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Article: Celecoxib Nanoformulations with Enhanced Solubility, Dissolution Rate, and Oral Bioavailability: Experimental Approaches over In Vitro/In Vivo Evaluation.

Arslan, Aslıhan / Yet, Barbaros / Nemutlu, Emirhan / Akdağ Çaylı, Yağmur / Eroğlu, Hakan / Öner, Levent

2023 Volume 15, Issue 2

Abstract: Celecoxib (CXB) is a Biopharmaceutical Classification System (BCS) Class II molecule with high permeability that is practically insoluble in water. Because of the poor water solubility, there is a wide range of absorption and limited bioavailability ... ...

Abstract	Celecoxib (CXB) is a Biopharmaceutical Classification System (BCS) Class II molecule with high permeability that is practically insoluble in water. Because of the poor water solubility, there is a wide range of absorption and limited bioavailability following oral administration. These unfavorable properties can be improved using dry co-milling technology, which is an industrial applicable technology. The purpose of this study was to develop and optimize CXB nanoformulations prepared by dry co-milling technology, with a quality by design approach to maintain enhanced solubility, dissolution rate, and oral bioavailability. The resulting co-milled CXB composition using povidone (PVP), mannitol (MAN) and sodium lauryl sulfate (SLS) showed the maximum solubility and dissolution rate in physiologically relevant media. Potential risk factors were determined with an Ishikawa diagram, important risk factors were selected with Plackett-Burman experimental design, and CXB compositions were optimized with Central Composite design (CCD) and Bayesian optimization (BO). Physical characterization, intrinsic dissolution rate, solubility, and stability experiments were used to evaluate the optimized co-milled CXB compositions. Dissolution and permeability studies were carried out for the resulting CXB nanoformulation. Oral pharmacokinetic studies of the CXB nanoformulation and reference product were performed in rats. The results of in vitro and in vivo studies show that the CXB nanoformulations have enhanced solubility (over 4.8-fold (8.6 ± 1.06 µg/mL vs. 1.8 ± 0.33 µg/mL) in water when compared with celecoxib pure powder), and dissolution rate (at least 85% of celecoxib is dissolved in 20 min), and improved oral pharmacokinetic profile (the relative bioavailability was 145.2%, compared to that of Celebrex
Language	English
Publishing date	2023-01-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics15020363
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A Narrative Review of COVID-19 Vaccines

Barbaros Eroglu / Rina Fajri Nuwarda / Iqbal Ramzan / Veysel Kayser

Vaccines, Vol 10, Iss 62, p

2022 Volume 62

Abstract: The COVID-19 pandemic has shaken the world since early 2020 and its health, social, economic, and societal negative impacts at the global scale have been catastrophic. Since the early days of the pandemic, development of safe and effective vaccines was ... ...

Abstract	The COVID-19 pandemic has shaken the world since early 2020 and its health, social, economic, and societal negative impacts at the global scale have been catastrophic. Since the early days of the pandemic, development of safe and effective vaccines was judged to be the best possible tool to minimize the effects of this pandemic. Drastic public health measures were put into place to stop the spread of the virus, with the hope that vaccines would be available soon. Thanks to the extraordinary commitments of many organizations and individuals from around the globe and the collaborative effort of many international scientists, vaccines against COVID-19 received regulatory approval for emergency human use in many jurisdictions in less than a year after the identification of the viral sequence. Several of these vaccines have been in use for some time; however, the pandemic is still ongoing and likely to persist for the foreseeable future. This is due to many reasons including reduced compliance with public health restrictions, limited vaccine manufacturing/distribution capacity, high rates of vaccine hesitancy, and the emergence of new variants with the capacity to spread more easily and to evade current vaccines. Here we discuss the discovery and availability of COVID-19 vaccines and evolving issues around mass vaccination programs.
Keywords	COVID-19 ; COVID-19 vaccines ; SARS-CoV-2 ; vaccination ; vaccine hesitancy ; Medicine ; R
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: A Narrative Review of COVID-19 Vaccines.

Eroglu, Barbaros / Nuwarda, Rina Fajri / Ramzan, Iqbal / Kayser, Veysel

Vaccines

2021 Volume 10, Issue 1

Abstract	The COVID-19 pandemic has shaken the world since early 2020 and its health, social, economic, and societal negative impacts at the global scale have been catastrophic. Since the early days of the pandemic, development of safe and effective vaccines was judged to be the best possible tool to minimize the effects of this pandemic. Drastic public health measures were put into place to stop the spread of the virus, with the hope that vaccines would be available soon. Thanks to the extraordinary commitments of many organizations and individuals from around the globe and the collaborative effort of many international scientists, vaccines against COVID-19 received regulatory approval for emergency human use in many jurisdictions in less than a year after the identification of the viral sequence. Several of these vaccines have been in use for some time; however, the pandemic is still ongoing and likely to persist for the foreseeable future. This is due to many reasons including reduced compliance with public health restrictions, limited vaccine manufacturing/distribution capacity, high rates of vaccine hesitancy, and the emergence of new variants with the capacity to spread more easily and to evade current vaccines. Here we discuss the discovery and availability of COVID-19 vaccines and evolving issues around mass vaccination programs.
Language	English
Publishing date	2021-12-31
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines10010062
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Article ; Online: Current Advancements in Addressing Key Challenges of Therapeutic Antibody Design, Manufacture, and Formulation.

Sifniotis, Vicki / Cruz, Esteban / Eroglu, Barbaros / Kayser, Veysel

Antibodies (Basel, Switzerland)

2019 Volume 8, Issue 2

Abstract: Therapeutic antibody technology heavily dominates the biologics market and continues to present as a significant industrial interest in developing novel and improved antibody treatment strategies. Many noteworthy advancements in the last decades have ... ...

Abstract	Therapeutic antibody technology heavily dominates the biologics market and continues to present as a significant industrial interest in developing novel and improved antibody treatment strategies. Many noteworthy advancements in the last decades have propelled the success of antibody development; however, there are still opportunities for improvement. In considering such interest to develop antibody therapies, this review summarizes the array of challenges and considerations faced in the design, manufacture, and formulation of therapeutic antibodies, such as stability, bioavailability and immunological engagement. We discuss the advancement of technologies that address these challenges, highlighting key antibody engineered formats that have been adapted. Furthermore, we examine the implication of novel formulation technologies such as nanocarrier delivery systems for the potential to formulate for pulmonary delivery. Finally, we comprehensively discuss developments in computational approaches for the strategic design of antibodies with modulated functions.
Language	English
Publishing date	2019-06-03
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2661514-9
ISSN	2073-4468 ; 2073-4468
ISSN (online)	2073-4468
ISSN	2073-4468
DOI	10.3390/antib8020036
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Article ; Online: Assessment of silicon, glass, FR4, PDMS and PMMA as a chip material for acoustic particle/cell manipulation in microfluidics.

Açıkgöz, Hande N / Karaman, Alara / Şahin, M Akif / Çaylan, Ömer R / Büke, Göknur C / Yıldırım, Ender / Eroğlu, İrem C / Erson-Bensan, A Elif / Çetin, Barbaros / Özer, M Bülent

Ultrasonics

2022 Volume 129, Page(s) 106911

Abstract: In the present study, the capabilities of different chip materials for acoustic particle manipulation have been assessed with the same microfluidic device architecture, under the same actuator and flow conditions. Silicon, glass, epoxy with fiberglass ... ...

Abstract	In the present study, the capabilities of different chip materials for acoustic particle manipulation have been assessed with the same microfluidic device architecture, under the same actuator and flow conditions. Silicon, glass, epoxy with fiberglass filling (FR4), polydimethylsiloxane (PDMS) and polymethyl methacrylate (PMMA) are considered as chip materials. The acoustophoretic chips in this study were manufactured with four different fabrication methods: plasma etching, chemical etching, micromachining and molding. A novel chip material, FR4, has been employed as a microfluidic chip material in acoustophoretic particle manipulation for the first time in literature, which combines the ease of manufacturing of polymer materials with improved acoustic performance. The acoustic particle manipulation performance is evaluated through acoustophoretic focusing experiments with 2μm and 12μm polystyrene microspheres and cultured breast cancer cell line (MDA-MB-231). Unlike the common approach in the literature, the piezoelectric materials were actuated with partitioned cross-polarized electrodes which allowed effective actuation of different family of chip materials. Different from previous studies, this study evaluates the performance of each acoustophoretic device through the perspective of synchronization of electrical, vibrational and acoustical resonances, considers the thermal performance of the chip materials with their effects on cell viability as well as manufacturability and scalability of their fabrication methods. We believe our study is an essential work towards the commercialization of acoustophoretic devices since it brings a critical understanding of the effect of chip material on device performance as well as the cost of achieving that performance.
MeSH term(s)	Microfluidics ; Polymethyl Methacrylate ; Silicon ; Acoustics ; Dimethylpolysiloxanes
Chemical Substances	Polymethyl Methacrylate (9011-14-7) ; Silicon (Z4152N8IUI) ; baysilon (63148-62-9) ; Dimethylpolysiloxanes
Language	English
Publishing date	2022-12-09
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	200839-7
ISSN	1874-9968 ; 0041-624X
ISSN (online)	1874-9968
ISSN	0041-624X
DOI	10.1016/j.ultras.2022.106911
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Article: Novel Thiazolidinone-Azole Hybrids: Design, Synthesis and Antimycobacterial Activity Studies.

Eroglu, Barbaros / Ozadali-Sari, Keriman / Unsal-Tan, Oya / Dharmarajan, Sriram / Yogeeswari, Perumal / Balkan, Ayla

Iranian journal of pharmaceutical research : IJPR

2017 Volume 15, Issue 4, Page(s) 783–790

Abstract: To develop novel antimycobacterial agents, a new series of thiazolidinone-azole hybrids 4a-b, 5a-b and 6-13 were designed and synthesized. Thiazolidin-4-ones (4a-b and 5a-b) were obtained by the reaction ... ...

Abstract	To develop novel antimycobacterial agents, a new series of thiazolidinone-azole hybrids 4a-b, 5a-b and 6-13 were designed and synthesized. Thiazolidin-4-ones (4a-b and 5a-b) were obtained by the reaction of
Language	English
Publishing date	2017-01-24
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2578271-X
ISSN	1726-6890 ; 1735-0328 ; 1735-0328
ISSN (online)	1726-6890 ; 1735-0328
ISSN	1735-0328
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Article: Thigh-worn accelerometry for measuring movement and posture across the 24-hour cycle: a scoping review and expert statement.

Stevens, Matthew L / Gupta, Nidhi / Inan Eroglu, Elif / Crowley, Patrick Joseph / Eroglu, Barbaros / Bauman, Adrian / Granat, Malcolm / Straker, Leon / Palm, Peter / Stenholm, Sari / Aadahl, Mette / Mork, Paul / Chastin, Sebastien / Rangul, Vegar / Hamer, Mark / Koster, Annemarie / Holtermann, Andreas / Stamatakis, Emmanuel

BMJ open sport & exercise medicine

2020 Volume 6, Issue 1, Page(s) e000874

Abstract: Introduction: The Prospective Physical Activity Sitting and Sleep consortium (ProPASS) is an international collaboration platform committed to harmonise thigh-worn accelerometry data. The aim of this paper is to (1) outline observational thigh-worn ... ...

Abstract	Introduction: The Prospective Physical Activity Sitting and Sleep consortium (ProPASS) is an international collaboration platform committed to harmonise thigh-worn accelerometry data. The aim of this paper is to (1) outline observational thigh-worn accelerometry studies and (2) summarise key strategic directions arising from the inaugural ProPASS meeting. Methods: (1) We performed a systematic scoping review for observational studies of thigh-worn triaxial accelerometers in free-living adults (n≥100, 24 hours monitoring protocols). (2)Attendees of the inaugural ProPASS meeting were sent a survey focused on areas related to developing ProPASS: important terminology (Q1); accelerometry constructs (Q2); advantages and distinct contribution of the consortium (Q3); data pooling and harmonisation (Q4); data access and sharing (Q5 and Q6). Results: (1) Eighty eligible articles were identified (22 primary studies; n~17 685). The accelerometers used most often were the ActivPAL3 and ActiGraph GT3X. The most commonly collected health outcomes were cardiometabolic and musculoskeletal. (2) None of the survey questions elicited the predefined 60% agreement. Survey responses recommended that ProPASS: use the term physical behaviour or movement behaviour rather than 'physical activity' for the data we are collecting (Q1); make only minor changes to ProPASS's accelerometry construct (Q2); prioritise developing standardised protocols/tools (Q4); facilitate flexible methods of data sharing and access (Q5 and Q6). Conclusions: Thigh-worn accelerometry is an emerging method of capturing movement and posture across the 24 hours cycle. In 2020, the literature is limited to 22 primary studies from high-income western countries. This work identified ProPASS's strategic directions-indicating areas where ProPASS can most benefit the field of research: use of clear terminology, refinement of the measured construct, standardised protocols/tools and flexible data sharing.
Language	English
Publishing date	2020-12-24
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2817580-3
ISSN	2055-7647
ISSN	2055-7647
DOI	10.1136/bmjsem-2020-000874
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Article ; Online: Thigh-worn accelerometry for measuring movement and posture across the 24-hour cycle

Mark Hamer / Annemarie Koster / Andreas Holtermann / Leon Straker / Vegar Rangul / Mette Aadahl / Malcolm Granat / Peter Palm / Patrick Joseph Crowley / Nidhi Gupta / Sebastien Chastin / Adrian Bauman / Matthew L Stevens / Elif Inan Eroglu / Barbaros Eroglu / Paul Mork

BMJ Open Sport & Exercise Medicine, Vol 6, Iss

a scoping review and expert statement

2020 Volume 1

Abstract: Introduction The Prospective Physical Activity Sitting and Sleep consortium (ProPASS) is an international collaboration platform committed to harmonise thigh-worn accelerometry data. The aim of this paper is to (1) outline observational thigh-worn ... ...

Abstract	Introduction The Prospective Physical Activity Sitting and Sleep consortium (ProPASS) is an international collaboration platform committed to harmonise thigh-worn accelerometry data. The aim of this paper is to (1) outline observational thigh-worn accelerometry studies and (2) summarise key strategic directions arising from the inaugural ProPASS meeting.Methods (1) We performed a systematic scoping review for observational studies of thigh-worn triaxial accelerometers in free-living adults (n≥100, 24 hours monitoring protocols). (2)Attendees of the inaugural ProPASS meeting were sent a survey focused on areas related to developing ProPASS: important terminology (Q1); accelerometry constructs (Q2); advantages and distinct contribution of the consortium (Q3); data pooling and harmonisation (Q4); data access and sharing (Q5 and Q6).Results (1) Eighty eligible articles were identified (22 primary studies; n~17 685). The accelerometers used most often were the ActivPAL3 and ActiGraph GT3X. The most commonly collected health outcomes were cardiometabolic and musculoskeletal. (2) None of the survey questions elicited the predefined 60% agreement. Survey responses recommended that ProPASS: use the term physical behaviour or movement behaviour rather than ‘physical activity’ for the data we are collecting (Q1); make only minor changes to ProPASS’s accelerometry construct (Q2); prioritise developing standardised protocols/tools (Q4); facilitate flexible methods of data sharing and access (Q5 and Q6).Conclusions Thigh-worn accelerometry is an emerging method of capturing movement and posture across the 24 hours cycle. In 2020, the literature is limited to 22 primary studies from high-income western countries. This work identified ProPASS’s strategic directions—indicating areas where ProPASS can most benefit the field of research: use of clear terminology, refinement of the measured construct, standardised protocols/tools and flexible data sharing.
Keywords	Medicine (General) ; R5-920
Language	English
Publishing date	2020-04-01T00:00:00Z
Publisher	BMJ Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: THE NEED FOR PROTECTION OF HUMAN RIGHTS IN CYBERSPACE

Iwona Barbara Florek / Susran Erkan Eroglu

Journal of Modern Science, Vol 42, Iss 3, Pp 27-

2019 Volume 36

Abstract: Objectives Technology is an integral part of social life. The widespread use of computers and the development of information and communication technologies have made people dependent on this technology in many ways. The developments in information ... ...

Abstract	Objectives Technology is an integral part of social life. The widespread use of computers and the development of information and communication technologies have made people dependent on this technology in many ways. The developments in information technologies attract the attention of the international community as much as the individuals and affect this society as well. In particular, the tools and methods that are created by using computers have created cyber area life in addition to the real world, and this area has begun to provide significant benefits and facilities in the daily lives of individuals and communities. Material and methods The work is of sociological nature. Stą uses research methods specific to social sciences: literature analysis and legal-dogmatic and descriptive method. In this article the relation between cyberspace and protection of human rights in this sphere are examined socially and legally. Results The result of the work is the characteristic of determinants of human functioning in virtual reality and an indication of the need to protect individual rights also in this aspect. In addition, the authors present selected acts of international law on this subject. Conclusions The protection of rights is crucial as our life goes more to cyberspace in XXI century, but the level of protection is not sufficient. It can be seen that the protection of human rights in cyberspace, just like in the case of real reality, is more effectively implemented in the European system than at the universal level, due to the binding nature of legal acts. However, there are still groups more sensitive that need both: special protection and education. In addition to controlling or monitoring content posted in cyberspace, a wide-ranging educational campaign is needed.
Keywords	human rights ; cyberspace ; individual rights ; protection ; values ; Social Sciences ; H
Subject code	340
Language	English
Publishing date	2019-10-01T00:00:00Z
Publisher	Wyższa Szkoła Gospodarki Euroregionalnej im. Alcide De Gasperi
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Crisis and Emergency Risk Messaging in Mass Media News Stories: Is the Public Getting the Information They Need to Protect Their Health?

Parmer, John / Baur, Cynthia / Eroglu, Dogan / Lubell, Keri / Prue, Christine / Reynolds, Barbara / Weaver, James

Health communication

2016 Volume 31, Issue 10, Page(s) 1215–1222

Abstract: The mass media provide an important channel for delivering crisis and emergency risk information to the public. We conducted a content analysis of 369 newspaper and television broadcast stories covering natural disaster and foodborne outbreak events and ... ...

Abstract	The mass media provide an important channel for delivering crisis and emergency risk information to the public. We conducted a content analysis of 369 newspaper and television broadcast stories covering natural disaster and foodborne outbreak events and coded for seven best practices in crisis and emergency risk messaging. On average, slightly less than two (1.86) of the seven best practices were included in each story. The proportion of stories including individual best practices ranged from 4.6% for "expressing empathy" to 83.7% for "explaining what is known" about the event's impact to human health. Each of the other five best practices appeared in less than 25% of stories. These results suggest much of the risk messaging the public receives via mass media does not follow best practices for effective crisis and emergency communication, potentially compromising public understanding and actions in response to events.
Language	English
Publishing date	2016-10
Publishing country	England
Document type	Journal Article
ZDB-ID	1038723-7
ISSN	1532-7027 ; 1041-0236
ISSN (online)	1532-7027
ISSN	1041-0236
DOI	10.1080/10410236.2015.1049728
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