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  1. Article ; Online: An Organocatalytic Oxy-Cope/Michael Cascade Reaction.

    Barrett, Ryan R G / Campbell, Donald A / Gleason, James L

    Organic letters

    2023  Volume 25, Issue 5, Page(s) 777–781

    Abstract: ... an intramolecular Michael reaction to furnish cyclopentane-containing products. The reaction proceeds with a range ...

    Abstract Ethyl diazepane carboxylate catalyzes the oxy-Cope rearrangement of 4-hydroxy- and 4-alkoxy-1,5-hexadiene-2-carboxaldehydes via iminium ion activation. The resulting intermediate undergoes an intramolecular Michael reaction to furnish cyclopentane-containing products. The reaction proceeds with a range of substrates, including both cyclic and acyclic substrates, and tolerates substitution on the vinyl substituent. Substrates fused on a cycloalkane framework undergo net ring expansion/cyclopentannulation with a high degree of stereocontrol via chairlike transition states. The reaction extends iminium organocatalysis to the oxy-Cope rearrangement, embedded within a complexity-generating cascade transformation.
    Language English
    Publishing date 2023-01-26
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.2c04269
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Inhibition of mammalian legumain by Michael acceptors and AzaAsn-halomethylketones.

    Niestroj, André J / Feussner, Kirstin / Heiser, Ulrich / Dando, Pam M / Barrett, Alan / Gerhartz, Bernd / Demuth, Hans-Ulrich

    Biological chemistry

    2002  Volume 383, Issue 7-8, Page(s) 1205–1214

    Abstract: ... inhibitors such as cystatin C. A series of Michael acceptor inhibitors based on the backbone Cbz-L-Ala-L-Ala ...

    Abstract Legumain is a lysosomal cysteine peptidase specific for an asparagine residue in the P1-position. It has been classified as a member of clan CD peptidases due to predicted structural similarities to caspases and gingipains. So far, inhibition studies on legumain are limited by the use of endogenous inhibitors such as cystatin C. A series of Michael acceptor inhibitors based on the backbone Cbz-L-Ala-L-Ala-L-Asn (Cbz= benzyloxycarbonyl) has been prepared and resulted in an irreversible inhibition of porcine legumain. Variation of the molecular size within the 'war head' revealed the best inhibition for the compound containing the allyl ester (kobs/I=766 M(-1) s(-1)). To overcome cyclisation between the amide moiety of the Asn residue and the 'war head', several asparagine analogues have been synthesised. Integrated in halomethylketone inhibitors, azaasparagine is accepted by legumain in the P1-position. The most potent inhibitor of this series, Cbz-L-Ala-L-Ala-AzaAsn-chloromethylketone, displays a k(obs)/I value of 139,000 M(-1) s(-1). Other cysteine peptidases, such as papain and cathepsin B, are not inhibited by this compound at concentrations up to 100 microM. The synthetic inhibitors described here represent useful tools for the investigation of the structural and physiological properties of this unique asparagine-specific peptidase.
    MeSH term(s) Animals ; Asparagine ; Cysteine Endopeptidases/chemistry ; Fluorescent Dyes ; Ketones/chemical synthesis ; Ketones/chemistry ; Kinetics ; Oligopeptides/chemical synthesis ; Oligopeptides/chemistry ; Protease Inhibitors/chemical synthesis ; Protease Inhibitors/chemistry ; Structure-Activity Relationship ; Swine
    Chemical Substances Fluorescent Dyes ; Ketones ; Oligopeptides ; Protease Inhibitors ; Asparagine (7006-34-0) ; Cysteine Endopeptidases (EC 3.4.22.-)
    Language English
    Publishing date 2002-07
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1334659-3
    ISSN 1437-4315 ; 1431-6730 ; 1432-0355
    ISSN (online) 1437-4315
    ISSN 1431-6730 ; 1432-0355
    DOI 10.1515/BC.2002.133
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  3. Article ; Online: The legacy of penicillin's first patient.

    Barrett, Michael P

    Pharmacological research

    2023  Volume 192, Page(s) 106772

    MeSH term(s) Humans ; History, 20th Century ; Anti-Bacterial Agents/adverse effects ; Penicillins/adverse effects
    Chemical Substances Anti-Bacterial Agents ; Penicillins
    Language English
    Publishing date 2023-04-14
    Publishing country Netherlands
    Document type Historical Article ; Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 1003347-6
    ISSN 1096-1186 ; 0031-6989 ; 1043-6618
    ISSN (online) 1096-1186
    ISSN 0031-6989 ; 1043-6618
    DOI 10.1016/j.phrs.2023.106772
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  4. Book ; Online: Chapter 48 In Vivo Bioluminescence Imaging to Assess Compound Efficacy Against Trypanosoma brucei

    Ritchie, Ryan / Barrett, Michael / Mottram, Jeremy / Myburgh, Elmarie

    2020  

    Keywords Biology, life sciences ; Firefly luciferase, Trypanosoma brucei brucei, In vivo imaging, Bioluminescence
    Size 1 electronic resource (17 pages)
    Publisher Springer Nature
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021044641
    ISBN 9781071602966 ; 1071602969
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Article ; Online: Toddler fractures immobilisation and complications: A retrospective review.

    Coveney, John / Barrett, Michael

    Injury

    2024  Volume 55, Issue 6, Page(s) 111566

    Abstract: Background: A Toddler's Fracture (TF) is classically an isolated, nondisplaced, distal-third diaphyseal tibial spiral fracture in younger children. A TF is stable and has a low risk of complication. There is lack of uniformity as to the optimal ... ...

    Abstract Background: A Toddler's Fracture (TF) is classically an isolated, nondisplaced, distal-third diaphyseal tibial spiral fracture in younger children. A TF is stable and has a low risk of complication. There is lack of uniformity as to the optimal treatment for TF. Immobilisation with full above knee casting, below knee casting, splinting, controlled ankle motion boots and no immobilisation are all strategies currently in use. There is limited data from European centres regarding those treated without immobilisation.
    Methods: A retrospective review of electronic medical and radiology records was performed to identify all children presenting to a multisite department of paediatric emergency medicine in Ireland from January to December 2022. Those with radiologically confirmed TF or a presumptive diagnosis of TF were included. Data retrieved for each child included initial treatment and the number of and reason for ED reattendances relating to the injury in the 6-month period following the injury.
    Results: 166 children were identified, 96 with radiologically confirmed TF and 70 with presumptive diagnosis TF. Girls accounted for 47 % of presentations. Fall from a standing height (33 %) was the most common mechanism. 13 % (22/166) children were managed without immobilisation. Those with radiologically confirmed fracture (91/96) were significantly more likely to be immobilised than those with a presumptive diagnosis (53/70) (p = 0.001). In total 28 patients (17 % of total) represented to the ED within 6 months. The representation rate in those immobilised was 17 %, while in those not immobilised was 13 % (p = 0.66).
    Conclusion: In this cohort, those with no radiological evidence of fracture are more likely to be managed without immobilisation. There was no significant difference in PED representations between those immobilised and not immobilised.
    Language English
    Publishing date 2024-04-12
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 218778-4
    ISSN 1879-0267 ; 0020-1383
    ISSN (online) 1879-0267
    ISSN 0020-1383
    DOI 10.1016/j.injury.2024.111566
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  6. Article ; Online: A child with rare post-traumatic bilateral shoulder deformities.

    Au Yong, Joo Ken / Barrett, Michael / Brenner, Clare

    Emergency medicine journal : EMJ

    2024  Volume 41, Issue 2, Page(s) 113–132

    MeSH term(s) Child ; Humans ; Shoulder ; Upper Extremity
    Language English
    Publishing date 2024-01-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2040124-3
    ISSN 1472-0213 ; 1472-0205
    ISSN (online) 1472-0213
    ISSN 1472-0205
    DOI 10.1136/emermed-2023-213135
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  7. Article ; Online: Spotlight on Age: An Overlooked Construct in Medical Sociology.

    Barrett, Anne E / Michael, Cherish

    Journal of health and social behavior

    2022  Volume 63, Issue 2, Page(s) 177–190

    Abstract: Medical sociology gives limited attention to age-a surprising observation given the aging of the population and the fact that age is among the strongest determinants of health. We examine this issue through an analysis of articles published ... ...

    Abstract Medical sociology gives limited attention to age-a surprising observation given the aging of the population and the fact that age is among the strongest determinants of health. We examine this issue through an analysis of articles published in
    MeSH term(s) Aging ; Gender Identity ; Humans ; Social Behavior ; Sociology ; Sociology, Medical
    Language English
    Publishing date 2022-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218206-3
    ISSN 2150-6000 ; 0022-1465
    ISSN (online) 2150-6000
    ISSN 0022-1465
    DOI 10.1177/00221465221077221
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  8. Article ; Online: High-Resolution Fluoro-Respirometry of Equine Skeletal Muscle.

    Davis, Michael Scott / Barrett, Montana Renae

    Journal of visualized experiments : JoVE

    2023  , Issue 192

    Abstract: Mitochondrial function-oxidative phosphorylation and the generation of reactive oxygen species-is critical in both health and disease. Thus, measuring mitochondrial function is fundamental in biomedical research. Skeletal muscle is a robust source of ... ...

    Abstract Mitochondrial function-oxidative phosphorylation and the generation of reactive oxygen species-is critical in both health and disease. Thus, measuring mitochondrial function is fundamental in biomedical research. Skeletal muscle is a robust source of mitochondria, particularly in animals with a very high aerobic capacity, such as horses, making them ideal subjects for studying mitochondrial physiology. This article demonstrates the use of high-resolution respirometry with concurrent fluorometry, with freshly harvested skeletal muscle mitochondria, to quantify the capacity to oxidize substrates under different mitochondrial states and determine the relative capacities of distinct elements of mitochondrial respiration. Tetramethylrhodamine methylester is used to demonstrate the production of mitochondrial membrane potential resulting from substrate oxidation, including calculation of the relative efficiency of the mitochondria by calculating the relative membrane potential generated per unit of concurrent oxygen flux. The conversion of ADP to ATP results in a change in the concentration of magnesium in the reaction chamber, due to differing affinities of the adenylates for magnesium. Therefore, magnesium green can be used to measure the rate of ATP synthesis, allowing the further calculation of the oxidative phosphorylation efficiency (ratio of phosphorylation to oxidation [P/O]). Finally, the use of Amplex UltraRed, which produces a fluorescent product (resorufin) when combined with hydrogen peroxide, allows the quantification of reactive oxygen species production during mitochondrial respiration, as well as the relationship between ROS production and concurrent respiration. These techniques allow the robust quantification of mitochondrial physiology under a variety of different simulated conditions, thus shedding light on the contribution of this critical cellular component to both health and disease.
    MeSH term(s) Animals ; Horses ; Magnesium ; Reactive Oxygen Species ; Membrane Potential, Mitochondrial ; Muscle, Skeletal ; Adenosine Triphosphate
    Chemical Substances Magnesium (I38ZP9992A) ; Reactive Oxygen Species ; Adenosine Triphosphate (8L70Q75FXE)
    Language English
    Publishing date 2023-02-03
    Publishing country United States
    Document type Journal Article ; Video-Audio Media ; Research Support, Non-U.S. Gov't
    ZDB-ID 2259946-0
    ISSN 1940-087X ; 1940-087X
    ISSN (online) 1940-087X
    ISSN 1940-087X
    DOI 10.3791/65075
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  9. Article ; Online: How Do Social Relationships Affect Later Life Planning?

    Barrett, Anne E / Mimbs, Hope / Michael, Cherish / Noblitt, Jessica

    International journal of aging & human development

    2024  , Page(s) 914150241231195

    Abstract: Relatively little is known about how social relationships affect later life planning. Our study focuses on an underexamined aspect of social relationships, frequency of contact - not only with family members but also with friends. Using data from a ... ...

    Abstract Relatively little is known about how social relationships affect later life planning. Our study focuses on an underexamined aspect of social relationships, frequency of contact - not only with family members but also with friends. Using data from a survey of Floridians aged 50 and older conducted between December 2020 and April 2021 (n = 3,832), we examine the association between frequency of contact and five planning types: finances, health care, living arrangements, driving retirement, and end-of-life. We found that more frequent contact was associated with greater likelihood of planning, and this result was largely consistent across types of relationships and types of planning. Our findings suggest that contact with family members and friends may encourage more planning, which could reduce the stress that can accompany later life transitions. Our study offers further evidence of social relationships' centrality to later life well-being and points to the many benefits of enhancing them.
    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 187072-5
    ISSN 1541-3535 ; 0091-4150
    ISSN (online) 1541-3535
    ISSN 0091-4150
    DOI 10.1177/00914150241231195
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  10. Article ; Online: Heel swelling after a fall.

    Bharadwaj, Aniket / Al-Uzri, Muntadhir / Barrett, Michael

    BMJ (Clinical research ed.)

    2023  Volume 380, Page(s) e073684

    MeSH term(s) Humans ; Heel/injuries ; Accidental Falls
    Language English
    Publishing date 2023-02-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj-2022-073684
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