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  1. Article ; Online: Growing synergy of nanodiamonds in neurodegenerative interventions.

    Saraf, Jackson / Kalia, Kiran / Bhattacharya, Pallab / Tekade, Rakesh Kumar

    Drug discovery today

    2018  Volume 24, Issue 2, Page(s) 584–594

    Abstract: Neurodegenerative diseases are complex in both their nature and prognosis. The difficulties associated with penetrating the blood-brain barrier (BBB), achieving site-specific targeting to the brain, and identifying the genetic etiologies responsible make ...

    Abstract Neurodegenerative diseases are complex in both their nature and prognosis. The difficulties associated with penetrating the blood-brain barrier (BBB), achieving site-specific targeting to the brain, and identifying the genetic etiologies responsible make treating neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), and stroke, challenging. The aim to treat disease at the molecular level has galvanized nanotechnology research. Among the forms of nanoparticles (NPs) explored thus far, nanodiamonds (NDs) have shown great potential. Their unique physicochemical properties, such as a nanometer size range, stable and inert core, tunable surface, intrinsic fluorescence without photobleaching, negligible toxicity, and the ability to form complexes with drugs, highlight their theranostic potential. The ability of NDs to penetrate the BBB and target specific affected areas of the brain could take research one step closer to understanding the underlying disease etiology and unlocking more efficient methods of delivering neuromedicine to specific areas of the brain. Here, we explore interactions between NDs and the neuronal circuitry with a focus on the therapeutic potential of NDs as treatments for neurodegenerative diseases.
    MeSH term(s) Animals ; Humans ; Nanodiamonds/therapeutic use ; Neurodegenerative Diseases/diagnosis ; Neurodegenerative Diseases/drug therapy ; Neurons/drug effects
    Chemical Substances Nanodiamonds
    Language English
    Publishing date 2018-11-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1324988-5
    ISSN 1878-5832 ; 1359-6446
    ISSN (online) 1878-5832
    ISSN 1359-6446
    DOI 10.1016/j.drudis.2018.10.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4725: Show issues Location:
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  2. Article ; Online: Correction to: Intra-arterial Stem Cell Therapy Diminishes Inflammasome Activation After Ischemic Stroke: a Possible Role of Acid Sensing Ion Channel 1a.

    Vats, Kanchan / Sarmah, Deepaneeta / Datta, Aishika / Saraf, Jackson / Kaur, Harpreet / Pravalika, Kanta / Wanve, Madhuri / Kalia, Kiran / Borah, Anupom / Dave, Kunjan R / Yavagal, Dileep R / Bhattacharya, Pallab

    Journal of molecular neuroscience : MN

    2021  Volume 71, Issue 2, Page(s) 427–429

    Language English
    Publishing date 2021-01-02
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 1043392-2
    ISSN 1559-1166 ; 0895-8696
    ISSN (online) 1559-1166
    ISSN 0895-8696
    DOI 10.1007/s12031-020-01731-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3006: Show issues Location:
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  3. Article ; Online: Aptamer-gold nanoparticle conjugates for the colorimetric detection of arboviruses and vector mosquito species.

    Bosak, Alexander / Saraf, Nileshi / Willenberg, Alicia / Kwan, Michael W C / Alto, Barry W / Jackson, George W / Batchelor, Robert H / Nguyen-Huu, Truong D / Sankarapani, Vinoth / Parks, Griffith D / Seal, Sudipta / Willenberg, Bradley Jay

    RSC advances

    2019  Volume 9, Issue 41, Page(s) 23752–23763

    Abstract: The real-time, colorimetric detection of ... ...

    Abstract The real-time, colorimetric detection of analytes
    Language English
    Publishing date 2019-07-31
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/c9ra02089f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A Friend or Foe

    Jackson Saraf / Pallab Bhattacharya / Kiran Kalia / Anupom Borah / Deepaneeta Sarmah / Harpreet Kaur / Kunjan R Dave / Dileep R Yavagal

    ACS Central Science, Vol 4, Iss 7, Pp 805-

    Calcineurin across the Gamut of Neurological Disorders

    2018  Volume 819

    Keywords Chemistry ; QD1-999
    Language English
    Publishing date 2018-06-01T00:00:00Z
    Publisher American Chemical Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: A Friend or Foe: Calcineurin across the Gamut of Neurological Disorders.

    Saraf, Jackson / Bhattacharya, Pallab / Kalia, Kiran / Borah, Anupom / Sarmah, Deepaneeta / Kaur, Harpreet / Dave, Kunjan R / Yavagal, Dileep R

    ACS central science

    2018  Volume 4, Issue 7, Page(s) 805–819

    Abstract: The serine/threonine phosphatase calcineurin (CaN) is a unique but confounding calcium/calmodulin-mediated enzyme. CaN has shown to play essential roles from regulating calcium homeostasis to being an intricate part of learning and memory formation. ... ...

    Abstract The serine/threonine phosphatase calcineurin (CaN) is a unique but confounding calcium/calmodulin-mediated enzyme. CaN has shown to play essential roles from regulating calcium homeostasis to being an intricate part of learning and memory formation. Neurological disorders, despite differing in their etiology, share similar pathological outcomes, such as mitochondrial dysfunction and apoptotic signaling brought about by excitotoxic elements. CaN, being deeply integrated in vital neuronal functions, may be implicated in various neurological disorders. Understanding the enzyme and its physiological niche in the nervous system is vital in uncovering its roles in the spectrum of brain disorders. By reviewing the crosstalk in different neurological pathologies, a possible grasp of CaN's complex signaling may lead to forming better neurotherapy. This Outlook attempts to explore the various neuronal functions of CaN and investigate its pervasive role through the gamut of neurological disorders.
    Language English
    Publishing date 2018-06-27
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2374-7943
    ISSN 2374-7943
    DOI 10.1021/acscentsci.8b00230
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Intra-arterial stem cell therapy modulates neuronal calcineurin and confers neuroprotection after ischemic stroke.

    Saraf, Jackson / Sarmah, Deepaneeta / Vats, Kanchan / Kaur, Harpreet / Pravalika, Kanta / Wanve, Madhuri / Kalia, Kiran / Borah, Anupom / Dave, Kunjan R / Yavagal, Dileep R / Bhattacharya, Pallab

    The International journal of neuroscience

    2019  Volume 129, Issue 10, Page(s) 1039–1044

    Abstract: Aim: ...

    Abstract Aim:
    MeSH term(s) Animals ; Brain Ischemia/metabolism ; Brain Ischemia/therapy ; Calcineurin/biosynthesis ; Female ; Infusions, Intra-Arterial ; Mesenchymal Stem Cell Transplantation/methods ; Neurons/metabolism ; Neuroprotection/physiology ; Ovariectomy/adverse effects ; Ovariectomy/trends ; Rats ; Rats, Sprague-Dawley ; Stroke/metabolism ; Stroke/therapy
    Chemical Substances Calcineurin (EC 3.1.3.16)
    Language English
    Publishing date 2019-07-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 3061-2
    ISSN 1563-5279 ; 1543-5245 ; 0020-7454
    ISSN (online) 1563-5279 ; 1543-5245
    ISSN 0020-7454
    DOI 10.1080/00207454.2019.1633315
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 657: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Stroke Management: An Emerging Role of Nanotechnology.

    Sarmah, Deepaneeta / Saraf, Jackson / Kaur, Harpreet / Pravalika, Kanta / Tekade, Rakesh Kumar / Borah, Anupom / Kalia, Kiran / Dave, Kunjan R / Bhattacharya, Pallab

    Micromachines

    2017  Volume 8, Issue 9

    Abstract: Stroke is among the leading causes of mortality and morbidity worldwide. Stroke incidences and associated mortality are expected to rise to 23 million and 7.8 million, respectively, by 2030. Further, the aging population, imbalanced lifestyles, and ... ...

    Abstract Stroke is among the leading causes of mortality and morbidity worldwide. Stroke incidences and associated mortality are expected to rise to 23 million and 7.8 million, respectively, by 2030. Further, the aging population, imbalanced lifestyles, and environmental factors continue to shift the rate of stroke incidence, particularly in developing countries. There is an urgent need to develop new therapeutic approaches for treating stroke. Nanotechnology is a growing field, offering an encouraging future prospect for medical research in the management of strokes. The world market for nanotechnology derived products is expected to rise manyfold in the coming decades. Different types of nanomaterials such as perfluorocarbon nanoparticles, iron oxide nanoparticles, gold nanoparticles, polymeric nanoparticles, quantum dots, nanospheres, etc. have been developed for the diagnosis as well as therapy of strokes. Today, nanotechnology has also been integrated with stem cell therapy for treating stroke. However several obstacles remain to be overcome when using such nanomaterials for treating stroke and other neurological diseases.
    Language English
    Publishing date 2017-08-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2620864-7
    ISSN 2072-666X
    ISSN 2072-666X
    DOI 10.3390/mi8090262
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Intra-arterial Stem Cell Therapy Diminishes Inflammasome Activation After Ischemic Stroke: a Possible Role of Acid Sensing Ion Channel 1a.

    Vats, Kanchan / Sarmah, Deepaneeta / Datta, Aishika / Saraf, Jackson / Kaur, Harpreet / Pravalika, Kanta / Wanve, Madhuri / Kalia, Kiran / Borah, Anupom / Dave, Kunjan R / Yavagal, Dileep R / Bhattacharya, Pallab

    Journal of molecular neuroscience : MN

    2019  Volume 71, Issue 2, Page(s) 419–426

    Abstract: Studies from our lab demonstrated that 1 × ... ...

    Abstract Studies from our lab demonstrated that 1 × 10
    MeSH term(s) Acid Sensing Ion Channels/physiology ; Amiloride/therapeutic use ; Animals ; Brain Damage, Chronic/etiology ; Brain Damage, Chronic/prevention & control ; Female ; Infarction, Middle Cerebral Artery/complications ; Infarction, Middle Cerebral Artery/immunology ; Infarction, Middle Cerebral Artery/metabolism ; Infarction, Middle Cerebral Artery/therapy ; Inflammasomes/metabolism ; Injections, Intra-Arterial ; Mesenchymal Stem Cell Transplantation/methods ; Mesenchymal Stem Cells/physiology ; Nerve Tissue Proteins/physiology ; Ovariectomy ; Rats ; Rats, Sprague-Dawley ; Rotarod Performance Test ; Somatosensory Disorders/etiology ; Somatosensory Disorders/prevention & control
    Chemical Substances Acid Sensing Ion Channels ; Asic1 protein, rat ; Inflammasomes ; Nerve Tissue Proteins ; Amiloride (7DZO8EB0Z3)
    Language English
    Publishing date 2019-12-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1043392-2
    ISSN 1559-1166 ; 0895-8696
    ISSN (online) 1559-1166
    ISSN 0895-8696
    DOI 10.1007/s12031-019-01460-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3006: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Myeloperoxidase and Neurological Disorder: A Crosstalk.

    Pravalika, Kanta / Sarmah, Deepaneeta / Kaur, Harpreet / Wanve, Madhuri / Saraf, Jackson / Kalia, Kiran / Borah, Anupom / Yavagal, Dileep R / Dave, Kunjan R / Bhattacharya, Pallab

    ACS chemical neuroscience

    2018  Volume 9, Issue 3, Page(s) 421–430

    Abstract: Myeloperoxidase (MPO) is a protein present in azurophilic granules, macrophages, and neutrophils that are released into extracellular fluid (ECF) during inflammation. MPO releases hypochlorous acid (HOCl) and other chlorinated species. It is derived from ...

    Abstract Myeloperoxidase (MPO) is a protein present in azurophilic granules, macrophages, and neutrophils that are released into extracellular fluid (ECF) during inflammation. MPO releases hypochlorous acid (HOCl) and other chlorinated species. It is derived from hydrogen peroxide (H
    MeSH term(s) Animals ; Humans ; Hypochlorous Acid/metabolism ; Inflammation/metabolism ; Nervous System Diseases/diagnosis ; Nervous System Diseases/metabolism ; Neutrophils/cytology ; Oxidative Stress/physiology ; Peroxidase/metabolism
    Chemical Substances Hypochlorous Acid (712K4CDC10) ; Peroxidase (EC 1.11.1.7)
    Language English
    Publishing date 2018-02-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ISSN 1948-7193
    ISSN (online) 1948-7193
    DOI 10.1021/acschemneuro.7b00462
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Mitochondrial Dysfunction in Stroke: Implications of Stem Cell Therapy.

    Sarmah, Deepaneeta / Kaur, Harpreet / Saraf, Jackson / Vats, Kanchan / Pravalika, Kanta / Wanve, Madhuri / Kalia, Kiran / Borah, Anupom / Kumar, Akhilesh / Wang, Xin / Yavagal, Dileep R / Dave, Kunjan R / Bhattacharya, Pallab

    Translational stroke research

    2018  

    Abstract: Stroke is a debilitating condition which is also the second leading cause of death and disability worldwide. Despite the benefits and promises shown by numerous neuroprotective agents in animal stroke models, their clinical translation has not been a ... ...

    Abstract Stroke is a debilitating condition which is also the second leading cause of death and disability worldwide. Despite the benefits and promises shown by numerous neuroprotective agents in animal stroke models, their clinical translation has not been a complete success. Hence, search for treatment options have directed researchers towards utilising stem cells. Mitochondria has a major involvement in the pathophysiology of stroke and a number of other conditions. Stem cells have shown the ability to transfer mitochondria to the damaged cells and to help revive cell energetics in the recipient cell. The present review discusses how stem cells could be employed to protect neurons and mitochondria in stroke and also the various mechanisms involved in neuroprotection.
    Language English
    Publishing date 2018-06-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2541897-X
    ISSN 1868-601X ; 1868-4483
    ISSN (online) 1868-601X
    ISSN 1868-4483
    DOI 10.1007/s12975-018-0642-y
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