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  1. Article ; Online: Representation of Women and Racially and Ethnically Marginalized Principal Investigators in Vascular Device Trials.

    Weaver, M Libby / Srinivas, Tara / Bose, Sanuja / Deery, Sarah E / Amendola, Michael Fiore / Black, James H / Hicks, Caitlin W

    JAMA surgery

    2024  Volume 159, Issue 4, Page(s) 459–461

    MeSH term(s) Humans ; Female ; Ethnicity ; Leadership
    Language English
    Publishing date 2024-01-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701841-6
    ISSN 2168-6262 ; 2168-6254
    ISSN (online) 2168-6262
    ISSN 2168-6254
    DOI 10.1001/jamasurg.2023.7174
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  2. Article ; Online: Free Reelin' Along the Platelet Surface.

    Hicks, Sarah M / Gardiner, Elizabeth E

    Arteriosclerosis, thrombosis, and vascular biology

    2020  Volume 40, Issue 10, Page(s) 2341–2343

    MeSH term(s) Cell Adhesion Molecules, Neuronal/genetics ; Cell Adhesion Molecules, Neuronal/metabolism ; Extracellular Matrix Proteins/genetics ; Extracellular Matrix Proteins/metabolism ; Integrin beta3 ; Phospholipase C gamma ; rho GTP-Binding Proteins
    Chemical Substances Cell Adhesion Molecules, Neuronal ; Extracellular Matrix Proteins ; Integrin beta3 ; Phospholipase C gamma (EC 3.1.4.3) ; rho GTP-Binding Proteins (EC 3.6.5.2)
    Language English
    Publishing date 2020-09-23
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1221433-4
    ISSN 1524-4636 ; 1079-5642
    ISSN (online) 1524-4636
    ISSN 1079-5642
    DOI 10.1161/ATVBAHA.120.314980
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  3. Article ; Online: Outpatient visits and antibiotic use due to higher valency pneumococcal vaccine serotypes.

    King, Laura M / Andrejko, Kristin L / Kabbani, Sarah / Tartof, Sara Y / Hicks, Lauri A / Cohen, Adam L / Kobayashi, Miwako / Lewnard, Joseph A

    The Journal of infectious diseases

    2024  

    Abstract: Background: In 2022-2023, 15- and 20-valent pneumococcal conjugate vaccines (PCV15/PCV20) were recommended for infants. We aimed to estimate the incidence of outpatient visits and antibiotic prescriptions in U.S. children (≤17 years) from 2016-2019 for ... ...

    Abstract Background: In 2022-2023, 15- and 20-valent pneumococcal conjugate vaccines (PCV15/PCV20) were recommended for infants. We aimed to estimate the incidence of outpatient visits and antibiotic prescriptions in U.S. children (≤17 years) from 2016-2019 for acute otitis media, pneumonia, and sinusitis associated with PCV15- and PCV20-additional (non-PCV13) serotypes to quantify PCV15/20 potential impacts.
    Methods: We estimated the incidence of PCV15/20-additional serotype-attributable visits and antibiotic prescriptions as the product of all-cause incidence rates, derived from national healthcare surveys and MarketScan databases, and PCV15/20-additional serotype-attributable fractions. We estimated serotype-specific attributable fractions using modified vaccine-probe approaches incorporating incidence changes post-PCV13 and ratios of PCV13 versus PCV15/20 serotype frequencies, estimated through meta-analyses.
    Results: Per 1000 children annually, PCV15-additional serotypes accounted for an estimated 2.7 (95% confidence interval 1.8-3.9) visits and 2.4 (1.6-3.4) antibiotic prescriptions. PCV20-additional serotypes resulted in 15.0 (11.2-20.4) visits and 13.2 (9.9-18.0) antibiotic prescriptions annually per 1,000 children. PCV15/20-additional serotypes account for 0.4% (0.2-0.6%) and 2.1% (1.5-3.0%) of pediatric outpatient antibiotic use.
    Conclusions: Compared with PCV15-additional serotypes, PCV20-additional serotypes account for >5 times the burden of visits and antibiotic prescriptions. Higher-valency PCVs, especially PCV20, may contribute to preventing pediatric pneumococcal respiratory infections and antibiotic use.
    Language English
    Publishing date 2024-03-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiae142
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  4. Article ; Online: Length of antibiotic therapy among adults hospitalized with uncomplicated community-acquired pneumonia, 2013-2020.

    McCarthy, Natalie L / Baggs, James / Wolford, Hannah / Kazakova, Sophia V / Kabbani, Sarah / Attell, Brandon K / Neuhauser, Melinda M / Walker, Lindsey / Yi, Sarah H / Hatfield, Kelly M / Reddy, Sujan / Hicks, Lauri A

    Infection control and hospital epidemiology

    2024  , Page(s) 1–7

    Abstract: Objective: The 2014 US National Strategy for Combating Antibiotic-Resistant Bacteria (CARB) aimed to reduce inappropriate inpatient antibiotic use by 20% for monitored conditions, such as community-acquired pneumonia (CAP), by 2020. We evaluated annual ... ...

    Abstract Objective: The 2014 US National Strategy for Combating Antibiotic-Resistant Bacteria (CARB) aimed to reduce inappropriate inpatient antibiotic use by 20% for monitored conditions, such as community-acquired pneumonia (CAP), by 2020. We evaluated annual trends in length of therapy (LOT) in adults hospitalized with uncomplicated CAP from 2013 through 2020.
    Methods: We conducted a retrospective cohort study among adults with a primary diagnosis of bacterial or unspecified pneumonia using
    Results: There were 44,976 and 400,928 uncomplicated CAP hospitalizations among patients aged 18-64 years and ≥65 years, respectively. From 2013 to 2020, the proportion of patients with total LOT >7 days decreased by 25% (68% to 51%) among patients aged 18-64 years and by 27% (68%-50%) among patients aged ≥65 years.
    Conclusions: Although likely excessive LOT for uncomplicated CAP patients decreased since 2013, the proportion of patients treated with LOT >7 days still exceeded 50% in 2020. Antibiotic stewardship programs should continue to pursue interventions to reduce likely excessive LOT for common infections.
    Language English
    Publishing date 2024-02-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639378-0
    ISSN 1559-6834 ; 0195-9417 ; 0899-823X
    ISSN (online) 1559-6834
    ISSN 0195-9417 ; 0899-823X
    DOI 10.1017/ice.2024.14
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  5. Article: Antibiotic Use Among Hospitalized Patients With COVID-19 in the United States, March 2020-June 2022.

    Kim, Christine / Wolford, Hannah / Baggs, James / Reddy, Sujan / Hicks, Lauri A / Neuhauser, Melinda M / Kabbani, Sarah

    Open forum infectious diseases

    2023  Volume 10, Issue 11, Page(s) ofad503

    Abstract: We conducted a retrospective study to describe antibiotic use among US adults hospitalized with a COVID-19 diagnosis. Despite a decrease in overall antibiotic use, most patients hospitalized with COVID-19 received antibiotics on admission (88.1%) ... ...

    Abstract We conducted a retrospective study to describe antibiotic use among US adults hospitalized with a COVID-19 diagnosis. Despite a decrease in overall antibiotic use, most patients hospitalized with COVID-19 received antibiotics on admission (88.1%) regardless of critical care status, highlighting that more efforts are needed to optimize antibiotic therapy.
    Language English
    Publishing date 2023-10-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofad503
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  6. Article ; Online: Comparison of outpatient antibiotic prescriptions among older adults in IQVIA Xponent and publicly available Medicare Part D data, 2018.

    Beshearse, Elizabeth M / Gouin, Katryna A / Fleming-Dutra, Katherine E / Tsay, Sharon / Hicks, Lauri A / Kabbani, Sarah

    Antimicrobial stewardship & healthcare epidemiology : ASHE

    2023  Volume 3, Issue 1, Page(s) e32

    Abstract: The distributions of antibiotic prescriptions by geography, antibiotic class, and prescriber specialty are similar in the US Centers for Medicare and Medicaid Services (CMS) Part D Prescriber Public Use Files and IQVIA Xponent dataset. Public health ... ...

    Abstract The distributions of antibiotic prescriptions by geography, antibiotic class, and prescriber specialty are similar in the US Centers for Medicare and Medicaid Services (CMS) Part D Prescriber Public Use Files and IQVIA Xponent dataset. Public health organizations and healthcare systems can use these data to track antibiotic use and guide antibiotic stewardship interventions for older adults.
    Language English
    Publishing date 2023-02-15
    Publishing country England
    Document type Journal Article
    ISSN 2732-494X
    ISSN (online) 2732-494X
    DOI 10.1017/ash.2022.332
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  7. Article ; Online: Characterization of an

    De Vitto, Humberto / Belfon, Kafi K J / Sharma, Nandini / Toay, Sarah / Abendroth, Jan / Dranow, David M / Lukacs, Christine M / Choi, Ryan / Udell, Hannah S / Willis, Sydney / Barrera, George / Beyer, Olive / Li, Teng Da / Hicks, Katherine A / Torelli, Andrew T / French, Jarrod B

    Biochemistry

    2024  

    Abstract: Thiamin and its phosphate derivatives are ubiquitous molecules involved as essential cofactors in many cellular processes. ... ...

    Abstract Thiamin and its phosphate derivatives are ubiquitous molecules involved as essential cofactors in many cellular processes. The
    Language English
    Publishing date 2024-02-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1108-3
    ISSN 1520-4995 ; 0006-2960
    ISSN (online) 1520-4995
    ISSN 0006-2960
    DOI 10.1021/acs.biochem.3c00640
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    Zs.A 217: Show issues Location:
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  8. Article: Ongoing evolution of the

    Stanley, Sydney / Wang, Xin / Liu, Qingyun / Kwon, Young Yon / Frey, Abigail M / Hicks, Nathan D / Vickers, Andrew J / Hui, Sheng / Fortune, Sarah M

    bioRxiv : the preprint server for biology

    2023  

    Abstract: The bacterial determinants that ... ...

    Abstract The bacterial determinants that facilitate
    Language English
    Publishing date 2023-10-09
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.10.09.561592
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  9. Article: Pediatric outpatient visits and antibiotic use attributable to higher valency pneumococcal conjugate vaccine serotypes.

    King, Laura M / Andrejko, Kristin L / Kabbani, Sarah / Tartof, Sara Y / Hicks, Lauri A / Cohen, Adam L / Kobayashi, Miwako / Lewnard, Joseph A

    medRxiv : the preprint server for health sciences

    2023  

    Abstract: Importance: Streptococcus pneumoniae: Objective: To estimate the incidence of outpatient visits and antibiotic prescriptions in U.S. children for acute otitis media, pneumonia, and sinusitis associated with PCV15- and PCV20-additional serotypes (non- ... ...

    Abstract Importance: Streptococcus pneumoniae
    Objective: To estimate the incidence of outpatient visits and antibiotic prescriptions in U.S. children for acute otitis media, pneumonia, and sinusitis associated with PCV15- and PCV20-additional serotypes (non-PCV13 serotypes) to quantify potential impacts of PCV15/20 on outpatient visits and antibiotic prescriptions for these conditions.
    Design: Multi-component study including descriptive analyses of cross-sectional and cohort data on outpatient visits and antibiotic prescriptions from 2016-2019 and meta-analyses of pneumococcal serotype distribution in non-invasive respiratory infections.
    Setting: Outpatient visits and antibiotic prescriptions among U.S. children.
    Participants: Pediatric visits and antibiotic prescriptions among children captured in the National Ambulatory Medical Care Survey (NAMCS), the National Hospital Ambulatory Medicare Care Survey (NHAMCS), and Merative MarketScan, collectively representing healthcare delivery across all outpatient settings. Incidence denominators estimated using census (NAMCS/NHAMCS) and enrollment (MarketScan) data.
    Main outcomes and measures: Pediatric outpatient visit and antibiotic prescription incidence for acute otitis media, pneumonia, and sinusitis associated with PCV15/20-additional serotypes.
    Results: We estimated that per 1000 children annually, PCV15-additional serotypes accounted for 2.7 (95% confidence interval 1.8-3.9) visits and 2.4 (1.6-3.4) antibiotic prescriptions. PCV20-additional serotypes resulted in 15.0 (11.2-20.4) visits and 13.2 (9.9-18.0) antibiotic prescriptions annually per 1,000 children. Projected to national counts, PCV15/20-additional serotypes account for 173,000 (118,000-252,000) and 968,000 (722,000-1,318,000) antibiotic prescriptions among U.S. children each year, translating to 0.4% (0.2-0.6%) and 2.1% (1.5-3.0%) of all outpatient antibiotic use among children.
    Conclusions and relevance: PCV15/20-additional serotypes account for a large burden of pediatric outpatient healthcare utilization. Compared with PCV15-additional serotypes, PCV20-additional serotypes account for >5 times the burden of visits and antibiotic prescriptions. These higher-valency PCVs, especially PCV20, may contribute to preventing ARIs and antibiotic use in children.
    Language English
    Publishing date 2023-08-25
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.08.24.23294570
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  10. Article ; Online: Tissue inhibitors of metalloproteinases (TIMPs) modulate platelet ADAM10 activity.

    Lee, Christine Shu Mei / Kaur, Amandeep / Montague, Samantha J / Hicks, Sarah M / Andrews, Robert K / Gardiner, Elizabeth E

    Platelets

    2023  Volume 34, Issue 1, Page(s) 2288213

    Abstract: Platelet-specific collagen receptor glycoprotein (GP)VI is stable on the surface of circulating platelets but undergoes ectodomain cleavage on activated platelets. Activation-dependent GPVI metalloproteolysis is primarily mediated by A Disintegrin And ... ...

    Abstract Platelet-specific collagen receptor glycoprotein (GP)VI is stable on the surface of circulating platelets but undergoes ectodomain cleavage on activated platelets. Activation-dependent GPVI metalloproteolysis is primarily mediated by A Disintegrin And Metalloproteinase (ADAM) 10. Regulation of platelet ADAMs activity is not well-defined however Tissue Inhibitors of Metalloproteinases (TIMPs) may play a role. As levels of TIMPs on platelets and the control of ADAMs-mediated shedding by TIMPs has not been evaluated, we quantified the levels of TIMPs on the surface of resting and activated platelets from healthy donors by flow cytometry and multiplex ELISA. Variable levels of all TIMPs could be detected on platelets. Plasma contained significant quantities of TIMP1 and TIMP2, but only trace amounts of TIMP3 and TIMP4. Recombinant TIMP3 strongly ablated resting and activated platelet ADAM10 activity, when monitored using a quenched fluorogenic peptide substrate with ADAM10 specificity. Whilst ADAM10-specific inhibitor GI254023X or ethylenediamine tetraacetic acid (EDTA) could modulate ligand-initiated shedding of GPVI, only recombinant TIMP2 achieved a modest (~20%) inhibition. We conclude that some platelet TIMPs are able to modulate platelet ADAM10 activity but none strongly regulate ligand-dependent shedding of GPVI. Our findings provide new insights into the regulation of platelet receptor sheddase activity.
    MeSH term(s) Humans ; Ligands ; Blood Platelets ; Platelet Membrane Glycoproteins ; ADAM10 Protein/genetics ; Peptides/pharmacology ; Metalloproteases ; Platelet Activation ; Membrane Proteins ; Amyloid Precursor Protein Secretases
    Chemical Substances Ligands ; Platelet Membrane Glycoproteins ; ADAM10 Protein (EC 3.4.24.81) ; Peptides ; Metalloproteases (EC 3.4.-) ; ADAM10 protein, human (EC 3.4.24.81) ; Membrane Proteins ; Amyloid Precursor Protein Secretases (EC 3.4.-)
    Language English
    Publishing date 2023-11-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 1034283-7
    ISSN 1369-1635 ; 0953-7104
    ISSN (online) 1369-1635
    ISSN 0953-7104
    DOI 10.1080/09537104.2023.2288213
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