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  1. Article ; Online: Social determinants of health screening and intervention: A cystic fibrosis quality improvement process.

    Jennings, Deirdre / List, Rhonda / Bruschwein, Heather / Compton, Martina / Somerville, Lindsay / Williamson, Lauren / Murray, Rachel / Evangelista, Brielle / Albon, Dana

    Pediatric pulmonology

    2022  Volume 57, Issue 12, Page(s) 3035–3043

    Abstract: Introduction: Lower socioeconomic status is associated with significantly poorer outcomes in weight, lung function, and pulmonary exacerbation rates in people with cystic fibrosis (PwCF).: Global aim: We aim to reduce health disparities and ... ...

    Abstract Introduction: Lower socioeconomic status is associated with significantly poorer outcomes in weight, lung function, and pulmonary exacerbation rates in people with cystic fibrosis (PwCF).
    Global aim: We aim to reduce health disparities and inequities faced by PwCF by screening for and addressing unmet social needs.
    Specific aims: We aimed to increase routine social determinants of health (SDoH) screening of eligible PwCF from 0% to 95% and follow-up within 2 weeks for those PwCF who screened positive and requested assistance from 0% to 95% by December 31, 2021.
    Methods: The Model for Improvement methodology was used. A process map and a simplified failure mode effects analysis chart were created for the screening and SDoH follow-up process. For those who screened positive for SDoH and requested assistance, follow-up contact was made to offer intervention.
    Intervention: Adult PwCF who had at least one UVA Clinic encounter in 2021 were screened for SDoH. The SDoH screening tool included eight domains: housing, food, transportation, utilities, health-care access, medication access, income/employment, and education. Follow-up was completed with all PwCF who screened positive for SDoH.
    Results: A total of 132 of 142 (93.0%) PwCF eligible for screening completed the SDoH screening. Of the PwCF who completed screening, 56 (42.4%) screened positive for SDoH. A follow-up rate of 100% was achieved in June 2021 and maintained through December 2021.
    Conclusion: Implementing screening for SDOH and follow-up to mitigate social difficulties in adult PwCF at UVA was successful and could be reproduced at other CF care centers.
    MeSH term(s) Adult ; Humans ; Social Determinants of Health ; Quality Improvement ; Cystic Fibrosis/diagnosis ; Mass Screening/methods ; Income
    Language English
    Publishing date 2022-09-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632784-9
    ISSN 1099-0496 ; 8755-6863
    ISSN (online) 1099-0496
    ISSN 8755-6863
    DOI 10.1002/ppul.26131
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Mental health screening of patients with cystic fibrosis through telehealth during COVID-19: Evaluation of feasibility and process adoption.

    Bruschwein, Heather M / Soper, Morgan / Jennings, Deirdre / Somerville, Lindsay / List, Rhonda / Compton, Martina H / Turner, Rachel / Albon, Dana

    Families, systems & health : the journal of collaborative family healthcare

    2022  Volume 40, Issue 3, Page(s) 397–402

    Abstract: Introduction: Persons with cystic fibrosis (CF) have higher rates of depression and anxiety compared to the general population. The Cystic Fibrosis Foundation guidelines recommend annual screening for depression and anxiety for people with CF. COVID-19 ... ...

    Abstract Introduction: Persons with cystic fibrosis (CF) have higher rates of depression and anxiety compared to the general population. The Cystic Fibrosis Foundation guidelines recommend annual screening for depression and anxiety for people with CF. COVID-19 and related social distancing has created challenges for administration of mental health screening by CF centers. The aim of this quality improvement project was to evaluate the feasibility of implementing mental health screening during multidisciplinary telehealth appointments for adult patients with CF during COVID-19, adoption of screening by CF mental health providers, and patient screening results before and after introduction of telehealth.
    Method: Patients were screened via telehealth using the PHQ-9 and GAD-7 between April and October 2020.
    Results: CF mental health providers implemented a mental health screening process via telehealth and 93.9% of patients seen during that time completed the screening. The screening did not increase clinic visit length and no significant differences were found between rates of depression and anxiety and 2019 clinic rates.
    Discussion: Implementation of mental health screening during a multidisciplinary telehealth clinic is feasible and can be adopted by providers and patients, even when health systems operations are impacted by COVID-19. It allows CF centers to maintain adherence to mental health screening and treatment guidelines. This method of screening can be applied to other patient populations and systems of care to expand access to mental health services during COVID-19 and beyond. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
    MeSH term(s) Adult ; COVID-19 ; Cystic Fibrosis/complications ; Cystic Fibrosis/diagnosis ; Cystic Fibrosis/psychology ; Feasibility Studies ; Humans ; Mental Health ; Telemedicine
    Language English
    Publishing date 2022-05-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1326859-4
    ISSN 1939-0602 ; 1091-7527 ; 0736-1718
    ISSN (online) 1939-0602
    ISSN 1091-7527 ; 0736-1718
    DOI 10.1037/fsh0000698
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Home spirometry utilisation in telemedicine clinic for cystic fibrosis care during COVID-19 pandemic

    Heather Bruschwein / Martina Compton / Rhonda List / Elissa Starheim / Lindsay Somerville / Lauren Williamson / Rachel Murray / Deirdre Jennings / Dana Albon

    BMJ Open Quality, Vol 10, Iss

    a quality improvement process

    2021  Volume 3

    Keywords Medicine (General) ; R5-920
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Home spirometry utilisation in telemedicine clinic for cystic fibrosis care during COVID-19 pandemic: a quality improvement process.

    Compton, Martina / List, Rhonda / Starheim, Elissa / Somerville, Lindsay / Williamson, Lauren / Murray, Rachel / Jennings, Deirdre / Bruschwein, Heather / Albon, Dana

    BMJ open quality

    2021  Volume 10, Issue 3

    Abstract: IntroductionThe Cystic Fibrosis (CF) Foundation chronic care guidelines recommend monitoring spirometry during quarterly multidisciplinary visits to identify early lung function decline. During the COVID-19 pandemic, the CF adult clinic at University of ... ...

    Abstract IntroductionThe Cystic Fibrosis (CF) Foundation chronic care guidelines recommend monitoring spirometry during quarterly multidisciplinary visits to identify early lung function decline. During the COVID-19 pandemic, the CF adult clinic at University of Virginia (UVA) transitioned from the classic CF care model to a model that included quarterly multidisciplinary telemedicine visits. While using telemedicine, CF care needed to include spirometry monitoring. Only a fraction of adult CF patients at UVA owned and used home spirometers (HS) in March 2020.
    Aim: The specific aims of this quality improvement (QI) project were to increase the percentage of eligible adult CF patients who owned an HSs from 37% to 85% and to increase the percentage of adult CF patients seen at UVA with available spirometry in telemedicine from 50% to 95% by 31 December 2020.
    Methods: Following the Model for Improvement QI methodology, a standardised process was developed for monitoring forced expiratory volume in 1 s with HS during multidisciplinary telemedicine visits during the COVID-19 pandemic.
    Intervention: (1) HSs were distributed to eligible patients and (2) Home spirometry was monitored in eligible patients with each telemedicine visit and results were used for clinical care decisions.
    Results: Both specific aims were achieved ahead of expected date. In March 2020, the beginning of the pandemic, 37% (49/131) of patients owned an HS and 50% (9/18) of patients seen via telemedicine performed spirometry at home. By September 2020, 97% (127/131) of adult patients at UVA owned an HS and by October 2020, 96% (24/25) of patients provided spirometry results during their telemedicine encounters.
    Conclusion: Employing QI tools to standardise the process of monitoring spirometry data with home devices via telemedicine is reliable and sustainable and can be replicated across centres that provide care for patients with CF.
    MeSH term(s) Adult ; COVID-19 ; Cystic Fibrosis/diagnosis ; Cystic Fibrosis/epidemiology ; Cystic Fibrosis/therapy ; Humans ; Pandemics ; Quality Improvement ; SARS-CoV-2 ; Spirometry ; Telemedicine
    Language English
    Publishing date 2021-08-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2399-6641
    ISSN (online) 2399-6641
    DOI 10.1136/bmjoq-2021-001529
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Preserving Multidisciplinary Care Model and Patient Safety During Reopening of Ambulatory Cystic Fibrosis Clinic for Nonurgent Care: A Hybrid Telehealth Model.

    List, Rhonda / Compton, Martina / Soper, Morgan / Bruschwein, Heather / Gettle, Lucy / Bailey, Molly / Starheim, Elissa / Kalmanek, John / Somerville, Lindsay / Albon, Dana

    Telemedicine journal and e-health : the official journal of the American Telemedicine Association

    2020  Volume 27, Issue 2, Page(s) 193–199

    Abstract: Introduction: ...

    Abstract Introduction:
    MeSH term(s) Adult ; Ambulatory Care/methods ; COVID-19 ; Cystic Fibrosis/therapy ; Humans ; Patient Safety ; Telemedicine/methods
    Keywords covid19
    Language English
    Publishing date 2020-09-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2035659-6
    ISSN 1556-3669 ; 1530-5627
    ISSN (online) 1556-3669
    ISSN 1530-5627
    DOI 10.1089/tmj.2020.0247
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A Feasibility Study of Urgent Implementation of Cystic Fibrosis Multidisciplinary Telemedicine Clinic in the Face of COVID-19 Pandemic: Single-Center Experience.

    Compton, Martina / Soper, Morgan / Reilly, Bonnie / Gettle, Lucy / List, Rhonda / Bailey, Molly / Bruschwein, Heather / Somerville, Lindsay / Albon, Dana

    Telemedicine journal and e-health : the official journal of the American Telemedicine Association

    2020  Volume 26, Issue 8, Page(s) 978–984

    Abstract: Introduction: ...

    Abstract Introduction:
    MeSH term(s) Appointments and Schedules ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Cystic Fibrosis/therapy ; Feasibility Studies ; Humans ; Insurance, Health, Reimbursement ; Pandemics ; Patient Care Team/organization & administration ; Pneumonia, Viral/epidemiology ; SARS-CoV-2 ; Telemedicine/organization & administration ; Triage ; United States
    Keywords covid19
    Language English
    Publishing date 2020-04-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2035659-6
    ISSN 1556-3669 ; 1530-5627
    ISSN (online) 1556-3669
    ISSN 1530-5627
    DOI 10.1089/tmj.2020.0091
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Syncytia Formation Promotes Virus Resistance to Interferon and Neutralizing Antibodies

    Li, Tiansheng / Kang, Insung / Hu, Zhe / Gibbs, James / Ye, Chengjin / Kosik, Ivan / Shi, Guoli / Holly, Jaroslav / Kosikova, Martina / Compton, Alex / Martinez-Sobrido, Luis / Johnson, Reed F. / Xie, Hang / Yewdell, Jonathan W.

    bioRxiv

    Abstract: SARS-CoV-2, like many viruses, generates syncytia. Using SARS-CoV-2 and S (S) expressing recombinant vesicular stomatitis and influenza A viruses, we show that S-mediated syncytia formation provides resistance to interferons in cultured cells, human ... ...

    Abstract SARS-CoV-2, like many viruses, generates syncytia. Using SARS-CoV-2 and S (S) expressing recombinant vesicular stomatitis and influenza A viruses, we show that S-mediated syncytia formation provides resistance to interferons in cultured cells, human small airway-derived air-liquid interface cultures and hACE2 transgenic mice. Amino acid substitutions that modulate fusogenicity in Delta- and Omicron-derived S have parallel effects on viral interferon resistance. Syncytia formation also decreases antibody virus neutralization activity in cultured cells. These findings explain the continued selection of fusogenic variants during SARS-CoV-2 evolution in humans and, more generally, the evolution of fusogenic viruses despite the adverse effects of syncytia formation on viral replication in the absence of innate or adaptive immune pressure.
    Keywords covid19
    Language English
    Publishing date 2023-12-13
    Publisher Cold Spring Harbor Laboratory
    Document type Article ; Online
    DOI 10.1101/2023.12.12.571262
    Database COVID19

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  8. Article ; Online: Syncytia Formation Promotes Virus Resistance to Interferon and Neutralizing Antibodies

    Li, Tiansheng / Kang, Insung / Hu, Zhe / Gibbs, James / Ye, Chengjin / Kosik, Ivan / Shi, Guoli / Holly, Jaroslav / Kosikova, Martina / Compton, Alex A. / Martinez-Sobrido, Luis / Johnson, Reed / Hang, Xie / Yewdell, Jonathan W

    bioRxiv

    Abstract: SARS-CoV-2, like many viruses, generates syncytia. Using SARS-CoV-2 and S (S) expressing recombinant vesicular stomatitis and influenza A viruses, we show that S-mediated syncytia formation provides resistance to interferons in cultured cells, human ... ...

    Abstract SARS-CoV-2, like many viruses, generates syncytia. Using SARS-CoV-2 and S (S) expressing recombinant vesicular stomatitis and influenza A viruses, we show that S-mediated syncytia formation provides resistance to interferons in cultured cells, human small airway-derived air-liquid interface cultures and hACE2 transgenic mice. Amino acid substitutions that modulate fusogenicity in Delta- and Omicron-derived S have parallel effects on viral interferon resistance. Syncytia formation also decreases antibody virus neutralization activity in cultured cells. These findings explain the continued selection of fusogenic variants during SARS-CoV-2 evolution in humans and, more generally, the evolution of fusogenic viruses despite the adverse effects of syncytia formation on viral replication in the absence of innate or adaptive immune pressure.
    Keywords covid19
    Language English
    Publishing date 2023-12-13
    Publisher Cold Spring Harbor Laboratory
    Document type Article ; Online
    DOI 10.1101/2023.12.12.571262
    Database COVID19

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  9. Article ; Online: Cognitive-behavioral therapy for youth anxiety: An effectiveness evaluation in community practice.

    Villabø, Marianne A / Narayanan, Martina / Compton, Scott N / Kendall, Philip C / Neumer, Simon-Peter

    Journal of consulting and clinical psychology

    2018  Volume 86, Issue 9, Page(s) 751–764

    Abstract: Objective: To compare the effectiveness of individual cognitive-behavioral therapy (ICBT) and group CBT (GCBT) for referred children with anxiety disorders within community mental health clinics.: Method: Children (N = 165; ages 7-13 years) referred ... ...

    Abstract Objective: To compare the effectiveness of individual cognitive-behavioral therapy (ICBT) and group CBT (GCBT) for referred children with anxiety disorders within community mental health clinics.
    Method: Children (N = 165; ages 7-13 years) referred to 5 clinics in Norway because of primary separation anxiety disorder (SAD), social anxiety disorder (SOC), or generalized anxiety disorder (GAD) based on Diagnostic and Statistical Manual of Mental Disorders (4th ed., text rev.) criteria participated in a randomized clinical trial. Participants were randomized to ICBT, GCBT, or wait list (WL). WL participants were randomized to 1 of the 2 active treatment conditions following the wait period. Primary outcome was loss of principal anxiety disorder over 12 weeks and 2-year follow-up.
    Results: Both ICBT and GCBT were superior to WL on all outcomes. In the intent-to-treat analysis, 52% in ICBT, 65% in GCBT, and 14% in WL were treatment responders. Planned pairwise comparisons found no significant differences between ICBT and GCBT. GCBT was superior to ICBT for children diagnosed with SOC. Improvement continued during 2-year follow-up with no significant between-groups differences.
    Conclusions: Among anxiety disordered children, both individual and group CBT can be effectively delivered in community clinics. Response rates were similar to those reported in efficacy trials. Although GCBT was more effective than ICBT for children with SOC following treatment, both treatments were comparable at 2-year follow-up. Dropout rates were lower in GCBT than in ICBT, suggesting that GCBT may be better tolerated. Response rates continued to improve over the follow-up period, with low rates of relapse. (PsycINFO Database Record
    MeSH term(s) Adolescent ; Anxiety Disorders/psychology ; Anxiety Disorders/therapy ; Child ; Cognitive Behavioral Therapy ; Female ; Humans ; Male ; Norway ; Treatment Outcome ; Waiting Lists
    Language English
    Publishing date 2018-08-23
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 121321-0
    ISSN 1939-2117 ; 0022-006X
    ISSN (online) 1939-2117
    ISSN 0022-006X
    DOI 10.1037/ccp0000326
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: An Aurora kinase A-BOD1L1-PP2A B56 Axis promotes chromosome segregation fidelity.

    Kucharski, Thomas J / Vlasac, Irma M / Higgs, Martin R / Christensen, Brock C / Bechstedt, Susanne / Compton, Duane A

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Cancer cells are often aneuploid and frequently display elevated rates of chromosome missegregation in a phenomenon called chromosomal instability (CIN). CIN is commonly caused by hyperstable kinetochore-microtubule (K-MT) attachments that reduces the ... ...

    Abstract Cancer cells are often aneuploid and frequently display elevated rates of chromosome missegregation in a phenomenon called chromosomal instability (CIN). CIN is commonly caused by hyperstable kinetochore-microtubule (K-MT) attachments that reduces the efficiency of correction of erroneous K-MT attachments. We recently showed that UMK57, a chemical agonist of MCAK (alias KIF2C) improves chromosome segregation fidelity in CIN cancer cells although cells rapidly develop adaptive resistance. To determine the mechanism of resistance we performed unbiased proteomic screens which revealed increased phosphorylation in cells adapted to UMK57 at two Aurora kinase A phosphoacceptor sites on BOD1L1 (alias FAM44A). BOD1L1 depletion or Aurora kinase A inhibition eliminated resistance to UMK57 in CIN cancer cells. BOD1L1 localizes to spindles/kinetochores during mitosis, interacts with the PP2A phosphatase, and regulates phosphorylation levels of kinetochore proteins, chromosome alignment, mitotic progression and fidelity. Moreover, the
    Language English
    Publishing date 2024-03-06
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.08.06.552174
    Database MEDical Literature Analysis and Retrieval System OnLINE

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