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  1. Article ; Online: Reply to André Pontes-Silva's Letter to the Editor re: Gabriela Ilie, Ricardo Rendon, Ross Mason, et al. A Comprehensive 6-mo Prostate Cancer Patient Empowerment Program Decreases Psychological Distress Among Men Undergoing Curative Prostate Cancer Treatment: A Randomized Clinical Trial. Eur Urol 2023;83:561-70.

    Ilie, Gabriela / Rutledge, Robert David Harold

    European urology

    2023  Volume 85, Issue 2, Page(s) e45–e46

    MeSH term(s) Humans ; Male ; Androgen Antagonists ; Patient Participation ; Prostatic Neoplasms/therapy ; Psychological Distress
    Chemical Substances Androgen Antagonists
    Language English
    Publishing date 2023-09-22
    Publishing country Switzerland
    Document type Letter
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2023.08.027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Reply to Matthias May, Ingmar Wolff, and Sabine D. Brookman-May's Letter to the Editor re: Gabriela Ilie, Ricardo Rendon, Ross Mason, et al. A Comprehensive 6-mo Prostate Cancer Patient Empowerment Program Decreases Psychological Distress Among Men Undergoing Curative Prostate Cancer Treatment: A Randomized Clinical Trial. Eur Urol 2023;83:561-70.

    Ilie, Gabriela / Rutledge, Robert David Harold

    European urology

    2023  Volume 85, Issue 2, Page(s) e49–e50

    MeSH term(s) Humans ; Male ; Patient Participation ; Prostatic Neoplasms ; Psychological Distress
    Language English
    Publishing date 2023-09-22
    Publishing country Switzerland
    Document type Letter
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2023.08.028
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  3. Article ; Online: Reply to Zhipeng Mai, Weigang Yan, and Zhien Zhou's Letter to the Editor re: Gabriela Ilie, Ricardo Rendon, Ross Mason, et al. A Comprehensive 6-mo Prostate Cancer Patient Empowerment Program Decreases Psychological Distress Among Men Undergoing Curative Prostate Cancer Treatment: A Randomized Clinical Trial. Eur Urol 2023;83:561-70.

    Ilie, Gabriela / Rutledge, Robert D H

    European urology

    2023  Volume 84, Issue 2, Page(s) e48–e49

    MeSH term(s) Male ; Humans ; Patient Participation ; Prostatic Neoplasms/therapy ; Psychological Distress
    Language English
    Publishing date 2023-05-26
    Publishing country Switzerland
    Document type Randomized Controlled Trial ; Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2023.05.015
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  4. Article ; Online: Reply to Mauricio Plata, Cesar Diaz Ritter, and Nicolás Badillo's Letter to the Editor re: Gabriela Ilie, Ricardo Rendon, Ross Mason, et al. A Comprehensive 6-mo Prostate Cancer Patient Empowerment Program Decreases Psychological Distress Among Men Undergoing Curative Prostate Cancer Treatment: A Randomized Clinical Trial. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2023.02.009.

    Ilie, Gabriela / David Harold Rutledge, Robert

    European urology

    2023  Volume 84, Issue 1, Page(s) e26–e27

    MeSH term(s) Male ; Humans ; Patient Participation ; Prostatic Neoplasms/therapy ; Psychological Distress
    Language English
    Publishing date 2023-04-29
    Publishing country Switzerland
    Document type Randomized Controlled Trial ; Letter ; Comment
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2023.04.019
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  5. Article ; Online: Post-Treatment Adverse Health Correlates among Prostate Cancer Survivors in a Sample of Men Residing in Atlantic Canada.

    Ilie, Gabriela / Rutledge, Robert / Sweeney, Ellen

    Current oncology (Toronto, Ont.)

    2021  Volume 28, Issue 4, Page(s) 2812–2822

    Abstract: Background: Recent large population-based studies have shed light on an association between prostate cancer (PCa) survivorship and mental health, which emerged when the comparison group was either men without a history of cancer or those with any other ... ...

    Abstract Background: Recent large population-based studies have shed light on an association between prostate cancer (PCa) survivorship and mental health, which emerged when the comparison group was either men without a history of cancer or those with any other type of cancer except prostate. Here we examine the role of surgery alone, compared to other types of treatment modalities in this association in a population-based sample of men with prostate or other types of cancer.
    Methods: A cross-sectional analysis was conducted on a subsample of 632 male participants aged 36-69 from the 2009-2015 survey cycle of the Atlantic PATH cohort study. The primary outcomes were the presence of mild, moderate or severe depression or anxiety indicators and were assessed using the seven-item generalized anxiety disorder (GAD-7) scale and the nine-item Patient Health Questionnaire (PHQ-9), respectively. The presence of a lifetime history of PCa or other form of cancer (except PCa) was the main predictor variable and was assessed in cancer treatment modality (surgery or other types of treatment modalities) stratified analyses. Covariates included age, marital status, household income, comorbidity, and survivorship time.
    Results: The presence of depression in this sample was prevalent among 17.7% of men, and of anxiety among 9.3% of men. Survivors who were treated with surgery for their PCa diagnosis had 7.55 statistically significantly higher odds of screening positive for current depression symptoms compared with those of other forms of cancer in controlled analyses. These differences were not observed for anxiety.
    Conclusions: These findings emphasize the need for multidisciplinary survivorship care plans among PCa patients, especially those who undergo surgery. Targeted programming aimed at prioritizing and delivering comprehensive mental health support to PCa survivors early in the survivorship journey is justified.
    MeSH term(s) Cancer Survivors ; Cohort Studies ; Cross-Sectional Studies ; Depression/epidemiology ; Depression/etiology ; Humans ; Male ; Prostatic Neoplasms/epidemiology ; Prostatic Neoplasms/therapy ; Quality of Life ; Risk Factors ; Survivors
    Language English
    Publishing date 2021-07-25
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1236972-x
    ISSN 1718-7729 ; 1198-0052
    ISSN (online) 1718-7729
    ISSN 1198-0052
    DOI 10.3390/curroncol28040246
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: An Examination of the Role of Socioeconomic Status in the Relationship between Depression and Prostate Cancer Survivorship in a Population-Based Sample of Men from Atlantic Canada.

    Ilie, Gabriela / Rutledge, Robert / Sweeney, Ellen

    Oncology

    2021  Volume 99, Issue 4, Page(s) 260–270

    Abstract: Objective: Prostate and skin cancer are among the most prevalent forms of cancer among men and have favorable survival rates compared to other, more aggressive forms of cancers. Recent studies have shown that the odds of depression among men with a ... ...

    Abstract Objective: Prostate and skin cancer are among the most prevalent forms of cancer among men and have favorable survival rates compared to other, more aggressive forms of cancers. Recent studies have shown that the odds of depression among men with a lifetime history of prostate cancer are higher compared to men without a lifetime history of prostate cancer. Here we extend previous findings and examine the role of socioeconomic status in the relationship between depression and cancer survivorship status in a population-based sample of men from Atlantic Canada.
    Methods: A cross-sectional analysis was conducted on a subsample of 6,585 male participants aged 49-69 years from the 2009-2015 survey cycle of the Atlantic PATH study. The primary outcome was screening positive for mild, moderate or severe depression using the Patient Health Questionnaire (PHQ-9). The main predictor variable was cancer survivorship status (the presence of a lifetime history of prostate cancer, skin cancer, forms of cancer other than prostate or skin cancer, or absence of a lifetime cancer diagnosis). Covariates included age, education, marital status, household income, province, ethnicity, comorbidity, and survivorship time.
    Results: An estimated 14.7% of men in this sample screened positive for mild, moderate or severe depression. Men with a history of prostate cancer were 2.60 (95% CI: 1.02, 6.65) times more likely to screen positive for depression than men with a history of any other form of cancer. The odds ratios were 10.23 (95% CI: 2.82, 37.49) or 4.00 (95% CI: 1.20, 13.34) times higher for survivors of prostate or skin cancer who reported a low household income to screen positive for depression compared to men with a history of any other form of cancer and high household income.
    Conclusions: These results extend current evidence of the association between prostate cancer survivorship and depression compared with men who never had a history of cancer diagnosis by indicating that this association still stands when the survivors of prostate cancer are compared to survivors of any other form of cancer, and further indicates that this association is moderated by household income. The findings highlight the importance of delivering mental health screening and support to prostate cancer survivors during the cancer journey, especially those with low household incomes.
    MeSH term(s) Adult ; Aged ; Canada/epidemiology ; Cancer Survivors/psychology ; Comorbidity ; Cross-Sectional Studies ; Depression/epidemiology ; Health Surveys ; Humans ; Incidence ; Income ; Longitudinal Studies ; Male ; Middle Aged ; Prostatic Neoplasms/epidemiology ; Prostatic Neoplasms/mortality ; Prostatic Neoplasms/psychology ; Quality of Life/psychology ; Skin Neoplasms/epidemiology ; Skin Neoplasms/mortality ; Skin Neoplasms/psychology ; Social Class ; Survival Rate ; Survivorship
    Language English
    Publishing date 2021-01-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 250101-6
    ISSN 1423-0232 ; 0030-2414
    ISSN (online) 1423-0232
    ISSN 0030-2414
    DOI 10.1159/000512444
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  7. Article: Nasal Embryonal Rhabdomyosarcoma in the Pediatric Population: Literature Review and Report of Midline Presentation.

    Larson, Jordan H / Rutledge, Rachel / Hunnell, Laura / Choi, Daniel K / Kellogg, Robert G / Naran, Sanjay

    Plastic and reconstructive surgery. Global open

    2021  Volume 9, Issue 4, Page(s) e3534

    Abstract: Background: Congenital midline nasal masses are rare anomalies and are typically benign nasal dermoid sinus cysts (NDSCs). Rhabdomyosarcomas (RMSs) are even less common, and only a fraction affect sites like the external nose, nasal cavity, nasopharynx, ...

    Abstract Background: Congenital midline nasal masses are rare anomalies and are typically benign nasal dermoid sinus cysts (NDSCs). Rhabdomyosarcomas (RMSs) are even less common, and only a fraction affect sites like the external nose, nasal cavity, nasopharynx, and paranasal sinuses. We review the clinical presentation and treatment of nasal, nasopharyngeal, and paranasal RMSs and report the first documented midline presentation.
    Methods: We queried PubMed for articles with titles containing the terms rhabdomyosarcoma or sarcoma botryoides and nose, nasal, paranasal, sinonasal, nasopharynx, or nasopharyngeal. We then searched the references of each included article using the same parameters and continued this process iteratively until no new articles were found.
    Results: The paranasal sinuses were the most commonly affected site, followed by the nasopharynx, nasal cavity, and external nose. Two patients presented with involvement of the external nose, but each presented with involvement of the right ala rather than a midline mass. The rates of intracranial extension and/or skull base involvement were comparable to those of NDSCs. The alveolar subtype was most common, followed by the embryonal subtype.
    Conclusions: Most midline nasal masses are benign; however, we report the first documented presentation of an RMS as a midline nasal mass. Accordingly, RMS should be included in the differential diagnosis of midline nasal masses in the pediatric population. Surgery for midline nasal masses is sometimes delayed due to the risks of interfering with developing structures and early anesthesia. However, early surgical treatment should be considered given this new differential and its predilection for early metastasis.
    Language English
    Publishing date 2021-04-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2851682-5
    ISSN 2169-7574 ; 2169-7574
    ISSN (online) 2169-7574
    ISSN 2169-7574
    DOI 10.1097/GOX.0000000000003534
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: A Java program for LRE-based real-time qPCR that enables large-scale absolute quantification.

    Rutledge, Robert G

    PloS one

    2011  Volume 6, Issue 3, Page(s) e17636

    Abstract: Background: Linear regression of efficiency (LRE) introduced a new paradigm for real-time qPCR that enables large-scale absolute quantification by eliminating the need for standard curves. Developed through the application of sigmoidal mathematics to ... ...

    Abstract Background: Linear regression of efficiency (LRE) introduced a new paradigm for real-time qPCR that enables large-scale absolute quantification by eliminating the need for standard curves. Developed through the application of sigmoidal mathematics to SYBR Green I-based assays, target quantity is derived directly from fluorescence readings within the central region of an amplification profile. However, a major challenge of implementing LRE quantification is the labor intensive nature of the analysis.
    Findings: Utilizing the extensive resources that are available for developing Java-based software, the LRE Analyzer was written using the NetBeans IDE, and is built on top of the modular architecture and windowing system provided by the NetBeans Platform. This fully featured desktop application determines the number of target molecules within a sample with little or no intervention by the user, in addition to providing extensive database capabilities. MS Excel is used to import data, allowing LRE quantification to be conducted with any real-time PCR instrument that provides access to the raw fluorescence readings. An extensive help set also provides an in-depth introduction to LRE, in addition to guidelines on how to implement LRE quantification.
    Conclusions: The LRE Analyzer provides the automated analysis and data storage capabilities required by large-scale qPCR projects wanting to exploit the many advantages of absolute quantification. Foremost is the universal perspective afforded by absolute quantification, which among other attributes, provides the ability to directly compare quantitative data produced by different assays and/or instruments. Furthermore, absolute quantification has important implications for gene expression profiling in that it provides the foundation for comparing transcript quantities produced by any gene with any other gene, within and between samples.
    MeSH term(s) Automation ; DNA, Complementary/analysis ; DNA, Complementary/genetics ; Databases, Genetic ; Linear Models ; Reverse Transcriptase Polymerase Chain Reaction/methods ; Software ; Time Factors ; User-Computer Interface
    Chemical Substances DNA, Complementary
    Language English
    Publishing date 2011-03-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0017636
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  9. Article ; Online: PC-PEP, a Comprehensive Daily Six-Month Home-Based Patient Empowerment Program Leads to Weight Loss in Men with Prostate Cancer: A Secondary Analysis of a Clinical Trial.

    MacNevin, Wyatt / Ilie, Gabriela / Rendon, Ricardo / Mason, Ross / Spooner, Jesse / Chedrawe, Emily / Patil, Nikhilesh / Bowes, David / Bailly, Greg / Bell, David / Wilke, Derek / Zahavich, Jeffery B L / MacDonald, Cody / Rutledge, Robert David Harold

    Current oncology (Toronto, Ont.)

    2024  Volume 31, Issue 3, Page(s) 1667–1688

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Male ; Humans ; Patient Participation ; Prostatic Neoplasms/therapy ; Exercise ; Weight Loss ; Exercise Therapy
    Language English
    Publishing date 2024-03-21
    Publishing country Switzerland
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 1236972-x
    ISSN 1718-7729 ; 1198-0052
    ISSN (online) 1718-7729
    ISSN 1198-0052
    DOI 10.3390/curroncol31030127
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  10. Article ; Online: Anxiety and depression symptoms in adult males in Atlantic Canada with or without a lifetime history of prostate cancer.

    Ilie, Gabriela / Rutledge, Robert / Sweeney, Ellen

    Psycho-oncology

    2019  Volume 29, Issue 2, Page(s) 280–286

    Abstract: Objective: Prostate cancer (PCa) is the most prevalent form of cancer among men and has one of the most favorable survival rates among all cancers. Here we examine the association between depression and anxiety symptoms in a population-based sample of ... ...

    Abstract Objective: Prostate cancer (PCa) is the most prevalent form of cancer among men and has one of the most favorable survival rates among all cancers. Here we examine the association between depression and anxiety symptoms in a population-based sample of men.
    Methods: A cross-sectional analysis was conducted on a subsample of 6 585 male participants aged 49-69 from 2009 to 2015 survey cycle of the Atlantic PATH. Mild, moderate or severe depression or anxiety indicators were primary outcomes and were assessed using the Generalized Anxiety Disorder (GAD-7) scale and the Patient Health Questionnaire (PHQ-9). The presence of a lifetime history of PCa, other forms of cancer (except PCa) or absence of either was the main predictor variable.
    Results: An estimated 3.9% of men self-identified as having had a history of PCa diagnosis, 11.3% of men identified as having had a history of other forms of cancer and 84.9% reported never having had a diagnosis of cancer in their lifetime, respectively. Survivors of PCa had 2.45 or 2.05 statistically significantly higher odds of screening positive for current anxiety or depressive symptoms, respectively, compared with those who identified as without a lifetime history of any form of cancer in controlled analyses (including survivorship time).
    Conclusions: Increased rates of anxiety and depression among men with a history of PCa highlight the need for mental health screening among PCa survivors. The findings highlight the importance of a multidisciplinary effort to prioritize and deliver comprehensive mental health support to PCa survivors.
    MeSH term(s) Aged ; Anxiety/epidemiology ; Anxiety/psychology ; Canada/epidemiology ; Cancer Survivors/psychology ; Cancer Survivors/statistics & numerical data ; Cross-Sectional Studies ; Depression/epidemiology ; Depression/psychology ; Humans ; Male ; Middle Aged ; Prostatic Neoplasms/epidemiology ; Prostatic Neoplasms/psychology
    Language English
    Publishing date 2019-12-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1118536-3
    ISSN 1099-1611 ; 1057-9249
    ISSN (online) 1099-1611
    ISSN 1057-9249
    DOI 10.1002/pon.5244
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