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  1. Article ; Online: Green Synthesized Polymeric Iodophors with Thyme as Antimicrobial Agents.

    Edis, Zehra / Bloukh, Samir Haj / Sara, Hamed Abu / Bloukh, Iman Haj

    International journal of molecular sciences

    2024  Volume 25, Issue 2

    Abstract: Antimicrobial resistance (AMR) is a growing concern for the future of mankind. Common antibiotics fail in the treatment of microbial infections at an alarming rate. Morbidity and mortality rates increase, especially among immune-compromised populations. ... ...

    Abstract Antimicrobial resistance (AMR) is a growing concern for the future of mankind. Common antibiotics fail in the treatment of microbial infections at an alarming rate. Morbidity and mortality rates increase, especially among immune-compromised populations. Medicinal plants and their essential oils, as well as iodine could be potential solutions against resistant pathogens. These natural antimicrobials abate microbial proliferation, especially in synergistic combinations. We performed a simple, one-pot synthesis to prepare our formulation with polyvinylpyrrolidone (PVP)-complexed iodine (I
    MeSH term(s) Thymus Plant ; Iodophors ; Anti-Infective Agents/pharmacology ; Anti-Bacterial Agents/pharmacology ; Povidone-Iodine ; Iodine ; Gossypium ; Polymers
    Chemical Substances Iodophors ; Anti-Infective Agents ; Anti-Bacterial Agents ; Povidone-Iodine (85H0HZU99M) ; Iodine (9679TC07X4) ; Polymers
    Language English
    Publishing date 2024-01-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25021133
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Antimicrobial V-Shaped Copper(II) Pentaiodide: Insights to Bonding Pattern and Susceptibility.

    Edis, Zehra / Bloukh, Samir Haj

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 19

    Abstract: Antimicrobial resistance (AMR) is a major concern for the survival of mankind. COVID-19 accelerated another silent pandemic of AMR through the uncontrolled use of antibiotics and biocides. New generations of antimicrobial agents are needed to combat ... ...

    Abstract Antimicrobial resistance (AMR) is a major concern for the survival of mankind. COVID-19 accelerated another silent pandemic of AMR through the uncontrolled use of antibiotics and biocides. New generations of antimicrobial agents are needed to combat resistant pathogens. Crown ethers can be used as models for drug action because they are similar to antibiotics. Iodine is a well-known microbicide but is characterized by instability and short-term effectivity. Iodine can be stabilized in the form of polyiodides that have a rich topology but are dependent on their immediate surroundings. In addition, copper has been successfully used since the beginning of history as a biocidal agent. We, therefore, combined iodine and copper with the highly selective crown ether 1,4,7,10-tetraoxacyclododecane (12-crown-4). The morphology and composition of the new pentaiodide [Cu(12-crown-4)
    MeSH term(s) Anti-Bacterial Agents ; Anti-Infective Agents/chemistry ; Anti-Infective Agents/pharmacology ; COVID-19 ; Copper/chemistry ; Crown Ethers/chemistry ; Disinfectants ; Halogens ; Humans ; Iodides ; Iodine/chemistry
    Chemical Substances Anti-Bacterial Agents ; Anti-Infective Agents ; Crown Ethers ; Disinfectants ; Halogens ; Iodides ; Copper (789U1901C5) ; pentaiodide (88385-95-9) ; Iodine (9679TC07X4) ; 12-crown-4 (K6069P2C2A)
    Language English
    Publishing date 2022-09-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27196437
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  3. Article ; Online: Facile Synthesis of Bio-Antimicrobials with "Smart" Triiodides.

    Edis, Zehra / Bloukh, Samir Haj

    Molecules (Basel, Switzerland)

    2021  Volume 26, Issue 12

    Abstract: Multi-drug resistant pathogens are a rising danger for the future of mankind. Iodine ( ... ...

    Abstract Multi-drug resistant pathogens are a rising danger for the future of mankind. Iodine (I
    MeSH term(s) Aloe/chemistry ; Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/chemistry ; Antifungal Agents/chemistry ; Gentamicins/chemistry ; Microbial Sensitivity Tests ; Microscopy, Electron, Scanning/methods ; Nystatin/chemistry ; Plant Extracts/chemistry ; Povidone/chemistry ; Salvia/chemistry ; Salvia officinalis/chemistry ; Spectrometry, X-Ray Emission/methods ; Spectroscopy, Fourier Transform Infrared/methods ; X-Ray Diffraction/methods
    Chemical Substances Anti-Bacterial Agents ; Antifungal Agents ; Gentamicins ; Plant Extracts ; Nystatin (1400-61-9) ; Povidone (FZ989GH94E)
    Language English
    Publishing date 2021-06-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules26123553
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  4. Article ; Online: Facile Synthesis of Antimicrobial Aloe Vera-"Smart" Triiodide-PVP Biomaterials.

    Edis, Zehra / Bloukh, Samir Haj

    Biomimetics (Basel, Switzerland)

    2020  Volume 5, Issue 3

    Abstract: Antibiotic resistance is an eminent threat for the survival of mankind. Nosocomial infections caused by multidrug resistant microorganisms are a reason for morbidity and mortality worldwide. Plant-based antimicrobial agents are based on synergistic ... ...

    Abstract Antibiotic resistance is an eminent threat for the survival of mankind. Nosocomial infections caused by multidrug resistant microorganisms are a reason for morbidity and mortality worldwide. Plant-based antimicrobial agents are based on synergistic mechanisms which prevent resistance and have been used for centuries against ailments. We suggest the use of cost-effective, eco-friendly
    Keywords covid19
    Language English
    Publishing date 2020-09-17
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2313-7673
    ISSN (online) 2313-7673
    DOI 10.3390/biomimetics5030045
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Antimicrobial Biomaterial on Sutures, Bandages and Face Masks with Potential for Infection Control.

    Edis, Zehra / Bloukh, Samir Haj / Sara, Hamed Abu / Azelee, Nur Izyan Wan

    Polymers

    2022  Volume 14, Issue 10

    Abstract: Antimicrobial resistance (AMR) is a challenge for the survival of the human race. The steady rise of resistant microorganisms against the common antimicrobials results in increased morbidity and mortality rates. Iodine and a plethora of plant secondary ... ...

    Abstract Antimicrobial resistance (AMR) is a challenge for the survival of the human race. The steady rise of resistant microorganisms against the common antimicrobials results in increased morbidity and mortality rates. Iodine and a plethora of plant secondary metabolites inhibit microbial proliferation. Antiseptic iodophors and many phytochemicals are unaffected by AMR. Surgical site and wound infections can be prevented or treated by utilizing such compounds on sutures and bandages. Coating surgical face masks with these antimicrobials can reduce microbial infections and attenuate their burden on the environment by re-use. The facile combination of
    Language English
    Publishing date 2022-05-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym14101932
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  6. Article ; Online: Facile Synthesis of Bio-Antimicrobials with “Smart” Triiodides

    Zehra Edis / Samir Haj Bloukh

    Molecules, Vol 26, Iss 3553, p

    2021  Volume 3553

    Abstract: Multi-drug resistant pathogens are a rising danger for the future of mankind. Iodine (I 2 ) is a centuries-old microbicide, but leads to skin discoloration, irritation, and uncontrolled iodine release. Plants rich in phytochemicals have a long history in ...

    Abstract Multi-drug resistant pathogens are a rising danger for the future of mankind. Iodine (I 2 ) is a centuries-old microbicide, but leads to skin discoloration, irritation, and uncontrolled iodine release. Plants rich in phytochemicals have a long history in basic health care. Aloe Vera Barbadensis Miller (AV) and Salvia officinalis L. (Sage) are effectively utilized against different ailments. Previously, we investigated the antimicrobial activities of smart triiodides and iodinated AV hybrids. In this work, we combined iodine with Sage extracts and pure AV gel with polyvinylpyrrolidone (PVP) as an encapsulating and stabilizing agent. Fourier transform infrared spectroscopy (FT-IR), Ultraviolet-visible spectroscopy (UV-Vis), Surface-Enhanced Raman Spectroscopy (SERS), microstructural analysis by scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), and X-Ray-Diffraction (XRD) analysis verified the composition of AV-PVP-Sage-I 2 . Antimicrobial properties were investigated by disc diffusion method against 10 reference microbial strains in comparison to gentamicin and nystatin. We impregnated surgical sutures with our biohybrid and tested their inhibitory effects. AV-PVP-Sage-I 2 showed excellent to intermediate antimicrobial activity in discs and sutures. The iodine within the polymeric biomaterial AV-PVP-Sage-I 2 and the synergistic action of the two plant extracts enhanced the microbial inhibition. Our compound has potential for use as an antifungal agent, disinfectant and coating material on sutures to prevent surgical site infections.
    Keywords iodine ; triiodides ; Salva officinalis L ; Aloe vera ; halogen bonding ; antimicrobial resistance ; Organic chemistry ; QD241-441
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Antimicrobial Hexaaquacopper(II) Complexes with Novel Polyiodide Chains.

    Edis, Zehra / Raheja, Radhika / Bloukh, Samir Haj / Bhandare, Richie R / Sara, Hamid Abu / Reiss, Guido J

    Polymers

    2021  Volume 13, Issue 7

    Abstract: The non-toxic inorganic antimicrobial agents iodine ( ... ...

    Abstract The non-toxic inorganic antimicrobial agents iodine (I
    Language English
    Publishing date 2021-03-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym13071005
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  8. Article: Antimicrobial Properties of

    Haj Bloukh, Samir / Edis, Zehra / Abu Sara, Hamid / Alhamaidah, Mustafa Ameen

    Pharmaceutics

    2021  Volume 13, Issue 9

    Abstract: Antibiotic resistance toward commonly used medicinal drugs is a dangerously growing threat to our existence. Plants are naturally equipped with a spectrum of biomolecules and metabolites with important biological activities. These natural compounds ... ...

    Abstract Antibiotic resistance toward commonly used medicinal drugs is a dangerously growing threat to our existence. Plants are naturally equipped with a spectrum of biomolecules and metabolites with important biological activities. These natural compounds constitute a treasure in the fight against multidrug-resistant microorganisms. The development of plant-based antimicrobials through green synthesis may deliver alternatives to common drugs.
    Language English
    Publishing date 2021-08-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics13091352
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  9. Article ; Online: Meta-Analysis of Cytotoxicity Studies Using Machine Learning Models on Physical Properties of Plant Extract-Derived Silver Nanoparticles.

    Desai, Anjana S / Ashok, Aparna / Edis, Zehra / Bloukh, Samir Haj / Gaikwad, Mayur / Patil, Rajendra / Pandey, Brajesh / Bhagat, Neeru

    International journal of molecular sciences

    2023  Volume 24, Issue 4

    Abstract: Silver nanoparticles (Ag-NPs) demonstrate unique properties and their use is exponentially increasing in various applications. The potential impact of Ag-NPs on human health is debatable in terms of toxicity. The present study deals with MTT(3-(4, 5- ... ...

    Abstract Silver nanoparticles (Ag-NPs) demonstrate unique properties and their use is exponentially increasing in various applications. The potential impact of Ag-NPs on human health is debatable in terms of toxicity. The present study deals with MTT(3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl-tetrazolium-bromide) assay on Ag-NPs. We measured the cell activity resulting from molecules' mitochondrial cleavage through a spectrophotometer. The machine learning models Decision Tree (DT) and Random Forest (RF) were utilized to comprehend the relationship between the physical parameters of NPs and their cytotoxicity. The input features used for the machine learning were reducing agent, types of cell lines, exposure time, particle size, hydrodynamic diameter, zeta potential, wavelength, concentration, and cell viability. These parameters were extracted from the literature, segregated, and developed into a dataset in terms of cell viability and concentration of NPs. DT helped in classifying the parameters by applying threshold conditions. The same conditions were applied to RF to extort the predictions. K-means clustering was used on the dataset for comparison. The performance of the models was evaluated through regression metrics, viz. root mean square error (RMSE) and R
    MeSH term(s) Cell Line ; Machine Learning ; Metal Nanoparticles/toxicity ; Plant Extracts ; Silver/toxicity
    Chemical Substances Plant Extracts ; Silver (3M4G523W1G)
    Language English
    Publishing date 2023-02-20
    Publishing country Switzerland
    Document type Meta-Analysis ; Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24044220
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: An In Vitro and In Vivo Study of the Efficacy and Toxicity of Plant-Extract-Derived Silver Nanoparticles.

    Desai, Anjana S / Singh, Akanksha / Edis, Zehra / Haj Bloukh, Samir / Shah, Prasanna / Pandey, Brajesh / Agrawal, Namita / Bhagat, Neeru

    Journal of functional biomaterials

    2022  Volume 13, Issue 2

    Abstract: Silver nanoparticles (AgNPs) display unique plasmonic and antimicrobial properties, enabling them to be helpful in various industrial and consumer products. However, previous studies showed that the commercially acquired silver nanoparticles exhibit ... ...

    Abstract Silver nanoparticles (AgNPs) display unique plasmonic and antimicrobial properties, enabling them to be helpful in various industrial and consumer products. However, previous studies showed that the commercially acquired silver nanoparticles exhibit toxicity even in small doses. Hence, it was imperative to determine suitable synthesis techniques that are the most economical and least toxic to the environment and biological entities. Silver nanoparticles were synthesized using plant extracts and their physico-chemical properties were studied. A time-dependent in vitro study using HEK-293 cells and a dose-dependent in vivo study using a
    Language English
    Publishing date 2022-05-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2648525-4
    ISSN 2079-4983
    ISSN 2079-4983
    DOI 10.3390/jfb13020054
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