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Article ; Online: Optimization of Kidney Health in Liver Transplant Candidates: Pretransplant Considerations and Modalities.

Jan, Muhammad Y / Patidar, Kavish R / Ghabril, Marwan S / Kubal, Chandrashekhar A

2024

Abstract: Patients with decompensated end-stage liver disease (ESLD) are at increased risk for mortality, and only liver transplantation (LT) offers meaningful hope for survival. These patients are at risk for kidney dysfunction through the continuum of care for ... ...

Abstract	Patients with decompensated end-stage liver disease (ESLD) are at increased risk for mortality, and only liver transplantation (LT) offers meaningful hope for survival. These patients are at risk for kidney dysfunction through the continuum of care for ESLD including LT. We discuss the role of accurate estimation and measurement of baseline glomerular filtration rate in assessment of kidney dysfunction among those with ESLD. Optimizing kidney function is a vital goal in the management of these patients before LT. In this review, we summarize salient aspects of assessing and optimizing kidney function in this patient population. Precipitating factors and different causes of acute kidney injury are discussed, including hepatorenal syndrome. We further review treatment options for acute kidney injury including volume management. The role of vasopressor therapy, renal replacement therapy, and transjugular intrahepatic portosystemic shunting are discussed.
Language	English
Publishing date	2024-01-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	208424-7
ISSN	1534-6080 ; 0041-1337
ISSN (online)	1534-6080
ISSN	0041-1337
DOI	10.1097/TP.0000000000004851
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Article ; Online: Bamlanivimab for Mild to Moderate COVID-19 in Kidney Transplant Recipients.

Jan, Muhammad Y / Sayegh, Skye E / Webb, Hanna T / Adebiyi, Oluwafisayo / Anderson, Melissa D / Mishler, Dennis P / Yaqub, Muhammad S / Taber, Tim / Sharfuddin, Asif A

Kidney international reports

2021 Volume 6, Issue 9, Page(s) 2468–2471

Language	English
Publishing date	2021-06-26
Publishing country	United States
Document type	Journal Article
ISSN	2468-0249
ISSN (online)	2468-0249
DOI	10.1016/j.ekir.2021.06.012
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Article ; Online: Nondirected Living Kidney Donation and Recipient Outcomes in the United States: A 20-Year Review.

Jan, Muhammad Y / Yaqub, Muhammad S / Adebiyi, Oluwafisayo O / Taber, Tim E / Anderson, Melissa D / Mishler, Dennis P / Burney, Heather N / Li, Yang / Li, Xiaochun / Sharfuddin, Asif A

Kidney international reports

2022 Volume 7, Issue 6, Page(s) 1289–1305

Abstract: Introduction: Nondirected donation (NDD) of the kidneys is a growing practice where donors who do not have any genetic or emotional relationship are selected to donate to a wide variety of recipients with a range of selection criteria and decisions ... ...

Abstract	Introduction: Nondirected donation (NDD) of the kidneys is a growing practice where donors who do not have any genetic or emotional relationship are selected to donate to a wide variety of recipients with a range of selection criteria and decisions which are left up to individual transplant centers. Methods: We review all adult living kidney donor-recipient (DR) pairs and outcomes from NDDs who were recorded in United Network for Organ Sharing (UNOS) database as code 10 (anonymous) from October 1997 to September 2017 for demographics and outcomes. Results: A total of 2174 DR pairs were identified. The number of NDDs increased from 18 in 2000 to 256 in 2016. Survival analysis showed higher death-censored-graft survival (DC-GS) when recipient was 20 years or more older than donor followed by recipient-donor within 20 years of age and lowest when donor was 20 years or more older than recipient ( Conclusion: Overall, the number of NDDs has increased significantly in the 20-year review period. Transplants from NDDs have excellent long-term outcomes. Better matching of controllable DR factors, such as age and body mass index (BMI), could further improve GS. Further research is needed to incorporate these DR factors into paired kidney donation programs potentially enhancing the utility and beneficence of this invaluable donation.
Language	English
Publishing date	2022-03-22
Publishing country	United States
Document type	Journal Article
ISSN	2468-0249
ISSN (online)	2468-0249
DOI	10.1016/j.ekir.2022.03.012
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Article ; Online: Vasopressin for Post-kidney Transplant Hypotension.

Jan, Muhammad Y / Moe, Sharon M / Adebiyi, Oluwafisayo / Chen, Jeannie / Powelson, John / Burney, Heather N / Yaqub, Muhammad S / Mishler, Dennis P / Moorthi, Ranjani N / Taber, Tim E / Anderson, Melissa D / Li, Yang / Li, Xiaochun / Fridell, Jonathan A / Goggins, William C / Sharfuddin, Asif A

Kidney international reports

2022 Volume 7, Issue 6, Page(s) 1364–1376

Abstract: Introduction: Hypotension after deceased donor kidney transplant (DDKT) is a risk factor for delayed graft function (DGF) and poor graft survival (GS). We hypothesize that vasopressin use in hypotensive DDKT recipients (DDKTRs) to increase blood ... ...

Abstract	Introduction: Hypotension after deceased donor kidney transplant (DDKT) is a risk factor for delayed graft function (DGF) and poor graft survival (GS). We hypothesize that vasopressin use in hypotensive DDKT recipients (DDKTRs) to increase blood pressure (BP) reduces DGF rates and is safe without increasing mortality. Methods: Group with vasopressin "study group" ( Results: Vasopressin group had lower mean maximum and minimum SBP and DBP in the operating room (OR). Median vasopressin start time post-DDKT was 2 hours (interquartile range [IQR] 1-6), and duration of use was 42 hours (IQR 24-63). DGF, creatinine at 1 year, and allograft biopsy rates were comparable. No deaths occurred during transplant hospitalization. Multivariable analysis did not find an effect of vasopressin use on GS. Conclusion: Treatment of hypotensive DDKTRs with vasopressin is safe and facilitated similar graft function and survival with that of nonhypotensive patients. In the absence of a randomized control trial, our study supports the safety of vasopressin therapy to prevent the adverse effects of hypotension.
Language	English
Publishing date	2022-04-07
Publishing country	United States
Document type	Journal Article
ISSN	2468-0249
ISSN (online)	2468-0249
DOI	10.1016/j.ekir.2022.03.035
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Article ; Online: A National Survey of Practice Patterns for Accepting Living Kidney Donors With Prior COVID-19.

Jan, Muhammad Y / Jawed, Areeba T / Barros, Nicolas / Adebiyi, Oluwafisayo / Diez, Alejandro / Fridell, Jonathan A / Goggins, William C / Yaqub, Muhammad S / Anderson, Melissa D / Mujtaba, Muhammad A / Taber, Tim E / Mishler, Dennis P / Kumar, Vineeta / Lentine, Krista L / Sharfuddin, Asif A

Kidney international reports

2021 Volume 6, Issue 8, Page(s) 2066–2074

Abstract: Introduction: A critical question facing transplant programs is whether, when, and how to safely accept living kidney donors (LKDs) who have recovered from COVID-19 infection. The purpose of the study is to understand current practices related to ... ...

Abstract	Introduction: A critical question facing transplant programs is whether, when, and how to safely accept living kidney donors (LKDs) who have recovered from COVID-19 infection. The purpose of the study is to understand current practices related to accepting these LKDs. Methods: We surveyed US transplant programs from 3 September through 3 November 2020. Center level and participant level responses were analyzed. Results: A total of 174 respondents from 115 unique centers responded, representing 59% of US LKD programs and 72.4% of 2019 and 72.5% of 2020 LKD volume (Organ Procurement and Transplantation Network-OPTN 2021). In all, 48.6% of responding centers had received inquiries from such LKDs, whereas 44.3% were currently evaluating. A total of 98 donors were in the evaluation phase, whereas 27.8% centers had approved 42 such donors to proceed with donation. A total of 50.8% of participants preferred to wait >3 months, and 91% would wait at least 1 month from onset of infection to LD surgery. The most common reason to exclude LDs was evidence of COVID-19-related AKI (59.8%) even if resolved, followed by COVID-19-related pneumonia (28.7%) and hospitalization (21.3%). The most common concern in accepting such donors was kidney health postdonation (59.2%), followed by risk of transmission to the recipient (55.7%), donor perioperative pulmonary risk (41.4%), and donor pulmonary risk in the future (29.9%). Conclusion: Practice patterns for acceptance of COVID-19-recovered LKDs showed considerable variability. Ongoing research and consensus building are needed to guide optimal practices to ensure safety of accepting such donors. Long-term close follow-up of such donors is warranted.
Language	English
Publishing date	2021-05-15
Publishing country	United States
Document type	Journal Article
ISSN	2468-0249
ISSN (online)	2468-0249
DOI	10.1016/j.ekir.2021.05.003
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Article ; Online: Incidence of postoperative seizures in neonates following cardiac surgery with regional cerebral perfusion and deep hypothermic circulatory arrest.

Hsia, Jill / Abend, Nicholas S / Gaynor, J William / Chen, Jonathan M / Fuller, Stephanie / Maeda, Katsuhide / Mavroudis, Constantine D / Nuri, Muhammad / Leonard, Jan / Ampah, Steve B / Licht, Daniel J / Massey, Shavonne L / Naim, Maryam Y

JTCVS open

2023 Volume 16, Page(s) 771–783

Abstract: Objectives: Historically, our center has primarily used deep hypothermic circulatory arrest, but in recent years some surgeons have selectively used regional cerebral perfusion as an alternative. We aimed to compare the incidence of postoperative ... ...

Abstract	Objectives: Historically, our center has primarily used deep hypothermic circulatory arrest, but in recent years some surgeons have selectively used regional cerebral perfusion as an alternative. We aimed to compare the incidence of postoperative electroencephalographic seizure incidence in neonates undergoing surgery with regional cerebral perfusion and deep hypothermic circulatory arrest. Methods: A retrospective analysis was performed in neonates who underwent surgery between 2012 and 2022 with either deep hypothermic circulatory arrest or regional cerebral perfusion with routine postoperative continuous electroencephalography monitoring for 48 hours. Propensity matching was performed to compare postoperative seizure risk between the 2 groups. Results: Among 1136 neonates undergoing cardiac surgery with cardiopulmonary bypass, regional cerebral perfusion was performed in 99 (8.7%) and deep hypothermic circulatory arrest in 604 (53%). The median duration of regional cerebral perfusion was 49 minutes (interquartile range, 38-68) and deep hypothermic circulatory arrest was 41 minutes (interquartile range, 31-49). The regional cerebral perfusion group had significantly longer total support, cardiopulmonary bypass, and aortic crossclamp times. Overall seizure incidence was 11% (N = 76) and 13% (N = 35) in the most recent era (2019-2022). The unadjusted seizure incidence was similar in neonates undergoing regional cerebral perfusion (N = 12, 12%) and deep hypothermic circulatory arrest (N = 64, 11%). After propensity matching, the seizure incidence was similar in neonates undergoing regional cerebral perfusion (N = 12, 12%) and deep hypothermic circulatory arrest (N = 37, 12%) (odds ratio, 0.97; 95% CI, 0.55-1.71; Conclusions: In this contemporary single-center experience, the incorporation of regional cerebral perfusion did not result in a change in seizure incidence in comparison with deep hypothermic circulatory arrest. However, unmeasured confounders may have impacted these findings. Further studies are needed to determine the impact, if any, of regional cerebral perfusion on postoperative seizure incidence.
Language	English
Publishing date	2023-10-31
Publishing country	Netherlands
Document type	Journal Article
ISSN	2666-2736
ISSN (online)	2666-2736
DOI	10.1016/j.xjon.2023.10.026
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Article ; Online: Transcranioplasty Ultrasonography Through a Sonolucent Prosthesis: A Review of Feasibility, Safety, and Benefits.

Rossitto, Christina P / Devarajan, Alex / Zhang, Jack Y / Benowitz, Reilly / Price, Gabrielle / Ali, Muhammad / Tabani, Halima / Hardigan, Trevor / Liang, John W / Dangayach, Neha S / Reynolds, Alexandra S / Burkhardt, Jan-Karl / Kellner, Christopher P

World neurosurgery

2023 Volume 178, Page(s) 152–161.e1

Abstract: Data on the effectiveness of transcranioplasty ultrasonography through sonolucent cranioplasty (SC) are new and heterogeneous. We performed the first systematic literature review on SC. Ovid Embase, Ovid Medline, and Web of Science Core Collection were ... ...

Abstract	Data on the effectiveness of transcranioplasty ultrasonography through sonolucent cranioplasty (SC) are new and heterogeneous. We performed the first systematic literature review on SC. Ovid Embase, Ovid Medline, and Web of Science Core Collection were systematically searched and published full text articles detailing new use of SC for the purpose of neuroimaging were critically appraised and extracted. Of 16 eligible studies, 6 reported preclinical research and 12 reported clinical experiences encompassing 189 total patients with SC. The cohort age ranged from teens to 80s and was 60% (113/189) female. Sonolucent materials in clinical use are clear PMMA (polymethylmethacrylate), opaque PMMA, polyetheretherketone, and polyolefin. Overall indications included hydrocephalus (20%, 37/189), tumor (15%, 29/189), posterior fossa decompression (14%, 26/189), traumatic brain injury (11%, 20/189), bypass (27%, 52/189), intracerebral hemorrhage (4%, 7/189), ischemic stroke (3%, 5/189), aneurysm and subarachnoid hemorrhage (3%, 5/189), subdural hematoma (2%, 4/189), and vasculitis and other bone revisions (2%, 4/189). Complications described in the entire cohort included revision or delayed scalp healing (3%, 6/189), wound infection (3%, 5/189), epidural hematoma (2%, 3/189), cerebrospinal fluid leaks (1%, 2/189), new seizure (1%, 2/189), and oncologic relapse with subsequent prosthesis removal (<1%, 1/189). Most studies utilized linear or phased array ultrasound transducers at 3-12 MHz. Sources of artifact on sonographic imaging included prosthesis curvature, pneumocephalus, plating system, and dural sealant. Reported findings were mainly qualitative. We, therefore, suggest that future studies should collect quantitative measurement data during transcranioplasty ultrasonography to validate imaging techniques.
Language	English
Publishing date	2023-07-06
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2023.06.136
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Article ; Online: Unlocking green innovation and environmental performance: the mediated moderation of green absorptive capacity and green innovation climate.

Akhtar, Sadaf / Li, Cai / Sohu, Jan Muhammad / Rasool, Yasir / Hassan, Muhammad Iatzaz Ul / Bilal, Muhammad

Environmental science and pollution research international

2023 Volume 31, Issue 3, Page(s) 4547–4562

Abstract: This study extends the foundations of the natural resource-based view (NRBV) by introducing a mediation-moderation framework by analyzing the influence of green intellectual capital (GIC) on both green innovation performance (GIP) and environmental ... ...

Abstract	This study extends the foundations of the natural resource-based view (NRBV) by introducing a mediation-moderation framework by analyzing the influence of green intellectual capital (GIC) on both green innovation performance (GIP) and environmental performance (EP) while simultaneously considering the mediating role of green absorptive capacity (GAC) and the moderating influence of the green innovation climate (GICL). The data for this study was gathered from a sample of 575 participants employed within small and medium enterprises' (SMEs') manufacturing firms. This dataset was utilized to evaluate the proposed model; this study uses the PLS-SEM approach to comprehensively examine the complex interactions among these variables. This model adds to the theoretical understanding of NRBV and enhances its practical applicability. The findings of this study reveal a positive relationship between GIC, GAC, GIP, and EP within organizations. Furthermore, our investigation reveals a positive correlation between a GICL and the relationships involving GIC, GAC, GIP, and EP. Importantly, this research introduces a novel perspective by clarifying the complex relations among these variables and highlighting the positive correlation between a GICL and the relationships involving GIC, GAC, GIP, and EP. This novel approach enhances the theoretical understanding of NRBV and its practical applicability in fostering GIP and EP within manufacturing SMEs operating in Pakistan.
MeSH term(s)	Humans ; Climate ; Commerce ; Natural Resources ; Pakistan
Language	English
Publishing date	2023-12-16
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-023-31403-w
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Article: Modulating root system architecture: cross-talk between auxin and phytohormones.

Jan, Mehmood / Muhammad, Sajid / Jin, Weicai / Zhong, Wenhao / Zhang, Shaolong / Lin, Yanjie / Zhou, Yueni / Liu, Jinlong / Liu, Haifeng / Munir, Raheel / Yue, Qiang / Afzal, Muhammad / Wang, Guoping

Frontiers in plant science

2024 Volume 15, Page(s) 1343928

Abstract: Root architecture is an important agronomic trait that plays an essential role in water uptake, soil compactions, nutrient recycling, plant-microbe interactions, and hormone-mediated signaling pathways. Recently, significant advancements have been made ... ...

Abstract	Root architecture is an important agronomic trait that plays an essential role in water uptake, soil compactions, nutrient recycling, plant-microbe interactions, and hormone-mediated signaling pathways. Recently, significant advancements have been made in understanding how the complex interactions of phytohormones regulate the dynamic organization of root architecture in crops. Moreover, phytohormones, particularly auxin, act as internal regulators of root development in soil, starting from the early organogenesis to the formation of root hair (RH) through diverse signaling mechanisms. However, a considerable gap remains in understanding the hormonal cross-talk during various developmental stages of roots. This review examines the dynamic aspects of phytohormone signaling, cross-talk mechanisms, and the activation of transcription factors (TFs) throughout various developmental stages of the root life cycle. Understanding these developmental processes, together with hormonal signaling and molecular engineering in crops, can improve our knowledge of root development under various environmental conditions.
Language	English
Publishing date	2024-02-08
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2613694-6
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2024.1343928
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Article ; Online: Pneumomediastinum and pneumoperitoneum caused by tracheostomy displacement.

Kniese, Christopher M / Jan, Muhammad Y / Diab, Khalil

BMJ case reports

2015 Volume 2015

MeSH term(s)	Adult ; Airway Obstruction/diagnostic imaging ; Airway Obstruction/etiology ; Airway Obstruction/surgery ; Female ; Humans ; Mediastinal Emphysema/diagnostic imaging ; Mediastinal Emphysema/etiology ; Mediastinal Emphysema/surgery ; Obesity, Morbid/complications ; Obesity, Morbid/surgery ; Pneumoperitoneum/diagnostic imaging ; Pneumoperitoneum/etiology ; Pneumoperitoneum/surgery ; Prader-Willi Syndrome/complications ; Prader-Willi Syndrome/surgery ; Respiration, Artificial ; Tomography, X-Ray Computed ; Tracheostomy/adverse effects ; Treatment Outcome
Language	English
Publishing date	2015-07-03
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2015-211238
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