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Article ; Online: miR-3648 promotes lung adenocarcinoma-genesis by inhibiting SOCS2 (suppressor of cytokine signaling 2).

Tu, Yanhong / Mei, Fan

2022 Volume 13, Issue 2, Page(s) 3044–3056

Abstract: Lung adenocarcinoma (LUAD) is the most common histologic subtype of lung cancer and is associated with high morbidity and mortality. We aimed to study the effects of microRNA-3648 (miR-3648) on LUAD by inhibiting its downstream target suppressor of ... ...

Abstract	Lung adenocarcinoma (LUAD) is the most common histologic subtype of lung cancer and is associated with high morbidity and mortality. We aimed to study the effects of microRNA-3648 (miR-3648) on LUAD by inhibiting its downstream target suppressor of cytokine signaling 2 (SOCS2) mRNA. miR-3648 expression was measured by real-time quantitative PCR in LUAD and normal lung epithelial cell lines. The direct interaction between miR-3648 and SOCS2 mRNA was identified through luciferase reporter and RNA pull-down assays. Cell viability, migration, and invasion were examined using cell functional assays. MiR-3648 was found to be overexpressed in LUAD cells and tissues. Overexpression of miR-3648 significantly enhanced cell proliferation, migration, and invasion abilities in LUAD cells. Furthermore, SOCS2 was targeted by miR-3648, and co-transfection of a miR-3648 inhibitor or si-SOCS2 reversed the suppressive effects of SOCS2 in PC9 and A549 cells. miR-3648 enhanced the proliferation and promoted migration and invasion of LUAD by inhibiting SOCS2. In conclusion, our results indicate that miR-3648 plays a pivotal role in LUADe progression and might thus provide a novel therapeutic strategy for patients with LUAD.
MeSH term(s)	A549 Cells ; Adenocarcinoma of Lung/genetics ; Adenocarcinoma of Lung/pathology ; Adult ; Aged ; Aged, 80 and over ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation/genetics ; Cell Transformation, Neoplastic/genetics ; Down-Regulation/genetics ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Male ; MicroRNAs/physiology ; Middle Aged ; Suppressor of Cytokine Signaling Proteins/genetics
Chemical Substances	MIRN3648-1 microRNA, human ; MicroRNAs ; SOCS2 protein, human ; Suppressor of Cytokine Signaling Proteins
Language	English
Publishing date	2022-01-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2737830-5
ISSN	2165-5987 ; 2165-5979
ISSN (online)	2165-5987
ISSN	2165-5979
DOI	10.1080/21655979.2021.2017577
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Relationship between Team Conflict and Performance in Green Enterprises

Yanhong Tu / Leilei Zhang

Complexity, Vol

A Cross-Level Model Moderated by Leaders’ Political Skills

2021 Volume 2021

Abstract: It is evident that, being a member of the organization, the team has to cue the influx of the green management concepts. This study focuses on the aspect of team management in green enterprises. Applying leadership theory to sample green enterprises, ... ...

Abstract	It is evident that, being a member of the organization, the team has to cue the influx of the green management concepts. This study focuses on the aspect of team management in green enterprises. Applying leadership theory to sample green enterprises, this paper proposes that political skills of team leadership have moderating effects on the relationship between team conflict (relationship conflict and task conflict) and performance at both the individual and team levels. Empirical data were collected from 85 dyads of leaders and team members in 36 green enterprises in China. It was found that the leaders’ political skills weakened the negative effects of relationship conflict on individual performance and team performance. Further, leaders’ political skills strengthened the positive effects of task conflict on individual and team performance. The results of this study deepen the cognition of two types of team conflict in theory and provide theoretical guidance for green enterprises in carrying out effective team conflict management and practical political skills training for leaders.
Keywords	Electronic computers. Computer science ; QA75.5-76.95
Subject code	650
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Hindawi-Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Industry Development Tendency and Innovation Strategy Preference of Five Typical Industries under the Background of Low-Carbon Sustainable Development in China

Yanhong Tu / Leilei Zhang / Xue Li

Complexity, Vol

2022 Volume 2022

Abstract: This paper tries to investigate the future development tendency of five typical industries in China and find out whether there exists a different innovation strategy preference between Chinese firms of low- and high-knowledge density industry in the ... ...

Abstract	This paper tries to investigate the future development tendency of five typical industries in China and find out whether there exists a different innovation strategy preference between Chinese firms of low- and high-knowledge density industry in the background of low-carbon sustainable development. First, this paper finds that the innovation driven-based trend of industrial development is further accelerated in China. Firms in industries with high knowledge and technology density, such as specialized-supplier, scale-intensive, and science-based industries, are more likely to choose exploratory innovation strategy than exploitative innovation strategy. Firms in industries with low knowledge and technology density like service- and supplier-dominated industries are more likely to choose the exploitative innovation strategy. Second, results indicate that exploratory innovation can bring higher technological innovation performance than exploitative innovation. And the effect of the ambidextrous strategy is better than the single exploitative strategy in industries with high knowledge and technology density like specialized-supplier, scale-intensive, and science-based industries. Third, this paper suggests that innovation strategy preference plays a mediating role between industry type and technology innovation and a moderating effect of knowledge management capacity between innovation strategy and firms’ technology innovation.
Keywords	Electronic computers. Computer science ; QA75.5-76.95
Subject code	690
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi-Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: SETDB2 interacts with BUBR1 to induce accurate chromosome segregation independently of its histone methyltransferase activity.

Tu, Yanhong / Zhang, Haomiao / Xia, Jialin / Zhao, Yu / Yang, Ruifang / Feng, Jing / Ma, Xueyun / Li, Jing

FEBS open bio

2024 Volume 14, Issue 3, Page(s) 444–454

Abstract: SETDB2 is a H3K9 histone methyltransferase required for accurate chromosome segregation. Its H3K9 histone methyltransferase activity was reported to be associated with chromosomes during metaphase. Here, we confirm that SETDB2 is required for mitosis and ...

Abstract	SETDB2 is a H3K9 histone methyltransferase required for accurate chromosome segregation. Its H3K9 histone methyltransferase activity was reported to be associated with chromosomes during metaphase. Here, we confirm that SETDB2 is required for mitosis and accurate chromosome segregation. However, these functions are independent of its histone methyltransferase activity. Further analysis showed that SETDB2 can interact with BUBR1, and is required for CDC20 binding to BUBR1 and APC/C complex and CYCLIN B1 degradation. The ability of SETDB2 to regulate the binding of CDC20 to BUBR1 or APC/C complex, and stabilization of CYCLIN B1 are also independent of its histone methyltransferase activity. These results suggest that SETDB2 interacts with BUBR1 to promote binding of CDC20 to BUBR1 and APC3, then degrades CYCLIN B1 to ensure accurate chromosome segregation and mitosis, independently of its histone methyltransferase activity.
MeSH term(s)	Protein Serine-Threonine Kinases/metabolism ; Anaphase-Promoting Complex-Cyclosome/genetics ; Anaphase-Promoting Complex-Cyclosome/metabolism ; Cyclin B1/genetics ; Cyclin B1/metabolism ; Cdc20 Proteins/genetics ; Cdc20 Proteins/metabolism ; Chromosome Segregation ; Spindle Apparatus/metabolism ; Cell Cycle Proteins/genetics
Chemical Substances	Protein Serine-Threonine Kinases (EC 2.7.11.1) ; Anaphase-Promoting Complex-Cyclosome (EC 2.3.2.27) ; Cyclin B1 ; Cdc20 Proteins ; Cell Cycle Proteins
Language	English
Publishing date	2024-01-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2651702-4
ISSN	2211-5463 ; 2211-5463
ISSN (online)	2211-5463
ISSN	2211-5463
DOI	10.1002/2211-5463.13761
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Article: Ultrasound Improved the Non-Covalent Interaction of β-Lactoglobulin with Luteolin: Regulating Human Intestinal Microbiota and Conformational Epitopes Reduced Allergy Risks.

Wang, Titi / Chen, Wenmei / Shao, Yanhong / Liu, Jun / Tu, Zongcai

Foods (Basel, Switzerland)

2022 Volume 11, Issue 7

Abstract: The present study aims to investigate the effects of ultrasound on the non-covalent interaction of β-lactoglobulin (β-LG) and luteolin (LUT) and to investigate the relationship between allergenicity and human intestinal microbiota. After treatment, the ... ...

Abstract	The present study aims to investigate the effects of ultrasound on the non-covalent interaction of β-lactoglobulin (β-LG) and luteolin (LUT) and to investigate the relationship between allergenicity and human intestinal microbiota. After treatment, the conformational structures of β-LG were changed, which reflected by the decrease in α-helix content, intrinsic fluorescence intensity and surface hydrophobicity, whereas the β-sheet content increased. Molecular docking studies revealed the non-covalent interaction of β-LG and LUT by hydrogen bond, van der Walls bond and hydrophobic bond. β-LG-LUT complex treated by ultrasound has a lower IgG/IgE binding ability and inhibits the allergic reaction of KU812 cells, depending on the changes in the conformational epitopes of β-LG. Meanwhile, the β-LG-LUT complex affected the composition of human intestinal microbiota, such as the relative abundance of
Language	English
Publishing date	2022-03-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods11070988
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Article ; Online: Nanoscale Zero-Valent Iron Dispersed by Sodium Alginate Enables Highly Efficient Removal of Lead (Pb) from Aqueous Solution

Chunli Zheng / Jieling Ren / Fei He / Yingying Yong / Yanhong Tu / Zhenxing Wang

Adsorption Science & Technology, Vol

2023 Volume 2023

Abstract: Nanozero-valent iron (NZVI) shows great potential in the remediation of water pollution, but its application is limited by its instability and tendency to aggregate. To enhance the dispersibility and antioxidant properties of NZVI, we prepared composites ...

Abstract	Nanozero-valent iron (NZVI) shows great potential in the remediation of water pollution, but its application is limited by its instability and tendency to aggregate. To enhance the dispersibility and antioxidant properties of NZVI, we prepared composites (SN) by wrapping NZVI with sodium alginate (SA) for the removal of Pb(II) from water. Various characterization methods such as SEM-EDS, BET, XPS, and FT-IR were used to study the structure of the materials, and the adsorption properties of Pb(II) in the materials were analyzed using adsorption kinetics and adsorption isotherm experiments. The results showed that SN had a specific surface area of 47.05 m2/g, which was significantly higher than the 7.56 m2/g of NZVI, and the surface passivation was reduced. The maximum adsorption amount of SN on Pb(II) was obtained by fitting the adsorption isotherm model at 70.92 mg/g. After five cycles of adsorption, SN exhibited a removal rate of 95.11% for Pb(II). The mechanism of Pb(II) removal by SN involved the synergistic effect of electrostatic adsorption, redox reaction, ion exchange, and coprecipitation. Notably, even after 90 days of aging, the removal rate of Pb(II) by SN remained high at 95.39%, demonstrating good reactivity. These results indicated that SN is an effective adsorbent to remove Pb(II) contamination.
Keywords	Physical and theoretical chemistry ; QD450-801
Subject code	541
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Hindawi - SAGE Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Association between Self-Rated Health and Health Self-Management Ability of Healthcare Undergraduates: The Chain Mediating Roles of eHealth Literacy and Resistance to Peer Influence.

Xu, Guangyi / Xu, Yanhong / Tu, Xiaomin / Hao, Shuaijia / Liu, Ting

International journal of environmental research and public health

2022 Volume 19, Issue 21

Abstract: Health self-management is important for healthcare undergraduates who are at the late adolescent or early adulthood stage, and will play an important part in health promotion for the general population. Previous research has shown that perceived health ... ...

Abstract	Health self-management is important for healthcare undergraduates who are at the late adolescent or early adulthood stage, and will play an important part in health promotion for the general population. Previous research has shown that perceived health status affects health self-management. However, few studies have uncovered the mechanism between self-rated health and health self-management among healthcare undergraduates. Based on social ecology theory and Pender's health promotion model, this study aimed to explore the associations between health self-management ability, self-rated health, eHealth literacy and resistance to peer influence of healthcare undergraduates, with a focus on identifying the mediating effects of eHealth literacy and resistance to peer influence. A cross-sectional study was conducted among 515 healthcare undergraduates in Eastern China between July and September 2021. Serial mediation analysis was performed using Haye's Model 6 PROCESS macro to examine the mediating effects. The study found that health self-management ability was significantly and positively correlated with eHealth literacy, resistance to peer influence and self-rated health. Self-rated health had a direct and positive predictive effect on health self-management, with a direct effect value of 0.654. eHealth literacy and resistance to peer influence played both an independent mediating and a chain-mediating role in the mechanism of self-rated health affecting health self-management among healthcare undergraduates, with indirect effect values of 0.085, 0.101, and 0.013, respectively. The results suggest that eHealth literacy and resistance to peer influence could be intervention targets in programs for improving these students' health self-management ability.
MeSH term(s)	Humans ; Adolescent ; Adult ; Health Literacy/methods ; Cross-Sectional Studies ; Self-Management ; Peer Influence ; Surveys and Questionnaires ; Telemedicine/methods ; Students
Language	English
Publishing date	2022-11-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph192114501
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Article ; Online: A Cured Coronavirus Disease 2019 Case of an 86-Year-Old With 13 Chronic Diseases: A Case Report.

Tu, Yanhong / Fang, Ji / Yin, Menghui / Yu, Weizhong / Li, Yinxiong

JTO clinical and research reports

2020 Volume 1, Issue 2, Page(s) 100038

Language	English
Publishing date	2020-12-22
Publishing country	United States
Document type	Case Reports
ISSN	2666-3643
ISSN (online)	2666-3643
DOI	10.1016/j.jtocrr.2020.100038
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Association between Self-Rated Health and Health Self-Management Ability of Healthcare Undergraduates

Guangyi Xu / Yanhong Xu / Xiaomin Tu / Shuaijia Hao / Ting Liu

International Journal of Environmental Research and Public Health, Vol 19, Iss 14501, p

The Chain Mediating Roles of eHealth Literacy and Resistance to Peer Influence

2022 Volume 14501

Abstract	Health self-management is important for healthcare undergraduates who are at the late adolescent or early adulthood stage, and will play an important part in health promotion for the general population. Previous research has shown that perceived health status affects health self-management. However, few studies have uncovered the mechanism between self-rated health and health self-management among healthcare undergraduates. Based on social ecology theory and Pender’s health promotion model, this study aimed to explore the associations between health self-management ability, self-rated health, eHealth literacy and resistance to peer influence of healthcare undergraduates, with a focus on identifying the mediating effects of eHealth literacy and resistance to peer influence. A cross-sectional study was conducted among 515 healthcare undergraduates in Eastern China between July and September 2021. Serial mediation analysis was performed using Haye’s Model 6 PROCESS macro to examine the mediating effects. The study found that health self-management ability was significantly and positively correlated with eHealth literacy, resistance to peer influence and self-rated health. Self-rated health had a direct and positive predictive effect on health self-management, with a direct effect value of 0.654. eHealth literacy and resistance to peer influence played both an independent mediating and a chain-mediating role in the mechanism of self-rated health affecting health self-management among healthcare undergraduates, with indirect effect values of 0.085, 0.101, and 0.013, respectively. The results suggest that eHealth literacy and resistance to peer influence could be intervention targets in programs for improving these students’ health self-management ability.
Keywords	health self-management ability ; eHealth literacy ; peer influence ; self-rated health ; healthcare undergraduates ; China ; Medicine ; R
Subject code	796 ; 360
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Structure and allergenicity of α-lactalbumin: effects of ultrasonic prior to glycation and subsequent phosphorylation

Chen, Wenmei / Chen, Qiongzhen / Zhou, Houze / Shao, Yanhong / Wang, Yang / Liu, Jun / Tu, Zongcai

Food Science and Human Wellness. 2023 May, v. 12, no. 3 p.825-831

2023

Abstract: Bovine α-lactalbumin (BLA) induced severe cow's milk allergy. In this study, a novel strategy combining ultrasonication, performed before glycation, and phosphorylation was proposed to reduce BLA allergenicity. Result showed that IgE- and IgG-binding ... ...

Abstract	Bovine α-lactalbumin (BLA) induced severe cow's milk allergy. In this study, a novel strategy combining ultrasonication, performed before glycation, and phosphorylation was proposed to reduce BLA allergenicity. Result showed that IgE- and IgG-binding capacities and the release rates of histamine and interleukin-6 from RBL-2H3 were reduced. Moreover, intrinsic fluorescence intensity and surface hydrophobicity were decreased, whereas glycated sites (R10, N44, K79, K108, N102 and K114) and phosphorylated sites (Y36 and S112) of BLA were increased. Minimum allergenicity was detected during BLA treatment after ultrasonic prior to glycation and subsequent phosphorylation because of considerable increase in glycated and phosphorylated sites. Therefore, the decrease in allergenicity of BLA, the effect correlated well with the shielding effect of glycated sites combined with phosphorylated sites and the conformational changes. This study provides important theoretical foundations for improving and using the ultrasonic technology combined with protein modification in allergenic protein processing.
Keywords	allergenicity ; allergens ; cattle ; fluorescence ; food science ; glycation ; histamine ; humans ; hydrophobicity ; interleukin-6 ; milk ; milk allergy ; phosphorylation ; ultrasonic treatment ; ultrasonics ; Bovine α-lactalbumin ; Ultrasonic ; Protein modification
Language	English
Dates of publication	2023-05
Size	p. 825-831.
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	2712869-6
ISSN	2213-4530
ISSN	2213-4530
DOI	10.1016/j.fshw.2022.09.021
Database	NAL-Catalogue (AGRICOLA)

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