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Article ; Online: Dupilumab Leads to Clinical Improvements including the Acquisition of Tolerance to Causative Foods in Non-Eosinophilic Esophagitis Eosinophilic Gastrointestinal Disorders.

Arakawa, Naoya / Yagi, Hisako / Shimizu, Mariko / Shigeta, Daisuke / Shimizu, Akihiko / Nomura, Shigeru / Takizawa, Takumi / Yamada, Yoshiyuki

Biomolecules

2023 Volume 13, Issue 1

Abstract: A recent report showed that most pediatric cases of non-eosinophilic esophagitis (EoE) eosinophilic gastrointestinal disorders (EGIDs) (non-EoE EGIDs) are persistent and severe compared with those of EoE, thus requiring further effective therapeutic ... ...

Abstract	A recent report showed that most pediatric cases of non-eosinophilic esophagitis (EoE) eosinophilic gastrointestinal disorders (EGIDs) (non-EoE EGIDs) are persistent and severe compared with those of EoE, thus requiring further effective therapeutic approaches. In this study, we present the first case based on a systematic search of non-EoE EGID for which tolerance to causative foods and histological and symptomatic improvements were achieved following dupilumab administration, after elimination diets and omalizumab and mepolizumab treatments. Driven by this case, we investigated the efficacies of biological treatments in non-EoE EGID cases based on the patient studied herein, and other patients identified in the conducted systematic review. Seven articles, including five different biologics, were reviewed. Both clinical efficacies and impact differences among the targeted molecules are demonstrated in this study. Our findings show that dupilumab may affect mechanisms that can suppress symptoms induced by offending foods that are different from those induced by other biologics as identified in the conducted systematic review. Additional studies are required to address the unmet needs of non-EoE EGID treatments.
MeSH term(s)	Child ; Humans ; Biological Products/pharmacology ; Biological Products/therapeutic use ; Esophagitis/drug therapy ; Esophagitis/immunology ; Treatment Outcome ; Immune Tolerance/drug effects
Chemical Substances	Biological Products ; dupilumab (420K487FSG)
Language	English
Publishing date	2023-01-05
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Systematic Review
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom13010112
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Persistent ADAMTS13 Inhibitor Delays Recovery of ADAMTS13 activity in Caplacizumab-Treated Japanese iTTP Patients.

Saito, Kenki / Sakai, Kazuya / Kubo, Masayuki / Azumi, Hidekazu / Hamamura, Atsushi / Ochi, Shinichi / Amagase, Hiroki / Kunieda, Hisako / Ogawa, Yoshiyuki / Yagi, Hideo / Matsumoto, Masanori

Blood advances

2024

Abstract: For patients with immune-mediated thrombotic thrombocytopenic purpura (iTTP), caplacizumab, a nanobody against von Willebrand factor A1 domain, has become crucial. Delayed normalization of ADAMTS13 activity during caplacizumab therapy has been identified. ...

Abstract	For patients with immune-mediated thrombotic thrombocytopenic purpura (iTTP), caplacizumab, a nanobody against von Willebrand factor A1 domain, has become crucial. Delayed normalization of ADAMTS13 activity during caplacizumab therapy has been identified. In a retrospective analysis, we compared platelet count, ADAMTS13 activity, its inhibitor, and anti-ADAMTS13 IgG levels in acute iTTP cases treated with caplacizumab (N=14) or without it (N=16). The median time from initial therapeutic plasma exchange (TPE) to the first rituximab administration was 12 days in the caplacizumab group (N=11) and 10 days in the group without caplacizumab (N=13). We evaluated ADAMTS13-related parameters at onset and once a week until day 28 after the first TPE. The number of days until the platelet counts reached >= 150×109/L was significantly shorter in the caplacizumab group than in the non-caplacizumab group. The median ADAMTS13 activity levels on days 14, 21, and 28 were significantly lower in the caplacizumab group than in the non-caplacizumab group. The median titers of the ADAMTS13 inhibitor and anti-ADAMTS13 IgG on the same days were significantly higher in the caplacizumab group than in the non-caplacizumab group. Furthermore, the median number of days from the first TPE until finally achieving an ADAMTS13 activity >= 10% was significantly longer in the caplacizumab group than in the non-caplacizumab group (42 days vs. 23 days, p=0.014). We observed delayed ADAMTS13 activity recovery and continued inhibitor and anti-ADAMTS13 IgG detection in acute iTTP patients on caplacizumab, possibly due to the decreased number of TPEs and delayed frontline rituximab.
Language	English
Publishing date	2024-02-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2915908-8
ISSN	2473-9537 ; 2473-9529
ISSN (online)	2473-9537
ISSN	2473-9529
DOI	10.1182/bloodadvances.2023012451
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Zs.A 7153: Show issues

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Article: [CURRENT AND FUTURE PERSPECTIVES ON EPIGENETICS IN ALLERGIC DISEASES].

Takizawa, Takumi / Yagi, Hisako / Nishida, Yutaka / Yamada, Satoshi / Arakawa, Naoya / Arakawa, Hirokazu

Arerugi = [Allergy

2020 Volume 69, Issue 10, Page(s) 968–971

MeSH term(s)	Epigenesis, Genetic ; Humans ; Hypersensitivity/genetics
Language	Japanese
Publishing date	2020-12-14
Publishing country	Japan
Document type	Journal Article
ZDB-ID	974201-3
ISSN	0021-4884
ISSN	0021-4884
DOI	10.15036/arerugi.69.968
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Zs.A 245: Show issues

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Article ; Online: Oxidative stress induces

Nishida, Yutaka / Yagi, Hisako / Ota, Masaya / Tanaka, Atsushi / Sato, Koichiro / Inoue, Takaharu / Yamada, Satoshi / Arakawa, Naoya / Ishige, Takashi / Kobayashi, Yasuko / Arakawa, Hirokazu / Takizawa, Takumi

FASEB bioAdvances

2023 Volume 5, Issue 4, Page(s) 171–181

Abstract: Oxidative stress increases the production of the predominant mucin MUC5AC in airway epithelial cells and is implicated in the pathogenesis of bronchial asthma and chronic obstructive pulmonary disease. Oxidative stress impairs mitochondria, releasing ... ...

Abstract	Oxidative stress increases the production of the predominant mucin MUC5AC in airway epithelial cells and is implicated in the pathogenesis of bronchial asthma and chronic obstructive pulmonary disease. Oxidative stress impairs mitochondria, releasing mitochondrial DNA into the cytoplasm and inducing inflammation through the intracytoplasmic DNA sensor STING (stimulator of interferon genes). However, the role of innate immunity in mucin production remains unknown. We aimed to elucidate the role of innate immunity in mucin production in airway epithelial cells under oxidative stress. Human airway epithelial cell line (NCI-H292) and normal human bronchial epithelial cells were used to confirm
Language	English
Publishing date	2023-02-17
Publishing country	United States
Document type	Journal Article
ISSN	2573-9832
ISSN (online)	2573-9832
DOI	10.1096/fba.2022-00081
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Article: Optimal Pore Size of Honeycomb Polylactic Acid Films for In Vitro Cartilage Formation by Synovial Mesenchymal Stem Cells.

Yagi, Misaki / Mizuno, Mitsuru / Fujisawa, Ryota / Katano, Hisako / Endo, Kentaro / Ozeki, Nobutake / Sakamaki, Yuriko / Koga, Hideyuki / Sekiya, Ichiro

Stem cells international

2021 Volume 2021, Page(s) 9239728

Abstract: Background: Tissue engineering of cartilage requires the selection of an appropriate artificial scaffold. Polylactic acid (PLA) honeycomb films are expected to be highly biodegradable and cell adhesive due to their high porosity. The purpose of this ... ...

Abstract	Background: Tissue engineering of cartilage requires the selection of an appropriate artificial scaffold. Polylactic acid (PLA) honeycomb films are expected to be highly biodegradable and cell adhesive due to their high porosity. The purpose of this study was to determine the optimal pore size of honeycomb PLA films for in vitro cartilage formation using synovial mesenchymal stem cells (MSCs). Methods: Suspensions of human synovial MSCs were plated on PLA films with different pore sizes (no pores, or with 5 Results: The 5 Conclusions: Honeycomb PLA films with 5
Language	English
Publishing date	2021-08-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2573856-2
ISSN	1687-9678 ; 1687-966X
ISSN (online)	1687-9678
ISSN	1687-966X
DOI	10.1155/2021/9239728
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Article ; Online: Oxidative stress induces MUC5AC expression through mitochondrial damage‐dependent STING signaling in human bronchial epithelial cells

Yutaka Nishida / Hisako Yagi / Masaya Ota / Atsushi Tanaka / Koichiro Sato / Takaharu Inoue / Satoshi Yamada / Naoya Arakawa / Takashi Ishige / Yasuko Kobayashi / Hirokazu Arakawa / Takumi Takizawa

FASEB BioAdvances, Vol 5, Iss 4, Pp 171-

2023 Volume 181

Abstract: Abstract Oxidative stress increases the production of the predominant mucin MUC5AC in airway epithelial cells and is implicated in the pathogenesis of bronchial asthma and chronic obstructive pulmonary disease. Oxidative stress impairs mitochondria, ... ...

Abstract	Abstract Oxidative stress increases the production of the predominant mucin MUC5AC in airway epithelial cells and is implicated in the pathogenesis of bronchial asthma and chronic obstructive pulmonary disease. Oxidative stress impairs mitochondria, releasing mitochondrial DNA into the cytoplasm and inducing inflammation through the intracytoplasmic DNA sensor STING (stimulator of interferon genes). However, the role of innate immunity in mucin production remains unknown. We aimed to elucidate the role of innate immunity in mucin production in airway epithelial cells under oxidative stress. Human airway epithelial cell line (NCI‐H292) and normal human bronchial epithelial cells were used to confirm MUC5AC expression levels by real‐time PCR when stimulated with hydrogen peroxide (H2O2). MUC5AC transcriptional activity was increased and mitochondrial DNA was released into the cytosol by H2O2. Mitochondrial antioxidants were used to confirm the effects of mitochondrial oxidative stress where antioxidants inhibited the increase in MUC5AC transcriptional activity. Cyclic GMP‐AMP synthase (cGAS) or STING knockout (KO) cells were generated to investigate their involvement. H2O2‐induced MUC5AC expression was suppressed in STING KO cells, but not in cGAS KO cells. The epidermal growth factor receptor was comparably expressed in STING KO and wild‐type cells. Thus, mitochondria and STING play important roles in mucin production in response to oxidative stress in airway epithelial cells.
Keywords	hydrogen peroxide ; mitochondria ; mtDNA ; MUC5AC ; oxidative stress ; STING ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
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Article ; Online: Clinical effects of a selective urate reabsorption inhibitor dotinurad in patients with hyperuricemia and treated hypertension: a multicenter, prospective, exploratory study (DIANA).

Tanaka, Atsushi / Taguchi, Isao / Hisauchi, Itaru / Yoshida, Hisako / Shimabukuro, Michio / Hongo, Hiroshi / Ishikawa, Tetsuya / Kadokami, Toshiaki / Yagi, Shusuke / Sata, Masataka / Node, Koichi

European journal of medical research

2023 Volume 28, Issue 1, Page(s) 238

Abstract: Introduction: Dotinurad is a newer urate-lowering agent that selectively inhibits urate transporter 1 in the renal proximal tubule and increases urinary urate excretion. Currently, little is known about the clinical efficacies of dotinurad in patients ... ...

Abstract	Introduction: Dotinurad is a newer urate-lowering agent that selectively inhibits urate transporter 1 in the renal proximal tubule and increases urinary urate excretion. Currently, little is known about the clinical efficacies of dotinurad in patients with hyperuricemia and hypertension. The aim of this study was to assess the clinical effects of a selective urate reabsorption inhibitor dotinurad on serum uric acid (SUA) levels and relevant vascular markers in patients with hyperuricemia and treated hypertension. Methods: This investigator-initiated, multicenter, prospective, single-arm, open-label, exploratory clinical trial in Japan enrolled patients with hyperuricemia and treated hypertension who received a 24-week dotinurad therapy (a starting dose at 0.5 mg once daily and up-titrated to 2 mg once daily). The primary endpoint was a percentage change in the SUA level from baseline to week 24. The secondary endpoints were cardiovascular and metabolic measurements, including changes in the cardio-ankle vascular index (CAVI) and derivatives of reactive oxygen metabolites (d-ROMs) concentration at week 24. Results: Fifty patients (mean age 70.5 ± 11.0 years, with 76.0% being men, and mean SUA level 8.5 ± 1.2 mg/dL) were included in the analysis. The percentage change from baseline in the SUA level at week 24 was - 35.8% (95% confidence interval [CI] - 39.7% to - 32.0%, P < 0.001), with approximately three quarters of patients achieving an SUA level of ≤ 6.0 mg/dL at week 24. The proportional changes from baseline in the geometric mean of CAVI and d-ROMs at week 24 were 0.96 (95% CI 0.92 to 1.00, P = 0.044) and 0.96 (95% CI 0.92 to 1.00, P = 0.044), respectively. Conclusion: In addition to meaningful SUA-lowering effects, 24 weeks of dotinurad therapy may favorably affect arterial stiffness and oxidative stress markers, suggesting off-target vascular protection of dotinurad. Further research is expected to verify our findings and elucidate the entire off-target effects of dotinurad. Trial registration jRCTs021210013, registration date June 24, 2021.
MeSH term(s)	Male ; Humans ; Middle Aged ; Aged ; Aged, 80 and over ; Female ; Hyperuricemia/drug therapy ; Uric Acid ; Prospective Studies ; Uricosuric Agents/therapeutic use ; Hypertension/drug therapy
Chemical Substances	Uric Acid (268B43MJ25) ; dotinurad (305EB53128) ; Uricosuric Agents
Language	English
Publishing date	2023-07-17
Publishing country	England
Document type	Multicenter Study ; Journal Article
ZDB-ID	1329381-3
ISSN	2047-783X ; 0949-2321
ISSN (online)	2047-783X
ISSN	0949-2321
DOI	10.1186/s40001-023-01208-1
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Zs.A 4636: Show issues

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Article: Regional differences in the prevalence of oral allergy syndrome among Japanese children: A questionnaire-based survey.

Ota, Masaya / Nishida, Yutaka / Yagi, Hisako / Sato, Koichiro / Yamada, Satoshi / Arakawa, Hirokazu / Takizawa, Takumi

Asian Pacific journal of allergy and immunology

2020 Volume 41, Issue 2, Page(s) 142–149

Abstract: Background: Oral allergy syndrome (OAS) is characterized by an immediate allergic reaction that mainly or partially affects the oral mucosa, pharynx, or lips, and it is usually caused by ingesting fresh fruits or vegetables. Most patients with OAS also ... ...

Abstract	Background: Oral allergy syndrome (OAS) is characterized by an immediate allergic reaction that mainly or partially affects the oral mucosa, pharynx, or lips, and it is usually caused by ingesting fresh fruits or vegetables. Most patients with OAS also have allergic rhinitis due to pollen. As allergic rhinitis is increasingly prevalent in the Japanese population and the age at disease development is decreasing, morbidity associated with OAS among the younger population is likely to increase. However, there is little information about the prevalence of this disease among Japanese children, specifically the influences of residency in regions with different environments. Objective: To investigate the prevalence of OAS and seasonal allergic rhinitis (SAR) among Japanese children and evaluate the relationship between OAS and SAR. Methods: We administered a questionnaire-based survey among children aged 7-15 years, living in 4 cities in central Japan. Results: The questionnaires were administered to 4103 children and completed by 3365 (82.0%). Overall, 524 children (15.6%) reported OAS-like symptoms after ingesting fruits or vegetables. The prevalence of seasonal SAR and oral symptoms significantly differed among the 4 cities. The total prevalence of oral symptoms co-occurring with SAR was 24.4%, which was significantly higher than the prevalence of symptoms occurring without SAR (10.2%, p < 0.001). Conclusions: Herein, oral symptoms were more likely to occur in patients with SAR than in those without SAR. The prevalence of SAR and food-induced oral symptoms significantly differed among the regions, suggesting they might be affected by regional differences in lifestyles and flora.
MeSH term(s)	Adolescent ; Child ; Humans ; East Asian People ; Food Hypersensitivity/complications ; Prevalence ; Rhinitis, Allergic/complications ; Rhinitis, Allergic, Seasonal/diagnosis ; Surveys and Questionnaires ; Mouth ; Pharynx
Language	English
Publishing date	2020-05-29
Publishing country	Thailand
Document type	Journal Article
ZDB-ID	605782-2
ISSN	2228-8694 ; 0125-877X
ISSN (online)	2228-8694
ISSN	0125-877X
DOI	10.12932/AP-130120-0739
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Article ; Online: Optimal Pore Size of Honeycomb Polylactic Acid Films for In Vitro Cartilage Formation by Synovial Mesenchymal Stem Cells

Misaki Yagi / Mitsuru Mizuno / Ryota Fujisawa / Hisako Katano / Kentaro Endo / Nobutake Ozeki / Yuriko Sakamaki / Hideyuki Koga / Ichiro Sekiya

Stem Cells International, Vol

2021 Volume 2021

Abstract: Background. Tissue engineering of cartilage requires the selection of an appropriate artificial scaffold. Polylactic acid (PLA) honeycomb films are expected to be highly biodegradable and cell adhesive due to their high porosity. The purpose of this ... ...

Abstract	Background. Tissue engineering of cartilage requires the selection of an appropriate artificial scaffold. Polylactic acid (PLA) honeycomb films are expected to be highly biodegradable and cell adhesive due to their high porosity. The purpose of this study was to determine the optimal pore size of honeycomb PLA films for in vitro cartilage formation using synovial mesenchymal stem cells (MSCs). Methods. Suspensions of human synovial MSCs were plated on PLA films with different pore sizes (no pores, or with 5 μm or 20 μm pores) and then observed by scanning electron microscopy. The numbers of cells remaining in the film and passing through the film were quantified. One day after plating, the medium was switched to chondrogenic induction medium, and the films were time-lapse imaged and observed histologically. Results. The 5 μm pore film showed MSCs with pseudopodia that extended between several pores, while the 20 μm pore film showed MSC bodies submerged into the pores. The number of adhered MSCs was significantly lower for the film without pores, while the number of MSCs that passed through the film was significantly higher for the 20 μm pore film. MSCs that were induced to form cartilage peeled off as a sheet from the poreless film after one day. MSCs formed thicker cartilage at two weeks when growing on the 5 μm pore films than on the 20 μm pore films. Conclusions. Honeycomb PLA films with 5 μm pores were suitable for in vitro cartilage formation by synovial MSCs.
Keywords	Internal medicine ; RC31-1245
Subject code	620
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
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Article ; Online: Expression of Leucine-rich Repeat-containing Protein 32 Following Lymphocyte Stimulation in Patients with Non-IgE-mediated Gastrointestinal Food Allergies.

Yagi, Hisako / Sato, Koichiro / Arakawa, Naoya / Inoue, Takaharu / Nishida, Yutaka / Yamada, Satoshi / Ishige, Takashi / Yamada, Yoshiyuki / Arakawa, Hirokazu / Takizawa, Takumi

The Yale journal of biology and medicine

2020 Volume 93, Issue 5, Page(s) 645–655

Abstract: The lymphocyte stimulation test (LST) facilitates the diagnosis of non-IgE-mediated gastrointestinal food allergies (non-IgE-GI-FAs). However, LSTs require large volumes of blood and prolonged culture durations. Recently, we found ... ...

Abstract	The lymphocyte stimulation test (LST) facilitates the diagnosis of non-IgE-mediated gastrointestinal food allergies (non-IgE-GI-FAs). However, LSTs require large volumes of blood and prolonged culture durations. Recently, we found that
MeSH term(s)	Animals ; Cattle ; Cells, Cultured ; Female ; Food Hypersensitivity ; Humans ; Immunoglobulin E ; Infant ; Leucine ; Leukocytes, Mononuclear ; Lymphocyte Activation ; Membrane Proteins/metabolism
Chemical Substances	LRRC32 protein, human ; Membrane Proteins ; Immunoglobulin E (37341-29-0) ; Leucine (GMW67QNF9C)
Language	English
Publishing date	2020-12-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	200515-3
ISSN	1551-4056 ; 0044-0086
ISSN (online)	1551-4056
ISSN	0044-0086
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