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Article ; Online: Efficacy of a gluten-restricted diet in treatment-resistant schizophrenia patients with immunological gluten sensitivity: A case report.

Motoyama, Mikuni / Yamada, Hisashi / Maebayashi, Kensei / Yoshimura, Chiho / Matsunaga, Hisato

2022 Volume 241, Page(s) 68–69

MeSH term(s)	Celiac Disease ; Diet ; Diet, Gluten-Free ; Glutens ; Humans ; Schizophrenia/complications ; Schizophrenia, Treatment-Resistant
Chemical Substances	Glutens (8002-80-0)
Language	English
Publishing date	2022-01-25
Publishing country	Netherlands
Document type	Case Reports ; Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	639422-x
ISSN	1573-2509 ; 0920-9964
ISSN (online)	1573-2509
ISSN	0920-9964
DOI	10.1016/j.schres.2022.01.015
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Article ; Online: Mitral Valve Replacement for Enlarged Libman-Sacks Endocarditis in a Patient with Persistent Primary Antiphospholipid Syndrome and Recurrent Stroke: A Case Report.

Takeuchi, Katsuya / Izumi, Tesseki / Nanaura, Hitoki / Yamada, Nanami / Hayata, Yoshihiro / Obayashi, Chiho / Sugie, Kazuma

The American journal of case reports

2023 Volume 24, Page(s) e938930

Abstract: BACKGROUND Anticardiolipin antibodies in patients with Libman-Sacks endocarditis (LS) are indicative of comorbid antiphospholipid syndrome (APS) and can result in cerebral infarctions. We describe a case of LS and primary APS with recurrent cerebral ... ...

Abstract	BACKGROUND Anticardiolipin antibodies in patients with Libman-Sacks endocarditis (LS) are indicative of comorbid antiphospholipid syndrome (APS) and can result in cerebral infarctions. We describe a case of LS and primary APS with recurrent cerebral infarctions despite anticoagulation treatment. The patient underwent surgery for enlarged LS vegetation with high titers of antiphospholipid antibodies. CASE REPORT A 41-year-old Japanese man was admitted to hospital for small cerebral infarction recurrence in a left parietal lesion. At age 35, the patient had suffered multiple cerebral infarctions. He was found to have high serum titers of all 3 antiphospholipid antibodies. Transesophageal echocardiography (TEE) findings were normal. Differential diagnosis ruled out other autoimmune diseases and a clinical diagnosis of primary APS was made. Warfarin anticoagulation was started. When cerebral infarction recurred 6 years after the first episode, serum titers of antiphospholipid antibodies remained high, and TEE showed a 7×8 mm area of mitral vegetation. A TEE results from his first admission revealed a 5×6 mm area of mitral vegetation, which was believed to be related to the current vegetation. As anticoagulation produced no improvement, the mitral valve was replaced with a mechanical valve. Examination of the excised vegetation found it to be consistent with LS. The patient made good progress within 3 years after surgery. CONCLUSIONS LS size can increase despite anticoagulation in cases with high titers of all 3 antiphospholipid antibodies and cerebral infarction. Such patients require ongoing TEE follow-up and surgical treatment should be considered.
MeSH term(s)	Male ; Humans ; Adult ; Mitral Valve/diagnostic imaging ; Mitral Valve/surgery ; Antiphospholipid Syndrome/complications ; Antiphospholipid Syndrome/diagnosis ; Endocarditis/complications ; Endocarditis/surgery ; Endocarditis/diagnosis ; Lupus Erythematosus, Systemic/complications ; Antibodies, Antiphospholipid ; Cerebral Infarction/etiology ; Anticoagulants/therapeutic use
Chemical Substances	Antibodies, Antiphospholipid ; Anticoagulants
Language	English
Publishing date	2023-02-06
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2517183-5
ISSN	1941-5923 ; 1941-5923
ISSN (online)	1941-5923
ISSN	1941-5923
DOI	10.12659/AJCR.938930
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Article ; Online: New aspects of clinical and immunological characteristics in patients with anti-asparaginyl tRNA synthetase (anti-KS) autoantibody.

Hosono, Yuji / Ishii, Akira / Izumi, Yuto / Sasaki, Noriko / Nogi, Shinichi / Yamada, Chiho / Sato, Shinji

Modern rheumatology

2023 Volume 34, Issue 1, Page(s) 122–128

Abstract: Objectives: Anti-asparaginyl tRNA synthetase (anti-KS) antibody is present in patients with interstitial lung disease (ILD) accompanied by polymyositis/dermatomyositis. We examined clinical/immunological features of these patients.: Methods: ... ...

Abstract	Objectives: Anti-asparaginyl tRNA synthetase (anti-KS) antibody is present in patients with interstitial lung disease (ILD) accompanied by polymyositis/dermatomyositis. We examined clinical/immunological features of these patients. Methods: Polymyositis/dermatomyositis or ILD patients were screened for autoantibodies, and clinical/immunological data were collected retrospectively. ILD was diagnosed by computed tomography, and clinical/immunological features of anti-KS-positive patients were compared with those of anti-Jo-1-positive patients. Results: Sixteen anti-KS-positive patients [female = 11; male = 5; average age 63.6 years (range, 40-81) years] were diagnosed: seven had ILD, four had clinically amyopathic DM (CADM) and ILD, three had Sjögren's syndrome (SS) and ILD one each had rheumatoid arthritis and ILD, or CADM/SS overlap and ILD. All patients had ILD with chronic onset and clinical course; 11/16 (69%) had nonspecific interstitial pneumonia, and five (31%) had usual interstitial pneumonia pattern. Regarding skin manifestations, 4 (27%) had typical DM rash and 11 (69%) had mechanic's hands. All anti-KS-positive patients had no clinical muscle weakness or serum creatine kinase elevation; 8/16 patients (50%) had sicca symptoms at a significantly high frequency compared with anti-Jo-1-positive patients (50% vs 11%, P = 0.01). Conclusions: Anti-KS-positive patients might form a distinguishable subset closely associated with sicca symptoms, CADM and chronic-type ILD with a relatively favourable prognosis.
MeSH term(s)	Humans ; Male ; Female ; Middle Aged ; Dermatomyositis ; Retrospective Studies ; Autoantibodies ; Lung Diseases, Interstitial/complications ; Prognosis ; Sjogren's Syndrome/complications ; Sjogren's Syndrome/diagnosis
Chemical Substances	Autoantibodies
Language	English
Publishing date	2023-12-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2078157-X
ISSN	1439-7609 ; 1439-7595
ISSN (online)	1439-7609
ISSN	1439-7595
DOI	10.1093/mr/road011
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Article ; Online: Changes in the levels of α-actinin-4 in differentiating human myeloid leukemia cells induced by retinoic acid.

Saito, Daisuke / Imai, Masahiko / Yamada, Chiho / Takahashi, Noriko

Biochimica et biophysica acta. Molecular cell research

2021 Volume 1868, Issue 6, Page(s) 118968

Abstract: Retinoic acid (RA) induces granulocytic differentiation and inhibits the growth of human promyelocytic leukemia HL60 cells. α-Actinin-4 is a member of the α-actinin family, which exhibits unique mechanosensory regulation. Herein, we elucidated the ... ...

Abstract	Retinoic acid (RA) induces granulocytic differentiation and inhibits the growth of human promyelocytic leukemia HL60 cells. α-Actinin-4 is a member of the α-actinin family, which exhibits unique mechanosensory regulation. Herein, we elucidated the effects of RA on α-actinin-4 expression during cell differentiation. RA increased the levels of α-actinin-4 protein significantly, while mRNA expression remained unchanged. In addition, RA treatment altered the intracellular localization of α-actinin-4 from the nucleus to the cytoplasm. Cells pretreated with RA, maintained α-actinin-4 protein levels after cycloheximide treatment as compared with control cells. The amount of ubiquitylated α-actinin-4 protein in RA-treated cells was less than in control cells. These results indicate that RA may inhibit nuclei transport and proteasomal degradation of α-actinin-4 protein. α-Actinin-4 may play a significant role in RA-induced differentiation, including the promotion of cytomorphology changes.
MeSH term(s)	Actinin/genetics ; Actinin/metabolism ; Cell Differentiation/drug effects ; Cell Line, Tumor ; Cell Nucleus/metabolism ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cycloheximide/pharmacology ; Cytoplasm/metabolism ; Gene Expression Regulation, Neoplastic/drug effects ; HL-60 Cells ; Humans ; Leukemia, Promyelocytic, Acute/drug therapy ; Leukemia, Promyelocytic, Acute/genetics ; Leukemia, Promyelocytic, Acute/metabolism ; Proteolysis ; Tretinoin/pharmacology ; Ubiquitination ; Up-Regulation
Chemical Substances	ACTN4 protein, human ; Actinin (11003-00-2) ; Tretinoin (5688UTC01R) ; Cycloheximide (98600C0908)
Language	English
Publishing date	2021-01-14
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	60-7
ISSN	1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
ISSN (online)	1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
ISSN	0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
DOI	10.1016/j.bbamcr.2021.118968
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Article ; Online: Home-based resistance training performed at either fast or slow speeds improves power output in older adults.

Hirata, Kosuke / Ito, Mari / Nomura, Yuta / Kawashima, Chiho / Yoshida, Tsukasa / Yamada, Yosuke / Tillin, Neale A / Power, Geoffrey A / Akagi, Ryota

Experimental gerontology

2024 Volume 190, Page(s) 112430

Abstract: Purpose: We investigated the effect of an unsupervised, body mass- home-based resistance training program in older adults performed at either a fast or slow contractile speed on changes to muscle-power, -volume, -architecture, and fatigue resistance of ... ...

Abstract	Purpose: We investigated the effect of an unsupervised, body mass- home-based resistance training program in older adults performed at either a fast or slow contractile speed on changes to muscle-power, -volume, -architecture, and fatigue resistance of the knee extensors. Methods: Thirty-two male older adults (age 65-88 years) were separated into 1) fast-speed exercise (Fast-group), 2) slow-speed exercise (Slow-group), and 3) no exercise (Control-group) groups. Participants in the exercise groups performed 30-45 repetitions of knee-extension and sit-to-stand exercises 3 times a week for 8 weeks with different exercise speed between the groups. Before and after the intervention period, the following variables were measured: Isotonic power, isometric strength, twitch contractile properties, muscle-activity, -architecture, and -quality, neuromuscular fatigue resistance of the knee extensors, and thigh muscle volume. Results: Peak power was increased in both the Fast-group (+24 %, P < 0.01, d = 0.65) and Slow-group (+12 %, P < 0.05, d = 0.33) but not in the Control-group. Training increased pennation angle of the vastus lateralis in both the Fast-group (+8 %, P < 0.01, d = 0.42) and Slow-group (+8 %, P < 0.01, d = 0.42), while only the Fast-group showed increase in pennation angle of the rectus femoris (+12 %, P < 0.01, d = 0.64) and thigh muscle volume (+16 %, P < 0.01, d = 0.52). There was no time × group interaction effect for the other neuromuscular measures. Conclusions: Unsupervised, body mass- and home-based resistance training performed at either fast or slow speeds can improve muscle power in older adults, while fast-speed exercise may be preferable over slow-speed owing to the relatively greater improvement of muscle-power, -volume, -architecture, and better time efficiency.
Language	English
Publishing date	2024-04-13
Publishing country	England
Document type	Journal Article
ZDB-ID	390992-x
ISSN	1873-6815 ; 0531-5565
ISSN (online)	1873-6815
ISSN	0531-5565
DOI	10.1016/j.exger.2024.112430
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Article ; Online: Detection and characterization of Hyaloklossia kasumiensis (Apicomplexa: Sarcocystidae) from Nagoya Daruma pond frog, Pelophylax porosus brevipodus.

Tokiwa, Toshihiro / Kezuka, Chiho / Yamada, Shoto / Chou, Shyun / Nakamura, Shin-Ichi

Parasitology international

2022 Volume 90, Page(s) 102614

Abstract: The Nagoya Daruma pond frog (Pelophylax porosus brevipodus) is an endangered anuran species endemic to the semi-aquatic environment of Japan. On June 11, 2021, four of the six Nagoya Daruma pond frogs captured from the wild and kept in an aquarium died ... ...

Abstract	The Nagoya Daruma pond frog (Pelophylax porosus brevipodus) is an endangered anuran species endemic to the semi-aquatic environment of Japan. On June 11, 2021, four of the six Nagoya Daruma pond frogs captured from the wild and kept in an aquarium died in rapid succession. Pathological and/or parasitological examinations of two of the four carcasses revealed protozoan infection in their kidneys. The pathogen identified as Hyaloklossia kasumiensis (Apicomplexa: Sarcocystidae: Hyaloklossiinae) based on their morphological and molecular characterization. This is a new host record of H. kasumiensis. Mitochondrial cox1 sequence analysis suggest that the present species detected from Nagoya Daruma pond frog belongs to the same lineage as those found in the Tokyo Daruma pond frog (P. p. porosus) from Ibaraki Prefecture, Japan. This particular lineage may be prevalent among Pelophylax porosus ssp. distributed in Japan.
MeSH term(s)	Animals ; Anura ; Japan ; Ponds ; Ranidae ; Sarcocystidae
Language	English
Publishing date	2022-06-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1363151-2
ISSN	1873-0329 ; 1383-5769
ISSN (online)	1873-0329
ISSN	1383-5769
DOI	10.1016/j.parint.2022.102614
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Article ; Online: Temperature and time after urine collection affect the detection of phenethylamine, a substance prohibited in sports.

Nara, Akina / Nakajima, Rie / Yamada, Chiho / Suyama, Manami / Kozakai, Yu / Yoshida, Masaki / Iwahara, Kaori / Takagi, Tetsuya

Drug testing and analysis

2023 Volume 15, Issue 6, Page(s) 701–705

Abstract: 2-Phenylethylamine (phenethylamine) and its derivatives are stimulant drugs, which are prohibited in sports because of their potential performance-enhancing properties. If phenethylamine is detected in an athlete's urine, the athlete may be subjected to ... ...

Abstract	2-Phenylethylamine (phenethylamine) and its derivatives are stimulant drugs, which are prohibited in sports because of their potential performance-enhancing properties. If phenethylamine is detected in an athlete's urine, the athlete may be subjected to serious sanctions, such as disqualification for both domestic and international competitions. Given the serious consequences athletes face for phenethylamine detection, great care should be taken to avoid false positive tests. In forensic medicine, it is widely known that phenethylamine is produced by putrefactive bacteria in autopsy urine samples; it is possible that this process could also occur in an athlete's urine sample without proper storage. In this study, human urine samples were stored at -20, 4, or 22°C for 14 days, and phenethylamine in the samples was quantitatively analyzed using ultra-high-performance liquid chromatography-tandem mass spectrometry. No phenethylamine was detected in urine samples stored at -20°C throughout 14-day period. Nevertheless, phenethylamine was detected after 6 days in these samples stored at 4°C and after only 1 day in samples stored at 22°C. Additionally, the concentration of phenethylamine in these samples increased each day after detection. These results suggest that urine samples should be stored immediately at -20°C after collection when testing athletes for phenethylamine, especially if the sample must be stored for extended period before testing.
MeSH term(s)	Humans ; Doping in Sports ; Urine Specimen Collection ; Temperature ; Tandem Mass Spectrometry/methods ; Substance Abuse Detection/methods
Chemical Substances	phenethylamine (327C7L2BXQ)
Language	English
Publishing date	2023-03-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2462336-2
ISSN	1942-7611 ; 1942-7603
ISSN (online)	1942-7611
ISSN	1942-7603
DOI	10.1002/dta.3466
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Article ; Online: Frontotemporal Lobar Degeneration With Unclassifiable 4-Repeat Tauopathy Mimicking Globular Glial Tauopathy.

Shimizu, Ai / Akagi, Akio / Ishida, Chiho / Sakai, Kenji / Komai, Kiyonobu / Kawamura, Mitsuru / Hasegawa, Masato / Ikeuchi, Takeshi / Yamada, Masahito

Journal of neuropathology and experimental neurology

2022 Volume 81, Issue 7, Page(s) 581–584

MeSH term(s)	Frontotemporal Dementia ; Frontotemporal Lobar Degeneration/diagnosis ; Frontotemporal Lobar Degeneration/genetics ; Humans ; Neuroglia ; Tauopathies/genetics ; tau Proteins
Chemical Substances	tau Proteins
Language	English
Publishing date	2022-05-27
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3088-0
ISSN	1554-6578 ; 0022-3069
ISSN (online)	1554-6578
ISSN	0022-3069
DOI	10.1093/jnen/nlac039
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Article: Detection and characterization of Hyaloklossia kasumiensis (Apicomplexa: Sarcocystidae) from Nagoya Daruma pond frog, Pelophylax porosus brevipodus

Tokiwa, Toshihiro / Kezuka, Chiho / Yamada, Shoto / Chou, Shyun / Nakamura, Shinichi

Parasitology international. 2022 June 19,

2022

Abstract	The Nagoya Daruma pond frog (Pelophylax porosus brevipodus) is an endangered anuran species endemic to the semi-aquatic environment of Japan. On June 11, 2021, four of the six Nagoya Daruma pond frogs captured from the wild and kept in an aquarium died in rapid succession. Pathological and/or parasitological examinations of two of the four carcasses revealed protozoan infection in their kidneys. The pathogen identified as Hyaloklossia kasumiensis (Apicomplexa: Sarcocystidae: Hyaloklossiinae) based on their morphological and molecular characterization. This is a new host record of H. kasumiensis. Mitochondrial cox1 sequence analysis suggest that the present species detected from Nagoya Daruma pond frog belongs to the same lineage as those found in the Tokyo Daruma pond frog (P. p. porosus) from Ibaraki Prefecture, Japan. This particular lineage may be prevalent among Pelophylax porosus ssp. distributed in Japan.
Keywords	Japan ; Pelophylax ; Sarcocystidae ; frogs ; mitochondria ; new host records ; parasitology ; pathogens ; protozoal infections ; sequence analysis
Language	English
Dates of publication	2022-0619
Publishing place	Elsevier B.V.
Document type	Article
Note	Pre-press version
ZDB-ID	1363151-2
ISSN	1383-5769
ISSN	1383-5769
DOI	10.1016/j.parint.2022.102614
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Article ; Online: Endoscopic mastectomy followed by immediate breast reconstruction with fat grafting for breast cancer.

Narui, Kazutaka / Satake, Toshihiko / Ishikawa, Takashi / Muto, Mayu / Tsunoda, Yui / Yamada, Akimitsu / Kawashima, Kei / Uenaka, Natsuki / Fujiwara, Yoshie / Oshi, Masanori / Adachi, Shoko / Suzuki, Chiho / Wada, Tomoko / Yamamoto, Shinya / Tanabe, Mikiko / Maegawa, Jiro / Endo, Itaru

Breast cancer (Tokyo, Japan)

2024 Volume 31, Issue 3, Page(s) 476–484

Abstract: Background: Although endoscopic mastectomy has been associated with good tolerance and enhanced patient satisfaction, limitations such as the implant or flap size for reconstruction with small incisions remain unresolved. Fat grafting (FG) can expand ... ...

Abstract	Background: Although endoscopic mastectomy has been associated with good tolerance and enhanced patient satisfaction, limitations such as the implant or flap size for reconstruction with small incisions remain unresolved. Fat grafting (FG) can expand tissue volume with pinhole skin incisions. Herein, we evaluated the safety and efficacy of endoscopic mastectomy followed by immediate FG. Methods: Patients who underwent endoscopic mastectomy with immediate FG reconstruction from 2015 to 2021 were retrospectively evaluated to establish surgical outcomes and prognosis. Results: Twenty-three patients with clinical stage 0 or I breast cancer underwent unilateral endoscopic mastectomy with immediate FG. The median age was 45 years (41-55), and the median body mass index was 19.3 kg/m Conclusion: To the best of our knowledge, this is the first report of endoscopic mastectomy with immediate FG for reconstruction. When compared with other immediate autologous reconstructions, our strategy could minimize the skin incision and procedure duration, as well as limit complications. Further prospective investigations are needed to evaluate oncological safety, surgical outcomes, and patient satisfaction.
MeSH term(s)	Humans ; Female ; Middle Aged ; Mammaplasty/methods ; Adult ; Retrospective Studies ; Endoscopy/methods ; Breast Neoplasms/surgery ; Breast Neoplasms/pathology ; Mastectomy/methods ; Mastectomy/adverse effects ; Adipose Tissue/transplantation ; Treatment Outcome ; Patient Satisfaction ; Follow-Up Studies
Language	English
Publishing date	2024-03-21
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2052429-8
ISSN	1880-4233 ; 1340-6868
ISSN (online)	1880-4233
ISSN	1340-6868
DOI	10.1007/s12282-024-01561-x
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