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Article: Integrated Network Analysis Reveals FOXM1 and MYBL2 as Key Regulators of Cell Proliferation in Non-small Cell Lung Cancer.

Ahmed, Firoz

2019 Volume 9, Page(s) 1011

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2019-10-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2019.01011
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Article ; Online: A Network-Based Analysis Reveals the Mechanism Underlying Vitamin D in Suppressing Cytokine Storm and Virus in SARS-CoV-2 Infection.

Ahmed, Firoz

Frontiers in immunology

2020 Volume 11, Page(s) 590459

Abstract: Background: SARS-CoV-2 causes ongoing pandemic coronavirus disease of 2019 (COVID-19), infects the cells of the lower respiratory tract that leads to a cytokine storm in a significant number of patients resulting in severe pneumonia, shortness of ... ...

Abstract	Background: SARS-CoV-2 causes ongoing pandemic coronavirus disease of 2019 (COVID-19), infects the cells of the lower respiratory tract that leads to a cytokine storm in a significant number of patients resulting in severe pneumonia, shortness of breathing, respiratory and organ failure. Extensive studies suggested the role of Vitamin D in suppressing cytokine storm in COVID-19 and reducing viral infection; however, the precise molecular mechanism is not clearly known. In this work, bioinformatics and systems biology approaches were used to understand SARS-CoV-2 induced cytokine pathways and the potential mechanism of Vitamin D in suppressing cytokine storm and enhancing antiviral response. Results: This study used transcriptome data and identified 108 differentially expressed host genes (DEHGs) in SARS-CoV-2 infected normal human bronchial epithelial (NHBE) cells compared to control. Then, the DEHGs was integrated with the human protein-protein interaction data to generate a SARS-CoV-2 induced host gene regulatory network ( Conclusion: This comprehensive study identified the pathways associated with cytokine storm in SARS-CoV-2 infection. The proposed underlying mechanism of Vitamin D could be promising in suppressing the cytokine storm and inducing a robust antiviral response in severe COVID-19 patients. The finding in this study urgently needs further experimental validations for the suitability of Vitamin D in combination with IFN-α to control severe COVID-19.
MeSH term(s)	Antiviral Agents/therapeutic use ; COVID-19/drug therapy ; Cytokine Release Syndrome/prevention & control ; Cytokines/blood ; Gene Expression Profiling ; Humans ; Pulmonary Fibrosis/pathology ; Pulmonary Fibrosis/prevention & control ; SARS-CoV-2/drug effects ; Systems Biology/methods ; Transcriptome/genetics ; Vitamin D/therapeutic use
Chemical Substances	Antiviral Agents ; Cytokines ; Vitamin D (1406-16-2)
Language	English
Publishing date	2020-12-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2020.590459
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Article ; Online: RNA Editing in Chloroplast: Advancements and Opportunities.

Mohammed, Taimyiah / Firoz, Ahmad / Ramadan, Ahmed M

Current issues in molecular biology

2022 Volume 44, Issue 11, Page(s) 5593–5604

Abstract: Many eukaryotic and prokaryotic organisms employ RNA editing (insertion, deletion, or conversion) as a post-transcriptional modification mechanism. RNA editing events are common in these organelles of plants and have gained particular attention due to ... ...

Abstract	Many eukaryotic and prokaryotic organisms employ RNA editing (insertion, deletion, or conversion) as a post-transcriptional modification mechanism. RNA editing events are common in these organelles of plants and have gained particular attention due to their role in the development and growth of plants, as well as their ability to cope with abiotic stress. Owing to rapid developments in sequencing technologies and data analysis methods, such editing sites are being accurately predicted, and many factors that influence RNA editing are being discovered. The mechanism and role of the pentatricopeptide repeat protein family of proteins in RNA editing are being uncovered with the growing realization of accessory proteins that might help these proteins. This review will discuss the role and type of RNA editing events in plants with an emphasis on chloroplast RNA editing, involved factors, gaps in knowledge, and future outlooks.
Language	English
Publishing date	2022-11-12
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2000024-8
ISSN	1467-3045 ; 1467-3037
ISSN (online)	1467-3045
ISSN	1467-3037
DOI	10.3390/cimb44110379
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Article ; Online: Surface-modified graphene oxide-based composites for advanced sequestration of basic blue 41 from aqueous solution.

Islam, Md Shahinoor / Roy, Hridoy / Ahmed, Tasnim / Firoz, Shakhawat H / Chang, Scott X

Chemosphere

2023 Volume 340, Page(s) 139827

Abstract: Advanced materials for the efficient treatment of textile wastewater need to be developed for the sustainable growth of the textile industry. In this study, graphene oxide (GO) was modified by the incorporation of natural clay (bentonite) and mixed metal ...

Abstract	Advanced materials for the efficient treatment of textile wastewater need to be developed for the sustainable growth of the textile industry. In this study, graphene oxide (GO) was modified by the incorporation of natural clay (bentonite) and mixed metal oxide (copper-cobalt oxide) to produce GO-based binary and ternary composites. Two binary composites, GO/bentonite and GO/Cu-Co Ox (oxide), and one ternary composite, GO/bentonite/Cu-Co Ox, were characterized by Fourier transform-infrared spectroscopy (FTIR), scanning electron microscope (SEM), energy dispersive spectrometer (EDS) and Brunauer-Emmett-Teller (BET) analysis. The adsorption efficiency of these composites was evaluated against a cationic dye, Basic Blue 41 (BB41). The composites had several surface functional groups, and the ternary composite had tubular porous structures formed by the cross-linking of the bentonite and GO planes. The BET surface area of the ternary composite was 50% higher than that of the GO. The BB41 removals were 92, 89, 80, and 69% for GO/bentonite/Cu-Co oxide, GO/bentonite, GO and GO/Cu-Co oxide, respectively. The pseudo-2nd-order and intraparticle diffusion models best describe the kinetics results, indicating chemisorption and slow pore diffusion-controlled adsorption processes. The Langmuir isotherm-derived adsorption capacity of GO/bentonite/Cu-Co oxide was 351.1 mg/g, which was very close to the measured value. After five consecutive cycles, the ternary composite retained 90% BB41 removal efficiency compared to its 1st cycle. Electrostatic interaction and pore diffusion were predicted to be the controlling mechanisms for the adsorption of the BB41. The GO-based ternary composite can be a feasible and scalable adsorbent for BB41 in wastewater treatment.
MeSH term(s)	Copper/chemistry ; Bentonite ; Oxides ; Graphite/chemistry ; Adsorption ; Water Pollutants, Chemical/analysis ; Kinetics ; Spectroscopy, Fourier Transform Infrared
Chemical Substances	cuprous oxide (T8BEA5064F) ; Copper (789U1901C5) ; graphene oxide ; Bentonite (1302-78-9) ; Oxides ; Graphite (7782-42-5) ; Water Pollutants, Chemical
Language	English
Publishing date	2023-08-14
Publishing country	England
Document type	Journal Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2023.139827
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Article ; Online: Retraction Note: Anti-diabetic, anti-oxidant and anti-hyperlipidemic activities of Melastoma malabathricum Linn. Leaves in streptozotocin induced diabetic rats.

Kumar, Vikas / Ahmed, Danish / Gupta, Pushpraj S / Anwar, Firoz / Mujeeb, Mohd

BMC complementary medicine and therapies

2023 Volume 23, Issue 1, Page(s) 159

Language	English
Publishing date	2023-05-17
Publishing country	England
Document type	Retraction of Publication
ISSN	2662-7671
ISSN (online)	2662-7671
DOI	10.1186/s12906-023-03996-9
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Article ; Online: Influence of Bulk and Surface Interactions from Thick, Porous, Soil-based Substrates on the Spreading Behavior of Different Viscosity Oils

Firoz Ahmed / Brenda Hutton-Prager

Environmental Challenges, Vol 3, Iss , Pp 100045- (2021)

2021

Abstract: Crude oils and motor oils are commonly identified in oil spills on land. Controlling and understanding their flow both across and into land is of paramount importance to minimize spread and subsequent damage to the ecosystem. Spreading kinetics and ... ...

Abstract	Crude oils and motor oils are commonly identified in oil spills on land. Controlling and understanding their flow both across and into land is of paramount importance to minimize spread and subsequent damage to the ecosystem. Spreading kinetics and surface energy studies were conducted with these oils over several realistic soil-based matrixes, consisting of topsoil (silt-dominant), sand, clay, and moisture. Spreading area through a 1.3 cm deep matrix was reduced with increased moisture content, densely packed matrixes, and higher viscosity oils. Initial contact angle (CA) measurements for all oils was typically lower on clay matrixes due to its sheet-like structure and high absorption capabilities. Individual droplet penetration took longer at lower MC in direct contradiction to bulk kinetics studies, suggesting different spreading behavior across the surface border. Low viscosity oils recorded the highest lateral spreads, and incomplete wetting profiles were identified for most conditions tested. Importantly, dimensionless profiles of droplet diameter and CA with time did not conform to universal behavior, with statistically significant influences of matrix heterogeneity, oil viscosity, and ill-controlled surface roughness identified. Flow regimes of oil droplets instead conformed to vertical spreading through thick matrixes, and a delayed lateral spreading that occurred quite late into the total penetration time of the droplet. These findings, obtained from studying realistic soil-based matrixes, draws new conclusions regarding the important influences of matrix thickness, variable porosity, and chemical heterogeneity on fluid flow behavior. This new knowledge will assist in the development of future containment efforts surrounding oil spills.
Keywords	Crude oil ; Motor oil ; Spreading kinetics ; Wettability ; Contact angle ; Thick porous substrates ; Environmental sciences ; GE1-350
Subject code	660
Language	English
Publishing date	2021-04-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article: Sugiol Suppresses the Proliferation of Human U87 Glioma Cells via Induction of Apoptosis and Cell Cycle Arrest.

Alharthy, Saif A / Tabrez, Shams / Mirza, Ahmed A / Zughaibi, Torki A / Firoz, Chelapram K / Dutta, Mycal

Evidence-based complementary and alternative medicine : eCAM

2022 Volume 2022, Page(s) 7658899

Abstract: The diterpenoid, sugiol, has been reported to exert anticancer effects against a number of human cancers. However, the anticancer effects of sugiol have not been evaluated against the human glioma cells. The present study was designed to examine the ... ...

Abstract	The diterpenoid, sugiol, has been reported to exert anticancer effects against a number of human cancers. However, the anticancer effects of sugiol have not been evaluated against the human glioma cells. The present study was designed to examine the effects of sugiol on the proliferation of human U87 glioma cells. The results showed that sugiol significantly (
Language	English
Publishing date	2022-05-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2022/7658899
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Article ; Online: Durable biobased hybrid compounds

Md. Ibrahim H. Mondal / Md. Inzamamul Haque / Firoz Ahmed

Arabian Journal of Chemistry, Vol 16, Iss 9, Pp 105093- (2023)

Potential modifying agents for the development of functional cotton fabrics

2023

Abstract: The advancement of antibacterial, stain-resistant, and easy-to-clean multifunctional cotton fabrics finds its scientific appeal and practical value due to their multidisciplinary uses in pharmacy, sanitation, clinics, etc. In this investigation, the ... ...

Abstract	The advancement of antibacterial, stain-resistant, and easy-to-clean multifunctional cotton fabrics finds its scientific appeal and practical value due to their multidisciplinary uses in pharmacy, sanitation, clinics, etc. In this investigation, the cotton fabric was immersed in chitosan- vinyltriethoxy silane (Ch-VTES) and N-(2-hydroxy)propyl-3-trimethylammonium chitosan chloride- vinyltriethoxy silane (HTACC-VTES), prepared via the cost-effective sol–gel process to produce self-cleaning and antimicrobial cotton fabrics for end-uses. The Ch-VTES and HTACC-VTES modified cotton fabrics showed encouraging water contact angles of 102° and 139° respectively i.e. closer to superhydrophobicity as well as strong self-cleaning behavior without compromising the physicochemical properties of unmodified cotton fabric. Notably, the modified fabric demonstrated enchanting bacterial killing efficiency with a noticeable zone of inhibition against E. coli (17 mm for Ch-VTES and 21 mm for HTACC-VTES modified fabrics) and S. aureus (20 mm for Ch-VTES and 25 mm for HTACC-VTES modified fabrics) bacteria. Both modified cotton textiles showed an absorption peak at 1208 cm−1 (Si-O-C bending) in FTIR, suggesting that silane binds to the cotton substrate more firmly. The stability and longevity of the modified cotton fabrics with desired properties remain unchanged till 15 cycles of washing for the antibacterial test and the 20 cycles for the water contact angle. The fabricated textiles would be used for a wide range of uses, including medical applications as well as personal care products.
Keywords	Antibacterial ; Easy-cleaning ; Cotton textile ; Quaternary chitosan ; Silane ; Chemistry ; QD1-999
Subject code	540
Language	English
Publishing date	2023-09-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Extraction, characterization and functionality assessment of Aloe vera, chitosan and silk sericin

Joykrisna Saha / Md. Ibrahim H. Mondal / Firoz Ahmed / Mahbubur Rahman

Arabian Journal of Chemistry, Vol 16, Iss 9, Pp 105087- (2023)

2023

Abstract: Aloe vera, chitosan, and silk sericin have been investigated for their physicochemical properties as well as functional characteristics such as antibacterial, antioxidant, and UV resistance. Aloe vera was extracted by methanol as a solvent. Silk sericin ... ...

Abstract	Aloe vera, chitosan, and silk sericin have been investigated for their physicochemical properties as well as functional characteristics such as antibacterial, antioxidant, and UV resistance. Aloe vera was extracted by methanol as a solvent. Silk sericin was prepared from a boiled water solution of silk cocoons through ethanol precipitation, while chitosan was synthesized by deacetylation of chitin. FT-IR, TGA, DSC, EDX, UV–vis, and XRD were used to characterize the extracted Aloe vera, chitosan, and sericin. Antibacterial activity, antioxidant activity and UV protection factors were also investigated. The TGA graph revealed that the significant weight loss at 400 °C was 39%, 51%, and 52%. for Aloe vera, chitosan, and sericin, respectively. For E. coli, Aloe vera, chitosan, and silk sericin, the zones of inhibition were 2.5 mm, 3 mm, and 1 mm, respectively, whereas for S. aureus, the zones of inhibition were 4 mm, 5 mm, and 1.5 mm. The free radical scavenging activity of 10 mg/ml Aloe vera, chitosan and sericin was 93%, 53% and 52%, respectively. All three UV radiation zones were absorbed by an Aloe vera solution. Chitosan and silk sericin solution exclusively absorbed UV-C rays. These almost priceless natural resources can contribute to health-related beneficial issues.
Keywords	Aloe vera ; Chitosan ; Silk sericin ; Antibacterial activity ; Anti-oxidant property and ultraviolet protection factor ; Chemistry ; QD1-999
Subject code	540
Language	English
Publishing date	2023-09-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Effects of examination-induced stress on memory and blood pressure.

Ahmed, Firoz / Dubey, Dinesh K / Garg, Rinku / Srivastava, Rani

Journal of family medicine and primary care

2023 Volume 12, Issue 11, Page(s) 2757–2762

Abstract: Stress has been defined in many ways as a state of psychological arousal that results when the external demand is beyond what one can cope with. Stress is caused by various factors called stressors. Medical students are subjected to different kinds of ... ...

Abstract	Stress has been defined in many ways as a state of psychological arousal that results when the external demand is beyond what one can cope with. Stress is caused by various factors called stressors. Medical students are subjected to different kinds of stressors, such as pressure of academics with obligation to succeed, an uncertain future and difficulties of integrating into the system and different teaching protocols, which may affect their learning ability and performance. Stress has a great impact on brain mainly in the form of impaired memory and on cardiovascular function in the form of increased heart rate and blood pressure. The study was planned to assess the effects of examination induced stress on memory and blood pressure. The study was longitudinal in nature conducted at Department of Physiology, Santosh Medical College, Ghaziabad, India. Initially 100 subjects were selected from 17-24 years of age group then all the subjects were divided into two groups of 'slow-learners' and 'fast-learners' based upon their past academic performances. Readings were taken at two stages of academic year, 05 months before pre-prof examination and 03 days before pre-prof examination. Blood Pressure were measured and the memory assessments were done by using 10 subtests of PGI memory scale. We found a significant increase in stress level 3 days before the examination, compared to 5 months before the examination which in turn affected both blood pressure and memory functions. But, slow-learners were affected more compared to fast-learners.
Language	English
Publishing date	2023-11-21
Publishing country	India
Document type	Journal Article
ZDB-ID	2735275-4
ISSN	2278-7135 ; 2249-4863
ISSN (online)	2278-7135
ISSN	2249-4863
DOI	10.4103/jfmpc.jfmpc_925_23
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