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Article ; Online: Analysis of Reported Adverse Events Related to Hemospray: An FDA MAUDE Database Study.

Ahmed, Khalid / Abdallah, Mohamed / Abbas, Daniyal / Jaber, Fouad / Abdalla, Abubaker O / Mohamed, Mouhand / McDonald, Nicholas / Hanson, Brian J / Bilal, Mohammad

Journal of clinical gastroenterology

2024 Volume 58, Issue 4, Page(s) 402–406

Abstract: Background: Topical hemostatic powder is a mineral powder that forms an adherent barrier and coagulates active bleeding in the gastrointestinal (GI) tract. Hemospray is the first hemostatic powder approved by the Food and Drug Administration (FDA) in ... ...

Abstract	Background: Topical hemostatic powder is a mineral powder that forms an adherent barrier and coagulates active bleeding in the gastrointestinal (GI) tract. Hemospray is the first hemostatic powder approved by the Food and Drug Administration (FDA) in the United States. Hemospray has been increasingly used to manage GI bleeding. However, data on the adverse events of hemostatic powders are lacking. Therefore, we aim to report and analyze adverse events associated with Hemospray using the FDA's "Manufacturer and User Facility Device Experience" database. Methods: We analyzed the postmarketing surveillance data from the FDA's Manufacturer and User Facility Device Experience database for Hemospray, initially known as TC-325, from June 2018 through April 2022. Results of the search were classified into device-related technical issues, patient-related adverse events and health care staff-related adverse events. Results: Five hundred two medical device reporting claims were identified from June 2018 through April 2022. Seven duplicate claims were identified, and some claims included more than one event type. Therefore, there were 558 device-related problems, 28 patient-related adverse events, and 2 adverse events in health care staff members. The most common device-related problems were activation failure or failure to fire (n = 385, 70.0%) and obstruction of carbon dioxide flow (n = 121, 21.7). The most common patient-related adverse events included tissue injury or bleeding (n = 21) and perforation (n = 5). Conclusion: Although Hemospray is a valuable tool in the armamentarium for endoscopists in managing GI bleeding, endoscopists must be mindful of deice-related problems and potential patient-related adverse events.
MeSH term(s)	Humans ; United States ; United States Food and Drug Administration ; Powders ; Minerals ; Hemostatics/adverse effects ; Databases, Factual
Chemical Substances	hemospray ; Powders ; Minerals ; Hemostatics
Language	English
Publishing date	2024-04-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	448460-5
ISSN	1539-2031 ; 0192-0790
ISSN (online)	1539-2031
ISSN	0192-0790
DOI	10.1097/MCG.0000000000001859
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Article ; Online: Adenomas and Sessile Serrated Lesions in 45- to 49-Year-Old Individuals Undergoing Colonoscopy: A Systematic Review and Meta-Analysis.

Abdallah, Mohamed / Mohamed, Mouhand F H / Abdalla, Abubaker O / Jaber, Fouad / Baliss, Michelle / Ahmed, Khalid / Eckmann, Jason / Bilal, Mohammad / Shaukat, Aasma

The American journal of gastroenterology

2024

Abstract: Introduction: Colorectal cancer (CRC) screening is now recommended at the age of 45 years in the United States. However, information regarding the adenomas detection rate (ADR) and sessile serrated lesions (SSLs) in 45- to 49-year-old individuals is ... ...

Abstract	Introduction: Colorectal cancer (CRC) screening is now recommended at the age of 45 years in the United States. However, information regarding the adenomas detection rate (ADR) and sessile serrated lesions (SSLs) in 45- to 49-year-old individuals is limited. In addition, the impact of lowering the screening age to 45 years on the ADR and the detection rate of SSLs is not well elucidated. This systematic review and meta-analysis aims to report the overall ADR and SSL detection rate in 45- to 49-year-old individuals undergoing colonoscopy. Methods: We searched MEDLINE, EMBASE, SCOPUS, Web of Science, ClinicalTrials.gov , and the Cochrane database from inception through October 2022 to identify studies reporting on ADR and SSL detection rates in 45- to 49-year-old individuals undergoing colonoscopies for all indications. This approach acknowledges the possibility of including individuals undergoing diagnostic colonoscopies or those with increased risk factors for CRC. We also conducted a separate analysis examining ADR in average-risk individuals undergoing screening colonoscopy. The pooled rates with their corresponding 95% confidence intervals (CIs) were generated using the fixed-effects model. I2 was used to adjudicate heterogeneity. Results: Sixteen studies met the inclusion criteria. All studies were retrospective except one; 3 had data from national/local registries. There were 41,709 adenomas detected across 150,436 colonoscopies. The pooled overall ADR was 23.1% (95% CI 19.7%-27.0%, I2 = 98.6%). The pooled ADR in individuals with average risk of CRC from 7 studies was 28.2% (95% CI 24.6%-32.0%, I2 = 96.5%). The pooled overall SSL detection rate from 6 studies was 6.3% (95% CI 3.8%-10.5%, I2 = 97%). The included studies were heterogeneous because of differences in the inclusion and exclusion criteria and patient population. Discussion: In 45- to 49-year-old individuals undergoing a colonoscopy for any indication, the ADR and SSL detection rates were 23.1% and 6.3%, respectively. We conclude that these outcomes in 45- to 49-year-olds are comparable with individuals aged 50-54 years.
Language	English
Publishing date	2024-04-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	390122-1
ISSN	1572-0241 ; 0002-9270
ISSN (online)	1572-0241
ISSN	0002-9270
DOI	10.14309/ajg.0000000000002735
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Article ; Online: Successful Treatment of a Case of Ectopic Jejunal Varices with Portal Venous Stenting.

Abdalla, Abubaker O / Abdallah, Mohamed A / Calvo, Lisa A

The American journal of case reports

2019 Volume 20, Page(s) 948–952

Abstract: BACKGROUND Management of patients with ectopic variceal bleeding can be challenging and requires a multidisciplinary approach. Ectopic bleeding from jejunal varices at the anastomotic site of choledochojejunostomy is rare and difficult to treat. CASE ... ...

Abstract	BACKGROUND Management of patients with ectopic variceal bleeding can be challenging and requires a multidisciplinary approach. Ectopic bleeding from jejunal varices at the anastomotic site of choledochojejunostomy is rare and difficult to treat. CASE REPORT We report a case of ectopic jejunal variceal bleeding secondary to portal vein stenosis at the anastomotic site of a prior choledochojejunostomy for pancreatic cancer. The patient was successfully treated with portal vein metallic stent placement that remained patent for 7 months. CONCLUSIONS The management of ectopic of variceal bleeding remains difficult and controversial. Portal vein stenting has been reported as a successful method of treatment that is minimally invasive especially in patients who had prior major surgeries.
MeSH term(s)	Aged ; Choledochostomy ; Constriction, Pathologic/complications ; Constriction, Pathologic/surgery ; Female ; Gastrointestinal Hemorrhage/etiology ; Humans ; Hypertension, Portal/complications ; Hypertension, Portal/surgery ; Jejunum/blood supply ; Jejunum/surgery ; Palliative Care ; Portal Vein/surgery ; Stents ; Treatment Outcome ; Varicose Veins/surgery
Language	English
Publishing date	2019-07-03
Publishing country	United States
Document type	Case Reports
ZDB-ID	2517183-5
ISSN	1941-5923 ; 1941-5923
ISSN (online)	1941-5923
ISSN	1941-5923
DOI	10.12659/AJCR.916003
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Article ; Online: Intrafamilial and interfamilial heterogeneity of PINK1-associated Parkinson's disease in Sudan.

Bakhit, Yousuf / Ibrahim, Mohamed O / Tesson, Christelle / Elhassan, Ali A / Ahmed, Mohamed Anwer / Alebeed, Mohamed A / Elrasheed, Salma M / Omar, Mawia A / Abubaker, Rayan / Eltom, Khalid / Shaheen, Mutaz T / Ibrahim, Yousuf A / Almak, Murad E / Ali, Hiba A / Abugrain, Ahmed A / Almahal, Mohamed A / MohamedSharif, Abubaker A / Tahir, Mohamed Y / Malik, Sawazen M /

Eldirdiri Abdelrahman, Hazim / Khidir, Reem J / Mohamed, Malaz T / Abdalla, Abdelmohaymin / Elsayed, Liena E O / Lesage, Suzanne / Corvol, Jean-Christophe / Seidi, Osheik / Wüllner, Ullrich

Parkinsonism & related disorders

2023 Volume 111, Page(s) 105401

Abstract: PINK1 is the second most predominant gene associated with autosomal recessive Parkinson's disease. Homozygous mutations in this gene are associated with an early onset of symptoms. Bradykinesia, tremors, and rigidity are common features, while dystonia, ... ...

Abstract	PINK1 is the second most predominant gene associated with autosomal recessive Parkinson's disease. Homozygous mutations in this gene are associated with an early onset of symptoms. Bradykinesia, tremors, and rigidity are common features, while dystonia, motor fluctuation, and non-motor symptoms occur in a lower percentage of cases and usually respond well to levodopa. We investigated 14 individuals with parkinsonism and eleven symptom-free siblings from three consanguineous Sudanese families, two of them multigenerational, using a custom gene panel screening 34 genes, 27 risk variants, and 8 candidate genes associated with parkinsonism. We found a known pathogenic nonsense PINK1 variant (NM_032409.3:c.1366C>T; p.(Gln456)), a novel pathogenic single base duplication (NM_032409.3:c.1597dup; p.(Gln533Profs29)), and another novel pathogenic insertion (NM_032409.3:c.1448_1449ins[1429_1443; TTGAG]; p.(Arg483Serfs*7)). All variants were homozygous and co-segregated in all affected family members. We also identified intrafamilial and interfamilial phenotypic heterogeneity associated with PINK1 mutations in these Sudanese cases, possibly reflecting the nature of the Sudanese population that has a large effective population size, which suggests a higher possibility of novel findings in monogenic and polygenic diseases in Sudan.
MeSH term(s)	Humans ; Parkinson Disease/genetics ; Sudan ; Parkinsonian Disorders/genetics ; Homozygote ; Mutation/genetics ; Protein Kinases/genetics ; Age of Onset
Chemical Substances	Protein Kinases (EC 2.7.-)
Language	English
Publishing date	2023-04-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1311489-x
ISSN	1873-5126 ; 1353-8020
ISSN (online)	1873-5126
ISSN	1353-8020
DOI	10.1016/j.parkreldis.2023.105401
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Zs.A 4553: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Efficacy and Safety of Cold Snare Endoscopic Mucosal Resection (CS-EMR) for Nonampullary Duodenal Polyps: Systematic Review and Meta-Analysis.

Mohamed, Mouhand F H / Ahmed, Khalid / Rajadurai, Suvithan / Jaber, Fouad / Hamid, Osama / Abdalla, Abubaker O / Johnson, Willie M / Umar, Shifa / Chandan, Saurabh / Abdallah, Mohamed / Bilal, Mohammad

Journal of clinical gastroenterology

2023

Abstract: Introduction: There is an increasing interest in cold snare endoscopic mucosal resection (CS-EMR), and studies have shown its safety and efficacy for colonic polyps. This meta-analysis aims to assess the safety and efficacy of CS-EMR for the removal of ... ...

Abstract	Introduction: There is an increasing interest in cold snare endoscopic mucosal resection (CS-EMR), and studies have shown its safety and efficacy for colonic polyps. This meta-analysis aims to assess the safety and efficacy of CS-EMR for the removal of duodenal adenomas. Methods: We conducted a comprehensive literature search of several databases, from inception through February 2023, for studies that addressed outcomes of CS-EMR for nonampullary duodenal adenomas. We used the random-effects model for the statistical analysis. The weighted pooled rates were used to summarize the technical success, polyp recurrence, bleeding, and perforation events. Cochran Q test and I2 statistics adjudicated heterogeneity. Results: Six studies were included in the analysis. In all, 178 duodenal polyps were resected using CS-EMR. The pooled rates were 95.8% (95% CI 89.1-98.5%, I2=21.5%) for technical success and 21.2% (95% CI 8.5-43.6%, I2=78%) for polyp recurrence. With regards to CS-EMR safety, the pooled rates were 4.2% (95% CI 1.6-10.5%, I2=12%) for immediate bleeding, 3.4% (95% CI 1.5-7.6%, I2=0%) for delayed bleeding, 2.8% (95% CI 1.1-6.7%, I2=0%) for perforation, and 2% (95% CL 0.5-7.5%, I2=0%) for post-polypectomy syndrome. Rates were not significantly different for large adenomas. Three studies reported data on CS-EMR and conventional EMR. Compared with conventional EMR, CS-EMR had lower odds of delayed bleeding, OR 0.11 (CI 0.02-0.62, P value 0.012, I2=0%). Conclusion: Our findings suggest that CS-EMR is a safe and effective strategy for the resection of nonampullary duodenal adenomas, with an acceptable recurrence rate. Data from larger randomized controlled studies are needed to validate our findings.
Language	English
Publishing date	2023-08-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	448460-5
ISSN	1539-2031 ; 0192-0790
ISSN (online)	1539-2031
ISSN	0192-0790
DOI	10.1097/MCG.0000000000001898
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Article ; Online: The outcomes of

Abdalla, Abubaker O / Narala, Sai B / Abdallah, Mohamed A / Doshi, Rajkumar / Gullapalli, Nageshwara

Scandinavian journal of gastroenterology

2019 Volume 54, Issue 11, Page(s) 1353–1356

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Aged ; Aged, 80 and over ; Bacterial Infections/complications ; Bacterial Infections/epidemiology ; Clostridiales ; Databases, Factual ; Diverticular Diseases/epidemiology ; Diverticular Diseases/microbiology ; Female ; Hospitalization/statistics & numerical data ; Humans ; Male ; Middle Aged ; Retrospective Studies ; United States
Language	English
Publishing date	2019-10-30
Publishing country	England
Document type	Journal Article
ZDB-ID	82042-8
ISSN	1502-7708 ; 0036-5521
ISSN (online)	1502-7708
ISSN	0036-5521
DOI	10.1080/00365521.2019.1683223
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Article: Outcomes of

Abdalla, Abubaker O / Pisipati, Sailaja / Elnaggar, Mohamed / Rishi, Mohit / Doshi, Rajkumar / Gullapalli, Nageshwara

Gastroenterology research

2020 Volume 13, Issue 2, Page(s) 53–57

Abstract: Background: Clostridioides difficile: Methods: We conducted a retrospective study from a large inpatient database. The National Inpatient Sample (NIS) was queried for CDI admissions between January 2012 and September 2015. Patients admitted with CDI ... ...

Abstract	Background: Clostridioides difficile Methods: We conducted a retrospective study from a large inpatient database. The National Inpatient Sample (NIS) was queried for CDI admissions between January 2012 and September 2015. Patients admitted with CDI were identified using the International Classification of Diseases, Ninth Revision, Clinical Modification codes. The outcomes included overall mortality, length of hospitalization, and healthcare expenditure related to hospitalization. Results: Out of all patients, 53,765 (3.97%) had concurrent CDI and liver cirrhosis. Diabetes mellitus, alcohol abuse, and acquired immunodeficiency were observed more in patients with liver cirrhosis. Overall mortality (adjusted odds ratio (aOR) 1.65, 95% confidence interval (CI) 1.53 - 1.77, P < 0.001), cost of hospitalization and length of hospital stay (11.0 vs. 10.4 days, P < 0.001) were significantly higher in patients with cirrhosis. Conclusions: Patients with CDI and liver cirrhosis have significantly higher mortality, prolonged hospitalization and healthcare expenditure. Further studies are recommended to look at reversible risk factors for CDI in patients with liver cirrhosis to guide quality measures that would ultimately improve outcomes.
Language	English
Publishing date	2020-04-22
Publishing country	Canada
Document type	Journal Article
ZDB-ID	2475913-2
ISSN	1918-2813 ; 1918-2805
ISSN (online)	1918-2813
ISSN	1918-2805
DOI	10.14740/gr1240
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Article: A fatal case of diffuse alveolar hemorrhage as the initial presentation of systemic lupus erythematosus: A case report and literature review.

Abdalla, Abubaker O / Al-Khafaji, Jaafar / Akella, Pydi M / Taha, Mohamed

Respiratory medicine case reports

2018 Volume 24, Page(s) 55–57

Abstract: Diffuse alveolar hemorrhage (DAH) is a rare fatal pulmonary complication of systemic lupus erythematosus (SLE). The clinical syndrome is characterized by hemoptysis, acute fall in hematocrit, hypoxemic respiratory failure, and diffuses pulmonary ... ...

Abstract	Diffuse alveolar hemorrhage (DAH) is a rare fatal pulmonary complication of systemic lupus erythematosus (SLE). The clinical syndrome is characterized by hemoptysis, acute fall in hematocrit, hypoxemic respiratory failure, and diffuses pulmonary infiltrates. We describe a case of 23-year-old female who presented with Ludwig's angina that was complicated by diffuse alveolar hemorrhage as the initial presentation of undiagnosed systemic lupus erythematosus. A high index of suspicion is need for prompt diagnosis and treatment in order to avoid the high mortality associated with such cases.
Language	English
Publishing date	2018-04-13
Publishing country	England
Document type	Case Reports
ZDB-ID	2666110-X
ISSN	2213-0071
ISSN	2213-0071
DOI	10.1016/j.rmcr.2018.04.006
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Article ; Online: Turmeric-Associated Liver Injury.

Abdallah, Mohamed A / Abdalla, Abdelmohaymin / Ellithi, Moataz / Abdalla, Abubaker O / Cunningham, Arwyn G / Yeddi, Ahmed / Rajendiran, Govarthanan

American journal of therapeutics

2019 Volume 27, Issue 6, Page(s) e642–e645

MeSH term(s)	Chemical and Drug Induced Liver Injury/diagnosis ; Chemical and Drug Induced Liver Injury/etiology ; Curcuma ; Humans ; Liver
Language	English
Publishing date	2019-07-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	1280786-2
ISSN	1536-3686 ; 1075-2765
ISSN (online)	1536-3686
ISSN	1075-2765
DOI	10.1097/MJT.0000000000001025
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Article ; Online: A Fatal Case of Non-Uremic Calciphylaxis: A Case Report and Literature Review.

Abdalla, Abubaker O / Al-Khafaji, Jaafar / Taha, Mohamed / Malik, Samira

The American journal of case reports

2018 Volume 19, Page(s) 804–807

Abstract: BACKGROUND Calciphylaxis is a rare cutaneous disease, also known as calcific uremic arteriolopathy, that occurs most frequently in patients with advanced chronic kidney disease and on long-term hemodialysis. CASE REPORT We describe the case of a 61-year- ... ...

Abstract	BACKGROUND Calciphylaxis is a rare cutaneous disease, also known as calcific uremic arteriolopathy, that occurs most frequently in patients with advanced chronic kidney disease and on long-term hemodialysis. CASE REPORT We describe the case of a 61-year-old female patient with worsening chronic kidney disease not on dialysis therapy, who presented with severe progressive calciphylaxis on both lower limbs. CONCLUSIONS Calcific uremic arteriolopathy is a rare fatal condition that requires prompt diagnosis and treatment. It is classically described in patients with end-stage kidney disease on long-term renal replacement therapy but can present in patients with an earlier stage of kidney disease. Non-uremic calciphylaxis should be suspected in patients with earlier stages of kidney disease, especially in those with other concurrent risk factors or co-morbid conditions, to avoid the high risk of morbidity and mortality associated with such cases.
MeSH term(s)	Calciphylaxis/etiology ; Fatal Outcome ; Female ; Humans ; Lower Extremity/blood supply ; Lower Extremity/pathology ; Middle Aged ; Renal Insufficiency, Chronic/complications ; Vascular Calcification/etiology
Language	English
Publishing date	2018-07-09
Publishing country	United States
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	2517183-5
ISSN	1941-5923 ; 1941-5923
ISSN (online)	1941-5923
ISSN	1941-5923
DOI	10.12659/AJCR.909546
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