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  1. Article ; Online: Lessons from Japan's sex work decriminalisation in the digital age.

    Suzuki, Yosuke / Sakatsume, Shingo / Hasegawa, Yuko / Tanimoto, Tetsuya

    Lancet (London, England)

    2024  Volume 403, Issue 10424, Page(s) 352–353

    MeSH term(s) Humans ; Japan ; Sex Work
    Language English
    Publishing date 2024-01-25
    Publishing country England
    Document type Letter
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(23)01800-7
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  2. Article: IMiD-Free Interval and IMiDs Sequence: Which Strategy Is Better Suited for Lenalidomide-Refractory Myeloma?

    Suzuki, Kazuhito / Yano, Shingo

    Life (Basel, Switzerland)

    2023  Volume 13, Issue 11

    Abstract: This review discusses immunomodulatory drug (IMiDs) sequencing and IMiD-free interval strategies for lenalidomide-refractory myeloma. IMiDs and proteasome inhibitors (PIs) improve clinical outcomes in patients with myeloma; however, refractoriness to ... ...

    Abstract This review discusses immunomodulatory drug (IMiDs) sequencing and IMiD-free interval strategies for lenalidomide-refractory myeloma. IMiDs and proteasome inhibitors (PIs) improve clinical outcomes in patients with myeloma; however, refractoriness to lenalidomide, a category of IMiD, predicts poor outcomes. Next-generation IMiDs, such as pomalidomide, are effective even for lenalidomide-refractory myeloma. Therefore, an IMiD-sequencing strategy from lenalidomide to pomalidomide would be desirable. PIs are an antimyeloma therapeutic agent with another mode of action that might restore cereblon, a target of IMiDs; therefore, an IMiD-free interval via class switching from lenalidomide to PIs may be a promising alternative for lenalidomide-refractory myeloma. Additionally, the anti-CD38 monoclonal antibody is a key drug for salvage therapy in anti-CD38 monoclonal antibody-naïve patients. In clinical practice, safety profiles and social convenience can play important roles in the choice of combination therapy. In the future, the selection of optimal treatments should be based on the status of the immunological environment and genetic alterations. This review aims to discuss IMiDs sequencing and IMiD-free interval strategies for lenalidomide- refractory myeloma.
    Language English
    Publishing date 2023-11-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life13112229
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  3. Article ; Online: Video-assisted transarterial modified Konno procedure with concurrent myectomy for hypertrophic obstructive cardiomyopathy.

    Suzuki, Hiroyuki / Kotani, Yasuhiro / Sano, Shunji / Kasahara, Shingo

    JTCVS techniques

    2023  Volume 22, Page(s) 261–264

    Language English
    Publishing date 2023-10-20
    Publishing country United States
    Document type Case Reports
    ISSN 2666-2507
    ISSN (online) 2666-2507
    DOI 10.1016/j.xjtc.2023.10.013
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  4. Article: Treatment Strategy for Ultra-High-Risk Multiple Myelomas with Chromosomal Aberrations Considering Minimal Residual Disease Status and Bone Marrow Microenvironment.

    Suzuki, Kazuhito / Yano, Shingo

    Cancers

    2023  Volume 15, Issue 9

    Abstract: Despite the development of anti-myeloma therapeutics, such as proteasome inhibitors, immunomodulatory drugs, anti-CD38 monoclonal antibodies, and autologous stem cell transplantation (ASCT), multiple myeloma remains incurable. A trial treatment combining ...

    Abstract Despite the development of anti-myeloma therapeutics, such as proteasome inhibitors, immunomodulatory drugs, anti-CD38 monoclonal antibodies, and autologous stem cell transplantation (ASCT), multiple myeloma remains incurable. A trial treatment combining four drugs-daratumumab, carfilzomib, lenalidomide, and dexamethasone-followed by ASCT frequently results in minimal residual disease (MRD) negativity and prevents progressive disease in patients with standard- and high-risk cytogenetics; however, it is insufficient to overcome the poor outcomes in patients with ultra-high-risk chromosomal aberration (UHRCA). In fact, MRD status in autografts can predict clinical outcomes after ASCT. Therefore, the current treatment strategy might be insufficient to overcome the negative impact of UHRCA in patients with MRD positivity after the four-drug induction therapy. High-risk myeloma cells lead to poor clinical outcomes not only by aggressive myeloma behavior but also via the generation of a poor bone marrow microenvironment. Meanwhile, the immune microenvironment effectively suppresses myeloma cells with a low frequency of high-risk cytogenetic abnormalities in early-stage myeloma compared to late-stage myeloma. Therefore, early intervention might be key to improving clinical outcomes in myeloma patients. The purpose of this review is to improve clinical outcomes in patients with UHRCA by considering MRD assessment results and improvement of the microenvironment.
    Language English
    Publishing date 2023-04-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15092418
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  5. Article ; Online: Surgical management of a low-birth-weight neonate with ductal-dependent pulmonary circulation.

    Inoue, Yoshinori / Suzuki, Hiroyuki / Kasahara, Shingo / Kotani, Yasuhiro

    The Journal of thoracic and cardiovascular surgery

    2023  Volume 167, Issue 4, Page(s) 1431–1434

    MeSH term(s) Infant, Newborn ; Humans ; Pulmonary Circulation ; Infant, Low Birth Weight ; Birth Weight
    Language English
    Publishing date 2023-08-02
    Publishing country United States
    Document type Case Reports
    ZDB-ID 3104-5
    ISSN 1097-685X ; 0022-5223
    ISSN (online) 1097-685X
    ISSN 0022-5223
    DOI 10.1016/j.jtcvs.2023.07.040
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  6. Article: A Rare Case of Leukemoid Reaction During Mechanical Circulatory Support in a Patient With Severe Heart Failure: An Autopsy Study.

    Kunioka, Shingo / Suzuki, Fumitaka / Nagata, Marino / Tsutsui, Masahiro / Kamiya, Hiroyuki

    Cureus

    2024  Volume 16, Issue 2, Page(s) e54603

    Abstract: The leukemoid reaction (LR) is reported to be caused by severe stress conditions such as infection, malignancies, intoxication, severe hemorrhage, or acute hemolysis; this condition is attributed to a very severe prognosis. Some reports have suggested ... ...

    Abstract The leukemoid reaction (LR) is reported to be caused by severe stress conditions such as infection, malignancies, intoxication, severe hemorrhage, or acute hemolysis; this condition is attributed to a very severe prognosis. Some reports have suggested that the LR was associated with a systemic stress response. A 36-year-old man who required mechanical circulatory support (MCS), including veno-arterial extracorporeal membrane oxygenation and Impella 5.5 due to severe heart failure, was transferred to our hospital. He showed a markedly elevated WBC count and died of multiple organ failure. The autopsy revealed the possibility that leukocytosis might have been due to an LR; however, the cause of the cardiac failure was unknown. To the best of our knowledge, this study is the first to report a rare case of LR in a patient with severe heart failure requiring MCS.
    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.54603
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  7. Article ; Online: Andexanet alpha-induced heparin resistance treated by nafamostat mesylate in a patient undergoing total aortic arch repair for Stanford type A acute aortic dissection: a case report.

    Suzuki, Yasuhito / Kikura, Mutsuhito / Kawashima, Shingo / Kimura, Tetsuro / Nakajima, Yoshiki

    JA clinical reports

    2024  Volume 10, Issue 1, Page(s) 6

    Abstract: Background: Andexanet alfa, an anti-Xa inhibitor antagonist, induces heparin resistance. Here, we report a case of successful management of cardiopulmonary bypass with andexanet alfa-induced heparin resistance using nafamostat mesylate.: Case ... ...

    Abstract Background: Andexanet alfa, an anti-Xa inhibitor antagonist, induces heparin resistance. Here, we report a case of successful management of cardiopulmonary bypass with andexanet alfa-induced heparin resistance using nafamostat mesylate.
    Case presentation: An 84-year-old female, with Stanford type A acute aortic dissection, underwent an emergency surgery for total aortic arch replacement. Andexanet alfa 400 mg was administered preoperatively to antagonize edoxaban, an oral Xa inhibitor. Heparin 300 IU/kg was administered before cardiopulmonary bypass, and the activated clotting time (ACT) was 291 s. The ACT was 361 s after another administration of heparin 200 IU/kg. According to our routine therapy for heparin resistance, an initial dose of nafamostat mesylate 10 mg was administered intravenously, followed by a continuous infusion of 20-30 mg/h. The ACT was prolonged to 500 s, and cardiopulmonary bypass was successfully established thereafter.
    Conclusions: This case report presents the successful management of cardiopulmonary bypass with andexanet alfa-induced heparin resistance using nafamostat mesilate. This report presents the successful management of cardiopulmonary bypass with andexanet alfa-induced heparin resistance using nafamostat mesilate.
    Language English
    Publishing date 2024-01-29
    Publishing country Germany
    Document type Journal Article
    ISSN 2363-9024
    ISSN (online) 2363-9024
    DOI 10.1186/s40981-024-00690-8
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  8. Article ; Online: Sinonasal manifestations of granulomatosis with polyangiitis: A retrospective analysis.

    Tateyama, Kaori / Umemoto, Shingo / Iwano, Shohei / Hirano, Takashi / Suzuki, Masashi

    Auris, nasus, larynx

    2024  Volume 51, Issue 4, Page(s) 625–630

    Abstract: Objective: This study aimed to examine the characteristics of nasal and imaging findings of sinonasal lesions in granulomatosis with polyangiitis (GPA) patients and how these lesions change over time in both the active and remission phases of the ... ...

    Abstract Objective: This study aimed to examine the characteristics of nasal and imaging findings of sinonasal lesions in granulomatosis with polyangiitis (GPA) patients and how these lesions change over time in both the active and remission phases of the disease.
    Methods: We retrospectively reviewed GPA patients with sinonasal lesions who were followed up at our department between January 2005 and December 2020. The following data were collected: age, sex, symptoms at initial presentation, anti-neutrophil cytoplasmic antibody (ANCA) type, and histopathological, nasal (initial and follow-up), and imaging (initial and follow-up) findings.
    Results: This study included 17 patients with GPA aged 30 to 79 years. Computed tomography (CT) of the sinuses showed mucosal thickening in 16 patients, bone thickening in 12, bone destruction in 4, and an orbital invasion mass in 3 at the time of diagnosis. After initiating treatment, mucosal thickening of the sinuses improved in 3 of 16 patients and remained unchanged in 13. Bone thickening at the time of diagnosis remained unchanged in 10 of 12 patients and worsened in 2; 1 patient displayed newly developed bone thickening. Destructive nasal findings on CT were positive for proteinase 3-ANCA.
    Conclusions: Our study revealed that mucosal thickening, bone thickening, bone destruction, and orbital invasion mass were major CT findings in patients with GPA. Intranasal findings such as granulations, crusting, and necrosis were seen in the active phase; moreover, saddle nose, loss of turbinate, and nasal septal perforation were subsequently seen in the course of the disease. Sinonasal findings of GPA vary depending on the disease stage and period.
    Language English
    Publishing date 2024-04-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 604552-2
    ISSN 1879-1476 ; 0385-8146
    ISSN (online) 1879-1476
    ISSN 0385-8146
    DOI 10.1016/j.anl.2024.04.002
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  9. Article ; Online: Physiologic biventricular repair in a patient with unrepaired adult congenital heart disease with severe cyanosis.

    Suzuki, Hiroyuki / Kuroko, Yosuke / Kotani, Yasuhiro / Kasahara, Shingo

    JTCVS techniques

    2022  Volume 15, Page(s) 220–223

    Language English
    Publishing date 2022-08-08
    Publishing country United States
    Document type Case Reports
    ISSN 2666-2507
    ISSN (online) 2666-2507
    DOI 10.1016/j.xjtc.2022.07.020
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  10. Article: Cryoballoon ablation for atrial fibrillation in a patient with esophageal dilatation due to achalasia.

    Nakatani, Yosuke / Sudo, Toshinaga / Suzuki, Junko / Take, Yutaka / Takizawa, Ryoya / Yoshimura, Shingo / Naito, Shigeto

    HeartRhythm case reports

    2023  Volume 9, Issue 7, Page(s) 461–464

    Language English
    Publishing date 2023-04-20
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2834871-0
    ISSN 2214-0271
    ISSN 2214-0271
    DOI 10.1016/j.hrcr.2023.04.010
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