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Article ; Online: Diagnosing Disorders of Facial Erythema.

Ohanenye, Chiamaka / Taliaferro, Sumayah / Callender, Valerie D

2023 Volume 41, Issue 3, Page(s) 377–392

Abstract: Identification of specific patterns, shades, and intensity of erythema in the skin has always been critical and fundamental to diagnostic accuracy in dermatology. Erythema is often less noticeable in darker skin types. The interplay of inflammation and ... ...

Abstract	Identification of specific patterns, shades, and intensity of erythema in the skin has always been critical and fundamental to diagnostic accuracy in dermatology. Erythema is often less noticeable in darker skin types. The interplay of inflammation and variance of skin tone contributes to appreciable differences in the clinical appearance of cutaneous disease in darker complexions. In this article, we discuss common disorders that present with facial erythema in skin of color and offer distinguishing features of each disorder to assist the clinician with diagnosing these conditions in the presence of deeply pigmented skin.
MeSH term(s)	Humans ; Rosacea/complications ; Rosacea/diagnosis ; Acne Vulgaris ; Erythema/etiology ; Skin
Language	English
Publishing date	2023-04-18
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	82798-8
ISSN	1558-0520 ; 0733-8635
ISSN (online)	1558-0520
ISSN	0733-8635
DOI	10.1016/j.det.2023.02.004
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Article: The art of prevention: It's too tight-Loosen up and let your hair down.

Mayo, Tiffany T / Callender, Valerie D

International journal of women's dermatology

2021 Volume 7, Issue 2, Page(s) 174–179

Abstract: Traction alopecia is prevalent in patients of color. Its significance in clinical practice may be underemphasized due to the transient nature of the condition; however, it has the potential to become permanent and cause significant psychosocial distress. ...

Abstract	Traction alopecia is prevalent in patients of color. Its significance in clinical practice may be underemphasized due to the transient nature of the condition; however, it has the potential to become permanent and cause significant psychosocial distress. Understanding of afro-textured hair and cultural practices, as well as early recognition and treatment, provides an opportunity to prevent permanent traction alopecia and long-term sequelae.
Language	English
Publishing date	2021-01-29
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2832233-2
ISSN	2352-6475
ISSN	2352-6475
DOI	10.1016/j.ijwd.2021.01.019
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Do Women with Skin of Color Think They Are Well Represented in Skin Aging Prevention Information?

Callender, Valerie D / Harvey, Valerie M / Hartman, Corey L / Gohara, Mona / Khan, Tanya T / Kwan, William / Ginn, Lisa R

The Journal of clinical and aesthetic dermatology

2024 Volume 17, Issue 4, Page(s) 18–22

Abstract: Objective: There are clinical differences in healthy skin requirements and skin-aging features by race and ethnicity. However, individuals of color are underrepresented in dermatology-related medical information. We sought to gather information from ... ...

Abstract	Objective: There are clinical differences in healthy skin requirements and skin-aging features by race and ethnicity. However, individuals of color are underrepresented in dermatology-related medical information. We sought to gather information from women of color regarding their attitudes about the importance of the prevention of skin aging, available information, and perception of representation in skin-aging prevention information. Methods: This study involved an observational, cross-sectional, online survey of women aged 18 to 70 years residing in the United States. Participants were placed into one of seven cohorts based on self-reported race/ethnicity. Relative frequencies of responses were compared across cohorts; adjusted logistic regression was used to assess perception of representation in skin-aging prevention information. Results: The mean age of the 1,646 participants was 44.4 years. The mean (standard deviation) rating (from 0, "not at all important" to 10, "extremely important") of the importance of the prevention of skin aging ranged from 7.3 to 8.2 across the seven cohorts. All cohorts reported the most trusted source of information for skin-aging prevention products and treatments was a skin-care professional, but not all cohorts believed they are well represented in available sources of information. Older age, lower median household income, and a race/ethnicity of Black, Asian, "Other," and "More Than One Race" were less likely to report being well represented. Limitations: People without internet access could not participate, potentially excluding some older and lower-income groups. Conclusion: Women of color are less likely to feel represented in available information on the prevention of skin aging.
Language	English
Publishing date	2024-04-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2571623-2
ISSN	1941-2789
ISSN	1941-2789
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Commentary on Considerations When Treating Cosmetic Concerns in Men of Color.

Callender, Valerie D

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.

2017 Volume 43 Suppl 2, Page(s) S151–S152

MeSH term(s)	Cosmetic Techniques ; Ethnic Groups ; Humans ; Male ; Pigmentation ; Skin Aging
Language	English
Publishing date	2017
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	1227586-4
ISSN	1524-4725 ; 1076-0512
ISSN (online)	1524-4725
ISSN	1076-0512
DOI	10.1097/DSS.0000000000001380
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Article: Comparing the Efficacy and Tolerability of Moderate to Severe Hyperpigmentation and Skin Unevenness.

Callender, Valerie D / Orlinsky, Diane / Simmons-O'Brien, Eva / Nwade, Nina C / Rhodes, Tanya / Byrd, Angel S

Journal of drugs in dermatology : JDD

2024 Volume 23, Issue 1, Page(s) 1260–1265

Abstract: Dyschromia is the result of irregular facial pigmentation. These cutaneous manifestations can have a significant impact on the quality of life of those affected, especially among females and skin of color. In this randomized, double-blinded, two-cell, ... ...

Abstract	Dyschromia is the result of irregular facial pigmentation. These cutaneous manifestations can have a significant impact on the quality of life of those affected, especially among females and skin of color. In this randomized, double-blinded, two-cell, single-center, 16-week clinical study, all subjects had moderate to severe (scores 4-9 on the modified Griffiths Scale) hyperpigmentation and skin unevenness of the face such that approximately 20% of subjects had post-inflammatory hyperpigmentation (PIH), 40% had overall mottled hyperpigmentation, and 40% had superficial melasma (Superficial Melasma was determined by Wood's Lamp Assessment). Study participants received either Product A (proprietary new formulation - Cysteamine HSA) or Product B (current marketed product - Cyspera®) and used the test product either in the morning or at night, beginning with every other day application, and then advanced to every day, or as tolerated. The results revealed that both Product A (Cysteamine HSA) and Product B (Cyspera®) had statistically significant improvement in facial hyperpigmentation and skin unevenness, however, Product A (Cysteamine HSA) had better tolerability results for scaling, peeling, burning, stinging, erythema, and dryness, indicating that Product A (Cysteamine HSA) outperformed Product B (Cyspera®). J Drugs Dermatol. 2024;23(1):1260-1265. doi:10.36849/JDD.7584.
MeSH term(s)	Female ; Humans ; Cysteamine ; Hyperpigmentation/diagnosis ; Hyperpigmentation/drug therapy ; Melanosis/diagnosis ; Melanosis/drug therapy ; Quality of Life ; Skin ; Double-Blind Method
Chemical Substances	Cysteamine (5UX2SD1KE2)
Language	English
Publishing date	2024-01-09
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2145090-0
ISSN	1545-9616
ISSN	1545-9616
DOI	10.36849/JDD.7584
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Article: Biotin Alone or a Science-Driven Nutraceutical Multi-Targeted Approach?

Callender, Valerie D. / Belpulsi, Danamarie

Journal of drugs in dermatology : JDD

2019 Volume 18, Issue 9, Page(s) 952–953

Abstract: ... Popularity? A Comparative Analysis of Clinical Efficacy versus Social Popularity.”1 First, I’d like to thank ...

Abstract	It is with great fervor that I revisit the article published in Journal of Drugs in Dermatology by Soleymani et al, titled “The Infatuation With Biotin Supplementation: Is There Truth Behind Its Rising Popularity? A Comparative Analysis of Clinical Efficacy versus Social Popularity.”1 First, I’d like to thank the authors for raising awareness of the overuse of biotin for hair loss and reminding us of the struggle we are faced with daily when debunking quick-fix myths propagated by media infatuation.
MeSH term(s)	Alopecia ; Biotin ; Dermatology ; Dietary Supplements ; Humans ; Treatment Outcome
Chemical Substances	Biotin (6SO6U10H04)
Language	English
Publishing date	2019-09-16
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2145090-0
ISSN	1545-9616
ISSN	1545-9616
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Article ; Online: Central Centrifugal Cicatricial Alopecia: Challenges and Treatments.

Lawson, Christina N / Bakayoko, Awa / Callender, Valerie D

Dermatologic clinics

2021 Volume 39, Issue 3, Page(s) 389–405

Abstract: Central centrifugal cicatricial alopecia (CCCA) is the most common form of primary scarring alopecia diagnosed in women of African descent. Although the etiology was originally attributed exclusively to hairstyling practices common among women of African ...

Abstract	Central centrifugal cicatricial alopecia (CCCA) is the most common form of primary scarring alopecia diagnosed in women of African descent. Although the etiology was originally attributed exclusively to hairstyling practices common among women of African descent, more recent research on CCCA supports the concept that there are several contributing factors, including variants in gene expression, hair grooming practices that increase fragility on the hair follicle, and associations with other systemic conditions. Treatment of CCCA involves a combination of patient counseling and education on alternative hairstyles, medical therapies, and procedural methods when necessary.
MeSH term(s)	African Americans ; Alopecia/etiology ; Alopecia/therapy ; Cicatrix/etiology ; Cicatrix/therapy ; Female ; Hair ; Hair Follicle/pathology ; Humans
Language	English
Publishing date	2021-05-15
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	82798-8
ISSN	1558-0520 ; 0733-8635
ISSN (online)	1558-0520
ISSN	0733-8635
DOI	10.1016/j.det.2021.03.004
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Article: Benefit of Topical Combination Therapy for Acne: Analyzing Effect Size Using Number Needed to Treat.

Feldman, Steven R / Han, George / Callender, Valerie D / Kircik, Leon H / Bhatia, Neal / Tyring, Stephen K / Zeichner, Joshua A / Gold, Linda Stein

Journal of drugs in dermatology : JDD

2024 Volume 23, Issue 2, Page(s) 42–49

Abstract: Background: Topical acne trials often are confounded by high vehicle response rates and differing outcome measures, making it difficult to compare treatments. Number needed to treat (NNT) can be a simple, clinically meaningful way to indirectly compare ... ...

Abstract	Background: Topical acne trials often are confounded by high vehicle response rates and differing outcome measures, making it difficult to compare treatments. Number needed to treat (NNT) can be a simple, clinically meaningful way to indirectly compare treatment options without head-to-head data. NNT is the number of patients who need to be treated with an intervention to observe one additional patient successfully achieving a desired outcome versus vehicle/placebo. While treatment attributes such as adverse events may not be captured, lower NNT is a good indicator of a more effective treatment. Methods: Following a search of combination topical treatments for acne vulgaris, all treatments that reported pivotal trial efficacy data consistent with the 2018 FDA definition of success were included in NNT analyses. Results: Of 13 treatments, 7 reported 12-week treatment success rates in 11 phase 3 trials, with similar baseline demographics/disease severity. Treatment success ranged from 26.8% with tretinoin 0.1%/benzoyl peroxide (BPO) 3% cream to 50% with triple-combination clindamycin phosphate 1.2%/adapalene 0.15%/BPO 3.1% gel. NNTs for the triple-combination gel were 4 and 5 (from 2 pivotal trials). Adapalene 0.3%/BPO 2.5% gel had an NNT of 5. Tretinoin/BPO had the largest range between trials, with NNTs of 4 and 9. The other 4 treatments had NNTs ranging from 6 to 8. Conclusion: A comparison of combination topical acne treatment trial data, using the same treatment outcome and similar patient populations, resulted in triple-combination clindamycin phosphate/adapalene/BPO gel and adapalene/BPO gel having the most favorable NNTs.J Drugs Dermatol. 2024;23(2):42-49. doi:10.36849/JDD.7927.
MeSH term(s)	Humans ; Dermatologic Agents ; Drug Combinations ; Acne Vulgaris/diagnosis ; Acne Vulgaris/drug therapy ; Acne Vulgaris/chemically induced ; Benzoyl Peroxide ; Adapalene ; Tretinoin/therapeutic use ; Treatment Outcome ; Gels/therapeutic use
Chemical Substances	Dermatologic Agents ; Drug Combinations ; Benzoyl Peroxide (W9WZN9A0GM) ; Adapalene (1L4806J2QF) ; Tretinoin (5688UTC01R) ; Gels
Language	English
Publishing date	2024-02-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2145090-0
ISSN	1545-9616
ISSN	1545-9616
DOI	10.36849/JDD.7927
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Article ; Online: Aesthetic considerations for treating the North American multi-ethnic patient: Thriving in diversity international roundtable series.

Fabi, Sabrina Guillen / Callender, Valerie D / Lee, Wendy W / Dayan, Steven

Journal of cosmetic dermatology

2022

Abstract: Background: The United States is becoming increasingly diverse, and between 2016 and 2019, an increase of 945 832 aesthetic procedures was recorded for Hispanic, African American, and Asian American patients combined. In aesthetics, where outcomes are ... ...

Abstract	Background: The United States is becoming increasingly diverse, and between 2016 and 2019, an increase of 945 832 aesthetic procedures was recorded for Hispanic, African American, and Asian American patients combined. In aesthetics, where outcomes are technique dependent and tied to the clinician's ability to tailor treatment to the needs of individual patients, a knowledge of ethnic differences in anatomy and how aesthetic issues can be safely and effectively addressed in different groups is paramount. Aims: To discuss similarities and difference in anatomy and treatment preferences of patients from a variety of ethnic and racial backgrounds and how these differences may influence the products or techniques utilized to achieve natural-looking results and minimize side effects. Patients/methods: In support of clinicians who wish to serve a diverse patient population, a 6-part international roundtable series focused on diversity in aesthetics was conducted from August 24, 2021, to May 16, 2022. Results: The results of the first roundtable in the series, the North American Multiethnic Patient, are described here. Conclusions: A diverse range of patients can benefit from the tailored use of fillers, fat transfer, neuromodulators, lasers, and energy-based devices, as long as differences in structural support, skin, and aging patterns, are appreciated.
Language	English
Publishing date	2022-09-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2280551-5
ISSN	1473-2165 ; 1473-2130
ISSN (online)	1473-2165
ISSN	1473-2130
DOI	10.1111/jocd.15422
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Article: Skin cancer in women of color: Epidemiology, pathogenesis and clinical manifestations.

Davis, DiAnne S / Robinson, Camille / Callender, Valerie D

International journal of women's dermatology

2021 Volume 7, Issue 2, Page(s) 127–134

Abstract: Malignant melanoma and nonmelanoma skin cancers (NMSC), which include basal cell carcinoma and squamous cell carcinoma, account for 40% of all neoplasms in white patients, making these cancers the most common malignancy in the United States. Given the ... ...

Abstract	Malignant melanoma and nonmelanoma skin cancers (NMSC), which include basal cell carcinoma and squamous cell carcinoma, account for 40% of all neoplasms in white patients, making these cancers the most common malignancy in the United States. Given the large number of NMSC cases in white patients, there is a correspondingly large body of literature addressing various aspects of epidemiology, pathogenesis, and treatment. The incidence of both malignant melanoma and NMSC is well established and remains significantly lower in patients with skin of color (SoC) when compared with white patients. Although there is a lower incidence of skin cancer in SoC, there is often a poorer prognosis among this group. There is even more limited data focusing on women of color, making an accurate determination of incidence and mortality difficult. This gender disparity causes decreased skin cancer awareness and index of suspicion among patients and providers, hindering appropriate evaluation and care. Therefore, there is a need for an increased understanding of skin cancer in women of color. In the traditional sense, SoC refers to people of African, Asian, Native American, Middle Eastern, and Hispanic backgrounds. Patients in these ethnic groups have richly pigmented skin that is usually categorized as Fitzpatrick types III through VI and thus have notable differences in skin disease and presentation compared with fair-skinned individuals. We present this review of skin cancer in women of color to give a reasonably comprehensive representation of the literature to advance our understanding and knowledge in this unique population.
Language	English
Publishing date	2021-02-02
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2832233-2
ISSN	2352-6475
ISSN	2352-6475
DOI	10.1016/j.ijwd.2021.01.017
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