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  1. Article: A Case of Pyoderma Gangrenosum Misdiagnosed as Necrotizing Infection: A Potential Diagnostic Catastrophe.

    Saffie, Medina G / Shroff, Anjali

    Case reports in infectious diseases

    2018  Volume 2018, Page(s) 8907542

    Abstract: In this article, we present a case of pyoderma gangrenosum (PG), misdiagnosed initially as a necrotizing infection that significantly worsened due to repeated surgical debridement and aggressive wound care therapy, almost resulting in limb amputation ... ...

    Abstract In this article, we present a case of pyoderma gangrenosum (PG), misdiagnosed initially as a necrotizing infection that significantly worsened due to repeated surgical debridement and aggressive wound care therapy, almost resulting in limb amputation despite antibiotic therapy. The PG lesions improved after pancytopenia were further investigated, and the diagnosis and treatment of an underlying hematologic malignancy was initiated. The diagnosis and management of PG is challenging given the paucity of robust clinical evidence, lack of standard diagnostic criteria, and absence of clinical practice guidelines. It is imperative that clinicians recognize PG as a clinical diagnosis that must be considered in any patient with enlarging, sterile, necrotic lesions that are unresponsive to prolonged and appropriate antibiotics. Early recognition can prevent devastating sequelae such as deep tissue and bone infections associated with a chronic open wound, severe cosmetic morbidity, and potential limb amputation.
    Language English
    Publishing date 2018-04-26
    Publishing country Egypt
    Document type Case Reports
    ZDB-ID 2627642-2
    ISSN 2090-6633 ; 2090-6625
    ISSN (online) 2090-6633
    ISSN 2090-6625
    DOI 10.1155/2018/8907542
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Listeria spondylodiscitis: an uncommon etiology of a common condition; a case report.

    Al Ohaly, Rand / Ranganath, Nischal / Saffie, Medina G / Shroff, Anjali

    BMC infectious diseases

    2020  Volume 20, Issue 1, Page(s) 559

    Abstract: Background: Listeriosis is a severe food-borne infection caused by the Gram-positive rod, Listeria monocytogenes. Despite the low incidence (3-8 cases per million), Listeriosis has a case fatality rate of 20-30% as it occurs predominantly in ... ...

    Abstract Background: Listeriosis is a severe food-borne infection caused by the Gram-positive rod, Listeria monocytogenes. Despite the low incidence (3-8 cases per million), Listeriosis has a case fatality rate of 20-30% as it occurs predominantly in immunocompromised individuals at extremes of age, diabetics and pregnant women. Listeriosis classically presents as a febrile gastroenteritis, isolated bacteremia, meningitis, or maternal-fetal infections. Focal bone and joint infection are rare and primarily involve orthopedic implant devices. Here, we present the first case of Listeria-associated spondylodiscitis.
    Case presentation: A 79-year-old male presents with acute-on-chronic back pain in the absence of risk factors or exposures, aside from age. On radiological imaging, spondylodiscitis of L3-L4 was diagnosed. Subsequently, a CT-guided biopsy was performed to aid in confirming microbiological aetiology. Listeria monocytogenes was grown in culture and patient received appropriate antibacterial therapy.
    Conclusion: The case highlights the utility of image-guided tissue sampling in aiding diagnosis and management in patients with vertebral osteomyelitis. It also encourages consideration of uncommon organisms such as Listeria as an etiology of vertebral osteomyelitis, even in the absence of prosthetic implants.
    MeSH term(s) Aged ; Anti-Bacterial Agents/therapeutic use ; Arthritis, Infectious/drug therapy ; Back Pain ; Bacteremia/microbiology ; Discitis/diagnostic imaging ; Discitis/drug therapy ; Humans ; Listeria monocytogenes/isolation & purification ; Listeria monocytogenes/pathogenicity ; Listeriosis/diagnosis ; Listeriosis/drug therapy ; Male ; Osteomyelitis/diagnostic imaging ; Risk Factors
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2020-07-31
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1471-2334
    ISSN (online) 1471-2334
    DOI 10.1186/s12879-020-05286-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: TB and COVID-19 co-infection: rationale and aims of a global study.

    Casco, N / Jorge, A L / Palmero, D / Alffenaar, J-W / Fox, G / Ezz, W / Cho, J-G / Skrahina, A / Solodovnikova, V / Bachez, P / Arbex, M A / Galvão, T / Rabahi, M / Pereira, G R / Sales, R / Silva, D R / Saffie, M M / Miranda, R C / Cancino, V /
    Carbonell, M / Cisterna, C / Concha, C / Cruz, A / Salinas, N E / Revillot, M E / Farias, J / Fernandez, I / Flores, X / Gallegos, P / Garavagno, A / Guajardo, C / Bahamondes, M H / Merino, L M / Muñoz, E / Muñoz, C / Navarro, I / Navarro, J / Ortega, C / Palma, S / Pardenas, A M / Pereira, G / Castillo, P P / Pinto, M / Pizarro, R / Rivas, F / Rodriguez, P / Sánchez, C / Serrano, A / Soto, A / Taiba, C / Venegas, M / Vergara, M S / Vilca, E / Villalon, C / Yucra, E / Li, Y / Guelvez, B / Plaza, R / Tello, K / Andréjak, C / Blanc, F-X / Dourmane, S / Froissart, A / Izadifar, A / Rivière, F / Schlemmer, F / Gupta, N / Ish, P / Mishra, G / Sharma, S / Singla, R / Udwadia, Z F / Manika, K / Diallo, B D / Hassane-Harouna, S / Artiles, N / Mejia, L A / Alladio, F / Calcagno, A / Centis, R / Codecasa, L R / D Ambrosio, L / Formenti, B / Gaviraghi, A / Giacomet, V / Goletti, D / Gualano, G / Kuksa, L / Danila, E / Diktanas, S / Miliauskas, S / Ridaura, R L / López, Fll / Torrico, M M / Rendon, A / Akkerman, O W / Piubello, A / Souleymane, M B / Aizpurua, E / Gonzales, R / Jurado, J / Loban, A / Aguirre, S / de Egea, V / Irala, S / Medina, A / Sequera, G / Sosa, N / Vázquez, F / Manga, S / Villanueva, R / Araujo, D / Duarte, R / Marques, T S / Grecu, V I / Socaci, A / Barkanova, O / Bogorodskaya, M / Borisov, S / Mariandyshev, A / Kaluzhenina, A / Stosic, M / Beh, D / Ng, D / Ong, Cwm / Solovic, I / Dheda, D / Gina, P / Caminero, J A / Cardoso-Landivar, J / de Souza Galvão, M L / Dominguez-Castellano, A / García-García, J-M / Pinargote, I M / Fernandez, S Q / Sánchez-Montalvá, A / Huguet, E T / Murguiondo, M Z / Bruchfeld, J / Bart, P-A / Mazza-Stalder, J / Tiberi, S / Arrieta, F / Heysell, S / Logsdon, J / Young, L

    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease

    2020  Volume 25, Issue 1, Page(s) 78–80

    MeSH term(s) COVID-19/complications ; Coinfection ; Global Health ; Humans ; Multicenter Studies as Topic ; Prospective Studies ; Research Design ; Tuberculosis, Pulmonary/complications
    Language English
    Publishing date 2020-12-15
    Publishing country France
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 1385624-8
    ISSN 1815-7920 ; 1027-3719
    ISSN (online) 1815-7920
    ISSN 1027-3719
    DOI 10.5588/ijtld.20.0786
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Long-term outcomes of the global tuberculosis and COVID-19 co-infection cohort.

    Casco, Nicolas / Jorge, Alberto Levi / Palmero, Domingo Juan / Alffenaar, Jan-Willem / Fox, Greg J / Ezz, Wafaa / Cho, Jin-Gun / Denholm, Justin / Skrahina, Alena / Solodovnikova, Varvara / Arbex, Marcos Abdo / Alves, Tatiana / Rabahi, Marcelo Fouad / Pereira, Giovana Rodrigues / Sales, Roberta / Silva, Denise Rossato / Saffie, Muntasir M / Salinas, Nadia Escobar / Miranda, Ruth Caamaño /
    Cisterna, Catalina / Concha, Clorinda / Fernandez, Israel / Villalón, Claudia / Vera, Carolina Guajardo / Tapia, Patricia Gallegos / Cancino, Viviana / Carbonell, Monica / Cruz, Arturo / Muñoz, Eduardo / Muñoz, Camila / Navarro, Indira / Pizarro, Rolando / Cristina Sánchez, Gloria Pereira / Vergara Riquelme, Maria Soledad / Vilca, Evelyn / Soto, Aline / Flores, Ximena / Garavagno, Ana / Bahamondes, Martina Hartwig / Merino, Luis Moyano / Pradenas, Ana María / Revillot, Macarena Espinoza / Rodriguez, Patricia / Salinas, Angeles Serrano / Taiba, Carolina / Valdés, Joaquín Farías / Subiabre, Jorge Navarro / Ortega, Carlos / Palma, Sofia / Castillo, Patricia Perez / Pinto, Mónica / Bidegain, Francisco Rivas / Venegas, Margarita / Yucra, Edith / Li, Yang / Cruz, Andres / Guelvez, Beatriz / Victoria Plaza, Regina / Tello Hoyos, Kelly Yoana / Cardoso-Landivar, José / Van Den Boom, Martin / Andréjak, Claire / Blanc, François-Xavier / Dourmane, Samir / Froissart, Antoine / Izadifar, Armine / Rivière, Frédéric / Schlemmer, Frédéric / Manika, Katerina / Diallo, Boubacar Djelo / Hassane-Harouna, Souleymane / Artiles, Norma / Mejia, Licenciada Andrea / Gupta, Nitesh / Ish, Pranav / Mishra, Gyanshankar / Patel, Jigneshkumar M / Singla, Rupak / Udwadia, Zarir F / Alladio, Francesca / Angeli, Fabio / Calcagno, Andrea / Centis, Rosella / Codecasa, Luigi Ruffo / De Lauretis, Angelo / Esposito, Susanna M R / Formenti, Beatrice / Gaviraghi, Alberto / Giacomet, Vania / Goletti, Delia / Gualano, Gina / Matteelli, Alberto / Migliori, Giovanni Battista / Motta, Ilaria / Palmieri, Fabrizio / Pontali, Emanuele / Prestileo, Tullio / Riccardi, Niccolò / Saderi, Laura / Saporiti, Matteo / Sotgiu, Giovanni / Spanevello, Antonio / Stochino, Claudia / Tadolini, Marina / Torre, Alessandro / Villa, Simone / Visca, Dina / Kurhasani, Xhevat / Furjani, Mohammed / Rasheed, Najia / Danila, Edvardas / Diktanas, Saulius / Ridaura, Ruy López / Luna López, Fátima Leticia / Torrico, Marcela Muñoz / Rendon, Adrian / Akkerman, Onno W / Chizaram, Onyeaghala / Al-Abri, Seif / Alyaquobi, Fatma / Althohli, Khalsa / Aguirre, Sarita / Teixeira, Rosarito Coronel / De Egea, Viviana / Irala, Sandra / Medina, Angélica / Sequera, Guillermo / Sosa, Natalia / Vázquez, Fátima / Llanos-Tejada, Félix K / Manga, Selene / Villanueva-Villegas, Renzo / Araujo, David / Sales Marques, Raquel DuarteTânia / Socaci, Adriana / Barkanova, Olga / Bogorodskaya, Maria / Borisov, Sergey / Mariandyshev, Andrei / Kaluzhenina, Anna / Vukicevic, Tatjana Adzic / Stosic, Maja / Beh, Darius / Ng, Deborah / Ong, Catherine W M / Solovic, Ivan / Dheda, Keertan / Gina, Phindile / Caminero, José A / De Souza Galvão, Maria Luiza / Dominguez-Castellano, Angel / García-García, José-María / Pinargote, Israel Molina / Fernandez, Sarai Quirós / Sánchez-Montalvá, Adrián / Huguet, Eva Tabernero / Murguiondo, Miguel Zabaleta / Bart, Pierre-Alexandre / Mazza-Stalder, Jesica / D'Ambrosio, Lia / Kamolwat, Phalin / Bakko, Freya / Barnacle, James / Bird, Sophie / Brown, Annabel / Chandran, Shruthi / Killington, Kieran / Man, Kathy / Papineni, Padmasayee / Ritchie, Flora / Tiberi, Simon / Utjesanovic, Natasa / Zenner, Dominik / Hearn, Jasie L / Heysell, Scott / Young, Laura

    The European respiratory journal

    2023  Volume 62, Issue 5

    Abstract: Background: Longitudinal cohort data of patients with tuberculosis (TB) and coronavirus disease 2019 (COVID-19) are lacking. In our global study, we describe long-term outcomes of patients affected by TB and COVID-19.: Methods: We collected data from ...

    Abstract Background: Longitudinal cohort data of patients with tuberculosis (TB) and coronavirus disease 2019 (COVID-19) are lacking. In our global study, we describe long-term outcomes of patients affected by TB and COVID-19.
    Methods: We collected data from 174 centres in 31 countries on all patients affected by COVID-19 and TB between 1 March 2020 and 30 September 2022. Patients were followed-up until cure, death or end of cohort time. All patients had TB and COVID-19; for analysis purposes, deaths were attributed to TB, COVID-19 or both. Survival analysis was performed using Cox proportional risk-regression models, and the log-rank test was used to compare survival and mortality attributed to TB, COVID-19 or both.
    Results: Overall, 788 patients with COVID-19 and TB (active or sequelae) were recruited from 31 countries, and 10.8% (n=85) died during the observation period. Survival was significantly lower among patients whose death was attributed to TB and COVID-19
    Conclusions: In our global cohort, death was the outcome in >10% of patients with TB and COVID-19. A range of demographic and clinical predictors are associated with adverse outcomes.
    MeSH term(s) Humans ; Male ; COVID-19/complications ; HIV Infections/complications ; Coinfection ; Risk Factors ; Tuberculosis, Miliary ; Retrospective Studies
    Language English
    Publishing date 2023-11-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.00925-2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 292: Show issues

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