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Article ; Online: Reactivation of low avidity tumor-specific CD8

Sugiyarto, Gessa / Lau, Doreen / Hill, Samuel Luke / Arcia-Anaya, David / Boulanger, Denise S M / Parkes, Eileen / James, Edward / Elliott, Tim

Journal for immunotherapy of cancer

2023 Volume 11, Issue 8

Abstract: Background: CD8: Methods: CT26 models were treated with anti-PD-1 on days 3, 6 and 9 following subcutaneous tumor implantation generating variable responses during early tumor development. Tetramer staining was performed to determine the frequency ... ...

Abstract	Background: CD8 Methods: CT26 models were treated with anti-PD-1 on days 3, 6 and 9 following subcutaneous tumor implantation generating variable responses during early tumor development. Tetramer staining was performed to determine the frequency and avidity of CD8 Results: Treatment success with anti-PD-1 was associated with the preferential expansion of low avidity (Tet Conclusions: Targeting subdominant T cell responses with lower avidity against pMHC affinity neoepitopes showed potential for improving PD-1 immunotherapy. Future interventions may consider expanding low avidity populations via vaccination or adoptive transfer.
MeSH term(s)	Humans ; Adoptive Transfer ; Apoptosis ; CD8-Positive T-Lymphocytes ; Neoplasms/drug therapy ; Receptors, Antigen, T-Cell ; Immunotherapy
Chemical Substances	Receptors, Antigen, T-Cell
Language	English
Publishing date	2023-08-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2719863-7
ISSN	2051-1426 ; 2051-1426
ISSN (online)	2051-1426
ISSN	2051-1426
DOI	10.1136/jitc-2023-007114
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Tapasin-mediated editing of the MHC I immunopeptidome is epitope specific and dependent on peptide off-rate, abundance, and level of tapasin expression.

Boulanger, Denise S M / Douglas, Leon R / Duriez, Patrick J / Kang, Yoyel / Dalchau, Neil / James, Edd / Elliott, Tim

Frontiers in immunology

2022 Volume 13, Page(s) 956603

Abstract: Tapasin, a component of the major histocompatibility complex (MHC) I peptide loading complex, edits the repertoire of peptides that is presented at the cell surface by MHC I and thereby plays a key role in shaping the hierarchy of CD8+ T-cell responses ... ...

Abstract	Tapasin, a component of the major histocompatibility complex (MHC) I peptide loading complex, edits the repertoire of peptides that is presented at the cell surface by MHC I and thereby plays a key role in shaping the hierarchy of CD8+ T-cell responses to tumors and pathogens. We have developed a system that allows us to tune the level of tapasin expression and independently regulate the expression of competing peptides of different off-rates. By quantifying the relative surface expression of peptides presented by MHC I molecules, we show that peptide editing by tapasin can be measured in terms of "tapasin bonus," which is dependent on both peptide kinetic stability (off-rate) and peptide abundance (peptide supply). Each peptide has therefore an individual tapasin bonus fingerprint. We also show that there is an optimal level of tapasin expression for each peptide in the immunopeptidome, dependent on its off-rate and abundance. This is important, as the level of tapasin expression can vary widely during different stages of the immune response against pathogens or cancer and is often the target for immune escape.
MeSH term(s)	Epitopes ; Histocompatibility Antigens Class I ; Peptides ; Histocompatibility Antigens ; Major Histocompatibility Complex
Chemical Substances	tapasin ; Epitopes ; Histocompatibility Antigens Class I ; Peptides ; Histocompatibility Antigens
Language	English
Publishing date	2022-10-31
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.956603
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Article: A Mechanistic Model for Predicting Cell Surface Presentation of Competing Peptides by MHC Class I Molecules.

Boulanger, Denise S M / Eccleston, Ruth C / Phillips, Andrew / Coveney, Peter V / Elliott, Tim / Dalchau, Neil

Frontiers in immunology

2018 Volume 9, Page(s) 1538

Abstract: Major histocompatibility complex-I (MHC-I) molecules play a central role in the immune response to viruses and cancers. They present peptides on the surface of affected cells, for recognition by cytotoxic T cells. Determining which peptides are presented, ...

Abstract	Major histocompatibility complex-I (MHC-I) molecules play a central role in the immune response to viruses and cancers. They present peptides on the surface of affected cells, for recognition by cytotoxic T cells. Determining which peptides are presented, and in what proportion, has profound implications for developing effective, medical treatments. However, our ability to predict peptide presentation levels is currently limited. Existing prediction algorithms focus primarily on the binding affinity of peptides to MHC-I, and do not predict the relative abundance of individual peptides on the surface of antigen-presenting cells
Language	English
Publishing date	2018-07-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606827-8
ISSN	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2018.01538
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Article ; Online: Absence of tapasin alters immunodominance against a lymphocytic choriomeningitis virus polytope.

Boulanger, Denise S M / Oliveira, Roberta / Ayers, Lisa / Prior, Stephen H / James, Edward / Williams, Anthony P / Elliott, Tim

Journal of immunology (Baltimore, Md. : 1950)

2010 Volume 184, Issue 1, Page(s) 73–83

Abstract: Tapasin edits the peptide repertoire presented to CD8(+) T cells by favoring loading of slow off-rate peptides on MHC I molecules. To investigate the role of tapasin on T cell immunodominance we used poxvirus viral vectors expressing a polytope of ... ...

Abstract	Tapasin edits the peptide repertoire presented to CD8(+) T cells by favoring loading of slow off-rate peptides on MHC I molecules. To investigate the role of tapasin on T cell immunodominance we used poxvirus viral vectors expressing a polytope of lymphocytic choriomeningitis virus epitopes with different off-rates. In tapasin-deficient mice, responses to subdominant fast off-rate peptides were clearly favored. This alteration of the CD8(+) T cell hierarchy was a consequence of tapasin editing and not a consequence of the alteration of the T cell repertoire in tapasin-deficient mice, because bone marrow chimeric mice (wild-type recipients reconstituted with tapasin knockout bone marrow) showed the same hierarchy as the tapasin knockout mice. Tapasin editing is therefore a contributing factor to the phenomenon of immunodominance. Although tapasin knockout cells have low MHC I surface expression, Ag presentation was efficient and resulted in strong T cell responses involving T cells with increased functional avidity. Therefore, in this model, tapasin-deficient mice do not have a reduced but rather have an altered immune response.
MeSH term(s)	Animals ; Antigen Presentation/immunology ; CD8-Positive T-Lymphocytes/immunology ; Chromatography, High Pressure Liquid ; Epitopes, T-Lymphocyte/immunology ; Histocompatibility Antigens Class I/immunology ; Immunodominant Epitopes/immunology ; Lymphocyte Activation/immunology ; Lymphocytic choriomeningitis virus/immunology ; Membrane Transport Proteins/immunology ; Membrane Transport Proteins/metabolism ; Mice ; Mice, Knockout
Chemical Substances	Epitopes, T-Lymphocyte ; Histocompatibility Antigens Class I ; Immunodominant Epitopes ; Membrane Transport Proteins ; tapasin
Language	English
Publishing date	2010-01-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.0803489
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Article ; Online: The Human Affectome.

Schiller, Daniela / Yu, Alessandra N C / Alia-Klein, Nelly / Becker, Susanne / Cromwell, Howard C / Dolcos, Florin / Eslinger, Paul J / Frewen, Paul / Kemp, Andrew H / Pace-Schott, Edward F / Raber, Jacob / Silton, Rebecca L / Stefanova, Elka / Williams, Justin H G / Abe, Nobuhito / Aghajani, Moji / Albrecht, Franziska / Alexander, Rebecca / Anders, Silke /

Aragón, Oriana R / Arias, Juan A / Arzy, Shahar / Aue, Tatjana / Baez, Sandra / Balconi, Michela / Ballarini, Tommaso / Bannister, Scott / Banta, Marlissa C / Barrett, Karen Caplovitz / Belzung, Catherine / Bensafi, Moustafa / Booij, Linda / Bookwala, Jamila / Boulanger-Bertolus, Julie / Boutros, Sydney Weber / Bräscher, Anne-Kathrin / Bruno, Antonio / Busatto, Geraldo / Bylsma, Lauren M / Caldwell-Harris, Catherine / Chan, Raymond C K / Cherbuin, Nicolas / Chiarella, Julian / Cipresso, Pietro / Critchley, Hugo / Croote, Denise E / Demaree, Heath A / Denson, Thomas F / Depue, Brendan / Derntl, Birgit / Dickson, Joanne M / Dolcos, Sanda / Drach-Zahavy, Anat / Dubljević, Olga / Eerola, Tuomas / Ellingsen, Dan-Mikael / Fairfield, Beth / Ferdenzi, Camille / Friedman, Bruce H / Fu, Cynthia H Y / Gatt, Justine M / de Gelder, Beatrice / Gendolla, Guido H E / Gilam, Gadi / Goldblatt, Hadass / Gooding, Anne Elizabeth Kotynski / Gosseries, Olivia / Hamm, Alfons O / Hanson, Jamie L / Hendler, Talma / Herbert, Cornelia / Hofmann, Stefan G / Ibanez, Agustin / Joffily, Mateus / Jovanovic, Tanja / Kahrilas, Ian J / Kangas, Maria / Katsumi, Yuta / Kensinger, Elizabeth / Kirby, Lauren A J / Koncz, Rebecca / Koster, Ernst H W / Kozlowska, Kasia / Krach, Sören / Kret, Mariska E / Krippl, Martin / Kusi-Mensah, Kwabena / Ladouceur, Cecile D / Laureys, Steven / Lawrence, Alistair / Li, Chiang-Shan R / Liddell, Belinda J / Lidhar, Navdeep K / Lowry, Christopher A / Magee, Kelsey / Marin, Marie-France / Mariotti, Veronica / Martin, Loren J / Marusak, Hilary A / Mayer, Annalina V / Merner, Amanda R / Minnier, Jessica / Moll, Jorge / Morrison, Robert G / Moore, Matthew / Mouly, Anne-Marie / Mueller, Sven C / Mühlberger, Andreas / Murphy, Nora A / Muscatello, Maria Rosaria Anna / Musser, Erica D / Newton, Tamara L / Noll-Hussong, Michael / Norrholm, Seth Davin / Northoff, Georg / Nusslock, Robin / Okon-Singer, Hadas / Olino, Thomas M / Ortner, Catherine / Owolabi, Mayowa / Padulo, Caterina / Palermo, Romina / Palumbo, Rocco / Palumbo, Sara / Papadelis, Christos / Pegna, Alan J / Pellegrini, Silvia / Peltonen, Kirsi / Penninx, Brenda W J H / Pietrini, Pietro / Pinna, Graziano / Lobo, Rosario Pintos / Polnaszek, Kelly L / Polyakova, Maryna / Rabinak, Christine / Helene Richter, S / Richter, Thalia / Riva, Giuseppe / Rizzo, Amelia / Robinson, Jennifer L / Rosa, Pedro / Sachdev, Perminder S / Sato, Wataru / Schroeter, Matthias L / Schweizer, Susanne / Shiban, Youssef / Siddharthan, Advaith / Siedlecka, Ewa / Smith, Robert C / Soreq, Hermona / Spangler, Derek P / Stern, Emily R / Styliadis, Charis / Sullivan, Gavin B / Swain, James E / Urben, Sébastien / Van den Stock, Jan / Vander Kooij, Michael A / van Overveld, Mark / Van Rheenen, Tamsyn E / VanElzakker, Michael B / Ventura-Bort, Carlos / Verona, Edelyn / Volk, Tyler / Wang, Yi / Weingast, Leah T / Weymar, Mathias / Williams, Claire / Willis, Megan L / Yamashita, Paula / Zahn, Roland / Zupan, Barbra / Lowe, Leroy

Neuroscience and biobehavioral reviews

2023 Volume 158, Page(s) 105450

Abstract: Over the last decades, theoretical perspectives in the interdisciplinary field of the affective sciences have proliferated rather than converged due to differing assumptions about what human affective phenomena are and how they work. These metaphysical ... ...

Abstract	Over the last decades, theoretical perspectives in the interdisciplinary field of the affective sciences have proliferated rather than converged due to differing assumptions about what human affective phenomena are and how they work. These metaphysical and mechanistic assumptions, shaped by academic context and values, have dictated affective constructs and operationalizations. However, an assumption about the purpose of affective phenomena can guide us to a common set of metaphysical and mechanistic assumptions. In this capstone paper, we home in on a nested teleological principle for human affective phenomena in order to synthesize metaphysical and mechanistic assumptions. Under this framework, human affective phenomena can collectively be considered algorithms that either adjust based on the human comfort zone (affective concerns) or monitor those adaptive processes (affective features). This teleologically-grounded framework offers a principled agenda and launchpad for both organizing existing perspectives and generating new ones. Ultimately, we hope the Human Affectome brings us a step closer to not only an integrated understanding of human affective phenomena, but an integrated field for affective research.
MeSH term(s)	Humans ; Arousal ; Emotions
Language	English
Publishing date	2023-11-03
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	282464-4
ISSN	1873-7528 ; 0149-7634
ISSN (online)	1873-7528
ISSN	0149-7634
DOI	10.1016/j.neubiorev.2023.105450
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Article ; Online: The Canadian STOP-PAIN project - Part 2: What is the cost of pain for patients on waitlists of multidisciplinary pain treatment facilities?

Canadian journal of anaesthesia = Journal canadien d'anesthesie

2010 Volume 57, Issue 6, Page(s) 549–558

Abstract: Purpose: The Canadian STOP-PAIN Project was designed to document the human and economic burden of chronic pain in individuals on waitlists of Multidisciplinary Pain Treatment Facilities (MPTF). This paper describes the societal costs of their pain.: ... ...

Abstract	Purpose: The Canadian STOP-PAIN Project was designed to document the human and economic burden of chronic pain in individuals on waitlists of Multidisciplinary Pain Treatment Facilities (MPTF). This paper describes the societal costs of their pain. Methods: A subgroup of 370 patients was selected randomly from The Canadian STOP-PAIN Project. Participants completed a self-administered costing tool (the Ambulatory and Home Care Record) on a daily basis for three months. They provided information about publicly financed resources, such as health care professional consultations and diagnostic tests as well as privately financed costs, including out-of-pocket expenditures and time devoted to seeking, receiving, and providing care. To determine the cost of care, resources were valued using various costing methods, and multivariate linear regression was used to predict total cost. Results: Overall, the median monthly cost of care was $1,462 (CDN) per study participant. Ninety-five percent of the total expenditures were privately financed. The final regression model consisted of the following determinants: educational level, employment status, province, pain duration, depression, and health-related quality of life. This model accounted for 35% of the variance in total expenditure (P < 0.001). Conclusion: The economic burden of chronic pain is substantial in patients on waitlists of MPTFs. Consequently, it is essential to consider this burden when making decisions regarding resource allocation and waitlist assignment for a MPTF. Resource allocation decision-making should include the economic implications of having patients wait for an assessment and for care.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Canada ; Chronic Disease ; Cost of Illness ; Costs and Cost Analysis ; Female ; Humans ; Linear Models ; Male ; Middle Aged ; Multivariate Analysis ; Pain/economics ; Pain Clinics/statistics & numerical data ; Pain Management ; Prospective Studies ; Quality of Life ; Time Factors ; Waiting Lists ; Young Adult
Language	English
Publishing date	2010-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	91002-8
ISSN	1496-8975 ; 0832-610X
ISSN (online)	1496-8975
ISSN	0832-610X
DOI	10.1007/s12630-010-9306-4
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Article ; Online: The Canadian STOP-PAIN project - Part 1: Who are the patients on the waitlists of multidisciplinary pain treatment facilities?

Canadian journal of anaesthesia = Journal canadien d'anesthesie

2010 Volume 57, Issue 6, Page(s) 539–548

Abstract: Purpose: The Canadian STOP-PAIN Project assessed the human and economic burden of chronic pain in individuals on waitlists of Multidisciplinary Pain Treatment Facilities (MPTF). This article presents the patients' bio-psycho-social profile.: Methods: ...

Abstract	Purpose: The Canadian STOP-PAIN Project assessed the human and economic burden of chronic pain in individuals on waitlists of Multidisciplinary Pain Treatment Facilities (MPTF). This article presents the patients' bio-psycho-social profile. Methods: A sample of 728 patients was recruited from waitlists of eight university-affiliated MPTFs across Canada. Subjects completed validated questionnaires to: 1) assess the characteristics and impact of their pain; and 2) evaluate their emotional functioning and quality of life (QoL). Follow-up questionnaires were completed by a subgroup of 271 patients three months later. Results: Close to 2/3 of the participants reported severe pain (> or = 7/10) that interfered substantially with various aspects of their daily living and QoL. Severe or extremely severe levels of depression were common (50.0%) along with suicidal ideation (34.6%). Patients aged > 60 yr were twice as likely to experience severe pain (> or = 7/10) as their younger counterparts (P = 0.002). Patients with frequent sleep problems were more at risk of reporting severe pain (P < or = 0.003). Intense pain was also associated with a greater tendency to catastrophize (P < 0.0001) severe depressive symptoms (P = 0.003) and higher anger levels (P = 0.016). Small but statistically significant changes in pain intensity and emotional distress were observed over a three-month wait time (all P < 0.05). Conclusion: This study highlights the severe impairment that patients experience waiting for treatment in MPTFs. Knowing that current facilities cannot meet the clinical demand, it is clear that effective prevention/treatment strategies are needed earlier in primary and secondary care settings to minimize suffering and chronicity.
MeSH term(s)	Activities of Daily Living/psychology ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Canada ; Chronic Disease ; Cross-Sectional Studies ; Depression/etiology ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Pain/physiopathology ; Pain/psychology ; Pain Clinics/statistics & numerical data ; Pain Management ; Prospective Studies ; Quality of Life ; Severity of Illness Index ; Sleep Wake Disorders/etiology ; Suicide/psychology ; Surveys and Questionnaires ; Time Factors ; Waiting Lists ; Young Adult
Language	English
Publishing date	2010-06
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	91002-8
ISSN	1496-8975 ; 0832-610X
ISSN (online)	1496-8975
ISSN	0832-610X
DOI	10.1007/s12630-010-9305-5
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Article ; Online: 2023 Canadian Surgery Forum: Sept. 20-23, 2023.

Brière, Raphaëlle / Émond, Marce / Benhamed, Axel / Blanchard, Pierre-Gilles / Drolet, Sébastien / Habashi, Rogeh / Golbon, Bahar / Shellenberger, Jonas / Pasternak, Jesse / Merchant, Shaila / La, Julie / Sawhney, Monakshi / Brogly, Susan / Cadili, Lina / Horkoff, Michael / Ainslie, Scott / Demetrick, Jeffrey / Chai, Brian / Wiseman, Kevin /

Hwang, Hamish / Alhumoud, Zainab / Salem, Amro / Lau, Rebecca / Aw, Katherine / Nessim, Carolyn / Gawad, Nada / Alibhai, Kameela / Towaij, Chelsea / Doan, Danielle / Raîche, Isabelle / Valji, Rahim / Turner, Simon / Balmes, Patricia Nicole / Hameed, S Morad / Tan, Jun Guang Kendric / Wijesuriya, Ruwan / Hew, Nicole Lee Chui / Lund, Matthew / Hawel, Jeffrey / Gregor, Jamie / Leslie, Ken / Lenet, Tori / McIsaac, Daniel / Hallet, Julie / Jerath, Angela / Lalu, Manoj / Nicholls, Stuart / Presseau, Justin / Tinmouth, Alan / Verret, Michael / Wherrett, Christopher / Fergusson, Dean / Martel, Guillaume / Sharma, Sahil / McKechnie, Tyler / Talwar, Gaurav / Patel, Janhavi / Heimann, Luke / Doumouras, Aristithes / Hong, Dennis / Eskicioglu, Cagla / Wang, Christine / Guo, Michael / Huang, Longlong / Sun, Shaun / Davis, Noelle / Wang, Julian / Skulsky, Samuel / Sikora, Lindsey / Son, Hyo Jin / Gee, Denise / Gomez, David / Jung, James / Selvam, Rajajee / Seguin, Nieve / Zhang, Lisa / Lacaille-Ranger, Ariane / Moloo, Husein / Follett, Alicia / Holly / Organ, Michael / Pace, David / Balvardi, Saba / Kaneva, Pepa / Semsar-Kazerooni, Koorosh / Mueller, Carmen / Vassiliou, Melina / Al Mahroos, Mohammed / Fiore, Julio F / Schwartzman, Kevin / Feldman, Liane / Karimuddin, Ahmer / Liu, Gui Ping / Crump, Trafford / Sutherland, Jason / Hickey, Kala / Bonisteel, Erin M / Umali, Jurgienne / Dogar, Ibrahim / Warden, Geoffrey / Boone, Darrell / Mathieson, Alexander / Hogan, Michael / Li, Yiran / Best, Gordon / Leong, Rachel / Wiseman, Sam / Alaoui, Ahmed Amine / Hajjar, Roy / Wassef, Evelyne / Metellus, Danny Sebastien / Dagbert, François / Loungnarath, Rasmy / Ratelle, Richard / Schwenter, Frank / Debroux, Éric / Wassef, Ramses / Gagnon-Konamna, Marianne / Pomp, Alfons / Richard, Carole S / Sebajang, Herawaty / Santos, Manuela M / Shi, Ge / Leung, Regina / Lim, Christina / Knowles, Sarah / Parmar, Simran / Debru, Estifanos / Mohamed, Fardowsa / Anakin, Megan / Lee, Yung / Samarasinghe, Yasith / Khamar, Jigish / Petrisor, Bradley / Yang, Ilun / Mughal, Hanaa N / Bhugio, Mumtaz / Gok, Muhammed A / Khan, Usman A / Fernandes, Alisha R / Spence, Richard / Porter, Geoffrey / Hoogerboord, C Marius / Neumann, Katerina / Pillar, Michal / Manhas, Neraj / Melck, Adrienne / Kazi, Tania / Jessani, Ghazal / Tessier, Léa / Archer, Vicki / Park, Lily / Cohen, Dan / Parpia, Sameer / Bhandari, Mohit / Dionne, Joanna / Bolin, Sara / Afford, Rebecca / Armstrong, Madeleine / Grant, Aaron / Van Koughnett, Julie Ann / Clement, Elizabeth / Lange, Claire / Roshan, Aishwi / Scott, Tracy / Nadeau, Kara / Macmillan, Jennifer / Wilson, Jaime / Deschenes, Madeleine / Nurullah, Aruba / Cahill, Caitlin / Chen, Victoria H / Patterson, Keiko M / Wiseman, Sam M / Wen, Betty / Bhudial, Joshua / Barton, Anise / Lie, Jessica / Park, Chan Mi / Yang, Laiji / Gouskova, Natalia / Kim, Dae Hyun / Morris-Janzen, Dunavan / McLellan, Alastair / Archer, Victoria / Cloutier, Zacharie / Berg, Annie / Wiercioch, Wojtek / Labonté, Joëlle / Bisson, Pascale / Bégin, André / Cheng-Oviedo, Sonia Gabriela / Collin, Yves / Hossain, Intekhab / Ellsmere, James / El-Kefraoui, Charbel / Do, Uyen / Miller, Andrew / Kouyoumdjian, Araz / Cui, David / Khorasani, Elahe / Landry, Tara / Amar-Zifkin, Alexandre / Lee, Lawrence / Fiore, Julio / Au, Tran Michelle / Oppenheimer, Mark / Logsetty, Sarvesh / AlShammari, Raghad / AlAbri, Mohammad / Brown, Carl / Raval, Manoj J / Phang, Paul Terry / Bird, Samantha / Baig, Zarrukh / Abu-Omar, Nawaf / Gill, Dilip / Suresh, Soumiya / Ginther, Nathan / Karpinski, Marta / Ghuman, Amandeep / Malik, Peter R A / Zabolotniuk, Taryn / Mashal, Sarah / Boulanger, Nathalie / Watt, Larry / Razek, Tarek / Fata, Paola / Grushka, Jeremy / Wong, Evan G / Landry, Maxim / Mackey, Sarah / Fairbridge, Nicholas / Greene, Alison / Borgoankar, Mark / Kim, Cullen / DeCarvalho, Diana / Wigen, Robin / Walser, Emily / Davidson, Jacob / Dorward, Michael / Muszynski, Leanne / Dann, Celia / Seemann, Natashia / Lam, Jennifer / Harding, Kaitlyn / Lowik, A J / Guinard, Caroline / Ma, Odelle / Mocanu, Valentin / Lin, Andrea / Karmali, Shahzeer / Bigam, David / Greaves, Grant / Parker, Brent / Nguyen, Vu / Ahmed, Azim / Yee, Belinda / Perren, Joël / Norman, Mathew / Grey, Morgan / Perini, Rafael / Jowhari, Fahd / Bak, Adrian / Drung, Jeremy / Allen, Laura / Wiseman, Daniele / Moffat, Bradley / Lee, Jeremy K H / McGuire, Catherine / Tudorache, Mihaela / Park, Lily J / Borges, Flavia K / Nenshi, Rahima / Jacka, Michael / Heels-Ansdell, Diane / Simunovic, Marko / Bogach, Jessica / Serrano, Pablo E / Thabane, Lehana / Devereaux, P J / Farooq, Sauleha / Lester, Erica / Kung, Janice / Bradley, Nori / Ahn, San / Prince, Nicole / Cheng-Boivin, Olivia / Wang, Harry / Quartermain, Liam / Tan, Sherry / Shamess, Jennifer / Simard, Mathilde / Vigil, Humberto / Hanna, Mary / Azam, Riordan / Ko, Gary / Zhu, Mayanne / Raveendran, Yanuga / Lam, Christine / Tang, Janet / Bajwa, Amrit / Englesakis, Marina / Reel, Emma / Cleland, Jordan / Snell, Laura / Lorello, Gianni / Cil, Tulin / Ahn, Hilalion San / Dube, Catherine / Smith, David / Leclerc, Alexie / Rostom, Alaa / Calo, Natalia / Thavorn, Kednapa / Laplante, Simon / Liu, Louis / Khan, Nadia / Okrainec, Allan / Bruyninx, Gladys / Georgescu, Ilinca / Khokhotva, Vladislav / Yang, Shuling / Spoyalo, Karina / Rebello, Thais Ayres / Chhipi-Shrestha, Gyan / Mayson, Kelly / Sadiq, Rehan / Hewage, Kasun / MacNeill, Andrea / Muncner, Susan / Li, Mo Yu / Mihajlovic, Igor / Dykstra, Mark / Snelgrove, Ryan / Wang, Haili / Schweitzer, Christina / Garcha, Ivneet / Jogiat, Uzair / Baracos, Vickie / Turner, Simon R / Eurich, Dean / Filafilo, Heather / Rouhi, Armin / Bédard, Alexandre / Bédard, Eric L R / Patel, Yogita S / Alaichi, Jacob A / Agzarian, John / Hanna, Wael C / Provost, Esther / Shayegan, Bobby / Adili, Anthony / Mistry, Nikkita / Gatti, Anthony A / Farrokhyar, Forough / Xie, Feng / Sullivan, Kerrie A / Liberman, Moishe / Gonzalez, Anne V / Nayak, Rahul / Yasufuku, Kazuhiro / Cross, Sam / Haché, Pier-Luc / Galvaing, Geraud / Simard, Serge / Grégoire, Jocelyn / Bussières, Jean / Lacasse, Yves / Sassi, Sami / Champagne, Catherine / Laliberté, Anne-Sophie / Jeong, Jin Yong / Wilson, Hillary / Blakely, Pam / Dang, Jerry / Sun, Warren / Wong, Clarence / Hakim, Suhail Yaqoob / Azizi, Samim / El-Menyar, Ayman / Rizoli, Sandro / Al-Thani, Hassan / French, Daniel / Li, Chao / Gossen, Shiloh / Bailey, Jon / Tibbo, Phil / Crocker, Candice / Bondzi-Simpson, Adom / Ribeiro, Tiago / Kidane, Biniam / Ko, Michael / Coburn, Natalie / Kulkarni, Girish / Ramzee, Ahmed Faidh / Afifi, Ibrahim / Alani, Mushrek / Chughtai, Talat / Huo, Bright / Manos, Daria / Xu, Zhaolin / Kontouli, Katerina-Maria / Chun, Samuel / Fris, John / Wallace, Allison M R / French, Daniel G / Giffin, Catherine / Dayan, Gabriel / Farivar, Alexander / Weessies, Cara / Robinson, Madeline / Bednarek, Leeann / Buduhan, Gordon / Liu, Richard / Tan, Lawrence / Srinathan, Sadeesh K / Nasralla, Awrad / Safieddine, Najib / Gazala, Sayf / Simone, Carmine / Ahmadi, Negar / Hilzenrat, Roy / Blitz, Maurice / Deen, Shaun / Humer, Michael / Jugnauth, Anand / Kerr, Laura / Sun, Simon / Browne, Ikennah / Patel, Yogita / Hanna, Wael / Loshusan, Brandon / Shamsil, Arefin / Naish, Michael D / Qiabi, Mehdi / Patel, Rajni / Malthaner, Richard / Pooja, Patel / Roberto, Ribeiro / Greg, Hirsch / Daniel, French / Huynh, Caroline / Sharma, Sohat / Vieira, Arthur / Jain, Fagun / Lee, Yejun / Mousa-Doust, Dorsa / Costa, Jonice / Mezei, Michelle / Chapman, Kristine / Briemberg, Hannah / Jack, Kristin / Grant, Kyle / Choi, James / Yee, John / McGuire, Anna L / Abdul, Sami Aftab / Khazoom, Francois / Gilbert, Sebastien / Sundaresan, Sudhir / Jones, Daniel / Seely, Andrew J E / Villeneuve, Patrick J / Maziak, Donna E / Pigeon, Claudie-Anne / Frigault, Jonathan / Roy, Ève-Marie / Bujold-Pitre, Kristopher / Courval, Valérie / Tessier, Lea / Gangam, Nirupa / Lee, Jay / Patel, Ashaka / Ichhpuniani, Simarpreet / Elder, Geoffrey / Chen, Andrew / Logie, Kathleen / Benko, Randy / Castelo, Matthew / Paszat, Lawrence / Hansen, Bettina / Scheer, Adena / Faught, Neil / Nguyen, Lena / Baxter, Nancy / Wu, Kathy / Passos, Edward / Sachdeva, Anjali / Fei, Linda Y N / Caycedo, Antonio / Patel, Sunil / Popa, Teodora / Boudreau, Lee / Grin, Andrea / Wang, Tao / Phang, Terry / Raval, Manoj / Candy, Sydney / Nanda, Kareena / Li, Christine / Kroeker, Karen / Roy, Haven / Helewa, Ramzi M / Johnson, Garrett / Singh, Harminder / Hyun, Eric / Moffatt, Dana / Vergis, Ashley / Balmes, Patricia / Liu, Jerry / Webber, Sandra / Shariff, Farhana / Hochman, Dave / Park, Jason / Robitaille, Stephan / Wang, Anna / Maalouf, Michael / Alali, Naser / Elhaj, Hiba / Liberman, Sender / Charlebois, Patrick / Stein, Barry / Hu, Richard / Williams, Lara / Musselman, Reilly / Lemke, Maddy / Samarasinghe, Nadeesha / Vogt, Kelly / Brackstone, Muriel / Zwiep, Terry / Alam, Armaghan / Ghuman, Anu / James, Nicholas / Laczko, Dora / Lee, Stephanie / Sritharan, Praveen / Hershorn, Olivia / Phang, P Terry / Chen, Alex / Boutros, Marylise / Caminsky, Natasha / Dumitra, Teodora / Faris-Sabboobeh, Sarah / Demian, Marie / Rigas, Georgia / Monton, Olivia / Smith, Allister / Moon, Jeongyoon / Garfinkle, Richard / Vasilevsky, Carol-Ann / Rajabiyazdi, Fateme / Courage, Emily / LeBlanc, Danielle / Benesch, Matthew / Hartwig, Katia / Armstrong, Casey / Engelbrecht, Reniel / Fagan, Mitchell / Borgaonkar, Mark / Shanahan, Jessica / Salama, Ebram / Arsenault, Mylène / Leon, Nathalie / Loiselle, Carmen / Rajabiyazdi, Fatemeh / Brennan, Kelly / Rai, Mandip / Farooq, Ameer / McClintock, Chad / Kong, Weidong / Boukhili, Neyla / Paradis, Tiffany / Liberman, A Sender / Feldman, Liane S / Abner, Deborah / Alam, Tarik / Beyer, Elaine / Evans, Michele / Hill, Mary / Johnston, Debra / Lohnes, Karla / Menard, Svea / Pitcher, Nicole / Sair, Kelly / Smith, Bev / Yarjau, Bonita / LeBlanc, Kimberly / Karimuddin, Ahmer A / Brown, Carl J / MacDonell, Karen / Harvey, Alexandra / Mckechnie, Tyler / Matta, Mirna / Baker, Laura / Hopkins, Jessica / Rochon, Ryan / Buie, Donald / MacLean, Anthony / Macdonald, Hugh / Wiseman, Vanessa / Booth, Chris / Hann, Tim / Ricci, Alessandro / Kakkar, Rohan / Gonzalez, Emmanuel / Fragoso, Gabriela / Oliero, Manon / Rendos, Hervé Vennin / Djediai, Souad / Cuisiniere, Thibault / Laplante, Patrick / Gerkins, Claire / Ajayi, Ayodeji Samuel / Diop, Khoudia / Taleb, Nassima / Thérien, Sophie / Schampaert, Frédéricke / Alratrout, Hefzi / Cailhier, Jean-François / Routy, Bertrand / Annabi, Borhane / Brereton, Nicholas J B / Richard, Carole / Gimon, Tamara / MacRae, Helen / de Buck van Overstraeten, Anthony / Brar, Mantaj / Chadi, Sami / Kennedy, Erin / Rashanov, Pavel / Alsayari, Rehab / Calvé, Annie / Cuisinière, Thibault / Debroux, Eric / Schmocker, Selina / Stotland, Peter / Jhaveri, Kartik / Kirsch, Richard / Alnajem, Hafssah / Alibrahim, Huseen / Giundi, Christian / Munir, Haroon / Safar, Ali / Sabboobeh, Sarah / Holland, Jessica / Abtahi, Sean / Chhor, Allison / Caminsky, Natasha Grace / Moon, Jenny Jeongyoon / Marinescu, Daniel / Pang, Allison / Al-Abri, Mohammed / Gee, Elliott / Morena, Nina / Ben-Zvi, Libby / Hayman, Victoria / Hou, Mary / Nguyen, Diana / Rentschler, Carrie A / Meguerditchian, Ari N / Mir, Zuhaib / Fei, Linda / McKeown, Sandra / Dinchong, Rachelle / Cofie, Nicholas / Dalgarno, Nancy / Cheifetz, Rona / Jaffer, Alisha / Cullinane, Carolyn / Feeney, Gerard / Jalali, Amirhossein / Merrigan, Anne / Baban, Chwanrow / Buckley, Juliette / Tormey, Shona / Wu, Rongrong / Takabe, Kazuaki / O'Brien, Shalana / Kazazian, Karineh / Abdalaty, Ali Hosni / Brezden, Christine / Burkes, Ron / Chen, Eric / Govindarajan, Anand / Jang, Raymond / Lukovic, Jelena / Mesci, Aruz / Quereshy, Fayez / Swallow, Carol / Marini, Wanda / Zheng, Weiyue / Murakami, Kiichi / Ohashi, Pamela / Reedijk, Michael / Ivankovic, Victoria / Han, Lewis / Gresham, Louise / Mallick, Ranjeeta / Auer, Rebecca / Fontebasso, Adam / Lee, Alex / Bernard-Bedard, Ericka / Wong, Boaz / Li, Heidi / Grose, Elysia / Brandts-Longtin, Olivier / Aw, Katie / Abed, Ahmad / Stevenson, James / Sheikh, Rahat / Chen, Richard / Johnson-Obaseki, Stephanie / Hennessey, Rachel Liu / Meneghetti, Adam T / Bildersheim, Michael / Bouchard-Fortier, Antoine / Nelson, Gregg / Mack, Lloyd / Ghasemi, Farhad / Naeini, Mahtab Malekian / Parsyan, Armen / Kaur, Yuvreet / Covelli, Andrea / Elimova, Elena / Panov, Elan / Brierley, James / Burnett, Bev / Eom, Ashley / Kirkwood, David / Hodgson, Nicole / Whelan, Timothy / Levine, Mark / Parvez, Elena / Ng, Deanna / Lee, Kiera / Lu, Yi Qing / Kim, Dae Kyum / Magalhaes, Marco / Grigor, Emma / Arnaout, Angel / Zhang, Jing / Yee, Elliott K / Look Hong, Nicole J / Wright, Frances C / Gandhi, Sonal / Jerzak, Katarzyna J / Eisen, Andrea / Roberts, Amanda / Ben Lustig, Daniel / Quan, May Lynn / Phan, Tien / Cao, Jeff / Bayley, Conrad / Watanabe, Akie / Yao, Susan / Prisman, Eitan / Groot, Gary / Mitmaker, Elliot / Walker, Ross / Wu, Jonn / Lai, Chi Kien / Eskander, Antoine / Wasserman, Jonathan / Mercier, Frederic / Roth, Kathryn / Gill, Sabrina / Villamil, Carlos / Goldstein, David / Munro, Vicki / Pathak, Alok / Lee, Debon / Nguyen, Anne / Rajendran, Luckshi / Claasen, Marco / Ivanics, Tommy / Selzner, Nazia / McGilvray, Ian / Cattral, Mark / Ghanekar, Anand / Moulton, Carol-Anne / Reichman, Trevor / Shwaartz, Chaya / Metser, Ur / Winter, Erin / Gallinger, Steven / Sapisochin, Gonzalo / Glinka, Juan / Waugh, Evelyn / Skaro, Anton / Tang, Epharaim / Charbonneau, Janyssa / Brind'Amour, Alexandre / Turgeon, Alexis F / O'Connor, Sarah / Couture, Thomas / Wang, Yifan / Yoshino, Osamu / Driedger, Michael / Beckman, Michael / Vrochides, Dionisios / Martinie, John / Alabduljabbar, Abdulrahman / Aali, Maral / Lightfoot, Christopher / Gala-Lopez, Boris / Labelle, Maud / D'Aragon, Frédérick / Hirpara, Dhruvin / Irish, Jonathan / Rashid, Mohammed / Martin, Tharsiya / Zhu, Alice / McKnight, Leah / Hunter, Amber / Jayaraman, Shiva / Wei, Alice / Wright, Frances / Mallette, Katlin / Elnahas, Ahmad / Alkhamesi, Nawar / Schlachta, Christopher / Tang, Ephraim / Punnen, Subin / Zhong, Jade / Yang, Yuwei / Streith, Lucas / Yu, Jordan / Chung, Stephen / Kim, Peter / Chartier-Plante, Stephanie / Segedi, Maja / Bleszynski, Michael / White, Molly / Tsang, Melanie E / Lam-Tin-Cheung, Kimberley / Tsang, Melanie / Greene, Brittany / Pouramin, Panthea / Allen, Susan / Evan Nelson, David / Walsh, Mark / Côté, Julien / Rebolledo, Rolando / Borie, Mélanie / Menaouar, Ahmed / Landry, Carolyne / Plasse, Marylène / Létourneau, Richard / Dagenais, Michel / Rong, Zhixia / Roy, André / Beaudry-Simoneau, Eve / Vandenbroucke-Menu, Franck / Lapointe, Réal / Ferraro, Pasquale / Sarkissian, Shant Der / Noiseux, Nicolas / Turcotte, Simon / Haddad, Yara / Bernard, Antoine / Lafortune, Clara / Brassard, Nathalie / Roy, Annie 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Geraldine / Molnar, Amber / Nguyen, Francis / Schneider, Romano / Fecso, Andras B / Sharma, Priya / Maeda, Azusa / Jackson, Timothy / McLean, Cheynne / MacVicar, Sarah / McLennan, Steffane / Purich, Kieran / Birch, Daniel W / Switzer, Noah J / Jeffery, Lisa / Ryley, Alexis / Schellenberg, Morgan / Owattanapanich, Natthida / Emigh, Brent / Nichols, Chance / Dilday, Joshua / Ugarte, Chaiss / Onogawa, Atsushi / Matsushima, Kazuhide / Martin, Matthew J / Inaba, Kenji / Shapiro, Doug / Im, Daniel / Lam, Lydia / Rezende-Neto, Joao / Lemke, Madeline / Leeper, William / Walser, Eric / Bateni, Sarah / Barabash, Victoria / Barr, Austin / Chan, Wing / Warraich, Ahmed / Gillman, Lawrence / Ziesmann, Markus / Momic, Jovana / Yassin, Nouf / Kim, Mella / Makish, Amy / Smith, Shane / Ball, Ian / Moffat, Brad / Parry, Neil / Kroeker, Jenna / Evans, David / Fansia, Nahal / Notik, Chana / Coyle, Guire / Seben, David / Smith, Jaiden / Tanenbaum, Brandy / Freedman, Corey / Nathens, Avery / Fowler, Robert / 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Canadian journal of surgery. Journal canadien de chirurgie

2023 Volume 66, Issue 6 Suppl 1, Page(s) S54–S136

Language	English
Publishing date	2023-12-13
Publishing country	Canada
Document type	Journal Article
ZDB-ID	410651-9
ISSN	1488-2310 ; 0008-428X
ISSN (online)	1488-2310
ISSN	0008-428X
DOI	10.1503/cjs.014223
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Article ; Online: The Canadian STOP-PAIN project: the burden of chronic pain-does sex really matter?

The Clinical journal of pain

2014 Volume 30, Issue 5, Page(s) 443–452

Abstract: Objectives: The Canadian STOP-PAIN Project assessed the human and economic burden of chronic pain (CP) in individuals on waitlists of Canadian multidisciplinary pain treatment facilities. This article focuses on sex differences. Objectives were to (1) ... ...

Abstract	Objectives: The Canadian STOP-PAIN Project assessed the human and economic burden of chronic pain (CP) in individuals on waitlists of Canadian multidisciplinary pain treatment facilities. This article focuses on sex differences. Objectives were to (1) determine the pain characteristics and related biopsychosocial factors that best differentiated women and men with CP; and (2) examine whether public and private costs associated with CP differed according to sex. Materials and methods: Sample consisted of 441 women and 287 men who were evaluated using self-administered questionnaires and a structured interview protocol. A subsample (233 women and 137 men) recorded all pain-related expenditures in a comprehensive diary over 3 months. Results: Results revealed that the burden of illness associated with CP was comparable in both sexes for average and worst pain intensity, pain impact on daily living, quality of life, and psychological well-being. The same was true for pain-related costs. The results of a hierarchical logistic regression analysis, in which sex was treated as the dependent variable, showed that factors that differentiated men and women were: work status, certain circumstances surrounding pain onset, present pain intensity, intake of particular types of pain medication, use of certain pain management strategies, pain beliefs, and utilization of particular health care resources. Discussion: This study suggests that women and men who are referred to multidisciplinary pain treatment facilities do not differ significantly in terms of their pain-related experience. However, the aspects that differ may warrant further clinical attention when assessing and managing pain.
MeSH term(s)	Canada ; Chronic Pain/complications ; Chronic Pain/economics ; Chronic Pain/psychology ; Chronic Pain/therapy ; Cognition Disorders/etiology ; Cost-Benefit Analysis ; Cross-Sectional Studies ; Female ; Follow-Up Studies ; Humans ; Male ; Pain Management/economics ; Pain Management/methods ; Pain Measurement ; Psychiatric Status Rating Scales ; Sex Characteristics ; Surveys and Questionnaires
Language	English
Publishing date	2014-05
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	632582-8
ISSN	1536-5409 ; 0749-8047
ISSN (online)	1536-5409
ISSN	0749-8047
DOI	10.1097/AJP.0b013e3182a0de5e
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Article: Association of donor TNFRSF6 (FAS) gene polymorphism with acute rejection in renal transplant patients: a case-control study.

Cappellesso, Sandrine / Valentin, Jean-François / Giraudeau, Bruno / Boulanger, Marie-Denise / Al-Najjar, Azmi / Büchler, Mathias / Halimi, Jean-Michel / Nivet, Hubert / Bardos, Pierre / Lebranchu, Yvon / Watier, Hervé

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

2003 Volume 19, Issue 2, Page(s) 439–443

Abstract: Background: Genetic factors other than HLA have been reported to be associated with the outcome of organ transplantations. Because binding of FasL to its receptor Fas could play an important role in tubulitis and in the death of graft tubular epithelial ...

Abstract	Background: Genetic factors other than HLA have been reported to be associated with the outcome of organ transplantations. Because binding of FasL to its receptor Fas could play an important role in tubulitis and in the death of graft tubular epithelial cells during kidney allograft rejection, a gene polymorphism recently identified in position -671 in the promoter of the TNFRSF6 gene coding for Fas was investigated in donors. Methods: A case-control study was performed within a cohort of non-hyperimmunized adult patients who had received cadaveric kidney transplants based on the occurrence or absence of acute cellular rejection in the first 6 months after renal transplantation. Each recipient from the acute rejection group (n = 35) was matched for age (+/- 5 years) and number of HLA-DR mismatches with two recipients within the non-acute rejection group (n = 70). Results: The TNFRSF6-GG genotype was more frequent in donors in the group without rejection episodes. In contrast, patients who received a kidney from a TNFRSF6-A carrier were more likely to experience acute rejection episodes (relative risk nearly 2.1). Conclusion: This study suggests that donor TNFRSF6 polymorphism directly or indirectly influences acute kidney rejection episodes.
MeSH term(s)	Adult ; Analysis of Variance ; Base Sequence ; Case-Control Studies ; Female ; Graft Rejection/genetics ; Graft Survival ; HLA-DR Antigens/genetics ; Humans ; Kidney Failure, Chronic/diagnosis ; Kidney Failure, Chronic/surgery ; Kidney Transplantation/adverse effects ; Kidney Transplantation/methods ; Male ; Middle Aged ; Molecular Sequence Data ; Polymerase Chain Reaction ; Polymorphism, Genetic ; Probability ; Promoter Regions, Genetic ; Proportional Hazards Models ; Proteins/genetics ; Receptors, Tumor Necrosis Factor ; Reference Values ; Risk Assessment ; Sensitivity and Specificity ; Tissue Donors ; fas Receptor
Chemical Substances	FAS protein, human ; HLA-DR Antigens ; Proteins ; Receptors, Tumor Necrosis Factor ; fas Receptor
Language	English
Publishing date	2003-07-11
Publishing country	England
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	90594-x
ISSN	1460-2385 ; 0931-0509
ISSN (online)	1460-2385
ISSN	0931-0509
DOI	10.1093/ndt/gfg548
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