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  1. Article: Effectiveness of X-stop Interspinous Distractor Device Versus Laminectomy for Treatment of Lumbar Stenosis: A Systematic Review and Meta-Analysis.

    Ekhator, Chukwuyem / Griepp, Daniel / Urbi, Alyssa / Fiani, Brian

    Cureus

    2023  Volume 15, Issue 4, Page(s) e37535

    Abstract: Lumbar spinal stenosis refers to the narrowing of the spinal canal in the lumbar region. There is an increasing need to determine the treatment modality for lumbar spinal stenosis by comparing the outcomes of X-stop interspinous distractors and ... ...

    Abstract Lumbar spinal stenosis refers to the narrowing of the spinal canal in the lumbar region. There is an increasing need to determine the treatment modality for lumbar spinal stenosis by comparing the outcomes of X-stop interspinous distractors and laminectomy. The objective of this study is to determine the effectiveness of the X-stop interspinous distractor compared to laminectomy. This systematic review fundamentally abides by the procedures delineated in the Cochrane methodology while the reporting is done according to the Preferred Reporting Items for Systematic Review and Meta-Analyses guidelines. Three databases searched generated a total of 943 studies, with PubMed being the source for the bulk of the articles. Six studies were selected for inclusion in this study. The effectiveness of the interspinous distractor devices and laminectomy can be determined through their impact on the quality of life, rates of complications, and the amount of money utilized. This meta-analysis fundamentally emphasizes that laminectomy is a more effective intervention for the treatment of lumbar spinal stenosis as it is more cost-effective and results in fewer complications in the long term.
    Language English
    Publishing date 2023-04-13
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.37535
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  2. Article ; Online: An early analysis of Codman® CerebroFlo® Endexo coated ventricular catheters in the setting of intraventricular hemorrhage.

    Fiani, Brian / Jarrah, Ryan

    Journal of neurosurgical sciences

    2021  Volume 66, Issue 1, Page(s) 62–66

    Abstract: Intraventricular hemorrhages (IVH) are a potentially fatal diagnosis that must be managed properly to avoid devastating complications. While existing catheters have offered relative success, their reactive composition makes them prone to eventual ... ...

    Abstract Intraventricular hemorrhages (IVH) are a potentially fatal diagnosis that must be managed properly to avoid devastating complications. While existing catheters have offered relative success, their reactive composition makes them prone to eventual obstruction and thrombotic activation. This problematic outcome has led to emergence of the Codman
    MeSH term(s) Catheters ; Cerebral Hemorrhage/therapy ; Cerebral Ventricles/surgery ; Humans ; Treatment Outcome
    Language English
    Publishing date 2021-09-21
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 193139-8
    ISSN 1827-1855 ; 0390-5616 ; 0026-4881
    ISSN (online) 1827-1855
    ISSN 0390-5616 ; 0026-4881
    DOI 10.23736/S0390-5616.21.05421-7
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  3. Article ; Online: Laser oromaxillofacial photobiomodulation therapy: molecular mechanisms, outcomes and considerations.

    Fiani, Brian / Jarrah, Ryan / Nathani, Karim Rizwan

    Regenerative medicine

    2022  Volume 17, Issue 9, Page(s) 611–615

    Abstract: Tweetable abstract Photobiomodulation therapy is largely characterized as a safe therapeutic model that can modulate the activity of inflammatory and immune biomarkers while facilitating a metabolic response that can regenerate damaged tissue. ...

    Abstract Tweetable abstract Photobiomodulation therapy is largely characterized as a safe therapeutic model that can modulate the activity of inflammatory and immune biomarkers while facilitating a metabolic response that can regenerate damaged tissue.
    MeSH term(s) Biomarkers/metabolism ; Lasers ; Low-Level Light Therapy
    Chemical Substances Biomarkers
    Language English
    Publishing date 2022-06-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2274500-2
    ISSN 1746-076X ; 1746-0751
    ISSN (online) 1746-076X
    ISSN 1746-0751
    DOI 10.2217/rme-2022-0091
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  4. Article: Spontaneous cervical epidural hematoma: Insight into this occurrence with case examples.

    Fiani, Brian / Jarrah, Ryan / Fiani, Nicholas J / Runnels, Juliana

    Surgical neurology international

    2021  Volume 12, Page(s) 79

    Abstract: Background: First characterized in the 19: Case description: Herein, the authors present two case examples describing the clinical presentation of SSEH, while also reviewing the literature to provide a comprehensive overview of its presentation, ... ...

    Abstract Background: First characterized in the 19
    Case description: Herein, the authors present two case examples describing the clinical presentation of SSEH, while also reviewing the literature to provide a comprehensive overview of its presentation, pathology, and treatment. The first case is a patient with nontraumatic sudden onset neck pain with rapidly progressing weakness. The second case is a patient with painless weakness that developed while taking 325 mg of aspirin daily.
    Conclusion: Clinicians should keep SSEH in their differential diagnosis when seeing patients with nontraumatic sources of weakness in their extremities. The appropriate steps should be followed to diagnose and treat this condition with magnetic resonance imaging and surgical decompression if there are progressive neurological deficits. There is a continued need for more extensive database-driven studies to understand better SSEHs clinical presentation, etiology, and ultimate treatment.
    Language English
    Publishing date 2021-03-02
    Publishing country United States
    Document type Case Reports
    ISSN 2229-5097
    ISSN 2229-5097
    DOI 10.25259/SNI_15_2021
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  5. Article: Expanding indications of full endoscopic spine surgery.

    Gadjradj, Pravesh S / Fiani, Brian / Sommer, Fabian / Ramirez, Rodrigo Navarro / Harhangi, Biswadjiet S

    Journal of spine surgery (Hong Kong)

    2023  Volume 9, Issue 3, Page(s) 229–232

    Language English
    Publishing date 2023-06-27
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2874556-5
    ISSN 2414-4630 ; 2414-469X
    ISSN (online) 2414-4630
    ISSN 2414-469X
    DOI 10.21037/jss-23-65
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  6. Article: A Review of Mechanisms on the Beneficial Effect of Exercise on Atherosclerosis.

    Chacon, Daniel / Fiani, Brian

    Cureus

    2020  Volume 12, Issue 11, Page(s) e11641

    Abstract: Cardiovascular disease has affected a large percentage of the world, and as a result, we have had major advancements in pharmacological and procedural intervention of this disease. With the increased burden of rising healthcare costs, alternative ... ...

    Abstract Cardiovascular disease has affected a large percentage of the world, and as a result, we have had major advancements in pharmacological and procedural intervention of this disease. With the increased burden of rising healthcare costs, alternative treatment with exercise has shown to be much more cost effective and just as beneficial to patients compared to pharmacological and procedural treatment. We highlight some of the major mechanisms behind the beneficial effect of exercise on atherosclerosis and hope to encourage patients and providers to attempt to adopt this form of treatment that has not only shown to be beneficial to heart disease, but diseases such as diabetes and obesity as well.
    Language English
    Publishing date 2020-11-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.11641
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  7. Article: Holocord spontaneous pneumorrhachis in the setting of refractory emesis.

    Houston, Rebecca / Fiani, Brian / Musch, Brian / Tayag, Emilio

    Surgical neurology international

    2021  Volume 12, Page(s) 602

    Abstract: Background: Pneumorrhachis (PNR) is the presence of air within the spinal canal and may be either intramedullary or extramedullary in location. The etiology is most commonly iatrogenic or traumatic in nature. Treatment is dependent on underlying cause ... ...

    Abstract Background: Pneumorrhachis (PNR) is the presence of air within the spinal canal and may be either intramedullary or extramedullary in location. The etiology is most commonly iatrogenic or traumatic in nature. Treatment is dependent on underlying cause and physical exam.
    Case description: Herein, we describe the second case in the literature of spontaneous holocord PNR in a young patient without risk factors. A 22-year-old male with no past medical history presented to the hospital for 2 days of vomiting and cramping in his hands and feet secondary to severe dehydration. He recently started a new job as a manual laborer and had to leave work early 2 days prior due to overexertion working outside in heat ranging from 100 to 120 degrees Fahrenheit. CT abdomen and pelvis demonstrated spontaneous pneumomediastinum and extramedullary PNR extending upward from L3 throughout the thoracic spine to the upper limit of the scan. Subsequent CT cervical and thoracic spine showed the full length of the extradural air from C2-T12 and again at L3.
    Conclusion: Spontaneous PNR is an uncommon, typically self-limited condition in which air is introduced into the spinal axis. Anatomic predisposition makes the extradural, dorsal cord in the cervicothoracic region the most common location. Patients are rarely symptomatic, and treatment is supportive in nature once secondary causes with high rates of morbidity and mortality are ruled out.
    Language English
    Publishing date 2021-12-08
    Publishing country United States
    Document type Case Reports
    ISSN 2229-5097
    ISSN 2229-5097
    DOI 10.25259/SNI_1046_2021
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  8. Article: The "Kickstand Rod" Technique for Coronal Imbalance in Patients With Spinal Deformity: A Case Report With Review of Literature.

    Fiani, Brian / Jarrah, Ryan M

    Cureus

    2020  Volume 12, Issue 12, Page(s) e11876

    Abstract: Coronal imbalance is a type of spinal deformity with deviation from midline in the coronal plane. It is challenging to correct even in the hands of experienced spine surgeons. Many conventional techniques lead to unsuccessful results or complications. ... ...

    Abstract Coronal imbalance is a type of spinal deformity with deviation from midline in the coronal plane. It is challenging to correct even in the hands of experienced spine surgeons. Many conventional techniques lead to unsuccessful results or complications. However, the incorporation of "kickstand rod" (KR) instrumentation is now understood to provide a more supported coronal correction and improve spinal deformities. Sometimes it can be used to provide additional spinal support in instances where spinal fusion has already occurred. The KR is placed from a posterior approach along the lateral spine from lumbar spine to ilium and exerts distraction forces that counteract misaligned spinal segments. Our objective is to present a clinical case example with a brief review of literature. Herein, we present a case of a 62-year-old male with the development of significant coronal imbalance following his posterior lumbosacral instrumentation and fusion 11 years prior to presentation. KR supplementation to his hardware improved his functional outcome significantly. Further, we provide a literature review of the surgical characteristics, indications, and functional outcomes of KR instrumentation. A term search of "kickstand rod" was performed in PubMed, and relevant English language publications were included. The literature search yielded only six publications. A total of 45 patients across three studies were assessed. A mean postoperative coronal balance magnitude of 26.83 mm was calculated compared to the preoperative coronal magnitude of 64.16 mm. Results also showed only four cases of intraoperative or postoperative complications. Moreover, the presented case reported successful KR implementation without any intraoperative complications. KR instrumentation is a safe and effective technique for coronal imbalance correction. The results show favorable outcomes in terms of coronal adjustment and low complication rates. Nevertheless, we caution the fact that further studies are warranted with long-term follow-ups.
    Language English
    Publishing date 2020-12-03
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.11876
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  9. Article ; Online: Placental-based allograft use for tissue regeneration and scar prevention for neurosurgical wounds.

    Fiani, Brian / Jarrah, Ryan / Nathani, Karim Rizwan / Bhandarkar, Archis R

    Regenerative medicine

    2022  Volume 17, Issue 8, Page(s) 517–519

    Abstract: Tweetable abstract Proper wound healing, including internal and surface tissue regeneration with the minimization of scar formation, is one of the most significant topics in surgical discussions and ... ...

    Abstract Tweetable abstract Proper wound healing, including internal and surface tissue regeneration with the minimization of scar formation, is one of the most significant topics in surgical discussions and EpiFix
    MeSH term(s) Allografts ; Amnion/transplantation ; Chorion ; Cicatrix/prevention & control ; Female ; Humans ; Placenta ; Pregnancy ; Wound Healing
    Language English
    Publishing date 2022-05-31
    Publishing country England
    Document type Editorial
    ZDB-ID 2274500-2
    ISSN 1746-076X ; 1746-0751
    ISSN (online) 1746-076X
    ISSN 1746-0751
    DOI 10.2217/rme-2022-0074
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  10. Article: Genetic Predictors of Early-Onset Spinal Intervertebral Disc Degeneration: Part Two of Two.

    Fiani, Brian / Covarrubias, Claudia / Jarrah, Ryan

    Cureus

    2021  Volume 13, Issue 5, Page(s) e15183

    Abstract: Understanding genetic indicators is a fundamental aspect to characterizing the pathophysiology of chronic diseases such as intervertebral disc degeneration (IVDD). In our previous spinal genetics review, we characterized some more common genetic ... ...

    Abstract Understanding genetic indicators is a fundamental aspect to characterizing the pathophysiology of chronic diseases such as intervertebral disc degeneration (IVDD). In our previous spinal genetics review, we characterized some more common genetic influencers in the context of IVDD. In this second part of our two-part comprehensive spinal genetics review, we characterize the more infrequently studied genes that have pathophysiological relevance. In doing so, we aim to expand upon the current gene-library for IVDD. The genes of interest include:
    Language English
    Publishing date 2021-05-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.15183
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