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Article ; Online: A 56-Year-Old Male With Weight Loss, Night Sweats, Dyspnea, and Bladder Cancer.

Sanville, Bradley C / Kuhn, Brooks T

Journal of investigative medicine high impact case reports

2021 Volume 9, Page(s) 2324709621997246

Abstract: A 56-year-old man presented with subacute night sweats, fever, and weight loss with worsening dyspnea. Computed tomography (CT) scan demonstrated miliary pattern of nodules evenly distributed throughout all lung fields. Given the patient's CT findings ... ...

Abstract	A 56-year-old man presented with subacute night sweats, fever, and weight loss with worsening dyspnea. Computed tomography (CT) scan demonstrated miliary pattern of nodules evenly distributed throughout all lung fields. Given the patient's CT findings and temporal association with Bacille Calmette-Guerin (BCG) immunotherapy for bladder cancer, the patient was diagnosed with disseminated
MeSH term(s)	Administration, Intravesical ; Dyspnea/etiology ; Humans ; Male ; Middle Aged ; Sweat ; Urinary Bladder Neoplasms/complications ; Urinary Bladder Neoplasms/drug therapy ; Weight Loss
Language	English
Publishing date	2021-03-01
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2710326-2
ISSN	2324-7096 ; 2324-7096
ISSN (online)	2324-7096
ISSN	2324-7096
DOI	10.1177/2324709621997246
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A 56-Year-Old Male With Weight Loss, Night Sweats, Dyspnea, and Bladder Cancer

Bradley C. Sanville MD / Brooks T. Kuhn MD

Journal of Investigative Medicine High Impact Case Reports, Vol

2021 Volume 9

Abstract	A 56-year-old man presented with subacute night sweats, fever, and weight loss with worsening dyspnea. Computed tomography (CT) scan demonstrated miliary pattern of nodules evenly distributed throughout all lung fields. Given the patient’s CT findings and temporal association with Bacille Calmette-Guerin (BCG) immunotherapy for bladder cancer, the patient was diagnosed with disseminated Mycobacterium bovis secondary to BCG bladder instillations.
Keywords	Medicine (General) ; R5-920 ; Pathology ; RB1-214
Language	English
Publishing date	2021-02-01T00:00:00Z
Publisher	SAGE Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Biomechanical Analysis of Combined Medial Calcar and Lateral Locked Plating Versus Isolated Lateral Locked Plating of Proximal Humerus Fractures.

Kotler, Joshua A / Zuppke, Julia N / Abraham, Vivek M / Sanville, Jennifer A / Nabet, Austin C / Carofino, Bradley / Gardner, Michael J / Smith, Christopher S

Journal of orthopaedic trauma

2023 Volume 37, Issue 9, Page(s) e355–e360

Abstract: Objective: Medial calcar buttress plating combined with lateral locked plating is biomechanically tested against isolated lateral locked plating in synthetic humeri models for the treatment of proximal humerus fractures.: Methods: Proximal humerus ... ...

Abstract	Objective: Medial calcar buttress plating combined with lateral locked plating is biomechanically tested against isolated lateral locked plating in synthetic humeri models for the treatment of proximal humerus fractures. Methods: Proximal humerus fractures (OTA/AO type 11-A2.1) were manufactured in 10 pairs of Sawbones humeri models (Sawbones, Pacific Research Laboratories, Vashon Island, WA). Specimen were randomly assigned and instrumented with either medial calcar buttress plating combined with lateral locked plating (CP) or isolated lateral locked plating (LP). Nondestructive torsional and axial load tests were performed to evaluate construct stiffness. Large-cycle axial tests were conducted followed by destructive ramp-to-failure tests. Cyclic stiffness was compared in both nondestructive and ultimate failure loads. Failure displacement was recorded and compared between groups. Results: The addition of medial calcar buttress plating to lateral locked plating constructs significantly increased the axial ( P < 0.01) and torsional ( P < 0.01) stiffness of the construct compared with isolated lateral locked plating by 95.56% and 37.46%, respectively. All models demonstrated greater axial stiffness ( P < 0.01) after 5000 cycles of axial compression, not dependent on the fixation method. During destructive testing, the CP construct withstood 45.35% larger load ( P < 0.01) and congruently exhibited 58% less humeral head displacement ( P = 0.02) before failure when compared with the LP construct. Conclusion: This study demonstrates the biomechanical superiority of medial calcar buttress plating when combined with lateral locked plating as compared with isolated lateral locked plating of OTA/AO type 11-A2.1 proximal humerus in synthetic humeri models.
MeSH term(s)	Humans ; Biomechanical Phenomena ; Bone Plates ; Bone Screws ; Cadaver ; Fracture Fixation, Internal/methods ; Humeral Fractures/surgery ; Humeral Head ; Shoulder Fractures/surgery
Language	English
Publishing date	2023-04-20
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	639099-7
ISSN	1531-2291 ; 0890-5339
ISSN (online)	1531-2291
ISSN	0890-5339
DOI	10.1097/BOT.0000000000002619
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The use of ivacaftor in an adult with severe lung disease due to cystic fibrosis (ΔF508/G551D).

Polenakovik, Hari M / Sanville, Bradley

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

2013 Volume 12, Issue 5, Page(s) 530–531

Abstract: We report on an adult with cystic fibrosis (ΔF508/G551D) with severe lung disease (forced expiratory volume (FEV1) in one second 24% predicted) who was admitted for a pulmonary exacerbation. He was managed with maximal medical therapy, but did not have ... ...

Abstract	We report on an adult with cystic fibrosis (ΔF508/G551D) with severe lung disease (forced expiratory volume (FEV1) in one second 24% predicted) who was admitted for a pulmonary exacerbation. He was managed with maximal medical therapy, but did not have significant improvement until after he was started on ivacaftor on hospital day 15. He subsequently had significant improvement in lung function with normalization of hypercarbia, oxygen saturation on room air, and increase in FEV1 to 36% predicted. Prior to use of ivacaftor he was being assessed for a lung transplant. However, after ivacaftor therapy for 6 months, he is no longer considering this treatment modality due to his improvement of lung function and functional status.
MeSH term(s)	Adult ; Aminophenols/therapeutic use ; Cystic Fibrosis/complications ; Cystic Fibrosis/physiopathology ; Forced Expiratory Volume ; Humans ; Lung Diseases/drug therapy ; Lung Diseases/etiology ; Lung Diseases/physiopathology ; Male ; Quinolones/therapeutic use ; Severity of Illness Index
Chemical Substances	Aminophenols ; Quinolones ; ivacaftor (1Y740ILL1Z)
Language	English
Publishing date	2013-09
Publishing country	Netherlands
Document type	Case Reports ; Journal Article
ZDB-ID	2091075-7
ISSN	1873-5010 ; 1569-1993
ISSN (online)	1873-5010
ISSN	1569-1993
DOI	10.1016/j.jcf.2012.12.004
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Article ; Online: Simulator-Based Training in FoCUS with Skill-Based Metrics for Feedback

Robert Morgan / Bradley Sanville / Shashank Bathula / Shaban Demirel / Serene Perkins / Gordon E. Johnson

POCUS Journal, Vol 4, Iss

An Efficacy Study

2019 Volume 2

Abstract: Introduction: Focused Cardiac Ultrasound (FoCUS) is a relatively new technology that requires training and mentoring. The use of a FoCUS simulator is a novel training method that may prompt greater adoption of this technology by physicians at different ... ...

Abstract	Introduction: Focused Cardiac Ultrasound (FoCUS) is a relatively new technology that requires training and mentoring. The use of a FoCUS simulator is a novel training method that may prompt greater adoption of this technology by physicians at different levels of training and experience. The objective of this study was to determine if simulation training using an advanced echo simulator (Real Ultrasound®) is a feasible means of delivering training in FoCUS. Methods: Twenty-five residents and attending physicians participated in this study. After performing a pretest, training on the Real Ultrasound® was administered. Improvement was assessed immediately after simulator training. Additionally, some participants were retested six months after training to determine whether learned skills were retained. Results: Of the 25 participants recruited, all completed the pretest phase, and 17 completed the training and immediate posttest assessment. At pretest, the median angular deviation of acquired images from anatomically correct was 37°, which improved to 30° after training (p<0.002). Technical skill was largely maintained at six months of follow-up, with a median angle error of 27 and 31°, respectively (p=0.093) in 8 participants who completed the post and six-month retention assessments. The median pretest image interpretation score improved from 55% to 70% (p=0.028); median post and six month scores in the 8 participants were 72 and 68%, respectively (p=0.735). Conclusions: Simulation training in FoCUS significantly improves skills in image acquisition. These skills appear to be retained over time. This study adds support for the use of advanced echocardiographic simulators to enhance formal FoCUS training in a real-world setting.
Keywords	Internal medicine ; RC31-1245 ; Medical technology ; R855-855.5
Subject code	796
Language	English
Publishing date	2019-11-01T00:00:00Z
Publisher	CINQUILL Medical Publishers Inc.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A Community-transmitted Case of Severe Acute Respiratory Distress Syndrome (SARS) Due to SARS-CoV-2 in the United States.

Sanville, Bradley / Corbett, Rebecca / Pidcock, Wesley / Hardin, Kaitlyn / Sebat, Christian / Nguyen, Minh-Vu / Thompson, George R / Haczku, Angela / Schivo, Michael / Cohen, Stuart

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2020 Volume 71, Issue 16, Page(s) 2222–2226

Abstract: This is the first known community transmission case of the novel coronavirus disease (COVID-19) in the United States, with significant public health implications. Diagnosis of COVID-19 is currently confirmed with PCR based testing of appropriate ... ...

Abstract	This is the first known community transmission case of the novel coronavirus disease (COVID-19) in the United States, with significant public health implications. Diagnosis of COVID-19 is currently confirmed with PCR based testing of appropriate respiratory samples. Given the absence of travel or known exposure history, this patient did not meet the criteria for testing according to CDC guidelines at the time of her presentation. Since this case, any patient with severe disease (eg, ARDS or pneumonia) requiring hospitalization without an explanatory diagnosis can be tested even if no clear source of exposure is identified. While influencing national health policies for revising screening criteria, this case also highlighted significant knowledge gaps in diagnosis and treatment and a desperate need for early, widespread, fast and cheap testing for COVID-19.
MeSH term(s)	Adenosine Monophosphate/analogs & derivatives ; Adenosine Monophosphate/therapeutic use ; Adult ; Alanine/analogs & derivatives ; Alanine/therapeutic use ; Antiviral Agents/therapeutic use ; COVID-19/complications ; COVID-19/diagnostic imaging ; COVID-19/drug therapy ; Community-Acquired Infections/drug therapy ; Community-Acquired Infections/virology ; Female ; Humans ; Middle Aged ; Respiratory Distress Syndrome/diagnostic imaging ; Respiratory Distress Syndrome/virology ; Risk Factors ; Shock, Septic/etiology ; Thorax/diagnostic imaging ; Tomography, X-Ray Computed ; Treatment Outcome ; United States/epidemiology
Chemical Substances	Antiviral Agents ; remdesivir (3QKI37EEHE) ; Adenosine Monophosphate (415SHH325A) ; Alanine (OF5P57N2ZX)
Keywords	covid19
Language	English
Publishing date	2020-03-29
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciaa347
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Zs.MO 480: Show issues

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Article: A Community Transmitted Case of Severe Acute Respiratory Distress Syndrome due to SARS CoV2 in the United States

Sanville, Bradley / Corbett, Rebecca / Pidcock, Wesley / Hardin, Kaitlyn / Sebat, Christian / Nguyen, Minh-Vu / Thompson, George R / Haczku, Angela / Schivo, Michael / Cohen, Stuart

Clin. infect. dis

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #19458
Database	COVID19

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Article ; Online: A Community-transmitted Case of Severe Acute Respiratory Distress Syndrome (SARS) Due to SARS-CoV-2 in the United States

Sanville, Bradley / Corbett, Rebecca / Pidcock, Wesley / Hardin, Kaitlyn / Sebat, Christian / Nguyen, Minh-Vu / Thompson, George R / Haczku, Angela / Schivo, Michael / Cohen, Stuart

Clinical Infectious Diseases ; ISSN 1058-4838 1537-6591

2020

Abstract: Abstract This is the first known community transmission case of the novel coronavirus disease (COVID-19) in the United States, with significant public health implications. Diagnosis of COVID-19 is currently confirmed with PCR based testing of appropriate ...

Abstract	Abstract This is the first known community transmission case of the novel coronavirus disease (COVID-19) in the United States, with significant public health implications. Diagnosis of COVID-19 is currently confirmed with PCR based testing of appropriate respiratory samples. Given the absence of travel or known exposure history, this patient did not meet the criteria for testing according to CDC guidelines at the time of her presentation. Since this case, any patient with severe disease (eg, ARDS or pneumonia) requiring hospitalization without an explanatory diagnosis can be tested even if no clear source of exposure is identified. While influencing national health policies for revising screening criteria, this case also highlighted significant knowledge gaps in diagnosis and treatment and a desperate need for early, widespread, fast and cheap testing for COVID-19.
Keywords	Microbiology (medical) ; Infectious Diseases ; covid19
Language	English
Publisher	Oxford University Press (OUP)
Publishing country	uk
Document type	Article ; Online
DOI	10.1093/cid/ciaa347
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A Community Transmitted Case of Severe Acute Respiratory Distress Syndrome due to SARS CoV2 in the United States.

Sanville, Bradley / Corbett, Rebecca / Pidcock, Wesley / Hardin, Kaitlyn / Sebat, Christian / Nguyen, Minh-Vu / Thompson, George R / Haczku, Angela / Schivo, Michael / Cohen, Stuart

2020

Abstract	Abstract This is the first known community transmission case of the novel coronavirus disease (COVID-19) in the United States, with significant public health implications. Diagnosis of COVID-19 is currently confirmed with PCR based testing of appropriate respiratory samples. Given the absence of travel or known exposure history, this patient did not meet the criteria for testing according to CDC guidelines at the time of her presentation. Since this case, any patient with severe disease (eg, ARDS or pneumonia) requiring hospitalization without an explanatory diagnosis can be tested even if no clear source of exposure is identified. While influencing national health policies for revising screening criteria, this case also highlighted significant knowledge gaps in diagnosis and treatment and a desperate need for early, widespread, fast and cheap testing for COVID-19.
Keywords	Microbiology ; Biological Sciences ; Medical and Health Sciences ; covid19
Publishing date	2020-03-30
Publisher	eScholarship, University of California
Publishing country	us
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Viral genome methylation as an epigenetic defense against geminiviruses.

Raja, Priya / Sanville, Bradley C / Buchmann, R Cody / Bisaro, David M

Journal of virology

2008 Volume 82, Issue 18, Page(s) 8997–9007

Abstract: Geminiviruses encapsidate single-stranded DNA genomes that replicate in plant cell nuclei through double-stranded DNA intermediates that associate with cellular histone proteins to form minichromosomes. Like most plant viruses, geminiviruses are targeted ...

Abstract	Geminiviruses encapsidate single-stranded DNA genomes that replicate in plant cell nuclei through double-stranded DNA intermediates that associate with cellular histone proteins to form minichromosomes. Like most plant viruses, geminiviruses are targeted by RNA silencing and encode suppressor proteins such as AL2 and L2 to counter this defense. These related proteins can suppress silencing by multiple mechanisms, one of which involves interacting with and inhibiting adenosine kinase (ADK), a cellular enzyme associated with the methyl cycle that generates S-adenosyl-methionine, an essential methyltransferase cofactor. Thus, we hypothesized that the viral genome is targeted by small-RNA-directed methylation. Here, we show that Arabidopsis plants with mutations in genes encoding cytosine or histone H3 lysine 9 (H3K9) methyltransferases, RNA-directed methylation pathway components, or ADK are hypersensitive to geminivirus infection. We also demonstrate that viral DNA and associated histone H3 are methylated in infected plants and that cytosine methylation levels are significantly reduced in viral DNA isolated from methylation-deficient mutants. Finally, we demonstrate that Beet curly top virus L2- mutant DNA present in tissues that have recovered from infection is hypermethylated and that host recovery requires AGO4, a component of the RNA-directed methylation pathway. We propose that plants use chromatin methylation as a defense against DNA viruses, which geminiviruses counter by inhibiting global methylation. In addition, our results establish that geminiviruses can be useful models for genome methylation in plants and suggest that there are redundant pathways leading to cytosine methylation.
MeSH term(s)	Adenosine Kinase/genetics ; Adenosine Kinase/metabolism ; Arabidopsis/genetics ; Arabidopsis/virology ; Chromatin/metabolism ; DNA, Viral/metabolism ; DNA-Cytosine Methylases ; Epigenesis, Genetic ; Geminiviridae/genetics ; Geminiviridae/pathogenicity ; Genome, Viral ; Histone-Lysine N-Methyltransferase/genetics ; Histones/metabolism ; Methylation ; Models, Genetic ; Mutation ; Plant Diseases/virology
Chemical Substances	Chromatin ; DNA, Viral ; Histones ; DNA-Cytosine Methylases (EC 2.1.1.-) ; Histone-Lysine N-Methyltransferase (EC 2.1.1.43) ; Adenosine Kinase (EC 2.7.1.20)
Language	English
Publishing date	2008-07-02
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/JVI.00719-08
Database	MEDical Literature Analysis and Retrieval System OnLINE

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