevention
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Human-to-Animal Transmission of SARS-CoV-2, South Korea, 2021.

    Bae, Jinsun / Ro, Changseek / Kang, Yunhee / Ga, Eulhae / Na, Woonsung / Song, Daesub

    Emerging infectious diseases

    2023  Volume 29, Issue 5, Page(s) 1066–1067

    Abstract: To investigate SARS-CoV-2 transmission from humans to animals in Seoul, South Korea, we submitted samples from companion animals owned by persons with confirmed COVID-19. Real-time PCR indicated higher SARS-CoV-2 viral infection rates for dogs and cats ... ...

    Abstract To investigate SARS-CoV-2 transmission from humans to animals in Seoul, South Korea, we submitted samples from companion animals owned by persons with confirmed COVID-19. Real-time PCR indicated higher SARS-CoV-2 viral infection rates for dogs and cats than previously reported from the United States and Europe. Host-specific adaptations could introduce mutant SARS-CoV-2 to humans.
    MeSH term(s) Animals ; Cats ; Dogs ; Humans ; Cat Diseases/epidemiology ; COVID-19/veterinary ; Dog Diseases/epidemiology ; Republic of Korea/epidemiology ; SARS-CoV-2/genetics ; Respiratory Tract Infections
    Language English
    Publishing date 2023-04-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/eid2905.221359
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4778: Show issues Location:
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  3. Article ; Online: Self-Assembled Nanostructures Presenting Repetitive Arrays of Subunit Antigens for Enhanced Immune Response.

    Park, Geunseon / Na, Woonsung / Lim, Jong-Woo / Park, Chaewon / Lee, Sojeong / Yeom, Minjoo / Ga, Eulhae / Hwang, Jaehyun / Moon, Suyun / Jeong, Dae Gwin / Jeong, Hyoung Hwa / Song, Daesub / Haam, Seungjoo

    ACS nano

    2024  Volume 18, Issue 6, Page(s) 4847–4861

    Abstract: Infectious diseases pose persistent threats to public health, demanding advanced vaccine technologies. Nanomaterial-based delivery systems offer promising solutions to enhance immunogenicity while minimizing reactogenicity. We introduce a self-assembled ... ...

    Abstract Infectious diseases pose persistent threats to public health, demanding advanced vaccine technologies. Nanomaterial-based delivery systems offer promising solutions to enhance immunogenicity while minimizing reactogenicity. We introduce a self-assembled vaccine (SAV) platform employing antigen-polymer conjugates designed to facilitate robust immune responses. The SAVs exhibit efficient cellular uptake by dendritic cells (DCs) and macrophages, which are crucial players in the innate immune system. The high-density antigen presentation of this SAV platform enhances the affinity for DCs through multivalent recognition, significantly augmenting humoral immunity. SAV induced high levels of immunoglobulin G (IgG), IgG1, and IgG2a, suggesting that mature DCs efficiently induced B cell activation through multivalent antigen recognition. Universality was confirmed by applying it to respiratory viruses, showcasing its potential as a versatile vaccine platform. Furthermore, we have also demonstrated strong protection against influenza A virus infection with SAV containing hemagglutinin, which is used in influenza A virus subunit vaccines. The efficacy and adaptability of this nanostructured vaccine present potential utility in combating infectious diseases.
    MeSH term(s) Humans ; Influenza Vaccines ; Antigens ; Immunity, Humoral ; Immunoglobulin G ; Influenza A virus ; Nanostructures ; Communicable Diseases ; Antibodies, Viral ; Adjuvants, Immunologic
    Chemical Substances Influenza Vaccines ; Antigens ; Immunoglobulin G ; Antibodies, Viral ; Adjuvants, Immunologic
    Language English
    Publishing date 2024-01-08
    Publishing country United States
    Document type Journal Article
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.3c09672
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Assessment of the immune interference effects of multivalent vaccine for influenza epidemic strain in 2022-2023 and evaluation of its efficacy.

    Ga, Eulhae / Kang, Jung-Ah / Hwang, Jaehyun / Moon, Suyun / Choi, Jaeseok / Bae, Eunseo / Seol, Hyein / Mun, Yubin / Song, Daesub / Jeong, Dae Gwin / Na, Woonsung

    Heliyon

    2024  Volume 10, Issue 6, Page(s) e28326

    Abstract: The various strains of influenza virus cause respiratory symptoms in humans every year and annual vaccinations are recommended. Due to its RNA-type genes and segmented state, it belongs to a virus that mutates frequently with antigenic drift and shift, ... ...

    Abstract The various strains of influenza virus cause respiratory symptoms in humans every year and annual vaccinations are recommended. Due to its RNA-type genes and segmented state, it belongs to a virus that mutates frequently with antigenic drift and shift, giving rise to various strains. Each year, the World Health Organization identifies the epidemic strains and operates a global surveillance system to suggest the viral composition for the influenza vaccine. Influenza viruses, which have multiple viral strains, are produced in the format of multivalent vaccine. However, the multivalent vaccine has a possibility of causing immune interference by introducing multiple strain-specific antigens in a single injection. Therefore, evaluating immune interference phenomena is essential when assessing multivalent vaccines. In this study, the protective ability and immunogenicity of multivalent and monovalent vaccines were evaluated in mice to assess immune interference in the multivalent vaccine. Monovalent and multivalent vaccines were manufactured using the latest strain of the 2022-2023 seasonal influenza virus selected by the World Health Organization. The protective abilities of both types of vaccines were tested through hemagglutination inhibition test. The immunogenicity of multivalent and monovalent vaccines were tested through enzyme-linked immunosorbent assay to measure the cellular and humoral immunity expression rates. As a result of the protective ability and immunogenicity test, higher level of virus neutralizing ability and greater amount of antibodies in both IgG1 and IgG2 were confirmed in the multivalent vaccine. No immune interference was found to affect the protective capacity and immune responses of the multivalent vaccines.
    Language English
    Publishing date 2024-03-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e28326
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A COVID-19 Vaccine for Dogs Prevents Reverse Zoonosis

    Eulhae Ga / Yongkwan Won / Jaehyun Hwang / Suyun Moon / Minju Yeom / Kwangsoo Lyoo / Daesub Song / Jeonghee Han / Woonsung Na

    Vaccines, Vol 10, Iss 676, p

    2022  Volume 676

    Abstract: COVID-19 is caused by severe acute respiratory syndrome virus type 2 (SARS-CoV-2), which can infect both humans and animals. SARS-CoV-2 originated from bats and can affect various species capable of crossing the species barrier due to active mutation. ... ...

    Abstract COVID-19 is caused by severe acute respiratory syndrome virus type 2 (SARS-CoV-2), which can infect both humans and animals. SARS-CoV-2 originated from bats and can affect various species capable of crossing the species barrier due to active mutation. Although reports on reverse zoonosis (human-to-animal transmission) of SARS-CoV-2 remain limited, reverse zoonosis has been reported in many species such as cats, tigers, minks, etc. Therefore, transmission to more animals cannot be ruled out. Moreover, the wide distribution of SARS-CoV-2 in the human population could result in an increased risk of reverse zoonosis. To counteract reverse zoonosis, we developed the first COVID-19 subunit vaccines for dogs, which are representative companion animals, and the vaccine includes the SARS-CoV-2 recombinant protein of whole S1 protein and the receptor-binding domain (RBD). A subunit vaccine is a vaccine developed by purifying only the protein region that induces an immune response instead of the whole pathogen. This type of vaccine is safer than the whole virus vaccine because there is no risk of infection and proliferation through back-mutation of the virus. Vaccines were administered to beagles twice at an interval of 3 weeks subcutaneously and antibody formation rates were assessed in serum. We identified a titer, comparable to that of vaccinated people, shown to be sufficient to protect against SARS-CoV-2. Therefore, the vaccination of companion animals, such as dogs, may prevent reverse zoonosis by protecting animals from SARS-CoV-2; thus, reverse zoonosis of COVID-19 is preventable.
    Keywords SARS-CoV-2 ; COVID-19 ; Coronavirus ; vaccine ; subunit vaccine ; canine ; Medicine ; R
    Subject code 630
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: A COVID-19 Vaccine for Dogs Prevents Reverse Zoonosis.

    Ga, Eulhae / Won, Yongkwan / Hwang, Jaehyun / Moon, Suyun / Yeom, Minju / Lyoo, Kwangsoo / Song, Daesub / Han, Jeonghee / Na, Woonsung

    Vaccines

    2022  Volume 10, Issue 5

    Abstract: COVID-19 is caused by severe acute respiratory syndrome virus type 2 (SARS-CoV-2), which can infect both humans and animals. SARS-CoV-2 originated from bats and can affect various species capable of crossing the species barrier due to active mutation. ... ...

    Abstract COVID-19 is caused by severe acute respiratory syndrome virus type 2 (SARS-CoV-2), which can infect both humans and animals. SARS-CoV-2 originated from bats and can affect various species capable of crossing the species barrier due to active mutation. Although reports on reverse zoonosis (human-to-animal transmission) of SARS-CoV-2 remain limited, reverse zoonosis has been reported in many species such as cats, tigers, minks, etc. Therefore, transmission to more animals cannot be ruled out. Moreover, the wide distribution of SARS-CoV-2 in the human population could result in an increased risk of reverse zoonosis. To counteract reverse zoonosis, we developed the first COVID-19 subunit vaccines for dogs, which are representative companion animals, and the vaccine includes the SARS-CoV-2 recombinant protein of whole S1 protein and the receptor-binding domain (RBD). A subunit vaccine is a vaccine developed by purifying only the protein region that induces an immune response instead of the whole pathogen. This type of vaccine is safer than the whole virus vaccine because there is no risk of infection and proliferation through back-mutation of the virus. Vaccines were administered to beagles twice at an interval of 3 weeks subcutaneously and antibody formation rates were assessed in serum. We identified a titer, comparable to that of vaccinated people, shown to be sufficient to protect against SARS-CoV-2. Therefore, the vaccination of companion animals, such as dogs, may prevent reverse zoonosis by protecting animals from SARS-CoV-2; thus, reverse zoonosis of COVID-19 is preventable.
    Language English
    Publishing date 2022-04-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines10050676
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Intranasal immunization with the recombinant measles virus encoding the spike protein of SARS-CoV-2 confers protective immunity against COVID-19 in hamsters.

    Park, Sang-In / Park, Sohyun / Lee, Kunse / Kwak, Hye Won / Kim, Yong Kwan / Park, Hyeong-Jun / Bang, Yoo-Jin / Kim, Jae-Yong / Kim, Daegeun / Seo, Ki-Weon / Lee, Su Jeen / Kim, Hun / Kim, Yeonhwa / Kim, Do-Hyung / Park, Hyo-Jung / Jung, Seo-Yeon / Ga, Eulhae / Hwang, Jaehyun / Na, Woonsung /
    Hong, So-Hee / Lee, Sang-Myeong / Nam, Jae-Hwan

    Vaccine

    2023  Volume 42, Issue 2, Page(s) 69–74

    Abstract: Background: As the nasal mucosa is the initial site of infection for COVID-19, intranasal vaccines are more favorable than conventional vaccines. In recent clinical studies, intranasal immunization has been shown to generate higher neutralizing ... ...

    Abstract Background: As the nasal mucosa is the initial site of infection for COVID-19, intranasal vaccines are more favorable than conventional vaccines. In recent clinical studies, intranasal immunization has been shown to generate higher neutralizing antibodies; however, there is a lack of evidence on sterilizing immunity in the upper airway. Previously, we developed a recombinant measles virus encoding the spike protein of SARS-CoV-2 (rMeV-S), eliciting humoral and cellular immune responses against SARS-CoV-2.
    Objectives: In this study, we aim to provide an experiment on nasal vaccines focusing on a measles virus platform as well as injection routes.
    Study design: Recombinant measles viruses expressing rMeV-S were prepared, and 5 × 10
    Results: The intranasal immunization of rMeV-S elicits protective immune responses and alleviates virus-induced pathophysiology, such as body weight reduction and lung weight increase in hamsters. Furthermore, lung immunohistochemistry demonstrated that intranasal rMeV-S immunization induces effective SARS-CoV-2 clearance that correlates with viral RNA content, as determined by qRT-PCR, in the lung and nasal wash samples, SARS-CoV-2 viral titers in lung, nasal wash, BALF samples, serum RBD-specific IgG concentration, and RBD-specific IgA concentration in the BALF.
    Conclusion: An intranasal vaccine based on the measles virus platform is a promising strategy owing to the typical route of infection of the virus, the ease of administration of the vaccine, and the strong immune response it elicits.
    MeSH term(s) Animals ; Cricetinae ; SARS-CoV-2 ; Measles virus/genetics ; COVID-19/prevention & control ; Spike Glycoprotein, Coronavirus ; Immunization ; Measles ; Orthopoxvirus ; Nasal Mucosa ; Antibodies, Neutralizing ; Vaccines ; Immunoglobulin A ; Immunoglobulin G ; Antibodies, Viral ; Administration, Intranasal
    Chemical Substances spike protein, SARS-CoV-2 ; Spike Glycoprotein, Coronavirus ; Antibodies, Neutralizing ; Vaccines ; Immunoglobulin A ; Immunoglobulin G ; Antibodies, Viral
    Language English
    Publishing date 2023-12-14
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2023.12.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 458: Show issues

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