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Article ; Online: KMT2A-rearranged B-lymphoblastic leukemia/lymphoma with surface light chain restriction and lacking immature markers.

Fu, Lucy / Gong, Shunyou

2024 Volume 142, Issue 25, Page(s) 2220

MeSH term(s)	Humans ; Lymphoma/diagnosis ; Lymphoma/genetics
Chemical Substances	KMT2A protein, human
Language	English
Publishing date	2024-03-07
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	80069-7
ISSN	1528-0020 ; 0006-4971
ISSN (online)	1528-0020
ISSN	0006-4971
DOI	10.1182/blood.2023021556
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Article ; Online: From Left-Behind Children to Youth Labor Migrants

Cheng Chow / Xiaochen Zhou / Yao Fu / Aree Jampaklay / Lucy P. Jordan

Social Sciences, Vol 12, Iss 135, p

The Impact of Household Networks, Gendered Migration, and Relay Migration in Southeast Asia

2023 Volume 135

Abstract: Do children with migrant parents or migrant family members have a greater likelihood of migration as they reach adulthood? Three possible patterns of youth migration are examined in this study: (1) network migration, when families migrating first pave ... ...

Abstract	Do children with migrant parents or migrant family members have a greater likelihood of migration as they reach adulthood? Three possible patterns of youth migration are examined in this study: (1) network migration, when families migrating first pave the way for subsequent generations to follow; (2) gendered migration, where the gender of migrant parents and left-behind children influences the probability of youth migration; and (3) relay migration, which involves transgenerational migration switching within a family. We use data collected from Thailand in 2008/2010 (Wave 1) and tracked in 2019 (Wave 2) to understand how the migration of parents and other family members influenced youth migration in 2019. Within the network effect, household migration was one of the driving forces behind youth migration, while mother-involved migration appeared to be strongly associated with youth labor migration, especially among males. There is, however, no evidence that return migration, whether parental or non-parental in the same household, was associated with an increased likelihood of youth labor migration. This study demonstrates the relative strength of network effects of household migration when compared to relay migration on youth migration. The findings also highlight the complexity of gender-based migration in the Thai context. This research contributes to the larger field of left-behind children and youth migration by establishing the transition between these two roles and illustrating different reasons for migration in sending countries.
Keywords	left-behind children ; youth migration ; migration networks ; gendered migration ; relay migration ; Southeast Asia ; Social Sciences ; H
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article: A Framework for Maintaining a Fully Operational Autopsy Service at a Large Academic Teaching Institution During a Global Pandemic.

Fu, Lucy / Zak, Taylor / Shanes, Elisheva

Academic pathology

2021 Volume 8, Page(s) 23742895211006821

Abstract: The COVID-19 pandemic created new challenges in health care, and pathology departments have led with innovations in testing and education. While the medical community and public showed great interest in gross and histologic findings in COVID-affected ... ...

Abstract	The COVID-19 pandemic created new challenges in health care, and pathology departments have led with innovations in testing and education. While the medical community and public showed great interest in gross and histologic findings in COVID-affected patients, paradoxically many autopsy services nationwide closed due to uncertainties surrounding the proximity to infected patient tissue, shortages in personal protective equipment, and pressures to discontinue perceived nonessential hospital operations. These disruptions furthermore negatively impacted pathology trainee education. The autopsy division at Northwestern Memorial Hospital, with the belief that a fully functioning autopsy service is especially crucial at this time, adopted a framework for continuing at full capacity for both clinical care and education. New operations were modeled on national protocols by the Centers for Disease Control and Prevention and the College of American Pathologists, and the service continually adjusted policies to reflect rapidly changing guidelines and feedback from trainees and staff. Between January and December 2020, we performed 182 adult autopsies including 45 COVID-19 autopsies. Twelve residents, 4 staff, and 5 attendings rotated through the service. In exit interviews, participants expressed: (1) improved comfort managing both COVID-related and general autopsies; (2) sense of personal safety on service (despite the increased risk of exposure); (3) belief that both COVID-related and general autopsies contributed to their personal education and to the medical community. There have been zero known autopsy-related COVID-19 infections to date. We hope that our innovative autopsy service restructuring can serve as a framework for other academic programs during the current and in future pandemics.
Language	English
Publishing date	2021-04-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2819382-9
ISSN	2374-2895
ISSN	2374-2895
DOI	10.1177/23742895211006821
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Article ; Online: Extending the data collection from a clinical trial: The Extended Salford Lung Study research cohort.

Meeraus, Wilhelmine / Fu, Qinggong / Mu, George / Fry, Mark / Frith, Lucy / Pimenta, Jeanne M

NPJ primary care respiratory medicine

2023 Volume 33, Issue 1, Page(s) 4

Abstract: The Extended Salford Lung Study (Ext-SLS) is an extension of the Salford Lung Studies (SLS) in asthma and chronic obstructive pulmonary disease (COPD) through retrospective and prospective collection of patient-level electronic health record (EHR) data. ... ...

Abstract	The Extended Salford Lung Study (Ext-SLS) is an extension of the Salford Lung Studies (SLS) in asthma and chronic obstructive pulmonary disease (COPD) through retrospective and prospective collection of patient-level electronic health record (EHR) data. We compared the Ext-SLS cohort with the SLS intention-to-treat populations using descriptive analyses to determine if the strengths (e.g. randomization) of the clinical trial were maintained in the new cohort. Historical and patient-reported outcome data were captured from asthma-/COPD-specific questionnaires (e.g., Asthma Control Test [ACT]/COPD Assessment Test [CAT]). The Ext-SLS included 1147 participants (n = 798, SLS asthma; n = 349, SLS COPD). Of participants answering the ACT, 39% scored <20, suggesting poorly controlled asthma. For COPD, 61% of participants answering the CAT scored ≥21, demonstrating a high disease burden. Demographic/clinical characteristics of the cohorts were similar at SLS baseline. EHR data provided a long-term view of participants' disease, and questionnaires provided information not typically captured. The Ext-SLS cohort is a valuable resource for respiratory research, and ongoing prospective data collection will add further value and ensure the Ext-SLS is an important source of patient-level information on obstructive airways disease.
MeSH term(s)	Humans ; Retrospective Studies ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Asthma/drug therapy ; Surveys and Questionnaires ; Lung
Language	English
Publishing date	2023-01-18
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2780812-9
ISSN	2055-1010 ; 2055-1010
ISSN (online)	2055-1010
ISSN	2055-1010
DOI	10.1038/s41533-022-00322-7
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Article ; Online: Longitudinal associations between parental migration and children's psychological well-being in Southeast Asia: The roles of caregivers' mental health and caregiving quality.

Fu, Yao / Jordan, Lucy P / Zhou, Xiaochen / Chow, Cheng / Fang, Lue

Social science & medicine (1982)

2023 Volume 320, Page(s) 115701

Abstract: Objective: This study investigates the longer-term effects of parental migration on the psychological well-being of children who stay behind in two major labor-sending countries in Southeast Asia, namely, Indonesia and the Philippines. Adopting the ... ...

Abstract	Objective: This study investigates the longer-term effects of parental migration on the psychological well-being of children who stay behind in two major labor-sending countries in Southeast Asia, namely, Indonesia and the Philippines. Adopting the framework of the 'care triangle', we further examine how caregivers' mental health and caregiving quality moderate the associations between parental migration and children's psychological well-being. Methods: Using longitudinal data collected in 2008 and 2016/17, we assess children's psychological well-being during early childhood (aged 3-5 years) and again in adolescence (aged 11-13 years). We apply both fixed-effects and random-effects models, using the Hausman test to indicate the preferred model. Results: The findings indicate that there is no significant longer-term effect of parental migration on children's psychological well-being, but parental migration tends to show adverse effects on Filipino children's psychological well-being when they are cared for by a caregiver with poor mental health. Conclusions: The two-country comparison demonstrates the complexities of understanding the gender-based influences of parental migration on children's psychological well-being. The findings also highlight the caregiver's role in maintaining frequent communications with migrant parents within the care triangle, which is crucial to children's well-being.
MeSH term(s)	Adolescent ; Humans ; Child, Preschool ; Mental Health ; Caregivers/psychology ; Psychological Well-Being ; Parents ; Asia, Southeastern
Language	English
Publishing date	2023-01-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	4766-1
ISSN	1873-5347 ; 0037-7856 ; 0277-9536
ISSN (online)	1873-5347
ISSN	0037-7856 ; 0277-9536
DOI	10.1016/j.socscimed.2023.115701
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Article: Comparison of the three-dimensional chromatin structures of adolescent and adult peripheral blood B cells: implications for the study of pediatric autoimmune diseases.

Jiang, Kaiyu / Fu, Yao / Kelly, Jennifer A / Gaffney, Patrick M / Holmes, Lucy C / Jarvis, James N

bioRxiv : the preprint server for biology

2023

Abstract: Background/purpose: Knowledge of the 3D genome is essential to elucidate genetic mechanisms driving autoimmune diseases. The 3D genome is distinct for each cell type, and it is uncertain whether cell lines faithfully recapitulate the 3D architecture of ... ...

Abstract	Background/purpose: Knowledge of the 3D genome is essential to elucidate genetic mechanisms driving autoimmune diseases. The 3D genome is distinct for each cell type, and it is uncertain whether cell lines faithfully recapitulate the 3D architecture of primary human cells or whether developmental aspects of the pediatric immune system require use of pediatric samples. We undertook a systematic analysis of B cells and B cell lines to compare 3D genomic features encompassing risk loci for juvenile idiopathic arthritis (JIA), systemic lupus (SLE), and type 1 diabetes (T1D). Methods: We isolated B cells from healthy individuals, ages 9-17. HiChIP was performed using CTCF antibody, and CTCF peaks were identified. CTCF loops within the pediatric were compared to three datasets: 1) self-called CTCF consensus peaks called within the pediatric samples, 2) ENCODE's publicly available GM12878 CTCF ChIP-seq peaks, and 3) ENCODE's primary B cell CTCF ChIPseq peaks from two adult females. Differential looping was assessed within the pediatric samples and each of the three peak datasets. Results: The number of consensus peaks called in the pediatric samples was similar to that identified in ENCODE's GM12878 and primary B cell datasets. We observed <1% of loops that demonstrated significantly differential looping between peaks called within the pediatric samples themselves and when called using ENCODE GM12878 peaks . Significant looping differences were even less when comparing loops of the pediatric called peaks to those of the ENCODE primary B cell peaks. When querying loops found in juvenile idiopathic arthritis, type 1 diabetes, or systemic lupus erythematosus risk haplotypes, we observed significant differences in only 2.2%, 1.0%, and 1.3% loops, respectively, when comparing peaks called within the pediatric samples and ENCODE GM12878 dataset. The differences were even less apparent when comparing loops called with the pediatric vs ENCODE adult primary B cell peak datasets.The 3D chromatin architecture in B cells is similar across pediatric, adult, and EBVtransformed cell lines. This conservation of 3D structure includes regions encompassing autoimmune risk haplotypes. Conclusion: Thus, even for pediatric autoimmune diseases, publicly available adult B cell and cell line datasets may be sufficient for assessing effects exerted in the 3D genomic space.
Language	English
Publishing date	2023-09-14
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.09.11.557171
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Article ; Online: Cytology-histology correlation of myoepithelial tumors harboring EWSR1-POU5F1 fusions: A report of two cases.

Gelarden, Ian A / Fu, Lucy / Yap, Kai Lee / Richardson, Aida I / Chou, Pauline M

Diagnostic cytopathology

2022 Volume 50, Issue 6, Page(s) E163–E169

Abstract: Myoepithelial tumors (MET) constitute a group of neoplasms with a variety of morphologic, immunophenotypic, and molecular features. Approximately half of MET of soft tissue harbor EWSR1 gene rearrangements with a subset showing EWSR1-POU5F1 fusions and ... ...

Abstract	Myoepithelial tumors (MET) constitute a group of neoplasms with a variety of morphologic, immunophenotypic, and molecular features. Approximately half of MET of soft tissue harbor EWSR1 gene rearrangements with a subset showing EWSR1-POU5F1 fusions and demonstrating distinctive tendency towards aggressive behavior in children. Histologically, EWSR1-POU5F1-positive MET typically show clear-cell morphology with malignant features including marked pleomorphism and atypical mitotic figures. The cytomorphology of these tumors has not been well characterized. Reported here are the cytomorphologic features of two cases of EWSR1-POUF1-positive MET with histology correlation.
MeSH term(s)	Biomarkers, Tumor/genetics ; Child ; Humans ; Immunophenotyping ; Myoepithelioma/genetics ; Myoepithelioma/pathology ; Octamer Transcription Factor-3/genetics ; Oncogene Proteins, Fusion/genetics ; RNA-Binding Protein EWS/genetics ; Soft Tissue Neoplasms/genetics ; Soft Tissue Neoplasms/pathology
Chemical Substances	Biomarkers, Tumor ; EWSR1 protein, human ; Octamer Transcription Factor-3 ; Oncogene Proteins, Fusion ; POU5F1 protein, human ; RNA-Binding Protein EWS
Language	English
Publishing date	2022-02-06
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	632710-2
ISSN	1097-0339 ; 8755-1039
ISSN (online)	1097-0339
ISSN	8755-1039
DOI	10.1002/dc.24941
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Article ; Online: A self-indicating and antibacterial gelatine-chitosan blended hydrogel enabling real-time quality control and sustained bioactive agent delivery.

Lai, Wing-Fu / Reddy, Obireddy Sreekanth / Law, Lucy / Wu, Haicui / Wong, Wing-Tak

RSC advances

2023 Volume 13, Issue 17, Page(s) 11865–11873

Abstract: Hydrogels are one type of materials that are widely exploited for bioactive agent delivery, partly owing to their high biocompatibility and low toxicity. When hydrogels are used as carriers, their performance in agent loading and sustained agent release ... ...

Abstract	Hydrogels are one type of materials that are widely exploited for bioactive agent delivery, partly owing to their high biocompatibility and low toxicity. When hydrogels are used as carriers, their performance in agent loading and sustained agent release are predominately determined by the gel structure, which can be largely affected by variations during gel preparation. Till now, effective and easy methods to enable monitoring of such variations in real time have been lacking, making quality control of the generated gel-based carrier technically challenging. To address this technical gap, in this study we take advantage of the clusteroluminogenic properties of gelatine and chitosan to generate a crosslinked blended hydrogel which not only shows intrinsic antibacterial properties and high tunability in delivery performance but also shows a self-indicating capacity to enable quality control during hydrogel preparation. Upon fitting the curves of agent release into different kinetic models, the release profiles of the agent-loaded gels have been found to follow the Higuchi model well, with the non-Fickian mechanism being the major mechanism of the release process. Along with their high efficiency in agent loading, our gels warrant further exploitation for use in bioactive agent delivery and related biomedical applications.
Language	English
Publishing date	2023-04-17
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d2ra06802h
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Article ; Online: Clinical implications of additional chromosomal abnormalities in adult acute myeloid leukemia with inv (16)/t(16;16)/CBFB::MYH11.

Gao, Juehua / Santana-Santos, Lucas / Fu, Lucy / Alvey, Emily / Chen, Qing / Wolniak, Kristy / Xia, Zongjun / Aqil, Barina / Behdad, Amir / Ji, Peng / Sukhanova, Madina / Abaza, Yasmin / Altman, Jessica K / Chen, Yi-Hua / Lu, Xinyan

European journal of haematology

2024 Volume 112, Issue 6, Page(s) 964–974

Abstract: Objectives: This study assesses the clinical significance of additional cytogenetic abnormalities (ACAs) and/or the deletion of 3'CBFB (3'CBFB: Methods: We retrospectively evaluated the clinicopathologic features of 47 adult de novo AML with inv (16)/ ...

Abstract	Objectives: This study assesses the clinical significance of additional cytogenetic abnormalities (ACAs) and/or the deletion of 3'CBFB (3'CBFB Methods: We retrospectively evaluated the clinicopathologic features of 47 adult de novo AML with inv (16)/t(16;16)/CBFB::MYH11 fusion. There were 44 balanced and 3 unbalanced CBFB::MYH11 fusions. Given the low frequency of unbalanced cases, the latter group was combined with 19 published cases (N = 22) for statistic and meta-analysis. Results: Both balanced and unbalanced cases were characterized by frequent ACAs (56.5% and 72.7%, respectively), with +8, +22, and del(7q) as the most frequent abnormalities. The unbalanced group tends to be younger individuals (p = .04) and is associated with a lower remission rate (p = .02), although the median overall survival (OS) was not statistically different (p = .2868). In the balanced group, "ACA" subgroup had higher mortality (p = .013) and shorter OS (p = .011), and patients with relapsed disease had a significantly shorter OS (p = .0011). Cox multivariate regression analysis confirmed that ACAs and history of disease relapse are independent risk factors, irrespective of disease relapse status. In the combined cohort, cases with ACAs had shorter OS than those with "Sole" abnormality (p = .0109). Conclusions: ACAs are independent high-risk factors in adult AML with inv (16)/t(16;16)/CBFB::MYH11 fusion and should be integrated for risk stratification in this disease. Larger studies are needed to assess the clinical significance of the unbalanced CBFB::MYH11 fusion resulting from the 3'CBFB
MeSH term(s)	Humans ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/mortality ; Leukemia, Myeloid, Acute/diagnosis ; Adult ; Female ; Male ; Middle Aged ; Oncogene Proteins, Fusion/genetics ; Chromosome Inversion ; Aged ; Chromosomes, Human, Pair 16/genetics ; Chromosome Aberrations ; Prognosis ; Retrospective Studies ; Young Adult ; Core Binding Factor beta Subunit/genetics ; Adolescent ; Aged, 80 and over ; Translocation, Genetic ; Myosin Heavy Chains/genetics
Chemical Substances	Oncogene Proteins, Fusion ; Core Binding Factor beta Subunit ; CBFbeta-MYH11 fusion protein ; CBFB protein, human ; MYH11 protein, human ; Myosin Heavy Chains (EC 3.6.4.1)
Language	English
Publishing date	2024-02-22
Publishing country	England
Document type	Journal Article
ZDB-ID	392482-8
ISSN	1600-0609 ; 0902-4441
ISSN (online)	1600-0609
ISSN	0902-4441
DOI	10.1111/ejh.14192
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Article ; Online: Steric Control of Luminescence in Phenyl-Substituted Trityl Radicals.

Murto, Petri / Li, Biwen / Fu, Yao / Walker, Lucy E / Brown, Laura / Bond, Andrew D / Zeng, Weixuan / Chowdhury, Rituparno / Cho, Hwan-Hee / Yu, Craig P / Grey, Clare P / Friend, Richard H / Bronstein, Hugo

Journal of the American Chemical Society

2024 Volume 146, Issue 19, Page(s) 13133–13141

Abstract: Triphenylmethyl (trityl) radicals have shown potential for use in organic optoelectronic applications, but the design of practical trityl structures has been limited to donor/radical charge-transfer systems due to the poor luminescence of alternant ... ...

Abstract	Triphenylmethyl (trityl) radicals have shown potential for use in organic optoelectronic applications, but the design of practical trityl structures has been limited to donor/radical charge-transfer systems due to the poor luminescence of alternant symmetry hydrocarbons. Here, we circumvent the symmetry-forbidden transition of alternant hydrocarbons via excited-state symmetry breaking in a series of phenyl-substituted tris(2,4,6-trichlorophenyl)methyl (TTM) radicals. We show that 3-fold phenyl substitution enhances the emission of the TTM radical and that steric control modulates the optical properties in these systems. Simple
Language	English
Publishing date	2024-05-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.4c00292
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