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  1. Article ; Online: Retraction Note: Norcantharidin combined with Coix seed oil synergistically induces apoptosis and inhibits hepatocellular carcinoma growth by downregulating regulatory T cells accumulation.

    Wang, Dan / Yang, Chendong / Wang, Zhuien / Yang, Yi / Li, Defang / Ding, Xiaojie / Xu, Wenjuan / Zheng, Qiusheng

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 7143

    Language English
    Publishing date 2024-03-26
    Publishing country England
    Document type Retraction of Publication
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-57766-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Outer-Surface Functionalized Solid-State Nanochannels for Enhanced Sensing Properties: Progress and Perspective.

    Dai, Li / Zhang, Wei-Qi / Ding, Defang / Luo, Cihui / Jiang, Lei / Huang, Yu / Xia, Fan

    ACS nano

    2024  Volume 18, Issue 11, Page(s) 7677–7687

    Abstract: Solid-state nanochannel-based sensing systems have been established as vigorous tools for sensing plentiful biomarkers due to their label-free, highly sensitive, and high-throughput screening. However, research on solid-state nanochannels has ... ...

    Abstract Solid-state nanochannel-based sensing systems have been established as vigorous tools for sensing plentiful biomarkers due to their label-free, highly sensitive, and high-throughput screening. However, research on solid-state nanochannels has predominantly centered on the functional groups modified on the inner wall, neglecting investigations into the outer surface. Actually, the outer surface, as a part of the nanochannels, also plays a key role in regulating ionic current. When the target nears the entrance of the nanochannel and prepares to pass through, it would also interact with functional groups located on the nanochannel's outer surface, leading to subsequent alterations in the ionic current. Recently, the probes on the outer surface have experimentally demonstrated their ability to independently regulate ionic current, unveiling advantages in
    Language English
    Publishing date 2024-03-07
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.3c12270
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Discovery of Urea Derivatives of Celastrol as Selective Peroxiredoxin 1 Inhibitors against Colorectal Cancer Cells.

    Li, Yang / Zhu, Yuyuan / Shang, Fan-Fan / Xu, Lin / Jiang, Defang / Sun, Bin / Zhang, Lei / Luo, Cheng / Zhang, Ao / Zhang, Hao / Ding, Chunyong

    Journal of medicinal chemistry

    2024  

    Abstract: Peroxiredoxin (PRDX1) is a tumor-overexpressed antioxidant enzyme for eliminating excessive reactive oxygen species (ROS) to protect tumor cells from oxidative damage. Herein, a series of celastrol urea derivatives were developed based on its cocrystal ... ...

    Abstract Peroxiredoxin (PRDX1) is a tumor-overexpressed antioxidant enzyme for eliminating excessive reactive oxygen species (ROS) to protect tumor cells from oxidative damage. Herein, a series of celastrol urea derivatives were developed based on its cocrystal structure with PRDX1, with the aim of pursuing a PRDX1-specific inhibitor. Among them, derivative
    Language English
    Publishing date 2024-04-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.4c00023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 151: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MB 1: Show issues

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  4. Article ; Online: Bioinformatics and Experimental Study revealed LINC00982/ miR-183-5p/ABCA8 Axis Suppresses LUAD Progression.

    Ding, Defang / Zhong, Jingyu / Xing, Yue / Hu, Yangfan / Ge, Xiang / Yao, Weiwu

    Current cancer drug targets

    2023  

    Abstract: Background: Lung adenocarcinoma (LUAD) is a major health challenge worldwide with an undesirable prognosis. LINC00982 has been implicated as a tumor suppressor in diverse human cancers; however, its role in LUAD has not been fully characterized.: ... ...

    Abstract Background: Lung adenocarcinoma (LUAD) is a major health challenge worldwide with an undesirable prognosis. LINC00982 has been implicated as a tumor suppressor in diverse human cancers; however, its role in LUAD has not been fully characterized.
    Methods: Expression level and prognostic value of LINC00982 were investigated in pan-cancer and lung cancer from The Cancer Genome Atlas (TCGA) project. Differential expression analysis based on the LINC00982 expression level was performed in LUAD followed by gene set enrichment analysis (GSEA) and functional enrichment analyses. The association between LINC00982 expression and tumor immune microenvironment characteristics was evaluated. A potential ceRNA regulatory axis was identified and experimentally validated.
    Results: We found that LINC00982 expression was downregulated and correlated with poor prognosis in LUAD. Enrichment analyses revealed that LINC00982 could inhibit DNA damage repair and cell proliferation, but enhance tumor metabolic reprogramming. We identified a competing endogenous RNA network involving LINC00982, miR-183-5p, and ATP-binding cassette subfamily A member 8 (ABCA8). Luciferase assays confirmed that miR-183-5p can interact with LINC00982 and ABCA8. Forced miR-183-5p expression reduced LINC00982 transcript levels and suppressed ABCA8 expression.
    Conclusions: Our findings revealed the LINC00982/miR-183-5p/ABCA8 axis as a potential therapeutic target in LUAD.
    Language English
    Publishing date 2023-11-22
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2064824-8
    ISSN 1873-5576 ; 1568-0096
    ISSN (online) 1873-5576
    ISSN 1568-0096
    DOI 10.2174/0115680096266700231107071222
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5589: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: A Cured Patient With 2019-nCoV Pneumonia.

    Ding, Defang / Zhu, Caisong / Yao, Weiwu

    The American journal of medicine

    2020  Volume 133, Issue 11, Page(s) 1291–1292

    MeSH term(s) Aged ; Anti-Bacterial Agents/therapeutic use ; Antiviral Agents/therapeutic use ; Betacoronavirus ; COVID-19 ; China/epidemiology ; Coronavirus Infections/epidemiology ; Coronavirus Infections/therapy ; Female ; Humans ; Moxifloxacin/therapeutic use ; Oseltamivir/therapeutic use ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/therapy ; SARS-CoV-2
    Chemical Substances Anti-Bacterial Agents ; Antiviral Agents ; Oseltamivir (20O93L6F9H) ; Moxifloxacin (U188XYD42P)
    Keywords covid19
    Language English
    Publishing date 2020-03-20
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 80015-6
    ISSN 1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
    ISSN (online) 1555-7162 ; 1873-2178
    ISSN 0002-9343 ; 1548-2766
    DOI 10.1016/j.amjmed.2020.02.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.289: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: A high-performance and flexible thermoelectric generator based on the solution-processed composites of reduced graphene oxide nanosheets and bismuth telluride nanoplates.

    Ding, Defang / Sun, Fengming / Xia, Fan / Tang, Zhiyong

    Nanoscale advances

    2020  Volume 2, Issue 8, Page(s) 3244–3251

    Abstract: The fabrication of a flexible thermoelectric generator (TEG) with both high power output and good flexibility has drawn considerable attention. Solution-processed inorganic nanocrystals have good processibility in interface to retain excellent electrical ...

    Abstract The fabrication of a flexible thermoelectric generator (TEG) with both high power output and good flexibility has drawn considerable attention. Solution-processed inorganic nanocrystals have good processibility in interface to retain excellent electrical properties of nanocrystals and can be processed into thin films on a flexible substrate by an easy scale-up printing or coating method. However, a high-performance TEG device based on inorganic solution-processed materials also poses challenges when it comes to flexibility of the whole device. Herein, flexible planar TEG devices are fabricated by printing an ink mixture comprising solution-processed bismuth telluride (Bi
    Language English
    Publishing date 2020-06-12
    Publishing country England
    Document type Journal Article
    ISSN 2516-0230
    ISSN (online) 2516-0230
    DOI 10.1039/d0na00118j
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: miR-155 facilitates the synergistic replication between avian leukosis virus subgroup J and reticuloendotheliosis virus by targeting a dual pathway.

    Xue, Jingwen / Zhou, Defang / Zhou, Jing / Du, Xusheng / Zhang, Xinyue / Liu, Xiaoyang / Ding, Longying / Cheng, Ziqiang

    Journal of virology

    2023  Volume 97, Issue 11, Page(s) e0093723

    Abstract: Importance: The synergy of two oncogenic retroviruses is an essential phenomenon in nature. The synergistic replication of ALV-J and REV in poultry flocks increases immunosuppression and pathogenicity, extends the tumor spectrum, and accelerates viral ... ...

    Abstract Importance: The synergy of two oncogenic retroviruses is an essential phenomenon in nature. The synergistic replication of ALV-J and REV in poultry flocks increases immunosuppression and pathogenicity, extends the tumor spectrum, and accelerates viral evolution, causing substantial economic losses to the poultry industry. However, the mechanism of synergistic replication between ALV-J and REV is still incompletely elusive. We observed that microRNA-155 targets a dual pathway, PRKCI-MAPK8 and TIMP3-MMP2, interacting with the U3 region of ALV-J and REV, enabling synergistic replication. This work gives us new targets to modulate ALV-J and REV's synergistic replication, guiding future research on the mechanism.
    MeSH term(s) Animals ; Reticuloendotheliosis virus/genetics ; Avian Leukosis ; Avian Leukosis Virus/genetics ; Chickens ; Poultry Diseases ; MicroRNAs/genetics ; Virus Replication
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2023-11-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/jvi.00937-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 609: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: The Differences of Graphene Oxide Products Made from Three Kinds of Flake Graphites

    Yu Lin / Defang Ding / Chunyan Hu / Zhen Li / Yi Shen / Fan Xia

    ACS Omega, Vol 6, Iss 40, Pp 25996-

    2021  Volume 26003

    Keywords Chemistry ; QD1-999
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher American Chemical Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  10. Article ; Online: In Situ

    Wen, Qunlei / Lin, Yu / Yang, Yang / Gao, Ruijian / Ouyang, Nanqiu / Ding, Defang / Liu, Youwen / Zhai, Tianyou

    ACS nano

    2022  Volume 16, Issue 6, Page(s) 9572–9582

    Abstract: Engineering the reaction interface is necessary for advancing various electrocatalytic processes. However, most designed catalysts tend to be ineffective due to the inevitable structural reconstruction. Here we utilize that operando electrocatalysis ... ...

    Abstract Engineering the reaction interface is necessary for advancing various electrocatalytic processes. However, most designed catalysts tend to be ineffective due to the inevitable structural reconstruction. Here we utilize that operando electrocatalysis variations (
    Language English
    Publishing date 2022-06-09
    Publishing country United States
    Document type Journal Article
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.2c02838
    Database MEDical Literature Analysis and Retrieval System OnLINE

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