Article ; Online: Association between sleep apnea and ultrasound-defined liver fibrosis: Results from NHANES 2017 to 2020.
2024 Volume 103, Issue 17, Page(s) e37949
Abstract: Liver fibrosis is a critical factor in the advancement of nonalcoholic fatty liver disease towards cirrhosis. There is limited research exploring the association between obstructive sleep apnea (OSA) and liver fibrosis among community populations. The ... ...
Abstract | Liver fibrosis is a critical factor in the advancement of nonalcoholic fatty liver disease towards cirrhosis. There is limited research exploring the association between obstructive sleep apnea (OSA) and liver fibrosis among community populations. The present study aimed to assess the association between sleep apnea (SA) and liver fibrosis based on the National Health and Nutrition Examination Survey (NHANES). Data were acquired from NHANES survey cycle 2017 to 2020. We assessed liver fibrosis by the median values of liver stiffness measurement (LSM). The diagnosis of SA was based on participants' response to sleep questionnaire. Univariate and multivariate logistic regression were used to validate the association of SA and liver fibrosis. A total of 7615 participants were included in this study. The LSM level of SA group was significantly higher than non-SA group. The proportion of liver fibrosis in SA group was markedly higher than that in non-SA group (14.0% vs 7.3%, P < .001). Univariate logistic analysis showed that SA was positively associated with liver fibrosis (OR = 2.068, 95%CI = 1.715-2.494, P < .001). Further multivariate logistic analysis revealed that SA was independently associated with increased risk of liver fibrosis after adjusting for confounding factors (OR = 1.277, 95%CI = 1.003-1.625, P = .048). The current study demonstrated an independent association between self-reported SA and increased risk of ultrasound-defined liver fibrosis in community-based sample. |
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MeSH term(s) | Humans ; Male ; Female ; Liver Cirrhosis/epidemiology ; Liver Cirrhosis/diagnostic imaging ; Liver Cirrhosis/complications ; Middle Aged ; Nutrition Surveys ; Ultrasonography ; Adult ; Sleep Apnea Syndromes/epidemiology ; Risk Factors ; Cross-Sectional Studies ; Aged ; Sleep Apnea, Obstructive/epidemiology ; Sleep Apnea, Obstructive/complications |
Language | English |
Publishing date | 2024-04-26 |
Publishing country | United States |
Document type | Journal Article |
ZDB-ID | 80184-7 |
ISSN | 1536-5964 ; 0025-7974 |
ISSN (online) | 1536-5964 |
ISSN | 0025-7974 |
DOI | 10.1097/MD.0000000000037949 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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