LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 99

Search options

  1. Article ; Online: An Efficient and Improved Coronavirus Herd Immunity Algorithm Using Knowledge-Driven Variable Neighborhood Search for Flexible Job-Shop Scheduling Problems

    Xunde Ma / Li Bi / Xiaogang Jiao / Junjie Wang

    Processes, Vol 11, Iss 1826, p

    2023  Volume 1826

    Abstract: By addressing the flexible job shop scheduling problem (FJSP), this paper proposes a new type of algorithm for the FJSP. We named it the hybrid coronavirus population immunity optimization algorithm. Based on the characteristics of the problem, firstly, ... ...

    Abstract By addressing the flexible job shop scheduling problem (FJSP), this paper proposes a new type of algorithm for the FJSP. We named it the hybrid coronavirus population immunity optimization algorithm. Based on the characteristics of the problem, firstly, this paper redefined the discretized two-stage individual encoding and decoding scheme. Secondly, in order to realize the multi-scale search of the solution space, a multi-population update mechanism is designed, and a collaborative learning method is proposed to ensure the diversity of the population. Then, an adaptive mutation operation is introduced to enrich the diversity of the population, relying on the adaptive adjustment of the mutation operator to balance global search and local search capabilities. In order to realize a directional and efficient neighborhood search, this algorithm proposed a knowledge-driven variable neighborhood search strategy. Finally, the algorithm’s performance comparison experiment is carried out. The minimum makespans on the MK06 medium-scale case and MK10 large-scale case are 58 and 201, respectively. The experimental results verify the effectiveness of the hybrid algorithm.
    Keywords flexible job-shop scheduling ; coronavirus herd immunity algorithm ; multi-population ; adaptive mutation ; variable neighborhood search ; Chemical technology ; TP1-1185 ; Chemistry ; QD1-999
    Subject code 006
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: Genetically Engineered Hamster Models of Dyslipidemia and Atherosclerosis.

    Xian, Xunde / Wang, Yuhui / Liu, George

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2419, Page(s) 433–459

    Abstract: Animal models of human diseases play an extremely important role in biomedical research. Among them, mice are widely used animal models for translational research, especially because of ease of generation of genetically engineered mice. However, because ... ...

    Abstract Animal models of human diseases play an extremely important role in biomedical research. Among them, mice are widely used animal models for translational research, especially because of ease of generation of genetically engineered mice. However, because of the great differences in biology between mice and humans, translation of findings to humans remains a major issue. Therefore, the exploration of models with biological and metabolic characteristics closer to those of humans has never stopped.Although pig and nonhuman primates are biologically similar to humans, their genetic engineering is technically difficult, the cost of breeding is high, and the experimental time is long. As a result, the application of these species as model animals, especially genetically engineered model animals, in biomedical research is greatly limited.In terms of lipid metabolism and cardiovascular diseases, hamsters have several characteristics different from rats and mice, but similar to those in humans. The hamster is therefore an ideal animal model for studying lipid metabolism and cardiovascular disease because of its small size and short reproduction period. However, the phenomenon of zygote division, which was unexpectedly blocked during the manipulation of hamster embryos for some unknown reasons, had plagued researchers for decades and no genetically engineered hamsters have therefore been generated as animal models of human diseases for a long time. After solving the problem of in vitro development of hamster zygotes, we successfully prepared enhanced green fluorescent protein (eGFP) transgenic hamsters by microinjection of lentiviral vectors into the zona pellucida space of zygotes. On this basis, we started the development of cardiovascular disease models using the hamster embryo culture system combined with the novel genome editing technique of clustered regularly interspaced short palindromic repeats (CRISPR )/CRISPR associated protein 9 (Cas9). In this chapter, we will introduce some of the genetically engineered hamster models with dyslipidemia and the corresponding characteristics of these models. We hope that the genetically engineered hamster models can be further recognized and complement other genetically engineered animal models such as mice, rats, and rabbits. This will lead to new avenues and pathways for the study of lipid metabolism and its related diseases.
    MeSH term(s) Animals ; Animals, Genetically Modified ; Atherosclerosis/genetics ; CRISPR-Cas Systems ; Cricetinae ; Disease Models, Animal ; Dyslipidemias/genetics ; Genetic Engineering/methods ; Mice ; Rabbits ; Rats ; Swine
    Language English
    Publishing date 2022-03-02
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-1924-7_26
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Switching from fetal to adult hemoglobin.

    Wang, Xunde / Thein, Swee Lay

    Nature genetics

    2018  Volume 50, Issue 4, Page(s) 478–480

    MeSH term(s) Adult ; Cell Line, Tumor ; DNA-Binding Proteins ; Hemoglobins ; Humans ; Mutation ; Transcription Factors
    Chemical Substances DNA-Binding Proteins ; Hemoglobins ; Transcription Factors
    Language English
    Publishing date 2018-03-20
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1108734-1
    ISSN 1546-1718 ; 1061-4036
    ISSN (online) 1546-1718
    ISSN 1061-4036
    DOI 10.1038/s41588-018-0094-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3613: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 46: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Depletion of ApoA5 aggravates spontaneous and diet-induced nonalcoholic fatty liver disease by reducing hepatic NR1D1 in hamsters.

    Guo, Jiabao / Miao, Guolin / Zhang, Wenxi / Shi, Haozhe / Lai, Pingping / Xu, Yitong / Zhang, Lianxin / Chen, Gonglie / Han, Yufei / Zhao, Ying / Liu, Geroge / Zhang, Ling / Wang, Yuhui / Huang, Wei / Xian, Xunde

    Theranostics

    2024  Volume 14, Issue 5, Page(s) 2036–2057

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Animals ; Cricetinae ; Humans ; Mice ; Non-alcoholic Fatty Liver Disease/metabolism ; Liver/metabolism ; Triglycerides/metabolism ; Hyperlipidemias/metabolism ; Diet, High-Fat/adverse effects ; Mesocricetus ; RNA, Messenger/metabolism ; Mice, Inbred C57BL ; Nuclear Receptor Subfamily 1, Group D, Member 1/metabolism
    Chemical Substances Triglycerides ; RNA, Messenger ; NR1D1 protein, human ; Nuclear Receptor Subfamily 1, Group D, Member 1
    Language English
    Publishing date 2024-02-24
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2592097-2
    ISSN 1838-7640 ; 1838-7640
    ISSN (online) 1838-7640
    ISSN 1838-7640
    DOI 10.7150/thno.91084
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Remodeling Intestinal Microbiota Alleviates Severe Combined Hyperlipidemia-Induced Nonalcoholic Steatohepatitis and Atherosclerosis in LDLR

    Miao, Guolin / Guo, Jiabao / Zhang, Wenxi / Lai, Pingping / Xu, Yitong / Chen, Jingxuan / Zhang, Lianxin / Zhou, Zihao / Han, Yufei / Chen, Gonglie / Chen, Jinxuan / Tao, Yijun / Zheng, Lemin / Zhang, Ling / Huang, Wei / Wang, Yuhui / Xian, Xunde

    Research (Washington, D.C.)

    2024  Volume 7, Page(s) 363

    Abstract: Combined hyperlipidemia (CHL) manifests as elevated cholesterol and triglycerides, associated with fatty liver and cardiovascular diseases. Emerging evidence underscores the crucial role of the intestinal microbiota in metabolic disorders. However, the ... ...

    Abstract Combined hyperlipidemia (CHL) manifests as elevated cholesterol and triglycerides, associated with fatty liver and cardiovascular diseases. Emerging evidence underscores the crucial role of the intestinal microbiota in metabolic disorders. However, the potential therapeutic viability of remodeling the intestinal microbiota in CHL remains uncertain. In this study, CHL was induced in low-density lipoprotein receptor-deficient (LDLR
    Language English
    Publishing date 2024-04-29
    Publishing country United States
    Document type Journal Article
    ISSN 2639-5274
    ISSN (online) 2639-5274
    DOI 10.34133/research.0363
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: Genetically-engineered hamster models: applications and perspective in dyslipidemia and atherosclerosis-related cardiovascular disease.

    Liu, George / Lai, Pingping / Guo, Jiabao / Wang, Yuhui / Xian, Xunde

    Medical review (Berlin, Germany)

    2021  Volume 1, Issue 1, Page(s) 92–110

    Abstract: Cardiovascular disease is the leading cause of morbidity and mortality in both developed and developing countries, in which atherosclerosis triggered by dyslipidemia is the major pathological basis. Over the past 40 years, small rodent animals, such as ... ...

    Abstract Cardiovascular disease is the leading cause of morbidity and mortality in both developed and developing countries, in which atherosclerosis triggered by dyslipidemia is the major pathological basis. Over the past 40 years, small rodent animals, such as mice, have been widely used for understanding of human atherosclerosis-related cardiovascular disease (ASCVD) with the advantages of low cost and ease of maintenance and manipulation. However, based on the concept of precision medicine and high demand of translational research, the applications of mouse models for human ASCVD study would be limited due to the natural differences in metabolic features between mice and humans even though they are still the most powerful tools in this research field, indicating that other species with biological similarity to humans need to be considered for studying ASCVD in future. With the development and breakthrough of novel gene editing technology, Syrian golden hamster, a small rodent animal replicating the metabolic characteristics of humans, has been genetically modified, suggesting that gene-targeted hamster models will provide new insights into the precision medicine and translational research of ASCVD. The purpose of this review was to summarize the genetically-modified hamster models with dyslipidemia to date, and their potential applications and perspective for ASCVD.
    Language English
    Publishing date 2021-10-21
    Publishing country Germany
    Document type Journal Article
    ISSN 2749-9642
    ISSN (online) 2749-9642
    DOI 10.1515/mr-2021-0004
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article: Random forest classifiers trained on simulated data enable accurate short read-based genotyping of structural variants in the alpha globin region at Chr16p13.3.

    Hansen, Nancy F / Wang, Xunde / Tegegn, Mickias B / Liu, Zhi / Gouveia, Mateus H / Hill, Gracelyn / Lin, Jennifer C / Okulosubo, Temiloluwa / Shriner, Daniel / Thein, Swee Lay / Mullikin, James C

    bioRxiv : the preprint server for biology

    2023  

    Abstract: In regions where reads don't align well to a reference, it is generally difficult to characterize structural variation using short read sequencing. Here, we utilize machine learning classifiers and short sequence reads to genotype structural variants in ... ...

    Abstract In regions where reads don't align well to a reference, it is generally difficult to characterize structural variation using short read sequencing. Here, we utilize machine learning classifiers and short sequence reads to genotype structural variants in the alpha globin locus on chromosome 16, a medically-relevant region that is challenging to genotype in individuals. Using models trained only with simulated data, we accurately genotype two hard-to-distinguish deletions in two separate human cohorts. Furthermore, population allele frequencies produced by our methods across a wide set of ancestries agree more closely with previously-determined frequencies than those obtained using currently available genotyping software.
    Language English
    Publishing date 2023-11-27
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.11.27.568683
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article ; Online: Idol Depletion Protects against Spontaneous Atherosclerosis in a Hamster Model of Familial Hypercholesterolemia.

    Liang, Chenxi / Wang, Xiaowei / Peng, Kenan / Lai, Pingping / Liu, Ziwei / Ma, Jiaao / Chen, Xin / Liu, Gang / Zheng, Mingqi / Wang, Yuhui / Yang, Hongyuan / Liu, George / Xian, Xunde / Gao, Mingming

    Oxidative medicine and cellular longevity

    2022  Volume 2022, Page(s) 1889632

    Abstract: Inducible degrader of low-density lipoprotein (LDL) receptor (Idol) is an E3 ubiquitin ligase coded ... ...

    Abstract Inducible degrader of low-density lipoprotein (LDL) receptor (Idol) is an E3 ubiquitin ligase coded by
    MeSH term(s) Animals ; Atherosclerosis ; Cholesterol ; Cricetinae ; Disease Models, Animal ; Hyperlipoproteinemia Type II ; Lipoproteins, LDL ; Liver X Receptors ; Mice
    Chemical Substances Lipoproteins, LDL ; Liver X Receptors ; Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 2022-05-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2455981-7
    ISSN 1942-0994 ; 1942-0994
    ISSN (online) 1942-0994
    ISSN 1942-0994
    DOI 10.1155/2022/1889632
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article: Atherosclerosis: The Involvement of Immunity, Cytokines and Cells in Pathogenesis, and Potential Novel Therapeutics.

    Su, Chang / Lu, Yongzheng / Wang, Zeyu / Guo, Jiacheng / Hou, Yachen / Wang, Xiaofang / Qin, Zhen / Gao, Jiamin / Sun, Zhaowei / Dai, Yichen / Liu, Yu / Liu, Guozhen / Xian, Xunde / Cui, Xiaolin / Zhang, Jinying / Tang, Junnan

    Aging and disease

    2023  Volume 14, Issue 4, Page(s) 1214–1242

    Abstract: As a leading contributor to coronary artery disease (CAD) and stroke, atherosclerosis has become one of the major cardiovascular diseases (CVD) negatively impacting patients worldwide. The endothelial injury is considered to be the initial step of the ... ...

    Abstract As a leading contributor to coronary artery disease (CAD) and stroke, atherosclerosis has become one of the major cardiovascular diseases (CVD) negatively impacting patients worldwide. The endothelial injury is considered to be the initial step of the development of atherosclerosis, resulting in immune cell migration and activation as well as inflammatory factor secretion, which further leads to acute and chronic inflammation. In addition, the inflammation and lipid accumulation at the lesions stimulate specific responses from different types of cells, contributing to the pathological progression of atherosclerosis. As a result, recent studies have focused on using molecular biological approaches such as gene editing and nanotechnology to mediate cellular response during atherosclerotic development for therapeutic purposes. In this review, we systematically discuss inflammatory pathogenesis during the development of atherosclerosis from a cellular level with a focus on the blood cells, including all types of immune cells, together with crucial cells within the blood vessel, such as smooth muscle cells and endothelial cells. In addition, the latest progression of molecular-cellular based therapy for atherosclerosis is also discussed. We hope this review article could be beneficial for the clinical management of atherosclerosis.
    Language English
    Publishing date 2023-08-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2625789-0
    ISSN 2152-5250
    ISSN 2152-5250
    DOI 10.14336/AD.2022.1208
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Depleting LCAT Aggravates Atherosclerosis in LDLR-deficient Hamster with Reduced LDL-Cholesterol Level.

    Lin, Xiao / Zhang, Wei / Yang, Chun / Ma, Ping / He, Kunxiang / Chen, Gonglie / Tao, Yijun / Yan, Haizhao / Yang, Zhao / Zhang, Ling / Fan, Jianglin / Cui, Qinghua / Huang, Wei / Liu, George / Xian, Xunde / Wang, Yuhui

    Journal of advanced research

    2023  

    Abstract: Introduction: Lecithin cholesterol acyltransferase (LCAT) plays a crucial role in acyl-esterifying cholesterol in plasma, which is essential for reverse cholesterol transport (RCT). Previous studies indicated that its activity on both α and β ... ...

    Abstract Introduction: Lecithin cholesterol acyltransferase (LCAT) plays a crucial role in acyl-esterifying cholesterol in plasma, which is essential for reverse cholesterol transport (RCT). Previous studies indicated that its activity on both α and β lipoproteins interpret its effects on lipoproteins for many controversial investigations of atherosclerosis.
    Objectives: To better understand the relationship between LCAT, diet-induced dyslipidemia and atherosclerosis, we developed a double knockout (LCAT-/-&LDLR-/-, DKO) hamster model to evaluate the specific role of LCAT independent of LDL clearance effects.
    Methods: Plasma triglyceride (TG), total cholesterol (TC), high-density lipoprotein-cholesterol (HDL-C), and free cholesterol (FC) levels were measured using biochemical reagent kits. FPLC was performed to analyze the components of lipoproteins. Apolipoprotein content was assessed using western blotting (WB). The hamsters were fed a high cholesterol/high fat diet (HCHFD) to induce atherosclerosis. Oil Red O staining was employed to detect plaque formation. Peritoneal macrophages were studied to investigate the effects of LCAT on cholesterol uptake and efflux.
    Results: On HCHFD, DKO hamsters exhibited significantly elevated levels of TG and FC, while HDL-C was nearly undetectable without affecting TC levels, as compared to low-density lipoprotein receptor (LDLR)-deficient (LDLR-/-, LKO) hamsters. Lipoprotein profiling revealed a marked increase in plasma chylomicron/very low-density lipoprotein (CM/VLDL) fractions, along with an unexpected reduction in LDL fraction in DKO hamsters. Furthermore, DKO hamsters displayed aggravated atherosclerotic lesions in the aorta, aortic root, and coronary artery relative to LKO hamsters, attributed to a pro-atherogenic lipoprotein profile and impaired cholesterol efflux in macrophages.
    Conclusions: Our study demonstrates the beneficial role of LCAT in inhibiting atherosclerotic development and highlights the distinctive lipid metabolism characteristics in hamsters with familial hypercholesterolemia.
    Language English
    Publishing date 2023-11-02
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2541849-X
    ISSN 2090-1224 ; 2090-1224
    ISSN (online) 2090-1224
    ISSN 2090-1224
    DOI 10.1016/j.jare.2023.10.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top