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Article: Advanced imaging shows extra-articular abscesses in two out of three adult patients with septic arthritis of the native hip joint.

Cools, Jordi / Ghijselings, Stijn / Ruythooren, Fred / Jentjens, Sander / Noppe, Nathalie / Metsemakers, Willem-Jan / Vles, Georges

Journal of bone and joint infection

2024 Volume 9, Issue 1, Page(s) 27–35

Abstract: ... ...

Abstract	Background
Language	English
Publishing date	2024-02-02
Publishing country	Germany
Document type	Journal Article
ISSN	2206-3552
ISSN	2206-3552
DOI	10.5194/jbji-9-27-2024
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Article: Should treatment decisions in septic arthritis of the native hip joint be based on the route of infection?

Ruythooren, Fred / Ghijselings, Stijn / Cools, Jordi / Depypere, Melissa / De Munter, Paul / Metsemakers, Willem-Jan / Vles, George

Journal of bone and joint infection

2023 Volume 8, Issue 5, Page(s) 209–218

Abstract: ... ...

Abstract	Background
Language	English
Publishing date	2023-10-12
Publishing country	Germany
Document type	Journal Article
ISSN	2206-3552
ISSN	2206-3552
DOI	10.5194/jbji-8-209-2023
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Book ; Online: Advanced imaging shows extra-articular abscesses in two out of three adult patients with septic arthritis of the native hip joint

Cools, Jordi / Ghijselings, Stijn / Ruythooren, Fred / Jentjens, Sander / Noppe, Nathalie / Metsemakers, Willem-Jan / Vles, Georges

eISSN: 2206-3552

2024

Abstract: Background : Septic arthritis (SA) of the native adult hip is a rare orthopaedic emergency requiring prompt diagnosis and treatment. As clinical presentation and laboratory findings are frequently atypical, advanced imaging is often requested. This ... ...

Abstract	Background : Septic arthritis (SA) of the native adult hip is a rare orthopaedic emergency requiring prompt diagnosis and treatment. As clinical presentation and laboratory findings are frequently atypical, advanced imaging is often requested. This retrospective study aimed to investigate the prevalence and pattern of extra-articular infectious manifestations and their implications for pre-operative advanced imaging in patients with proven SA of the native hip joint. Methods : Out of 41 patients treated surgically for SA of the native hip during a 16-year period at our tertiary referral hospital, 25 received advanced imaging (computed tomography (CT), magnetic resonance imaging (MRI), or fluorodeoxyglucose positron emission tomography (FDG PET-CT)) prior to initial intervention. For each investigation, a specific set of variables was systematically interpreted, and the most suitable surgical approach was determined. The prognostic value was evaluated by comparing specific outcome measures and the extent of extra-articular involvement. Results : It was found that 32 % of patients had an abscess in one anatomical region, 32 % of patients had abscesses in multiple anatomical regions, and only 36 % of patients had no substantial abscess. Gluteal abscesses were especially common in patients with SA due to contiguous spread. Abscesses in the iliopsoas region were more common in patients with SA due to hematogenous seeding. A combination of several different surgical approaches was deemed necessary to adequately deal with the various presentations. No significant prognostic factors could be identified. Conclusion : We recommend performing advanced imaging in patients with suspected or proven septic arthritis of the native hip joint, as extra-articular abscesses are present in 64 % and might require varying anatomical approaches.
Subject code	610
Language	English
Publishing date	2024-02-02
Publishing country	de
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Multiplexed Surface Electrode Arrays Based on Metal Oxide Thin-Film Electronics for High-Resolution Cortical Mapping.

Londoño-Ramírez, Horacio / Huang, Xiaohua / Cools, Jordi / Chrzanowska, Anna / Brunner, Clément / Ballini, Marco / Hoffman, Luis / Steudel, Soeren / Rolin, Cédric / Mora Lopez, Carolina / Genoe, Jan / Haesler, Sebastian

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

2023 Volume 11, Issue 10, Page(s) e2308507

Abstract: Electrode grids are used in neuroscience research and clinical practice to record electrical activity from the surface of the brain. However, existing passive electrocorticography (ECoG) technologies are unable to offer both high spatial resolution and ... ...

Abstract	Electrode grids are used in neuroscience research and clinical practice to record electrical activity from the surface of the brain. However, existing passive electrocorticography (ECoG) technologies are unable to offer both high spatial resolution and wide cortical coverage, while ensuring a compact acquisition system. The electrode count and density are restricted by the fact that each electrode must be individually wired. This work presents an active micro-electrocorticography (µECoG) implant that tackles this limitation by incorporating metal oxide thin-film transistors (TFTs) into a flexible electrode array, allowing to address multiple electrodes through a single shared readout line. By combining the array with an incremental-ΔΣ readout integrated circuit (ROIC), the system is capable of recording from up to 256 electrodes virtually simultaneously, thanks to the implemented 16:1 time-division multiplexing scheme, offering lower noise levels than existing active µECoG arrays. In vivo validation is demonstrated acutely in mice by recording spontaneous activity and somatosensory evoked potentials over a cortical surface of ≈8×8 mm
MeSH term(s)	Animals ; Mice ; Brain Mapping ; Electrodes, Implanted ; Cerebral Cortex/physiology ; Electrocorticography ; Electronics
Language	English
Publishing date	2023-12-25
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2808093-2
ISSN	2198-3844 ; 2198-3844
ISSN (online)	2198-3844
ISSN	2198-3844
DOI	10.1002/advs.202308507
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Book ; Online: Should treatment decisions in septic arthritis of the native hip joint be based on the route of infection?

Ruythooren, Fred / Ghijselings, Stijn / Cools, Jordi / Depypere, Melissa / Munter, Paul / Metsemakers, Willem-Jan / Vles, Georges

eISSN: 2206-3552

2023

Abstract: Background : Surgical management of septic arthritis (SA) of the hip aims at treating the infection by either preserving, resecting or replacing the joint. In some cases, joint preservation should be attempted, whereas other cases would benefit from ... ...

Abstract	Background : Surgical management of septic arthritis (SA) of the hip aims at treating the infection by either preserving, resecting or replacing the joint. In some cases, joint preservation should be attempted, whereas other cases would benefit from immediate joint resection or replacement. Prognostic factors have been proposed to guide decision-making. We hypothesized that most of these factors can be simplified to three subgroups based on the route of infection: contiguous spreading, direct inoculation or hematogenous seeding. Methods : A total of 41 patients have been treated surgically for SA of the native hip at our tertiary hospital during the last 16 years. Medical records were studied, and various patient and disease characteristics were collated. Results : Significant differences between (1) level of fitness, (2) condition of the hip joint, (3) micro-organisms and (4) chance of femoral head preservation were found for patients with SA of the native hip resulting from the three aforementioned subgroups. Femoral head resection was necessary at one point in 85 % of patients. Patients with hematogenous infections of undamaged hips had a reasonable chance (53 %) of avoiding joint resection or replacement. Hip arthroplasty was performed on 46.3 % of patients, with an infection rate of 10.5 %. Conclusion : Patients with SA of the native hip resulting from contiguous spreading, hematogenous seeding or direct inoculation differ significantly and should be considered distinct clinical entities. Route of infection is directly related to the chance of femoral head preservation and should, therefore, guide decision-making. Only patients with hematogenous infection to a previously healthy hip had the possibility of femoral head preservation.
Subject code	616 ; 610
Language	English
Publishing date	2023-10-12
Publishing country	de
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: A Micropatterned Multielectrode Shell for 3D Spatiotemporal Recording from Live Cells.

Cools, Jordi / Jin, Qianru / Yoon, Eugene / Alba Burbano, Diego / Luo, Zhenxiang / Cuypers, Dieter / Callewaert, Geert / Braeken, Dries / Gracias, David H

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

2018 Volume 5, Issue 4, Page(s) 1700731

Abstract: Microelectrode arrays (MEAs) have proved to be useful tools for characterizing electrically active cells such as cardiomyocytes and neurons. While there exist a number of integrated electronic chips for recording from small populations or even single ... ...

Abstract	Microelectrode arrays (MEAs) have proved to be useful tools for characterizing electrically active cells such as cardiomyocytes and neurons. While there exist a number of integrated electronic chips for recording from small populations or even single cells, they rely primarily on the interface between the cells and 2D flat electrodes. Here, an approach that utilizes residual stress-based self-folding to create individually addressable multielectrode interfaces that wrap around the cell in 3D and function as an electrical shell-like recording device is described. These devices are optically transparent, allowing for simultaneous fluorescence imaging. Cell viability is maintained during and after electrode wrapping around the cel and chemicals can diffuse into and out of the self-folding devices. It is further shown that 3D spatiotemporal recordings are possible and that the action potentials recorded from cultured neonatal rat ventricular cardiomyocytes display significantly higher signal-to-noise ratios in comparison with signals recorded with planar extracellular electrodes. It is anticipated that this device can provide the foundation for the development of new-generation MEAs where dynamic electrode-cell interfacing and recording substitutes the traditional method using static electrodes.
Language	English
Publishing date	2018-01-04
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2808093-2
ISSN	2198-3844
ISSN	2198-3844
DOI	10.1002/advs.201700731
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Article ; Online: Towards comparable assessment of the soil nutrient status across scales-Review and development of nutrient metrics.

Van Sundert, Kevin / Radujković, Dajana / Cools, Nathalie / De Vos, Bruno / Etzold, Sophia / Fernández-Martínez, Marcos / Janssens, Ivan A / Merilä, Päivi / Peñuelas, Josep / Sardans, Jordi / Stendahl, Johan / Terrer, César / Vicca, Sara

Global change biology

2019 Volume 26, Issue 2, Page(s) 392–409

Abstract: Nutrient availability influences virtually every aspect of an ecosystem, and is a critical modifier of ecosystem responses to global change. Although this crucial role of nutrient availability in regulating ecosystem structure and functioning has been ... ...

Abstract	Nutrient availability influences virtually every aspect of an ecosystem, and is a critical modifier of ecosystem responses to global change. Although this crucial role of nutrient availability in regulating ecosystem structure and functioning has been widely acknowledged, nutrients are still often neglected in observational and experimental synthesis studies due to difficulties in comparing the nutrient status across sites. In the current study, we explain different nutrient-related concepts and discuss the potential of soil-, plant- and remote sensing-based metrics to compare the nutrient status across space. Based on our review and additional analyses on a dataset of European, managed temperate and boreal forests (ICP [International Co-operative Programme on Assessment and Monitoring of Air Pollution Effects on Forests] Forests dataset), we conclude that the use of plant- and remote sensing-based metrics that rely on tissue stoichiometry is limited due to their strong dependence on species identity. The potential use of other plant-based metrics such as Ellenberg indicator values and plant-functional traits is also discussed. We conclude from our analyses and review that soil-based metrics have the highest potential for successful intersite comparison of the nutrient status. As an example, we used and adjusted a soil-based metric, previously developed for conifer forests across Sweden, against the same ICP Forests data. We suggest that this adjusted and further adaptable metric, which included the organic carbon concentration in the upper 20 cm of the soil (including the organic fermentation-humus [FH] layer), the C:N ratio and
MeSH term(s)	Benchmarking ; Ecosystem ; Forests ; Nitrogen ; Nutrients ; Soil ; Sweden ; Trees
Chemical Substances	Soil ; Nitrogen (N762921K75)
Language	English
Publishing date	2019-09-19
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1281439-8
ISSN	1365-2486 ; 1354-1013
ISSN (online)	1365-2486
ISSN	1354-1013
DOI	10.1111/gcb.14802
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Article: Towards comparable assessment of the soil nutrient status across scales—Review and development of nutrient metrics

Van Sundert, Kevin / Radujković, Dajana / Cools, Nathalie / De Vos, Bruno / Etzold, Sophia / Fernández‐Martínez, Marcos / Janssens, Ivan A / Merilä, Päivi / Peñuelas, Josep / Sardans, Jordi / Stendahl, Johan / Terrer, César / Vicca, Sara

Global change biology. 2020 Feb., v. 26, no. 2

2020

Abstract	Nutrient availability influences virtually every aspect of an ecosystem, and is a critical modifier of ecosystem responses to global change. Although this crucial role of nutrient availability in regulating ecosystem structure and functioning has been widely acknowledged, nutrients are still often neglected in observational and experimental synthesis studies due to difficulties in comparing the nutrient status across sites. In the current study, we explain different nutrient‐related concepts and discuss the potential of soil‐, plant‐ and remote sensing‐based metrics to compare the nutrient status across space. Based on our review and additional analyses on a dataset of European, managed temperate and boreal forests (ICP [International Co‐operative Programme on Assessment and Monitoring of Air Pollution Effects on Forests] Forests dataset), we conclude that the use of plant‐ and remote sensing‐based metrics that rely on tissue stoichiometry is limited due to their strong dependence on species identity. The potential use of other plant‐based metrics such as Ellenberg indicator values and plant‐functional traits is also discussed. We conclude from our analyses and review that soil‐based metrics have the highest potential for successful intersite comparison of the nutrient status. As an example, we used and adjusted a soil‐based metric, previously developed for conifer forests across Sweden, against the same ICP Forests data. We suggest that this adjusted and further adaptable metric, which included the organic carbon concentration in the upper 20 cm of the soil (including the organic fermentation‐humus [FH] layer), the C:N ratio and pHCaCl2 of the FH layer, can be used as a complementary tool along with other indicators of nutrient availability, to compare the background nutrient status across temperate and boreal forests dominated by spruce, pine or beech. Future collection and provision of harmonized soil data from observational and experimental sites is crucial for further testing and adjusting the metric.
Keywords	Fagus ; Picea ; air pollution ; boreal forests ; carbon nitrogen ratio ; coniferous forests ; data collection ; ecosystems ; global change ; monitoring ; nutrient availability ; nutrients ; organic carbon ; soil ; soil nutrients ; stoichiometry ; Sweden
Language	English
Dates of publication	2020-02
Size	p. 392-409.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	REVIEW
ZDB-ID	1281439-8
ISSN	1365-2486 ; 1354-1013
ISSN (online)	1365-2486
ISSN	1354-1013
DOI	10.1111/gcb.14802
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Fratricide-resistant CD1a-specific CAR T cells for the treatment of cortical T-cell acute lymphoblastic leukemia.

Blood

2019 Volume 133, Issue 21, Page(s) 2291–2304

Abstract: Relapsed/refractory T-cell acute lymphoblastic leukemia (T-ALL) has a dismal outcome, and no effective targeted immunotherapies for T-ALL exist. The extension of chimeric antigen receptor (CAR) T cells (CARTs) to T-ALL remains challenging because the ... ...

Abstract	Relapsed/refractory T-cell acute lymphoblastic leukemia (T-ALL) has a dismal outcome, and no effective targeted immunotherapies for T-ALL exist. The extension of chimeric antigen receptor (CAR) T cells (CARTs) to T-ALL remains challenging because the shared expression of target antigens between CARTs and T-ALL blasts leads to CART fratricide. CD1a is exclusively expressed in cortical T-ALL (coT-ALL), a major subset of T-ALL, and retained at relapse. This article reports that the expression of CD1a is mainly restricted to developing cortical thymocytes, and neither CD34
MeSH term(s)	Animals ; Antigens, CD1/immunology ; Drug Resistance, Neoplasm/immunology ; Humans ; Immunotherapy, Adoptive ; Jurkat Cells ; Mice ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/immunology ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/pathology ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/therapy ; Receptors, Chimeric Antigen/immunology ; Xenograft Model Antitumor Assays
Chemical Substances	Antigens, CD1 ; CD1a antigen ; Receptors, Chimeric Antigen
Language	English
Publishing date	2019-02-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80069-7
ISSN	1528-0020 ; 0006-4971
ISSN (online)	1528-0020
ISSN	0006-4971
DOI	10.1182/blood-2018-10-882944
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Uh III Zs.140: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article: In vitro recording of neural activity using carbon nanosheet microelectrodes

Collaert, Nadine / Carolina Mora Lopez / Daire J. Cott / Dries Braeken / Jordi Cools / Michael De Volder

Carbon. 2014 Feb., v. 67

2014

Abstract: The advent of nanotechnology has revolutionised our ability to engineer electrode interfaces. These are particularly attractive to measure biopotentials, and to study the nervous system. In this work, we demonstrate enhanced in vitro recording of ... ...

Abstract	The advent of nanotechnology has revolutionised our ability to engineer electrode interfaces. These are particularly attractive to measure biopotentials, and to study the nervous system. In this work, we demonstrate enhanced in vitro recording of neuronal activity using electrodes decorated with carbon nanosheets (CNSs). This material comprises of vertically aligned, free standing conductive sheets of only a few graphene layers with a high surface-area-to-volume ratio, which makes them an interesting material for biomedical electrodes. Further, compared to carbon nanotubes, CNSs can be synthesised without the need for metallic catalysts like Ni, Co or Fe, thereby reducing potential cytotoxicity risks. Electrochemical measurements show a five times higher charge storage capacity, and an almost ten times higher double layer capacitance as compared to TiN. In vitro experiments were performed by culturing primary hippocampal neurons from mice on micropatterned electrodes. Neurophysiological recordings exhibited high signal-to-noise ratios of 6.4, which is a twofold improvement over standard TiN electrodes under the same conditions.
Keywords	capacitance ; carbon nanotubes ; catalysts ; cobalt ; cytotoxicity ; electrochemistry ; graphene ; in vitro studies ; iron ; mice ; microelectrodes ; nanosheets ; neurons ; neurophysiology ; nickel ; risk
Language	English
Dates of publication	2014-02
Size	p. 178-184.
Publishing place	Elsevier Ltd
Document type	Article
ISSN	0008-6223
DOI	10.1016/j.carbon.2013.09.079
Database	NAL-Catalogue (AGRICOLA)

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