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Article ; Online: Insulin resistance and CGM-derived parameters in people with type 1 diabetes: are they associated?

Clinck, Isabel / Mertens, Jonathan / Wouters, Kristien / Dirinck, Eveline / De Block, Christophe

The Journal of clinical endocrinology and metabolism

2024

Abstract: Background: Insulin resistance (IR) is increasingly more prevalent in people with type 1 diabetes (T1D). We investigated whether IR is associated with continuous glucose monitor (CGM)-derived parameters (glucometrics) such as time in range (TIR), time ... ...

Abstract	Background: Insulin resistance (IR) is increasingly more prevalent in people with type 1 diabetes (T1D). We investigated whether IR is associated with continuous glucose monitor (CGM)-derived parameters (glucometrics) such as time in range (TIR), time above range (TAR), time below range (TBR) and glycaemic variability (CV). Methods: This is a retrospective analysis of two databases: IR was quantified according to the estimated glucose disposal rate (eGDR) (NCT04664036) and by performing a hyperinsulinaemic-euglycaemic clamp (HEC) (NCT04623320). All glucometrics were calculated over 28 days. Results: A total of 287 subjects were included. Mean age was 46 ± 17 years, 55% were male, TIR was 57 ± 14% and eGDR was 7.6 (5.6 - 9.3) mg/kg min. The tertile of people with the lowest eGDR (highest level of IR) had a higher TAR compared to the tertile with the highest eGDR (39 ± 15% versus 33 ± 14, p = 0.043). Using logistic regression, a higher eGDR was associated with a higher chance to fall in a higher TIR- (OR 1.251, p < 0.001), a lower TAR- (OR 1.281, p < 0.001) and a higher TBR-tertile (OR 0.893, p = 0.039), adjusted for age, sex, diabetes duration, smoking status and alcohol intake. In the 48 people undergoing a HEC, no significant association between glucometrics and the HEC-determined glucose disposal rate (M-value) was observed. Conclusion: In people with T1D, an association between IR, measured by eGDR, and worse CGM profiles was observed.
Language	English
Publishing date	2024-01-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	3029-6
ISSN	1945-7197 ; 0021-972X
ISSN (online)	1945-7197
ISSN	0021-972X
DOI	10.1210/clinem/dgae015
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Article ; Online: The 13C glucose breath test accurately identifies insulin resistance in people with type 1 diabetes.

Mertens, Jonathan / Roosens, Laurence / Braspenning, Rie / Vandebeeck, Joeri / Francque, Sven / De Block, Christophe

The Journal of clinical endocrinology and metabolism

2024

Abstract: Objective: This study investigated whether the delta-over-baseline of exhaled 13CO2 (Δ13CO2), generated from a 13C glucose breath test (13C-GBT), measured insulin resistance (IR) in people with type 1 diabetes, using the hyperinsulinemic-euglycemic ... ...

Abstract	Objective: This study investigated whether the delta-over-baseline of exhaled 13CO2 (Δ13CO2), generated from a 13C glucose breath test (13C-GBT), measured insulin resistance (IR) in people with type 1 diabetes, using the hyperinsulinemic-euglycemic clamp (HEC) as reference method. Secondary objective was to compare the 13C-GBT with the estimated glucose disposal rate (eGDR). Methods: A 40 mU/m2/min HEC and two separate 13C-GBTs (euglycemic with insulin bolus and hyperglycemic without bolus) were consecutively performed in 44 adults with type 1 diabetes with varying body compositions. eGDR was calculated based on HbA1c, presence of hypertension and waist circumference. Results: Mean M-value was 5.9 ± 3.1 mg/kg/min, mean euglycemic Δ13CO2 was 6.4 ± 2.1 δ‰, while median eGDR was 5.9 [4.3 - 9.8] mg/kg/min. The hyperglycemic Δ13CO2 did not correlate with the M-value, while the euglycemic Δ13CO2 and the M-value correlated strongly (r = 0.74, p < 0.001). Correlation between M-value and eGDR was more moderate (Spearman's rho = 0.63, p < 0.001). Linear regression showed an association between Δ13CO2 and M-value, adjusted for age, sex and HbA1c (adjusted R² = 0.52, B = 1.16, 95% CI 0.80 - 1.52, p < 0.001). The AUROC for Δ13CO2 to identify subjects with IR (M-value < 4.9 mg/kg/min) was 0.81 (95% CI 0.68 - 0.94, p < 0.001). The optimal cut-off for Δ13CO2 to identify subjects with IR was ≤ 5.8 δ‰. Conclusions: Under euglycemic conditions, the 13C-GBT accurately identified individuals with type 1 diabetes and concurrent IR, suggesting its potential as a valuable non-invasive index.
Language	English
Publishing date	2024-03-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	3029-6
ISSN	1945-7197 ; 0021-972X
ISSN (online)	1945-7197
ISSN	0021-972X
DOI	10.1210/clinem/dgae175
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Article: An accidental finding of a giant intra-abdominal mass.

Mertens, Jonathan / Driessen, Ann / Komen, Niels

Acta chirurgica Belgica

2022 Volume 123, Issue 1, Page(s) 85–89

Abstract: Introduction: Mesenteric cysts are rare intra-abdominal tumours often found incidentally on imaging studies or during surgery. The clinical presentation is various with most subjects being asymptomatic, but complications can occur such as torsion, ... ...

Abstract	Introduction: Mesenteric cysts are rare intra-abdominal tumours often found incidentally on imaging studies or during surgery. The clinical presentation is various with most subjects being asymptomatic, but complications can occur such as torsion, rupture, hemorrhage or obstruction of nearby structures. The etiology of mesenteric cysts remains uncertain. Complete surgical resection is preferred, although there are no specific guidelines concerning optimal treatment strategy. Case report: We present a 61-year-old male with type 2 diabetes mellitus who underwent a routine abdominal ultrasound examination which accidentally uncovered a large mass. The patient had no complaints nor any physical discomfort. Magnetic resonance imaging and computed tomography revealed a giant thin-walled cyst with multiple septa spanning 24 × 24 cm Conclusion: Mesenteric cysts can develop asymptomatically and reach enormous proportions. They are often found accidentally. Imaging studies aid in the differential diagnosis, but histopathology remains the diagnostic gold standard. Surgical resection prevails compared to a conservative approach due to the risk of complications. The choice between open or laparoscopic surgery should be determined based on the perioperative risk.
MeSH term(s)	Male ; Humans ; Middle Aged ; Mesenteric Cyst/diagnosis ; Diabetes Mellitus, Type 2/complications ; Cysts ; Mesentery/pathology ; Ultrasonography
Language	English
Publishing date	2022-01-17
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	210274-2
ISSN	0001-5458
ISSN	0001-5458
DOI	10.1080/00015458.2021.1920668
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Article ; Online: Artifactual hypoglycemia in a patient with systemic sclerosis.

Mertens, Jonathan / Haddad, Maryam

Acta clinica Belgica

2020 Volume 77, Issue 2, Page(s) 400–405

Abstract: Artifactual hypoglycemia, defined as a discrepancy between different laboratory measurements and actual blood glucose levels, can occur due to clinical conditions affecting the capillary microcirculation leading to falsely low blood glucose assessment. ... ...

Abstract	Artifactual hypoglycemia, defined as a discrepancy between different laboratory measurements and actual blood glucose levels, can occur due to clinical conditions affecting the capillary microcirculation leading to falsely low blood glucose assessment. Systemic sclerosis, hallmarked by auto-immunity, fibrosis of the skin and/or internal organs and small vessel vasculopathy, can interfere with capillary point-of-care (POC) glycemia measurements, leading to the misdiagnosis of hypoglycemia. We report an 87-year-old woman with recurrent, asymptomatic hypoglycemia of unknown cause. Clinical examination revealed multiple features of limited cutaneous systemic sclerosis causing microvascular damage leading to artifactual hypoglycemia. Artifactual hypoglycemia is rarely considered by physicians and knowledge of its causes is generally lacking. Early identification of causes of inaccurate glycemia assessment can prevent unnecessary investigations and treatment. In the future, continuous glucose monitoring (CGM) could become a reliable alternative for inpatient glucose monitoring.
MeSH term(s)	Aged, 80 and over ; Blood Glucose ; Blood Glucose Self-Monitoring ; Diabetes Mellitus, Type 1 ; Female ; Humans ; Hypoglycemia/diagnosis ; Hypoglycemia/etiology ; Scleroderma, Systemic/complications ; Scleroderma, Systemic/diagnosis ; Skin
Chemical Substances	Blood Glucose
Language	English
Publishing date	2020-10-19
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	390201-8
ISSN	2295-3337 ; 0001-5512 ; 1784-3286
ISSN (online)	2295-3337
ISSN	0001-5512 ; 1784-3286
DOI	10.1080/17843286.2020.1837575
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Article: A Case of Steroid-Responsive, COVID-19 Immune Reconstitution Inflammatory Syndrome Following the Use of Granulocyte Colony-Stimulating Factor.

Mertens, Jonathan / Laghrib, Yassine / Kenyon, Chris

Open forum infectious diseases

2020 Volume 7, Issue 8, Page(s) ofaa326

Abstract: We present a case report of a 54-year-old male with metastasized nasopharyngeal carcinoma presenting to the hospital with dyspnea, anorexia and fever. Examination revealed chemotherapy-induced pancytopenia. The patient tested positive for SARSCoV-2, but ... ...

Abstract	We present a case report of a 54-year-old male with metastasized nasopharyngeal carcinoma presenting to the hospital with dyspnea, anorexia and fever. Examination revealed chemotherapy-induced pancytopenia. The patient tested positive for SARSCoV-2, but respiratory complications were mild. The patient was treated with granulocyte-colony stimulating factor (G-CSF) leading to amelioration of the neutropenia. However, severe acute respiratory distress syndrome (ARDS) occurred, prompting the diagnosis of immune reconstitution inflammatory syndrome (IRIS). GCSF is currently investigated as additional therapy in ARDS, but this case report emphasizes that risks and benefits must be carefully assessed. To our knowledge, this is the first case report of IRIS-induced ARDS in a COVID-19 patient.
Keywords	covid19
Language	English
Publishing date	2020-08-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2757767-3
ISSN	2328-8957
ISSN	2328-8957
DOI	10.1093/ofid/ofaa326
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Article ; Online: Cold shock proteins: from cellular mechanisms to pathophysiology and disease.

Lindquist, Jonathan A / Mertens, Peter R

Cell communication and signaling : CCS

2018 Volume 16, Issue 1, Page(s) 63

Abstract: Cold shock proteins are multifunctional RNA/DNA binding proteins, characterized by the presence of one or more cold shock domains. In humans, the best characterized members of this family are denoted Y-box binding proteins, such as Y-box binding protein- ... ...

Abstract	Cold shock proteins are multifunctional RNA/DNA binding proteins, characterized by the presence of one or more cold shock domains. In humans, the best characterized members of this family are denoted Y-box binding proteins, such as Y-box binding protein-1 (YB-1). Biological activities range from the regulation of transcription, splicing and translation, to the orchestration of exosomal RNA content. Indeed, the secretion of YB-1 from cells via exosomes has opened the door to further potent activities. Evidence links a skewed cold shock protein expression pattern with cancer and inflammatory diseases. In this review the evidence for a causative involvement of cold shock proteins in disease development and progression is summarized. Furthermore, the potential application of cold shock proteins for diagnostics and as targets for therapy is elucidated.
MeSH term(s)	Cold Shock Proteins and Peptides/metabolism ; Disease ; Feedback, Physiological ; Humans ; Stress, Physiological
Chemical Substances	Cold Shock Proteins and Peptides
Language	English
Publishing date	2018-09-26
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2126315-2
ISSN	1478-811X ; 1478-811X
ISSN (online)	1478-811X
ISSN	1478-811X
DOI	10.1186/s12964-018-0274-6
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Article: Corrigendum: Proximal hyperspectral imaging detects diurnal and drought-induced changes in maize physiology.

Mertens, Stien / Verbraeken, Lennart / Sprenger, Heike / Demuynck, Kirin / Maleux, Katrien / Cannoot, Bernard / De Block, Jolien / Maere, Steven / Nelissen, Hilde / Bonaventure, Gustavo / Crafts-Brandner, Steven J / Vogel, Jonathan T / Bruce, Wesley / Inzé, Dirk / Wuyts, Nathalie

Frontiers in plant science

2024 Volume 15, Page(s) 1379654

Abstract: This corrects the article DOI: 10.3389/fpls.2021.640914.]. ...

Abstract	[This corrects the article DOI: 10.3389/fpls.2021.640914.].
Language	English
Publishing date	2024-02-21
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2613694-6
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2024.1379654
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Article ; Online: Spectroscopic Characterization of Thiacarbocyanine Dye Molecules Adsorbed on Hexagonal Boron Nitride

Anne-Charlotte Nellissen / Eduard Fron / Jonathan B. F. Vandenwijngaerden / Steven De Feyter / Stijn F. L. Mertens / Mark Van der Auweraer

ACS Omega, Vol 8, Iss 39, Pp 35638-

a Time-Resolved Study

2023 Volume 35652

Keywords	Chemistry ; QD1-999
Language	English
Publishing date	2023-09-01T00:00:00Z
Publisher	American Chemical Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Spectroscopic Characterization of Thiacarbocyanine Dye Molecules Adsorbed on Hexagonal Boron Nitride: a Time-Resolved Study.

Nellissen, Anne-Charlotte / Fron, Eduard / Vandenwijngaerden, Jonathan B F / De Feyter, Steven / Mertens, Stijn F L / Van der Auweraer, Mark

ACS omega

2023 Volume 8, Issue 39, Page(s) 35638–35652

Abstract: Physisorption on hexagonal boron nitride (hBN) gained interest over the years thanks to its properties (chemically and thermally stable, insulating properties, etc.) and similarities to the well-known graphene. A recent study showed flat-on adsorption of ...

Abstract	Physisorption on hexagonal boron nitride (hBN) gained interest over the years thanks to its properties (chemically and thermally stable, insulating properties, etc.) and similarities to the well-known graphene. A recent study showed flat-on adsorption of several cationic thiacarbocyanine dyes on hBN with a tendency to form weakly coupled H- or I-type aggregates, while a zwitterionic thiacarbocyanine dye rather led to a tilted adsorption. With this in-depth time-resolved study using the TC-SPC technique, we confirm the results proven by adsorption isotherms, atomic force microscopy, and stationary state spectroscopy combined with molecular mechanics simulations and estimation of the corresponding exciton interaction. The absence of a systematic trend for the dependence of the decay times, normalized amplitudes of the decay components, and contribution of different components to the stationary emission spectra upon the emission wavelength observed for all studied dyes and coverages suggests the occurrence of a single emitting species. At low coverage levels, the non-mono-exponential character of the decays was attributed to adsorption on different sites characterized by different intramolecular rotational freedom or energy transfer to nonfluorescent traps or a combination of both. The difference between the decay rates of the four dyes reflects a different density of the nonfluorescent traps. Although the decay time of the unquenched dyes was in the order of magnitude of that of dye monomers in a rigid environment, it is also compatible with weakly coupled aggregates such as proposed earlier based on the stationary spectra. Hence, the adsorption leads to a rigid environment of the dyes, blocking internal conversion. Increasing the concentration of the dye solution from which the adsorption on hBN occurs increases not only the coverage of the hBN surface but also the extent of energy transfer to nonfluorescent traps. For TDC (5,5-dichloro-3-3'-diethyl-9-ethyl-thiacarbocyanine) and TD2 (3-3'-diethyl-9-ethyl-thiacarbocyanine), besides direct energy transfer to traps, exciton hopping between dye dimers followed by energy transfer to these traps occurs, which resulted in a decreasing decay time of the longest decaying component. For all dyes, it was also possible to analyze the fluorescence decays as a stretched exponential as would be expected for energy transfer to randomly distributed traps in a two-dimensional (2D) geometry. This analysis yielded a fluorescence decay time of the unquenched dyes similar to the longest decay time obtained by analysis of the fluorescence decays as a sum of three of four exponentials.
Language	English
Publishing date	2023-09-20
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.3c02020
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Article: The evolution of PAs in the Canadian Armed Forces.

Mertens, Jonathan / Descoteaux, Marc

JAAPA : official journal of the American Academy of Physician Assistants

2017 Volume 30, Issue 1, Page(s) 1–6

Abstract: This study documents the growing role of the physician assistant (PA) in the Canadian Armed Forces. PAs have served as the backbone of the Royal Canadian Medical Services' frontline medical operations since 1984, on land, aboard ships and submarines, and ...

Abstract	This study documents the growing role of the physician assistant (PA) in the Canadian Armed Forces. PAs have served as the backbone of the Royal Canadian Medical Services' frontline medical operations since 1984, on land, aboard ships and submarines, and domestically in garrison. Candidates begin as medical technicians and receive advanced training to become PAs at midcareer. The current rank of PAs as warrant officers is evolving and a commissioned status is under consideration.
MeSH term(s)	Canada ; Education, Medical/methods ; Military Personnel ; Physician Assistants
Language	English
Publishing date	2017-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2415226-2
ISSN	0893-7400 ; 1547-1896
ISSN (online)	0893-7400
ISSN	1547-1896
DOI	10.1097/01.JAA.0000511038.72316.b9
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