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  1. Book: Current topics in critical care for the anesthesiologist

    Chalkias, Athanasios

    (Anesthesiology clinics ; volume 41, number 1 (March 2023))

    2023  

    Author's details editors Athanasios Chalkias, Mary L. Jarzebowski, Kathryn Rosenblatt
    Series title Anesthesiology clinics ; volume 41, number 1 (March 2023)
    Collection
    Language English
    Size xviii, 316 Seiten, Illustrationen
    Publisher Elsevier
    Publishing place Philadelphia, Pennsylvania
    Publishing country United States
    Document type Book
    HBZ-ID HT030006294
    ISBN 978-0-323-96193-6 ; 0-323-96193-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 904 -41,1- not available for loan Lesesaal EG

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  2. Article ; Online: Lessons from aviation safety: unstabilised emergence from anaesthesia? Go-around!

    Chalkias, Athanasios

    British journal of anaesthesia

    2024  Volume 132, Issue 4, Page(s) 796–797

    MeSH term(s) Humans ; Anesthesia/adverse effects ; Safety Management ; Anesthesiology ; Aviation
    Language English
    Publishing date 2024-01-16
    Publishing country England
    Document type Letter
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
    DOI 10.1016/j.bja.2023.12.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Shear Stress and Endothelial Mechanotransduction in Trauma Patients with Hemorrhagic Shock: Hidden Coagulopathy Pathways and Novel Therapeutic Strategies.

    Chalkias, Athanasios

    International journal of molecular sciences

    2023  Volume 24, Issue 24

    Abstract: Massive trauma remains a leading cause of death and a global public health burden. Post-traumatic coagulopathy may be present even before the onset of resuscitation, and correlates with severity of trauma. Several mechanisms have been proposed to explain ...

    Abstract Massive trauma remains a leading cause of death and a global public health burden. Post-traumatic coagulopathy may be present even before the onset of resuscitation, and correlates with severity of trauma. Several mechanisms have been proposed to explain the development of abnormal coagulation processes, but the heterogeneity in injuries and patient profiles makes it difficult to define a dominant mechanism. Regardless of the pattern of death, a significant role in the pathophysiology and pathogenesis of coagulopathy may be attributed to the exposure of endothelial cells to abnormal physical forces and mechanical stimuli in their local environment. In these conditions, the cellular responses are translated into biochemical signals that induce/aggravate oxidative stress, inflammation, and coagulopathy. Microvascular shear stress-induced alterations could be treated or prevented by the development and use of innovative pharmacologic strategies that effectively target shear-mediated endothelial dysfunction, including shear-responsive drug delivery systems and novel antioxidants, and by targeting the venous side of the circulation to exploit the beneficial antithrombogenic profile of venous endothelial cells.
    MeSH term(s) Humans ; Shock, Hemorrhagic/complications ; Shock, Hemorrhagic/therapy ; Endothelial Cells ; Mechanotransduction, Cellular ; Blood Coagulation Disorders/etiology ; Blood Coagulation Disorders/therapy ; Blood Coagulation Disorders/metabolism ; Endothelium, Vascular/metabolism
    Language English
    Publishing date 2023-12-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms242417522
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Shear Stress and Endothelial Mechanotransduction in Trauma Patients with Hemorrhagic Shock

    Athanasios Chalkias

    International Journal of Molecular Sciences, Vol 24, Iss 24, p

    Hidden Coagulopathy Pathways and Novel Therapeutic Strategies

    2023  Volume 17522

    Abstract: Massive trauma remains a leading cause of death and a global public health burden. Post-traumatic coagulopathy may be present even before the onset of resuscitation, and correlates with severity of trauma. Several mechanisms have been proposed to explain ...

    Abstract Massive trauma remains a leading cause of death and a global public health burden. Post-traumatic coagulopathy may be present even before the onset of resuscitation, and correlates with severity of trauma. Several mechanisms have been proposed to explain the development of abnormal coagulation processes, but the heterogeneity in injuries and patient profiles makes it difficult to define a dominant mechanism. Regardless of the pattern of death, a significant role in the pathophysiology and pathogenesis of coagulopathy may be attributed to the exposure of endothelial cells to abnormal physical forces and mechanical stimuli in their local environment. In these conditions, the cellular responses are translated into biochemical signals that induce/aggravate oxidative stress, inflammation, and coagulopathy. Microvascular shear stress-induced alterations could be treated or prevented by the development and use of innovative pharmacologic strategies that effectively target shear-mediated endothelial dysfunction, including shear-responsive drug delivery systems and novel antioxidants, and by targeting the venous side of the circulation to exploit the beneficial antithrombogenic profile of venous endothelial cells.
    Keywords blood flow ; microcirculation ; endothelium ; endothelial cell ; mechanotransduction ; mechanosensing ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  5. Article ; Online: Letter to the editor: "The emerging concept of fluid tolerance: A position paper".

    Chalkias, Athanasios

    Journal of critical care

    2022  Volume 74, Page(s) 154235

    MeSH term(s) Humans ; Cardiac Output ; Hemodynamics ; Fluid Therapy ; Stroke Volume ; Blood Pressure
    Language English
    Publishing date 2022-12-20
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 632818-0
    ISSN 1557-8615 ; 0883-9441
    ISSN (online) 1557-8615
    ISSN 0883-9441
    DOI 10.1016/j.jcrc.2022.154235
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2152: Show issues Location:
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  6. Article: Current Challenges in the Management of Sepsis and Septic Shock: Personalized, Physiology-Guided Treatment.

    Chalkias, Athanasios

    Journal of clinical medicine

    2022  Volume 11, Issue 15

    Abstract: Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection affecting millions of people each year [ ... ]. ...

    Abstract Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection affecting millions of people each year [...].
    Language English
    Publishing date 2022-08-04
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11154565
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Current Challenges in the Management of Sepsis and Septic Shock

    Athanasios Chalkias

    Journal of Clinical Medicine, Vol 11, Iss 4565, p

    Personalized, Physiology-Guided Treatment

    2022  Volume 4565

    Abstract: Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection affecting millions of people each year [.] ...

    Abstract Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection affecting millions of people each year [.]
    Keywords n/a ; Medicine ; R
    Language English
    Publishing date 2022-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  8. Article ; Online: Increasing stress volume vs. increasing tissue perfusion in septic patients.

    Chalkias, Athanasios

    European journal of anaesthesiology

    2021  Volume 39, Issue 4, Page(s) 390–391

    MeSH term(s) Fluid Therapy ; Humans ; Microcirculation ; Perfusion ; Sepsis/diagnosis
    Language English
    Publishing date 2021-10-18
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 605770-6
    ISSN 1365-2346 ; 0265-0215
    ISSN (online) 1365-2346
    ISSN 0265-0215
    DOI 10.1097/EJA.0000000000001584
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Resuscitation preferences of the elderly: Implications for the need for regularly repeated end-of-life discussions.

    Mentzelopoulos, Spyros D / Chalkias, Athanasios

    Resuscitation

    2023  Volume 189, Page(s) 109877

    MeSH term(s) Humans ; Aged ; Resuscitation Orders ; Death ; Terminal Care ; Decision Making
    Language English
    Publishing date 2023-06-17
    Publishing country Ireland
    Document type Editorial ; Comment
    ZDB-ID 189901-6
    ISSN 1873-1570 ; 0300-9572
    ISSN (online) 1873-1570
    ISSN 0300-9572
    DOI 10.1016/j.resuscitation.2023.109877
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Introducing novel insights into the postresuscitation clinical course and care of cardiac arrest.

    Mentzelopoulos, Spyros D / Chalkias, Athanasios

    Resuscitation

    2023  Volume 183, Page(s) 109691

    MeSH term(s) Humans ; Heart Arrest/therapy ; Cardiopulmonary Resuscitation ; Disease Progression
    Language English
    Publishing date 2023-01-13
    Publishing country Ireland
    Document type Editorial
    ZDB-ID 189901-6
    ISSN 1873-1570 ; 0300-9572
    ISSN (online) 1873-1570
    ISSN 0300-9572
    DOI 10.1016/j.resuscitation.2023.109691
    Database MEDical Literature Analysis and Retrieval System OnLINE

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