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Article: HIV-Infected Hepatic Stellate Cells or HCV-Infected Hepatocytes Are Unable to Promote Latency Reversal among HIV-Infected Mononuclear Cells.

López, Cinthya Alicia Marcela / Freiberger, Rosa Nicole / Sviercz, Franco Agustín / Quarleri, Jorge / Delpino, María Victoria

Pathogens (Basel, Switzerland)

2024 Volume 13, Issue 2

Abstract: Due to a common mode of transmission through infected human blood, hepatitis C virus (HCV) and human immunodeficiency virus (HIV) co-infection is relatively prevalent. In alignment with this, HCV co-infection is associated with an increased size of the ... ...

Abstract	Due to a common mode of transmission through infected human blood, hepatitis C virus (HCV) and human immunodeficiency virus (HIV) co-infection is relatively prevalent. In alignment with this, HCV co-infection is associated with an increased size of the HIV reservoir in highly active antiretroviral therapy (HAART)-treated individuals. Hence, it is crucial to comprehend the physiological mechanisms governing the latency and reactivation of HIV in reservoirs. Consequently, our study delves into the interplay between HCV/HIV co-infection in liver cells and its impact on the modulation of HIV latency. We utilized the latently infected monocytic cell line (U1) and the latently infected T-cell line (J-Lat) and found that mediators produced by the infection of hepatic stellate cells and hepatocytes with HIV and HCV, respectively, were incapable of inducing latency reversal under the studied conditions. This may favor the maintenance of the HIV reservoir size among latently infected mononuclear cells in the liver. Further investigations are essential to elucidate the role of the interaction between liver cells in regulating HIV latency and/or reactivation, providing a physiologically relevant model for comprehending reservoir microenvironments in vivo.
Language	English
Publishing date	2024-02-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens13020134
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Article ; Online: Manipulation of microvillar proteins during

Felipe-López, Alfonso / Hansmeier, Nicole / Danzer, Claudia / Hensel, Michael

Frontiers in cellular and infection microbiology

2023 Volume 13, Page(s) 1137062

Abstract: Enterocyte invasion by the gastrointestinal ... ...

Abstract	Enterocyte invasion by the gastrointestinal pathogen
MeSH term(s)	Actins/metabolism ; Salmonella enterica/metabolism ; Microvilli ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Actin Cytoskeleton/metabolism ; Salmonella/metabolism
Chemical Substances	Actins ; Bacterial Proteins
Language	English
Publishing date	2023-03-02
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2023.1137062
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Article ; Online: Elucidating the factors and consequences of the severity of rumen acidosis in first-lactation Holstein cows during transition and early lactation.

Hartinger, Thomas / Castillo-Lopez, Ezequias / Reisinger, Nicole / Zebeli, Qendrim

Journal of animal science

2024 Volume 102

Abstract: First-lactation cows are particularly prone to subacute ruminal acidosis (SARA) during transition. Besides common risk factors of SARA, such as feeding of starch-rich diets, an individual severity of SARA in cows has been recently evidenced. Yet, the ... ...

Abstract	First-lactation cows are particularly prone to subacute ruminal acidosis (SARA) during transition. Besides common risk factors of SARA, such as feeding of starch-rich diets, an individual severity of SARA in cows has been recently evidenced. Yet, the factors that play a role in SARA severity have not been elucidated. The main goal of this research was to evaluate the factors of SARA severity in first-lactation cows during transition and early lactation, which go beyond high-grain feeding, and to explore their impact on behavior, health, and fermentation in the rumen and hindgut. Twenty-four first-lactation Holstein cows with the same feeding regime were used starting from 3 wk before the expected calving day until 10 wk postpartum. Cows received a close-up diet (32% concentrate) until calving and were then transitioned to a lactation diet (60% concentrate) within 1 week. The SARA severity was assessed by cluster analysis of several rumen pH metrics, which revealed exceptionally longer and more severe SARA in cows denominated as high (n = 9), as compared to moderate (n = 9) and low (n = 6) SARA severity cows (P < 0.01). The logistic analysis showed that the length of close-up feeding, age at parturition, and the level of dry matter intake (DMI) were the main factors that influenced the cows' odds for high SARA severity (each P ≤ 0.01). Moreover, the ANOVA hinted differences in the metabolic activity of the ruminal microbiome to promote SARA severity, as indicated by highest ruminal propionate proportions (P = 0.05) in high SARA severity cows, also with similar DMI. The distinct SARA severity was marginally reflected in behavior and there were no effects of SARA severity or high-grain feeding on blood inflammation markers, which peaked at parturition regardless of SARA severity (P < 0.01). Still, ongoing high-grain feeding increased liver enzyme concentrations from 6 wk postpartum on, compared to weeks before (P < 0.01), yet irrespectively of SARA severity. In conclusion, first-lactation cows differed in SARA severity under the same feeding regime, which was ascribed to management factors and differences in ruminal fermentation. Further research is warranted to validate these findings and to understand the mechanisms behind differences in the metabolic function of rumen microbiome, in particular in terms of evaluating markers for various SARA severity, as well as to evaluate potential long-term effects on health, performance, fertility, and longevity of dairy cows.
MeSH term(s)	Female ; Cattle ; Animals ; Rumen/metabolism ; Cattle Diseases/metabolism ; Hydrogen-Ion Concentration ; Lactation ; Diet/veterinary ; Diet/adverse effects ; Acidosis/veterinary ; Milk/metabolism
Language	English
Publishing date	2024-02-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	390959-1
ISSN	1525-3163 ; 0021-8812
ISSN (online)	1525-3163
ISSN	0021-8812
DOI	10.1093/jas/skae041
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Article: Brains vs Brawn: Relative brain size is sexually dimorphic amongst weapon bearing ruminants.

Lopez, Nicole / Moore Tupas, Jonathon / Stankowich, Theodore

Research square

2023

Abstract: Here, we investigate the relationship between relative brain size and sexual weapons in ruminants. In most cases, sexual weaponry is heavily male-biased, and costs resulting from growing, maintaining, or wielding weapons will be suffered primarily by ... ...

Abstract	Here, we investigate the relationship between relative brain size and sexual weapons in ruminants. In most cases, sexual weaponry is heavily male-biased, and costs resulting from growing, maintaining, or wielding weapons will be suffered primarily by males. We used comparative phylogenetic analyses to test whether increased investment in sexual weapon size (tusks, antlers, and horns) across four families (Tragulidae, Moschidae, Cervidae, and Bovidae) was associated with decrease in relative brain size, and whether the difference in weapon investment relative to conspecific females led to sexual differences in relative brain size. We found no relationship between relative brain size and relative weapon size within males or females, but when we compared males directly to conspecific females, we found that as males possessed larger weaponry, they had smaller brain sizes, regardless of weapon type. Our finding suggest male investment in some types of elaborate weapons could be related to male reduction in larger brains.
Language	English
Publishing date	2023-07-21
Publishing country	United States
Document type	Preprint
DOI	10.21203/rs.3.rs-3143852/v1
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Article ; Online: Fibroblast growth factor pathway component expression in the regenerating zebrafish fin.

Cudak, Nicole / López-Delgado, Alejandra Cristina / Keil, Sebastian / Knopf, Franziska

Gene expression patterns : GEP

2023 Volume 48, Page(s) 119307

Abstract: Adult zebrafish regenerate their appendages (fins) after amputation including the regeneration of bone structures (fin rays). Fibroblast growth factor (Fgf) signaling, which is involved in morphogenetic processes during development, has been shown to be ... ...

Abstract	Adult zebrafish regenerate their appendages (fins) after amputation including the regeneration of bone structures (fin rays). Fibroblast growth factor (Fgf) signaling, which is involved in morphogenetic processes during development, has been shown to be essential for the process of fin regeneration. Moreover, mutations in Fgf pathway component genes lead to abnormal skeletal growth in teleosts and mammals, including humans, illustrating the importance of Fgf signaling in the growth control of tissues. Here, we revisited Fgf signaling pathway component expression by RNA in situ hybridization to test for the expression of about half of the ligands and all receptors of the pathway in the regenerating zebrafish fin. Expression patterns of fgf7, fgf10b, fgf12b, fgf17b and fgfr1b have not been reported in the literature before. We summarize and discuss known and novel localization of expression and find that all five Fgf receptors (fgfr1a, fgfr1b, fgfr2, fgfr3 and fgfr4) and most of the tested ligands are expressed in specific regions of the regenerate. Our work provides a basis to study domain specific functions of Fgf signaling in the regenerating teleost appendage.
MeSH term(s)	Animals ; Humans ; Zebrafish/metabolism ; Fibroblast Growth Factors/genetics ; Fibroblast Growth Factors/metabolism ; Ligands ; Signal Transduction/genetics ; Zebrafish Proteins/genetics ; Zebrafish Proteins/metabolism ; Mammals/metabolism ; Receptor, Fibroblast Growth Factor, Type 3 ; Receptor, Fibroblast Growth Factor, Type 4/metabolism
Chemical Substances	Fibroblast Growth Factors (62031-54-3) ; Ligands ; Zebrafish Proteins ; fgfr3 protein, zebrafish (EC 2.7.10.1) ; Receptor, Fibroblast Growth Factor, Type 3 (EC 2.7.10.1) ; fgfr4 protein, zebrafish (EC 2.7.10.1) ; Receptor, Fibroblast Growth Factor, Type 4 (EC 2.7.10.1)
Language	English
Publishing date	2023-02-24
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2058346-1
ISSN	1872-7298 ; 1567-133X
ISSN (online)	1872-7298
ISSN	1567-133X
DOI	10.1016/j.gep.2023.119307
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Book: Peripheral nerve

Birn, Anne-Emanuelle / Necochea López, Raúl

health and medicine in Cold War Latin America

(American encounters/global interactions)

2020

Abstract: ... of Science in Revolutionary Bolivia / Nicole L. Pacino -- Cold War Mexico in a Time of "Wonder Drugs ... for further Research / Anne-Emanuelle Birn and Raúl Necochea López. ...

Institution	Latin America / Foreign relations / Soviet Union Soviet Union / Foreign relations / Latin America Latin America / Foreign relations / United States United States / Foreign relations / Latin America
Author's details	Anne-Emanuelle Birn and Raúl Necochea López
Series title	American encounters/global interactions
Abstract	Introduction: Alternative Destinies and Solidarities for Health and Medicine in Cold War Latin America / Anne-Emanuelle Birn -- Under Surveillance : Public Health, the FBI, and Exile in Cold War Mexico / -- Katherine E. Bliss -- National Politics and Scientific Pursuits : Medical Education and the Strategic Value of Science in Revolutionary Bolivia / Nicole L. Pacino -- Cold War Mexico in a Time of "Wonder Drugs" / Gabriela Soto Laveaga -- The Puerto Rico Family Life Study and the Cold War Politics of Fertility Surveys / Raúl Necochea López -- Parasitology and Communism : Public Health and Politics in Samuel Barnsley Pessoa's Brazil / Gilberto Hochman and Carlos Henrique Assunção Paiva -- Revolutionizing Cuban Psychiatry : The Freud Wars, 1955-1970 / Jennifer Lynn Lambe -- From Cold War Pressures to State Policy to People's Health : The Politics of Social Medicine and Socialized Medical Care in Chile / Jadwiga E. Pieper Mooney -- "Psychotherapy of the Oppressed" : Anti-imperialism and Psychoanalysis in Cold War Buenos Aires / Marco Ramos -- South-South Cooperation as a Cold War Tonic : Cuban Medical Diplomacy to Sandinista Nicaragua, 1979-1990 / Cheasty Anderson -- Epilogue: A Lingering Cold (War)? Reflections for the Present and an Agenda for further Research / Anne-Emanuelle Birn and Raúl Necochea López. "PERIPHERAL NERVE is an edited volume that brings together scholars from the United States, Canada, and Latin America to challenge the dominant narrative that the United States was the primary medical interlocutor in Latin America during the Cold War. It chronicles the experiences of Latin Americans who sought alternative channels of health and medical solidarity with the Soviet Union and via South-South solidarities within and beyond Latin America. These channels, which included anti-colonial psychoanalysis in Argentina and the emergence of local and specialized fertility research in Puerto Rico, were alternative to mainland U.S. interests and served as a vital part of health policy and medical developments in the Global South. Ultimately, the collection highlights the multivalent nature of the Latin American Cold War as a significant perspective for studies of medicine and public health, international development, and international relations.^ The volume is divided into three parts, with three or four chapters each, that explore leftist affinities and U.S. suspicions, expertise and contested ideologies, and health politics and publics. Part I includes a chapter by Katherine E. Bliss where she showcases the life and contributions of Lini de Vries, a community health worker who developed health education programs for Indigenous communities in Oaxaca, but who came to be viewed as a threat to national U.S. interests because of her communist ties. Chapter 2 by Nicole L. Pacino examines how the Rockefeller Foundation refused to fund medical schools in Bolivia because of the revolutionary consciousness and communist values of the country and its students.^
Keywords	Public health / Political aspects / Latin America / History ; Medical policy / Latin America / History ; Cold War / Social aspects / Latin America
Language	English
Size	xx, 356 Seiten
Publisher	Duke University Press
Publishing place	Durham ; London
Publishing country	United States ; Great Britain
Document type	Book
Note	Includes bibliographical references and index
HBZ-ID	HT020675545
ISBN	978-1-4780-0868-2 ; 978-1-4780-0956-6 ; 9781478012221 ; 1-4780-0868-7 ; 1-4780-0956-X ; 1478012226
Database	Catalogue ZB MED Medicine, Health

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Shelf mark	Loan status	Location
2023 A 1104	available for loan (reading room)	Lesesaal EG

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Article ; Online: The Impact of Pharmacists on Telehealth During Transitions of Care: A Literature Review.

Lopez, Nicole A / Kerelos, Theopeste / Hale, Genevieve

Journal of pharmacy practice

2022 Volume 36, Issue 5, Page(s) 1225–1231

Abstract: Purpose: ...

Abstract	Purpose:
MeSH term(s)	Adult ; Child ; Humans ; United States ; Patient Discharge ; Pharmacists ; Patient Readmission ; Telemedicine ; Pharmacy Service, Hospital ; Medication Reconciliation ; Randomized Controlled Trials as Topic
Language	English
Publishing date	2022-05-21
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1027474-1
ISSN	1531-1937 ; 0897-1900
ISSN (online)	1531-1937
ISSN	0897-1900
DOI	10.1177/08971900221104707
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Article ; Online: Compartmentalization and synergy of osteoblasts drive bone formation in the regenerating fin.

Cudak, Nicole / López-Delgado, Alejandra Cristina / Rost, Fabian / Kurth, Thomas / Lesche, Mathias / Reinhardt, Susanne / Dahl, Andreas / Rulands, Steffen / Knopf, Franziska

iScience

2024 Volume 27, Issue 2, Page(s) 108841

Abstract: Zebrafish regenerate their fins which involves a component of cell plasticity. It is currently unclear how regenerate cells divide labor to allow for appropriate growth and patterning. Here, we studied lineage relationships of fluorescence-activated cell ...

Abstract	Zebrafish regenerate their fins which involves a component of cell plasticity. It is currently unclear how regenerate cells divide labor to allow for appropriate growth and patterning. Here, we studied lineage relationships of fluorescence-activated cell sorting-enriched epidermal, bone-forming (osteoblast), and (non-osteoblast) blastemal fin regenerate cells by single-cell RNA sequencing, lineage tracing, targeted osteoblast ablation, and electron microscopy. Most osteoblasts in the outgrowing regenerate derive from
Language	English
Publishing date	2024-01-08
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2024.108841
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Article ; Online: Expanding the scope of planetary health education: the International Decade of Indigenous Languages.

Redvers, Nicole / Menzel, Kelly / Ricker, Adriann / Lopez-Carmen, Victor A / Blondin, Be'sha

The Lancet. Planetary health

2023 Volume 7, Issue 1, Page(s) e4–e5

MeSH term(s)	Health Education ; Language
Language	English
Publishing date	2023-01-04
Publishing country	Netherlands
Document type	Journal Article
ISSN	2542-5196
ISSN (online)	2542-5196
DOI	10.1016/S2542-5196(22)00140-1
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Article ; Online: HIV and gp120-induced lipid droplets loss in hepatic stellate cells contribute to profibrotic profile.

López, Cinthya Alicia Marcela / Freiberger, Rosa Nicole / Sviercz, Franco Agustín / Jarmoluk, Patricio / Cevallos, Cintia / Quarleri, Jorge / Delpino, María Victoria

Biochimica et biophysica acta. Molecular basis of disease

2024 Volume 1870, Issue 4, Page(s) 167084

Abstract: Liver fibrosis is the excessive accumulation of extracellular matrix proteins, primarily collagen, in response to liver injury caused by chronic liver diseases. HIV infection accelerates the progression of liver fibrosis in patients co-infected with HCV ... ...

Abstract	Liver fibrosis is the excessive accumulation of extracellular matrix proteins, primarily collagen, in response to liver injury caused by chronic liver diseases. HIV infection accelerates the progression of liver fibrosis in patients co-infected with HCV or HBV compared to those who are only mono-infected. The early event in the progression of liver fibrosis involves the activation of hepatic stellate cells (HSCs), which entails the loss of lipid droplets (LD) to fuel the production of extracellular matrix components crucial for liver tissue healing. Thus, we are examining the mechanism by which HIV stimulates the progression of liver fibrosis. HIV-R5 tropic infection was unable to induce the expression of TGF-β, collagen deposition, α-smooth muscle actin (α-SMA), and cellular proliferation. However, this infection induced the secretion of the profibrogenic cytokine IL-6 and the loss of LD. This process involved the participation of peroxisome proliferator-activated receptor (PPAR)-α and an increase in lysosomal acid lipase (LAL), along with the involvement of Microtubule-associated protein 1 A/1B-light chain 3 (LC3), strongly suggesting that LD loss could occur through acid lipolysis. These phenomena were mimicked by the gp120 protein from the R5 tropic strain of HIV. Preincubation of HSCs with the CCR5 receptor antagonist, TAK-779, blocked gp120 activity. Additionally, experiments performed with pseudotyped-HIV revealed that HIV replication could also contribute to LD loss. These results demonstrate that the cross-talk between HSCs and HIV involves a series of interactions that help explain some of the mechanisms involved in the exacerbation of liver damage observed in co-infected individuals.
MeSH term(s)	Humans ; Collagen/metabolism ; Hepatic Stellate Cells/metabolism ; HIV Infections/metabolism ; Lipid Droplets/metabolism ; Liver Cirrhosis/pathology ; Liver Diseases/pathology ; HIV Envelope Protein gp120
Chemical Substances	Collagen (9007-34-5) ; HIV Envelope Protein gp120
Language	English
Publishing date	2024-02-17
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	60-7
ISSN	1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
ISSN (online)	1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
ISSN	0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
DOI	10.1016/j.bbadis.2024.167084
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