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  1. Article ; Online: Structural Insights into the Penicillin-Binding Protein 4 (DacB) from

    Kang, Sung-Min / Kim, Do-Hee

    International journal of molecular sciences

    2024  Volume 25, Issue 2

    Abstract: Mycobacterium ... ...

    Abstract Mycobacterium tuberculosis
    MeSH term(s) Mycobacterium tuberculosis ; Penicillin-Binding Proteins/genetics ; Antitubercular Agents ; Cell Membrane ; Cell Wall
    Chemical Substances Penicillin-Binding Proteins ; Antitubercular Agents
    Language English
    Publishing date 2024-01-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25020983
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  2. Article ; Online: Beneficial Effects of Low-Grade Mitochondrial Stress on Metabolic Diseases and Aging.

    Min, Se Hee / Kang, Gil Myoung / Park, Jae Woo / Kim, Min-Seon

    Yonsei medical journal

    2024  Volume 65, Issue 2, Page(s) 55–69

    Abstract: Mitochondria function as platforms for bioenergetics, nutrient metabolism, intracellular signaling, innate immunity regulators, and modulators of stem cell activity. Thus, the decline in mitochondrial functions causes or correlates with diabetes mellitus ...

    Abstract Mitochondria function as platforms for bioenergetics, nutrient metabolism, intracellular signaling, innate immunity regulators, and modulators of stem cell activity. Thus, the decline in mitochondrial functions causes or correlates with diabetes mellitus and many aging-related diseases. Upon stress or damage, the mitochondria elicit a series of adaptive responses to overcome stress and restore their structural integrity and functional homeostasis. These adaptive responses to low-level or transient mitochondrial stress promote health and resilience to upcoming stress. Beneficial effects of low-grade mitochondrial stress, termed mitohormesis, have been observed in various organisms, including mammals. Accumulated evidence indicates that treatments boosting mitohormesis have therapeutic potential in various human diseases accompanied by mitochondrial stress. Here, we review multiple cellular signaling pathways and interorgan communication mechanisms through which mitochondrial stress leads to advantageous outcomes. We also discuss the relevance of mitohormesis in obesity, diabetes, metabolic liver disease, aging, and exercise.
    MeSH term(s) Animals ; Humans ; Health Promotion ; Mitochondria/metabolism ; Aging ; Metabolic Diseases ; Exercise/physiology ; Oxidative Stress ; Mammals
    Language English
    Publishing date 2024-01-08
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 303740-x
    ISSN 1976-2437 ; 0513-5796
    ISSN (online) 1976-2437
    ISSN 0513-5796
    DOI 10.3349/ymj.2023.0131
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    Zs.B 944: Show issues Location:
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  3. Article ; Online: Spatial Single-Cell Technologies for Exploring Gastrointestinal Tissue Transcriptome.

    Kang, Hyun Min / Lee, Jun Hee

    Comprehensive Physiology

    2023  Volume 13, Issue 3, Page(s) 4709–4718

    Abstract: In the gastrointestinal (GI) system, like in other organ systems, the histological structure is a key determinant of physiological function. Tissues form multiple layers in the GI tract to perform their specialized functions in secretion, absorption, and ...

    Abstract In the gastrointestinal (GI) system, like in other organ systems, the histological structure is a key determinant of physiological function. Tissues form multiple layers in the GI tract to perform their specialized functions in secretion, absorption, and motility. Even at the single layer, the heterogeneous cell population performs a diverse range of digestive or regulatory functions. Although many details of such functions at the histological and cell biological levels were revealed by traditional methods such as cell sorting, isolation, and culture, as well as histological methods such as immunostaining and RNA in situ hybridization, recent advances in spatial single-cell technologies could further contribute to our understanding of the molecular makeup of GI histological structures by providing a genome-wide overview of how different genes are expressed across individual cells and tissue layers. The current minireview summarizes recent advances in the spatial transcriptomics field and discusses how such technologies can promote our understanding of GI physiology. © 2023 American Physiological Society. Compr Physiol 13:4709-4718, 2023.
    MeSH term(s) Humans ; Transcriptome ; Gastrointestinal Tract/physiology
    Language English
    Publishing date 2023-06-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ISSN 2040-4603
    ISSN (online) 2040-4603
    DOI 10.1002/cphy.c210053
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  4. Article: Artificial Cultivation Characteristics and Bioactive Effects of Novel

    Min, Gyeong-Jin / Kang, Hee-Wan

    Mycobiology

    2021  Volume 49, Issue 2, Page(s) 161–172

    Abstract: ... ...

    Abstract Phellinus
    Language English
    Publishing date 2021-04-22
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2631580-4
    ISSN 2092-9323 ; 1229-8093
    ISSN (online) 2092-9323
    ISSN 1229-8093
    DOI 10.1080/12298093.2021.1892568
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  5. Article ; Online: Efficacy of leuprorelin in spinal and bulbar muscular atrophy: a 3-year observational study.

    Kang, Min-Gu / Kang, Minsung / Cho, Hee-Jin / Min, Yu-Sun / Park, Jin-Sung

    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

    2024  

    Abstract: Objective: This study aimed to investigate the long-term effects and functional outcomes of androgen suppression therapy using leuprorelin among Korean patients with spinal and bulbar muscular atrophy (SBMA).: Methods: This observational study ... ...

    Abstract Objective: This study aimed to investigate the long-term effects and functional outcomes of androgen suppression therapy using leuprorelin among Korean patients with spinal and bulbar muscular atrophy (SBMA).
    Methods: This observational study enrolled patients with genetically confirmed SBMA who provided informed consent. Leuprorelin was administered via subcutaneous injection every 12 weeks. The primary outcome measure was the change in total Spinal and Bulbar Muscular Atrophy Functional Rating Scale (SBMAFRS) scores.
    Results: A total of 48 SBMA patients were evaluated in this study. Among them, 39 patients underwent androgen suppression therapy over a 3-year period. The total SBMAFRS score decreased from 41.72 ± 5.55 to 36.74 ± 7.74 (p < 0.001) in patients who completed their treatment. The subgroup with a baseline SBMAFRS score of ≥ 42 had a significantly lower decline in SBMAFRS score than did those with a baseline SBMAFRS score of ≤ 41. We determined that at a baseline, SBMAFRS cutoff value of 41.5 could predict good prognosis, with a corresponding area under the curve of 0.689.
    Conclusion: Despite androgen suppression therapy, all enrolled participants exhibited a decrease in the overall SBMAFRS score. However, those with a baseline SBMAFRS of ≥ 42 showed a mild decrease in scores, indicating a more favorable prognosis. These findings suggest that a higher baseline motor function was a key prognostic indicator in SBMA treatment and that initiating early leuprorelin treatment in patients with high baseline function may lead to good clinical outcomes.
    Language English
    Publishing date 2024-02-24
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2016546-8
    ISSN 1590-3478 ; 1590-1874
    ISSN (online) 1590-3478
    ISSN 1590-1874
    DOI 10.1007/s10072-024-07410-1
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1877: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Adjuvant treatment for locally advanced gastric cancer: an Asian perspective.

    Kim, Hyung-Don / Ryu, Min-Hee / Kang, Yoon-Koo

    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association

    2024  Volume 27, Issue 3, Page(s) 439–450

    Abstract: Standard adjuvant treatment for locally advanced gastric cancer (LAGC) is regionally different. Whereas perioperative chemotherapy is the standard in Western populations, D2 gastrectomy followed by adjuvant chemotherapy has been the standard in East Asia. ...

    Abstract Standard adjuvant treatment for locally advanced gastric cancer (LAGC) is regionally different. Whereas perioperative chemotherapy is the standard in Western populations, D2 gastrectomy followed by adjuvant chemotherapy has been the standard in East Asia. Recently, the pivotal phase 3 PRODIGY and RESOLVE studies have demonstrated survival benefits of adding neoadjuvant chemotherapy to surgery followed by adjuvant chemotherapy over up-front surgery followed by adjuvant chemotherapy in Asian patients. Based on these results, neoadjuvant chemotherapy is considered one of the viable options for patients with LAGC. In this review, various aspects of neoadjuvant chemotherapy will be discussed for its optimal application in Asia. Candidates for neoadjuvant chemotherapy should be carefully chosen in consideration of the inaccurate aspects of radiological clinical staging and its potential benefit over up-front surgery followed by a decision on adjuvant chemotherapy according to the pathological stage. Efforts should continuously be made to optimally apply neoadjuvant chemotherapy to patients with LAGC, considering various factors, including a more accurate radiological assessment of the tumor burden and the optimization of post-operative chemotherapy. Future neoadjuvant trials involving novel agents for Asian patients should be designed based on proven Asian regimens rather than adopting Western regimens.
    MeSH term(s) Humans ; Stomach Neoplasms/drug therapy ; Stomach Neoplasms/pathology ; Neoplasm Staging ; Gastrectomy/methods ; Chemotherapy, Adjuvant ; Neoadjuvant Therapy/methods ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use
    Language English
    Publishing date 2024-03-15
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 1463526-4
    ISSN 1436-3305 ; 1436-3291
    ISSN (online) 1436-3305
    ISSN 1436-3291
    DOI 10.1007/s10120-024-01484-8
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    Zs.A 5290: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  7. Article ; Online: Letter to the editor: 5-year follow-up results of a JCOG1104 (OPAS-1) phase III non-inferiority trial to compare 4 courses and 8 courses of S-1 adjuvant chemotherapy for pathological stage II gastric cancer.

    Kim, Hyung-Don / Ryu, Min-Hee / Lee, Ji Sung / Kang, Yoon-Koo

    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association

    2024  

    Language English
    Publishing date 2024-04-11
    Publishing country Japan
    Document type Letter ; Comment
    ZDB-ID 1463526-4
    ISSN 1436-3305 ; 1436-3291
    ISSN (online) 1436-3305
    ISSN 1436-3291
    DOI 10.1007/s10120-024-01496-4
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5290: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Bacterial contamination of surgical gloves during clean orthopedic surgery.

    Lee, Jee Young / Yun, Sang Hee / Kang, Jae Won / Kong, Gyu Min

    Infection control and hospital epidemiology

    2024  , Page(s) 1–3

    Abstract: This study examines the presence of bacterial contamination on surgical gloves and suggests appropriate measures for an aseptic surgical environment. To prevent glove contamination during surgery, surgeons and assistants should change gloves periodically, ...

    Abstract This study examines the presence of bacterial contamination on surgical gloves and suggests appropriate measures for an aseptic surgical environment. To prevent glove contamination during surgery, surgeons and assistants should change gloves periodically, and scrub nurses should be careful when opening packages and handing over implants.
    Language English
    Publishing date 2024-04-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639378-0
    ISSN 1559-6834 ; 0195-9417 ; 0899-823X
    ISSN (online) 1559-6834
    ISSN 0195-9417 ; 0899-823X
    DOI 10.1017/ice.2024.49
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    Zs.A 1714: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  9. Article ; Online: Metabolic Modulation of Kynurenine Based on Kynureninase-Loaded Nanoparticle Depot Overcomes Tumor Immune Evasion in Cancer Immunotherapy.

    Chae, Se-Youl / Shin, Hojeong / Woo, Jiwon / Kang, Seounghun / Lee, Soo Min / Min, Dal-Hee

    ACS applied materials & interfaces

    2024  Volume 16, Issue 15, Page(s) 18490–18502

    Abstract: Evading recognition of immune cells is a well-known strategy of tumors used for their survival. One of the immune evasion mechanisms is the synthesis of kynurenine (KYN), a metabolite of tryptophan, which suppresses the effector T cells. Therefore, ... ...

    Abstract Evading recognition of immune cells is a well-known strategy of tumors used for their survival. One of the immune evasion mechanisms is the synthesis of kynurenine (KYN), a metabolite of tryptophan, which suppresses the effector T cells. Therefore, lowering the KYN concentration can be an efficient antitumor therapy by restoring the activity of immune cells. Recently, kynureninase (KYNase), which is an enzyme transforming KYN into anthranilate, was demonstrated to show the potential to decrease KYN concentration and inhibit tumor growth. However, due to the limited bioavailability and instability of proteins in vivo, it has been challenging to maintain the KYNase concentration sufficiently high in the tumor microenvironment (TME). Here, we developed a nanoparticle system loaded with KYNase, which formed a Biodegradable and Implantable Nanoparticle Depot named 'BIND' following subcutaneous injection. The BIND sustainably supplied KYNase around the TME while located around the tumor, until it eventually degraded and disappeared. As a result, the BIND system enhanced the proliferation and cytokine production of effector T cells in the TME, followed by tumor growth inhibition and increased mean survival. Finally, we showed that the BIND carrying KYNase significantly synergized with PD-1 blockade in three mouse models of colon cancer, breast cancer, and melanoma.
    MeSH term(s) Mice ; Animals ; Kynurenine/metabolism ; Tumor Escape ; Immunotherapy ; Melanoma ; Tumor Microenvironment ; Hydrolases
    Chemical Substances Kynurenine (343-65-7) ; kynureninase (EC 3.7.1.3) ; Hydrolases (EC 3.-)
    Language English
    Publishing date 2024-04-04
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.4c00513
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  10. Article ; Online: Author Correction: Delta (B1.617.2) variant of SARS-CoV-2 induces severe neurotropic patterns in K18-hACE2 mice.

    Yang, Ju-Hee / Yang, Myeon-Sik / Kim, Dae-Min / Kim, Bumseok / Tark, Dongseob / Kang, Sang-Min / Lee, Gun-Hee

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 3745

    Language English
    Publishing date 2023-03-06
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-30977-2
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