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  1. Article: The Role of Iron in

    van Dijk, Madeleine C / de Kruijff, Robin M / Hagedoorn, Peter-Leon

    Frontiers in cell and developmental biology

    2022  Volume 10, Page(s) 857237

    Abstract: Iron deficiency anemia can be treated with oral or intravenous Fe supplementation. Such supplementation has considerable effects on the human microbiome, and on opportunistic pathogenic micro-organisms. Molecular understanding of the control and ... ...

    Abstract Iron deficiency anemia can be treated with oral or intravenous Fe supplementation. Such supplementation has considerable effects on the human microbiome, and on opportunistic pathogenic micro-organisms. Molecular understanding of the control and regulation of Fe availability at the host-microbe interface is crucial to interpreting the side effects of Fe supplementation. Here, we provide a concise overview of the regulation of Fe by the opportunistic pathogen
    Language English
    Publishing date 2022-03-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2022.857237
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  2. Article ; Online: Membrane-based microfluidic solvent extraction of Ga-68 from aqueous Zn solutions: towards an automated cyclotron production loop.

    Trapp, Svenja / Lammers, Tom / Engudar, Gokce / Hoehr, Cornelia / Denkova, Antonia G / Paulssen, Elisabeth / de Kruijff, Robin M

    EJNMMI radiopharmacy and chemistry

    2023  Volume 8, Issue 1, Page(s) 9

    Abstract: ... achieved within 10 min, using the batch approach. Back-extraction of Ga-68 into 2 M HCl was accomplished ... 0.3% extraction efficiency and 95.8% ± 0.8% back-extraction efficiency into 6 M HCl. When executed ...

    Abstract Background: The radionuclide Ga-68 is commonly used in nuclear medicine, specifically in positron emission tomography (PET). Recently, the interest in producing Ga-68 by cyclotron irradiation of [
    Results: To eventually allow switching from batch to continuous production, conventional batch extraction and membrane-based microfluidic extraction were compared. In both approaches, Ga-68 was extracted using N-benzoyl-N-phenylhydroxylamine in chloroform as the organic extracting phase. Extraction efficiencies of up to 99.5% ± 0.6% were achieved within 10 min, using the batch approach. Back-extraction of Ga-68 into 2 M HCl was accomplished within 1 min with efficiencies of up to 94.5% ± 0.6%. Membrane-based microfluidic extraction achieved 99.2% ± 0.3% extraction efficiency and 95.8% ± 0.8% back-extraction efficiency into 6 M HCl. When executed on a solution irradiated with a 13 MeV cyclotron at TRIUMF, Canada, comparable efficiencies of 97.0% ± 0.4% were achieved. Zn contamination in the back-extracted Ga-68 solution was found to be below 3 ppm.
    Conclusions: Microfluidic solvent extraction is a promising method in the production of Ga-68 achieving high efficiencies in a short amount of time, potentially allowing for direct target recycling.
    Language English
    Publishing date 2023-05-05
    Publishing country England
    Document type Journal Article
    ISSN 2365-421X
    ISSN (online) 2365-421X
    DOI 10.1186/s41181-023-00195-2
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  3. Article: Thioanisole ester based logic gate cascade to control ROS-triggered micellar degradation.

    Piergentili, Irene / Bouwmans, Pepijn R / Reinalda, Luuk / Lewis, Reece W / Klemm, Benjamin / Liu, Huanhuan / de Kruijff, Robin M / Denkova, Antonia G / Eelkema, Rienk

    Polymer chemistry

    2022  Volume 13, Issue 16, Page(s) 2383–2390

    Abstract: In certain tumor and diseased tissues, reactive oxygen species (ROS), such as ... ...

    Abstract In certain tumor and diseased tissues, reactive oxygen species (ROS), such as H
    Language English
    Publishing date 2022-03-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2528812-X
    ISSN 1759-9962 ; 1759-9954
    ISSN (online) 1759-9962
    ISSN 1759-9954
    DOI 10.1039/d2py00207h
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  4. Article ; Online: Impact of the COVID-19 pandemic on mental health in parents of infants with colic and on healthcare use.

    de Graaf, Karola / Hartjes, Robin / Barbian, Claudia / Oberink, Ebba Gustafsson / Vlieger, Arine M / Benninga, Marc A / Kruijff, Ineke de

    Acta paediatrica (Oslo, Norway : 1992)

    2022  Volume 111, Issue 12, Page(s) 2352–2358

    Abstract: Aim: To examine the impact of the COVID-19 pandemic on the mental health of parents of infants with colic and on healthcare use.: Methods: Retrospective cohort study. Data of 64 parents of infants with colic prepandemic and 43 parents of infants with ...

    Abstract Aim: To examine the impact of the COVID-19 pandemic on the mental health of parents of infants with colic and on healthcare use.
    Methods: Retrospective cohort study. Data of 64 parents of infants with colic prepandemic and 43 parents of infants with colic during the pandemic were analysed using validated questionnaires on parental stress, depression and anxiety. Additionally, we evaluated the number of outpatient clinic visits and admission rates pre- and during the pandemic by collecting data on the diagnosis treatment combination 'excessive crying' from electronic patient files in three secondary hospitals in the Netherlands.
    Results: Mothers in the pandemic group reported significantly higher levels of depression than mothers in the prepandemic group (12.3 ± 7.0 and 8.8 ± 5.2; p = 0.04). Moreover, mothers showed a trend towards higher stress levels during the pandemic (29.6 ± 9.6 and 25.2 ± 8.1; p = 0.06). During the pandemic, admission numbers of infants with colic compared to prepandemic data increased with 34% (146 vs. 196).
    Conclusion: Mothers of infants with colic reported significantly more feelings of depression during the COVID-19 pandemic. Furthermore, the pandemic was associated with increased healthcare use amongst infants with colic. With the continuing pandemic, we recommend active perinatal support for this vulnerable population.
    MeSH term(s) Infant ; Female ; Humans ; Colic/epidemiology ; Crying/psychology ; Mental Health ; Pandemics ; COVID-19/epidemiology ; Retrospective Studies ; Parents/psychology ; Delivery of Health Care
    Language English
    Publishing date 2022-10-03
    Publishing country Norway
    Document type Journal Article
    ZDB-ID 203487-6
    ISSN 1651-2227 ; 0365-1436 ; 0803-5253
    ISSN (online) 1651-2227
    ISSN 0365-1436 ; 0803-5253
    DOI 10.1111/apa.16550
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  5. Article ; Online: The Role of Iron in Staphylococcus aureus Infection and Human Disease

    Madeleine C. van Dijk / Robin M. de Kruijff / Peter-Leon Hagedoorn

    Frontiers in Cell and Developmental Biology, Vol

    A Metal Tug of War at the Host—Microbe Interface

    2022  Volume 10

    Abstract: Iron deficiency anemia can be treated with oral or intravenous Fe supplementation. Such supplementation has considerable effects on the human microbiome, and on opportunistic pathogenic micro-organisms. Molecular understanding of the control and ... ...

    Abstract Iron deficiency anemia can be treated with oral or intravenous Fe supplementation. Such supplementation has considerable effects on the human microbiome, and on opportunistic pathogenic micro-organisms. Molecular understanding of the control and regulation of Fe availability at the host-microbe interface is crucial to interpreting the side effects of Fe supplementation. Here, we provide a concise overview of the regulation of Fe by the opportunistic pathogen Staphylococcus aureus. Ferric uptake regulator (Fur) plays a central role in controlling Fe uptake, utilization and storage in order to maintain a required value. The micro-organism has a strong preference for heme iron as an Fe source, which is enabled by the Iron-regulated surface determinant (Isd) system. The strategies it employs to overcome Fe restriction imposed by the host include: hijacking host proteins, replacing metal cofactors, and replacing functions by non-metal dependent enzymes. We propose that integrated omics approaches, which include metalloproteomics, are necessary to provide a comprehensive understanding of the metal tug of war at the host-microbe interface down to the molecular level.
    Keywords Staphylococcus aureus ; MRSA ; iron homeostasis ; nutritional immunity ; iron deficiency anemia ; ferric uptake regulator ; Biology (General) ; QH301-705.5
    Subject code 570
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Elucidating the Influence of Tumor Presence on the Polymersome Circulation Time in Mice.

    de Kruijff, Robin M / Raavé, René / Kip, Annemarie / Molkenboer-Kuenen, Janneke / Roobol, Stefan J / Essers, Jeroen / Heskamp, Sandra / Denkova, Antonia G

    Pharmaceutics

    2019  Volume 11, Issue 5

    Abstract: The use of nanoparticles as tumor-targeting agents is steadily increasing, and the influence of nanoparticle characteristics such as size and stealthiness have been established for a large number of nanocarrier systems. However, not much is known about ... ...

    Abstract The use of nanoparticles as tumor-targeting agents is steadily increasing, and the influence of nanoparticle characteristics such as size and stealthiness have been established for a large number of nanocarrier systems. However, not much is known about the impact of tumor presence on nanocarrier circulation times. This paper reports on the influence of tumor presence on the in vivo circulation time and biodistribution of polybutadiene-polyethylene oxide (PBd-PEO) polymersomes. For this purpose, polymersomes were loaded with the gamma-emitter
    Keywords covid19
    Language English
    Publishing date 2019-05-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics11050241
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  7. Article ; Online: Access to Metastable Gel States Using Seeded Self-Assembly of Low-Molecular-Weight Gelators.

    Wang, Yiming / de Kruijff, Robin M / Lovrak, Matija / Guo, Xuhong / Eelkema, Rienk / van Esch, Jan H

    Angewandte Chemie (International ed. in English)

    2019  Volume 58, Issue 12, Page(s) 3800–3803

    Abstract: Here we report on how metastable supramolecular gels can be formed through seeded self-assembly of multicomponent gelators. Hydrazone-based gelators decorated with non-ionic and anionic groups are formed in situ from hydrazide and aldehyde building ... ...

    Abstract Here we report on how metastable supramolecular gels can be formed through seeded self-assembly of multicomponent gelators. Hydrazone-based gelators decorated with non-ionic and anionic groups are formed in situ from hydrazide and aldehyde building blocks, and lead through multiple self-sorting processes to the formation of heterogeneous gels approaching thermodynamic equilibrium. Interestingly, the addition of seeds composing of oligomers of gelators bypasses the self-sorting processes and accelerates the self-assembly along a kinetically favored pathway, resulting in homogeneous gels of which the network morphologies and gel stiffness are markedly different from the thermodynamically more stable gel products. Importantly, over time, these metastable homogeneous gel networks are capable of converting into the thermodynamically more stable state. This seeding-driven formation of out-of-equilibrium supramolecular structures is expected to serve as a simple approach towards functional materials with pathway-dependent properties.
    Language English
    Publishing date 2019-02-14
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.201812412
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  8. Article: A Critical Review of Alpha Radionuclide Therapy-How to Deal with Recoiling Daughters?

    de Kruijff, Robin M / Wolterbeek, Hubert T / Denkova, Antonia G

    Pharmaceuticals (Basel, Switzerland)

    2015  Volume 8, Issue 2, Page(s) 321–336

    Abstract: This review presents an overview of the successes and challenges currently faced in alpha radionuclide therapy. Alpha particles have an advantage in killing tumour cells as compared to beta or gamma radiation due to their short penetration depth and high ...

    Abstract This review presents an overview of the successes and challenges currently faced in alpha radionuclide therapy. Alpha particles have an advantage in killing tumour cells as compared to beta or gamma radiation due to their short penetration depth and high linear energy transfer (LET). Touching briefly on the clinical successes of radionuclides emitting only one alpha particle, the main focus of this article lies on those alpha-emitting radionuclides with multiple alpha-emitting daughters in their decay chain. While having the advantage of longer half-lives, the recoiled daughters of radionuclides like 224Ra (radium), 223Ra, and 225Ac (actinium) can do significant damage to healthy tissue when not retained at the tumour site. Three different approaches to deal with this problem are discussed: encapsulation in a nano-carrier, fast uptake of the alpha emitting radionuclides in tumour cells, and local administration. Each approach has been shown to have its advantages and disadvantages, but when larger activities need to be used clinically, nano-carriers appear to be the most promising solution for reducing toxic effects, provided there is no accumulation in healthy tissue.
    Language English
    Publishing date 2015-06-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph8020321
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  9. Article ; Online: Uptake and subcellular distribution of radiolabeled polymersomes for radiotherapy.

    Roobol, Stefan J / Hartjes, Thomas A / Slotman, Johan A / de Kruijff, Robin M / Torrelo, Guzman / Abraham, Tsion E / Bruchertseifer, Frank / Morgenstern, Alfred / Kanaar, Roland / van Gent, Dik C / Houtsmuller, Adriaan B / Denkova, Antonia G / van Royen, Martin E / Essers, Jeroen

    Nanotheranostics

    2020  Volume 4, Issue 1, Page(s) 14–25

    Abstract: Polymersomes have the potential to be applied in targeted alpha radionuclide therapy, while in addition preventing release of recoiling daughter isotopes. In this study, we investigated the cellular uptake, post uptake processing and intracellular ... ...

    Abstract Polymersomes have the potential to be applied in targeted alpha radionuclide therapy, while in addition preventing release of recoiling daughter isotopes. In this study, we investigated the cellular uptake, post uptake processing and intracellular localization of polymersomes.
    MeSH term(s) Animals ; Bismuth/chemistry ; Bismuth/pharmacokinetics ; Cell Line ; Cell Line, Tumor ; Drug Carriers/chemistry ; Drug Carriers/pharmacokinetics ; Endocytosis ; Humans ; Membranes, Artificial ; Mice ; Microscopy, Confocal ; Nanoparticles/chemistry ; Nanoparticles/metabolism ; Organic Chemicals/chemistry ; Organic Chemicals/pharmacokinetics ; Polymers/chemistry ; Polymers/pharmacokinetics ; Radioisotopes/chemistry ; Radioisotopes/pharmacokinetics ; Radiotherapy
    Chemical Substances Drug Carriers ; Membranes, Artificial ; Organic Chemicals ; PKH67 ; Polymers ; Radioisotopes ; Bismuth (U015TT5I8H)
    Language English
    Publishing date 2020-01-01
    Publishing country Australia
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2206-7418
    ISSN (online) 2206-7418
    DOI 10.7150/ntno.37080
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A Critical Review of Alpha Radionuclide Therapy—How to Deal with Recoiling Daughters?

    Robin M. de Kruijff / Hubert T. Wolterbeek / Antonia G. Denkova

    Pharmaceuticals, Vol 8, Iss 2, Pp 321-

    2015  Volume 336

    Abstract: This review presents an overview of the successes and challenges currently faced in alpha radionuclide therapy. Alpha particles have an advantage in killing tumour cells as compared to beta or gamma radiation due to their short penetration depth and high ...

    Abstract This review presents an overview of the successes and challenges currently faced in alpha radionuclide therapy. Alpha particles have an advantage in killing tumour cells as compared to beta or gamma radiation due to their short penetration depth and high linear energy transfer (LET). Touching briefly on the clinical successes of radionuclides emitting only one alpha particle, the main focus of this article lies on those alpha-emitting radionuclides with multiple alpha-emitting daughters in their decay chain. While having the advantage of longer half-lives, the recoiled daughters of radionuclides like 224Ra (radium), 223Ra, and 225Ac (actinium) can do significant damage to healthy tissue when not retained at the tumour site. Three different approaches to deal with this problem are discussed: encapsulation in a nano-carrier, fast uptake of the alpha emitting radionuclides in tumour cells, and local administration. Each approach has been shown to have its advantages and disadvantages, but when larger activities need to be used clinically, nano-carriers appear to be the most promising solution for reducing toxic effects, provided there is no accumulation in healthy tissue.
    Keywords alpha-emitters ; recoils ; radionuclide therapy ; Medicine ; R ; Pharmacy and materia medica ; RS1-441
    Subject code 610
    Language English
    Publishing date 2015-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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