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  1. Article ; Online: Unveiling the Power of Gabapentin-Loaded Nanoceria with Multiple Therapeutic Capabilities for the Treatment of Dry Eye Disease.

    Yang, Chia-Jung / Anand, Anisha / Huang, Chih-Ching / Lai, Jui-Yang

    ACS nano

    2023  Volume 17, Issue 24, Page(s) 25118–25135

    Abstract: Dry eye (DE) disease, which is primarily linked to aqueous deficiency, is an escalating health issue worldwide, mainly due to the widespread use of electronic devices. The major obstacles in DE pharmacotherapy include insufficient therapeutic efficacy ... ...

    Abstract Dry eye (DE) disease, which is primarily linked to aqueous deficiency, is an escalating health issue worldwide, mainly due to the widespread use of electronic devices. The major obstacles in DE pharmacotherapy include insufficient therapeutic efficacy and low ocular bioavailability. This study presents the development of a ceria-based nanosystem to carry gabapentin (GBT), aiming to offer comprehensive relief from DE symptoms. We prepared multifunctional nanoceria capped with thiolated gelatin followed by cross-linking with glutaraldehyde, yielding a nanocarrier with desirable biocompatibility and antioxidant, anti-inflammatory, antiangiogenic, antiapoptotic, and neuronal protective activities. Specifically, the highly abundant thiol groups on gelatin increased the cellular uptake of the nanocarrier by 2.3-fold and its mucin-binding efficiency by 10-fold, thereby extending ocular retention and amplifying therapeutic activity. Moderate cross-linking of the thiolated gelatin not only enhanced the ocular bioavailability of the nanoceria but also provided slow, degradation-controlled release of GBT to promote the lacrimal stimulation to restore the tear film. In a rabbit model of DE, topical administration of our GBT/nanoceria nanoformulation resulted in comprehensive alleviation of symptoms, including repairing corneal epithelial damage, preserving corneal nerve density, and stimulating tear secretion, demonstrating superior performance in comparison to the free drug. These results underscore the safety and potential of this innovative nanoformulation for DE pharmacotherapy.
    MeSH term(s) Animals ; Rabbits ; Dry Eye Syndromes/drug therapy ; Dry Eye Syndromes/diagnosis ; Gabapentin/therapeutic use ; Gelatin ; Tears
    Chemical Substances ceric oxide (619G5K328Y) ; Gabapentin (6CW7F3G59X) ; Gelatin (9000-70-8)
    Language English
    Publishing date 2023-12-05
    Publishing country United States
    Document type Journal Article
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.3c07817
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Production of Bioactive Porcine Lactoferrin through a Novel Glucose-Inducible Expression System in

    Yen, Chih-Ching / Wu, Pei-Ying / Ou-Yang, Huan / Chen, Hsiao-Ling / Chong, Kowit-Yu / Chang, Ro-Lin / Chen, Chuan-Mu

    International journal of molecular sciences

    2024  Volume 25, Issue 3

    Abstract: Lactoferrin (LF) stands as one of the extensively investigated iron-binding glycoproteins within milk, exhibiting diverse biological functionalities. The global demand for LF has experienced consistent growth. Biotechnological strategies aimed at ... ...

    Abstract Lactoferrin (LF) stands as one of the extensively investigated iron-binding glycoproteins within milk, exhibiting diverse biological functionalities. The global demand for LF has experienced consistent growth. Biotechnological strategies aimed at enhancing LF productivity through microbial expression systems offer substantial cost-effective advantages and exhibit fewer constraints compared to traditional animal bioreactor technologies. This study devised a novel recombinant plasmid, wherein the
    MeSH term(s) Animals ; Cattle ; Humans ; Anti-Infective Agents/pharmacology ; Escherichia coli/metabolism ; Fermentation ; Glucose/metabolism ; Lactoferrin/biosynthesis ; Lactoferrin/genetics ; Lactoferrin/pharmacology ; Pichia/metabolism ; Recombinant Proteins/biosynthesis ; Recombinant Proteins/genetics ; Recombinant Proteins/pharmacology ; Saccharomycetales ; Staphylococcus aureus/drug effects ; Swine
    Chemical Substances Anti-Infective Agents ; Glucose (IY9XDZ35W2) ; Lactoferrin (EC 3.4.21.-) ; Recombinant Proteins
    Language English
    Publishing date 2024-02-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25031818
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  3. Article: Measuring health indicators and allocating health resources: a DEA-based approach.

    Yang, Chih-Ching

    Health care management science

    2016  Volume 20, Issue 3, Page(s) 365–378

    Abstract: This paper suggests new empirical DEA models for the measurement of health indicators and the allocation of health resources. The proposed models were developed by first suggesting a population-based health indicator. By introducing the suggested ... ...

    Abstract This paper suggests new empirical DEA models for the measurement of health indicators and the allocation of health resources. The proposed models were developed by first suggesting a population-based health indicator. By introducing the suggested indicator into DEA models, a new approach that solves the problem of health resource allocation has been developed. The proposed models are applied to an empirical study of Taiwan's health system. Empirical findings show that the suggested indicator can successfully accommodate the differences in health resource demands between populations, providing more reliable performance information than traditional indicators such as physician density. Using our models and a commonly used allocation mechanism, capitation, to allocate medical expenditures, it is found that the proposed model always obtains higher performance than those derived from capitation, and the superiority increases as allocated expenditures rise.
    Language English
    Publishing date 2016-02-03
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1469148-6
    ISSN 1572-9389 ; 1386-9620
    ISSN (online) 1572-9389
    ISSN 1386-9620
    DOI 10.1007/s10729-016-9358-2
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    In stock of ZB MED Cologne/Königswinter

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  4. Article: Determinants and Prevention Strategies for Household Food Waste: An Exploratory Study in Taiwan.

    Teng, Chih-Ching / Chih, Chueh / Yang, Wen-Ju / Chien, Chia-Hui

    Foods (Basel, Switzerland)

    2021  Volume 10, Issue 10

    Abstract: Given the large amount of food waste coming from households, reducing household food waste is essential to the mitigation of overall food waste and the provision of multi-faceted benefits for both people and the planet. This study identifies factors and ... ...

    Abstract Given the large amount of food waste coming from households, reducing household food waste is essential to the mitigation of overall food waste and the provision of multi-faceted benefits for both people and the planet. This study identifies factors and management strategies for the reduction of household food waste in the Taiwanese household setting. Using snowball sampling, semi-structured interviews are conducted to collect data from 27 household food providers in Taipei. The research findings identify four critical motivators and four barriers to minimizing household food waste in Taiwan. The most frequently mentioned motivator for the reduction of food waste is a convenient shopping environment, and the most important barrier is lack of knowledge for assessing the edibility of food. Additionally, four major prevention strategies are identified to help reduce household food waste: (1) planned purchase schedule; (2) skills to keep food fresh and longer; (3) understanding family preferences and leftover management, and (4) sharing additional food and co-procurement and cooking. The results of this study not only help improve the understanding and application of Chinese household food waste reduction, but also demonstrate the significance of its socio-cultural impacts in future studies.
    Language English
    Publishing date 2021-09-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods10102331
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  5. Article ; Online: Fluorescent carbon dots for labeling of bacteria: mechanism and prospects-a review.

    Anand, Anisha / Huang, Chih-Ching / Lai, Jui-Yang / Bano, Darakhshan / Pardede, Helen Indah / Hussain, Amina / Saleem, Sehresh / Unnikrishnan, Binesh

    Analytical and bioanalytical chemistry

    2024  

    Abstract: The search for bacteria-labeling agents that are more efficient and less toxic compared to existing staining dyes is ongoing. Fluorescent quantum dots and carbon dots (CDs) have been extensively researched for various bioimaging applications. Priority is ...

    Abstract The search for bacteria-labeling agents that are more efficient and less toxic compared to existing staining dyes is ongoing. Fluorescent quantum dots and carbon dots (CDs) have been extensively researched for various bioimaging applications. Priority is given to CDs due to several advantages, including lower toxicity, versatility in tuning their properties, and better photostability compared to metal-based quantum dots. Although significant progress is still needed to replace existing dyes with CDs for bacteria labeling, they offer promising potential for further improvement in efficiency. Surface charges and functional groups have been reported as decisive factors for bacterial discrimination and live/dead assays; however, a complete guideline for preparing CDs with optimum properties for efficient staining and predicting their labeling performance is lacking. In this review, we discuss the application of fluorescent CDs for bacterial labeling and the underlying mechanisms and principles. We primarily focus on the application and mechanism of CDs for Gram differentiation, live imaging, live/dead bacteria differentiation, bacterial viability testing, biofilm imaging, and the challenges associated with application of CDs. Based on proposed mechanisms of bacterial labeling and ambiguous results reported, we provide our view and guidelines for the researchers in this field to overcome the challenges associated with bacteria labeling using fluorescent CDs.
    Language English
    Publishing date 2024-04-24
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 201093-8
    ISSN 1618-2650 ; 0016-1152 ; 0372-7920
    ISSN (online) 1618-2650
    ISSN 0016-1152 ; 0372-7920
    DOI 10.1007/s00216-024-05300-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 4' 69/97: Show issues
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  6. Article ; Online: Sodium thiosulfate through preserving mitochondrial dynamics ameliorates oxidative stress induced renal apoptosis and ferroptosis in 5/6 nephrectomized rats with chronic kidney diseases.

    Cheng, Yu-Hsuan / Yao, Chien-An / Yang, Chih-Ching / Hsu, Shih-Ping / Chien, Chiang-Ting

    publication RETRACTED

    PloS one

    2023  Volume 18, Issue 2, Page(s) e0277652

    Abstract: Chronic kidney disease (CKD) progression may be evoked through dysregulated mitochondrial dynamics enhanced oxidative stress and inflammation contributing to high cardiovascular morbidity and mortality. Previous study has demonstrated sodium thiosulfate ( ...

    Abstract Chronic kidney disease (CKD) progression may be evoked through dysregulated mitochondrial dynamics enhanced oxidative stress and inflammation contributing to high cardiovascular morbidity and mortality. Previous study has demonstrated sodium thiosulfate (STS, Na2S2O3) could effectively attenuate renal oxidative injury in the animal model of renovascular hypertension. We explored whether the potentially therapeutic effect of STS is available on the attenuating CKD injury in thirty-six male Wistar rats with 5/6 nephrectomy. We determined the STS effect on reactive oxygen species (ROS) amount in vitro and in vivo by an ultrasensitive chemiluminescence-amplification method, ED-1 mediated inflammation, Masson's trichrome stained fibrosis, mitochondrial dynamics (fission and fusion) and two types of programmed cell death, apoptosis and ferroptosis by western blot and immunohistochemistry. Our in vitro data showed STS displayed the strongest scavenging ROS activity at the dosage of 0.1 g. We applied STS at 0.1 g/kg intraperitoneally 5 times/week for 4 weeks to these CKD rats. CKD significantly enhanced the degree in arterial blood pressure, urinary protein, BUN, creatinine, blood and kidney ROS amount, leukocytes infiltration, renal 4-HNE expression, fibrosis, dynamin-related protein 1 (Drp1) mediated mitochondrial fission, Bax/c-caspase 9/c-caspase 3/poly (ADP-ribose) polymerase (PARP) mediated apoptosis, iron overload/ferroptosis and the decreased xCT/GPX4 expression and OPA-1 mediated mitochondrial fusion. STS treatment significantly ameliorated oxidative stress, leukocyte infiltration, fibrosis, apoptosis and ferroptosis and improved mitochondrial dynamics and renal dysfunction in CKD rats. Our results suggest that STS as drug repurposing strategy could attenuate CKD injury through the action of anti-mitochondrial fission, anti-inflammation, anti-fibrosis, anti-apoptotic, and anti-ferroptotic mechanisms.
    MeSH term(s) Rats ; Male ; Animals ; Reactive Oxygen Species/metabolism ; Mitochondrial Dynamics ; Ferroptosis ; Rats, Wistar ; Kidney/metabolism ; Oxidative Stress ; Renal Insufficiency, Chronic/drug therapy ; Renal Insufficiency, Chronic/metabolism ; Apoptosis
    Chemical Substances Reactive Oxygen Species ; sodium thiosulfate (HX1032V43M)
    Language English
    Publishing date 2023-02-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Retracted Publication
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0277652
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  7. Article ; Online: Current Status of Long-term Care in Taiwan: Transition of Long-term Care Plan From 1.0 to 2.0.

    Yang, Chih-Ching / Hsueh, Jui-Yuan / Wei, Cheng-Yu

    International journal of health policy and management

    2020  Volume 9, Issue 8, Page(s) 363–364

    MeSH term(s) Health Policy ; Humans ; Long-Term Care ; Taiwan
    Language English
    Publishing date 2020-08-01
    Publishing country Iran
    Document type Letter
    ZDB-ID 2724317-5
    ISSN 2322-5939 ; 2322-5939
    ISSN (online) 2322-5939
    ISSN 2322-5939
    DOI 10.15171/ijhpm.2019.115
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  8. Article: Reduction of non-performing loans in the banking industry

    Yang, Chih-ching

    Journal of business economics and management Vol. 18, No. 5 , p. 833-851

    an application of data envelopment analysis

    2017  Volume 18, Issue 5, Page(s) 833–851

    Author's details Chih-Ching Yang
    Keywords banking industry ; non-performing loan ; risk management ; data envelopment analysis ; undesirable output ; Taiwan
    Language English
    Publisher VTGU Press Technika
    Publishing place Vilnius
    Document type Article
    ZDB-ID 2208925-1 ; 2400520-4
    ISSN 2029-4433 ; 1611-1699
    ISSN (online) 2029-4433
    ISSN 1611-1699
    Database ECONomics Information System

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  9. Article: Measuring health indicators and allocating health resources

    Yang, Chih-ching

    Health care management science Vol. 20, No. 3 , p. 365-378

    a DEA-based approach

    2017  Volume 20, Issue 3, Page(s) 365–378

    Author's details Chih-Ching Yang
    Keywords Health indicator ; Health resource allocation ; Data envelopment analysis ; Taiwan
    Language English
    Publisher Springer Science + Business Media
    Publishing place Norwell, Mass. [u.a.]
    Document type Article
    ZDB-ID 1469148-6
    ISSN 1572-9389 ; 1386-9620
    ISSN (online) 1572-9389
    ISSN 1386-9620
    Database ECONomics Information System

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    In stock of ZB MED Cologne/Königswinter

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  10. Article: Green Tea Polyphenol Catechins Inhibit Coronavirus Replication and Potentiate the Adaptive Immunity and Autophagy-Dependent Protective Mechanism to Improve Acute Lung Injury in Mice.

    Yang, Chih-Ching / Wu, Chang-Jer / Chien, Chen-Yen / Chien, Chiang-Ting

    Antioxidants (Basel, Switzerland)

    2021  Volume 10, Issue 6

    Abstract: Effective antiviral therapeutics are urgently required to fight severe acute respiratory syndrome (SARS) caused by a SARS coronavirus (SARS-CoV). Because polyphenol catechins could confer antioxidative, anti-inflammatory, antiviral, and antimicrobial ... ...

    Abstract Effective antiviral therapeutics are urgently required to fight severe acute respiratory syndrome (SARS) caused by a SARS coronavirus (SARS-CoV). Because polyphenol catechins could confer antioxidative, anti-inflammatory, antiviral, and antimicrobial activities, we assessed the therapeutic effects of catechins against SARS-CoV replication in Vero E6 cells, the preventive effect of catechins on CD25/CD69/CD94/CD8
    Language English
    Publishing date 2021-06-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox10060928
    Database MEDical Literature Analysis and Retrieval System OnLINE

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