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Artikel ; Online: Correction: Multimodal imaging of Hypotrichosis with juvenile macular dystrophy: a case report.

Carnovale-Scalzo, Giovanna / Carnevali, Adriano / Piccoli, Gabriele / Ceravolo, Domenico / Bruzzichessi, Donatella / Iuliano, Rodolfo / Tallerico, Rossana / Gatti, Valentina / Giannaccare, Giuseppe / Scorcia, Vincenzo

BMC ophthalmology

2024 Band 24, Heft 1, Seite(n) 26

Sprache	Englisch
Erscheinungsdatum	2024-01-19
Erscheinungsland	England
Dokumenttyp	Published Erratum
ZDB-ID	2050436-6
ISSN	1471-2415 ; 1471-2415
ISSN (online)	1471-2415
ISSN	1471-2415
DOI	10.1186/s12886-024-03288-x
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: RANBP1, a member of the nuclear-cytoplasmic trafficking-regulator complex, is the terminal-striking point of the SGK1-dependent Th17

Brescia, Carolina / Dattilo, Vincenzo / D'Antona, Lucia / Chiarella, Emanuela / Tallerico, Rossana / Audia, Salvatore / Rocca, Valentina / Iuliano, Rodolfo / Trapasso, Francesco / Perrotti, Nicola / Amato, Rosario

Frontiers in immunology

2023 Band 14, Seite(n) 1213805

Abstract: ... The ... ...

Abstract	The Th17
Mesh-Begriff(e)	ran GTP-Binding Protein/metabolism ; Nuclear Proteins/genetics ; Cell Nucleus/metabolism ; Cytoplasm/metabolism
Chemische Substanzen	ran-binding protein 1 ; ran GTP-Binding Protein (EC 3.6.5.2) ; Nuclear Proteins
Sprache	Englisch
Erscheinungsdatum	2023-06-27
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1213805
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Comparison of Allplex™ 2019-nCoV and TaqPath™ COVID-19 Assays

Manuela Colosimo / Pasquale Minchella / Rossana Tallerico / Ilenia Talotta / Cinzia Peronace / Luca Gallelli / Giulio Di Mizio / Erika Cione

Reports, Vol 5, Iss 14, p

2022 Band 14

Abstract: The clinical presentation of COVID-19 is non-specific, and to improve and limit the spread of the SARS-CoV-2 virus, an accurate diagnosis with a robust method is needed. A total of 500 nasopharyngeal swab specimens were tested for SARS-CoV-2. Of these, ... ...

Abstract	The clinical presentation of COVID-19 is non-specific, and to improve and limit the spread of the SARS-CoV-2 virus, an accurate diagnosis with a robust method is needed. A total of 500 nasopharyngeal swab specimens were tested for SARS-CoV-2. Of these, 184 samples were found to be positive with Allplex™ 2019-nCoV Assay, which is fully automated. All the positive samples were retested with TaqPath™ COVID-19 CE-IVD RT-PCR Kit (after this, referred to as TaqPath™ COVID-19), semi-automated. The comparison of RT-qPCR for SARS-CoV-2 genes target points shows only one target point in common, the N gene. Therefore, the N gene was used to compare both assays. We noticed different Ct values between the tests. Therefore, samples were divided into four groups depending to the Ct value results: (1) Ct < 25, (2) Ct 25–30, (3) Ct 30–35, (4) Ct > 35. TaqPath™ COVID-19 Kit reconfirmed the results obtained from Allplex™ 2019-nCoV Assay. In conclusion, both the Allplex™ 2019-nCoV assay and TaqPath™ COVID-19 tests accurately confirm the diagnosis of SARS-CoV-2 infection. Even if TaqPath™ COVID-19 has a semi-automated workflow, it does not introduce bias in the diagnostic screening of SARS-CoV-2, and it supports the indirect identification of variants of concern to undergo sequencing.
Schlagwörter	COVID-19 ; RNA ; Allplex™ 2019-nCoV ; TaqPath™ COVID-19 ; safety of care ; Medicine (General) ; R5-920 ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Thema/Rubrik (Code)	630
Sprache	Englisch
Erscheinungsdatum	2022-04-01T00:00:00Z
Verlag	MDPI AG
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel: A New Biological Feature of Natural Killer Cells: The Recognition of Solid Tumor-Derived Cancer Stem Cells.

Tallerico, Rossana / Garofalo, Cinzia / Carbone, Ennio

Frontiers in immunology

2016 Band 7, Seite(n) 179

Abstract: Natural killer (NK) cells are classified as a member of the innate lymphoid cells (ILCs) group 1. ILCs have been recently identified and grouped on the basis of their phenotypical and functional characteristics. They are effectors of innate immunity and ... ...

Abstract	Natural killer (NK) cells are classified as a member of the innate lymphoid cells (ILCs) group 1. ILCs have been recently identified and grouped on the basis of their phenotypical and functional characteristics. They are effectors of innate immunity and are involved in secondary lymphoid organ generation and tissue remodeling. NK cells are powerful cytotoxic lymphocytes able to recognize and eliminate tumor- and virus-infected cells by limiting their spread and tissue damage. The recognition of tumor cells is mediated by both activating and inhibitory receptors. While in hematological malignancies the role played by NK cells is widely known, their role in recognizing solid tumors remains unclear. Recently, tumor cell populations have been divided into two compartments: cancer-initiating cells (CICs) or cancer stem cells (CSCs) and senescent tumor cells. Here, CSC will be used. CSCs are a small subset of malignant cells with stem-like properties that are involved in tumor maintenance and recurrence due to their ability to survive to traditional therapies; they are, moreover, poorly recognized by T lymphocytes. Recent data showed that NK cells recognize in vitro cancer-initiating cells derived from colon cancer, glioblastoma, and melanoma. However, more in vivo studies are urgently required to fully understand whether these new antitumor NK cells with cytotoxic capability may be considered in the design of new immunotherapeutic interventions.
Sprache	Englisch
Erscheinungsdatum	2016
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article ; Review
ZDB-ID	2606827-8
ISSN	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2016.00179
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Validation of GeneFinder COVID-19 Ag Plus Rapid Test and Its Potential Utility to Slowing Infection Waves: A Single-Center Laboratory Evaluation Study.

Peronace, Cinzia / Tallerico, Rossana / Colosimo, Manuela / Sacco, Vanessa / Talarico, Roberta / De Fazio, Marco / Pasceri, Federica / Talotta, Ilenia / Panduri, Giuseppina / Kim, Jung-Hee / Cione, Erika / Minchella, Pasquale

Diagnostics (Basel, Switzerland)

2022 Band 12, Heft 5

Abstract: Diagnostic laboratory tools are essential to keep everyone safe and track newly emerging variants; on the other hand, "filter" screening tests recognizing positivity are valuable tools to avoid hectic laboratory work that, besides COVID-19, are also part ...

Abstract	Diagnostic laboratory tools are essential to keep everyone safe and track newly emerging variants; on the other hand, "filter" screening tests recognizing positivity are valuable tools to avoid hectic laboratory work that, besides COVID-19, are also part of the routine. Therefore, complementary assays, such as rapid antigen tests (RATs), are essential in controlling and monitoring virus spread within the community, especially in the asymptomatic population. A subset of nasopharyngeal swab specimens resulted in SARS-CoV-2 positive and investigated for genomic characterization were used for RAT validation. RATs were performed immediately after sampling, following the manufacturer's instructions (reading at 15 min). RT-PCRs were carried out within 24 h of specimens' collection. Out of 603 patients, 145 (24.05%) tested positive by RT-PCR and RAT and 451 (74.79%) tested negative by both methods; discordant results (RT-PCR+/RAT- or RT-PCR-/RAT+) were obtained in 7 patients (1.16%). RATs' overall specificity and sensitivity were 96.03% (95%CI: 91.55-98.53%) and 99.78% (95%CI: 98.77-99.99%), respectively, taking RT-PCR as the reference. Overall, RAT negative predictive value was 98.69% (95%CI 97.17-99.40%). The GeneFinder COVID-19 Ag Plus Rapid Test performed well as a screening test for early diagnosis of COVID-19, especially in asymptomatic subjects. The data suggested that patients with RT-PCR-proven COVID-19 testing negative by RAT are unlikely to be infectious. GeneFinder COVID-19 Ag Plus Rapid Test also works on variants of concern (VOC) delta and omicron BA.1 and BA.2.
Sprache	Englisch
Erscheinungsdatum	2022-05-01
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics12051126
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Validation of GeneFinder COVID-19 Ag Plus Rapid Test and Its Potential Utility to Slowing Infection Waves

Cinzia Peronace / Rossana Tallerico / Manuela Colosimo / Vanessa Sacco / Roberta Talarico / Marco De Fazio / Federica Pasceri / Ilenia Talotta / Giuseppina Panduri / Jung-Hee Kim / Erika Cione / Pasquale Minchella

Diagnostics, Vol 12, Iss 1126, p

A Single-Center Laboratory Evaluation Study

2022 Band 1126

Abstract: Diagnostic laboratory tools are essential to keep everyone safe and track newly emerging variants; on the other hand, “filter” screening tests recognizing positivity are valuable tools to avoid hectic laboratory work that, besides COVID-19, are also part ...

Abstract	Diagnostic laboratory tools are essential to keep everyone safe and track newly emerging variants; on the other hand, “filter” screening tests recognizing positivity are valuable tools to avoid hectic laboratory work that, besides COVID-19, are also part of the routine. Therefore, complementary assays, such as rapid antigen tests (RATs), are essential in controlling and monitoring virus spread within the community, especially in the asymptomatic population. A subset of nasopharyngeal swab specimens resulted in SARS-CoV-2 positive and investigated for genomic characterization were used for RAT validation. RATs were performed immediately after sampling, following the manufacturer’s instructions (reading at 15 min). RT-PCRs were carried out within 24 h of specimens’ collection. Out of 603 patients, 145 (24.05%) tested positive by RT-PCR and RAT and 451 (74.79%) tested negative by both methods; discordant results (RT-PCR+/RAT− or RT-PCR−/RAT+) were obtained in 7 patients (1.16%). RATs’ overall specificity and sensitivity were 96.03% (95%CI: 91.55–98.53%) and 99.78% (95%CI: 98.77–99.99%), respectively, taking RT-PCR as the reference. Overall, RAT negative predictive value was 98.69% (95%CI 97.17–99.40%). The GeneFinder COVID-19 Ag Plus Rapid Test performed well as a screening test for early diagnosis of COVID-19, especially in asymptomatic subjects. The data suggested that patients with RT-PCR-proven COVID-19 testing negative by RAT are unlikely to be infectious. GeneFinder COVID-19 Ag Plus Rapid Test also works on variants of concern (VOC) delta and omicron BA.1 and BA.2.
Schlagwörter	COVID-19 ; early diagnosis ; rapid antigen detection test ; variants of concern ; Medicine (General) ; R5-920
Thema/Rubrik (Code)	610
Sprache	Englisch
Erscheinungsdatum	2022-05-01T00:00:00Z
Verlag	MDPI AG
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel: The First Identification in Italy of SARS-CoV-2 Omicron BA.4 Harboring KSF141_del: A Genomic Comparison with Omicron Sub-Variants.

Peronace, Cinzia / Tallerico, Rossana / Colosimo, Manuela / Fazio, Marco De / Pasceri, Federica / Talotta, Ilenia / Panduri, Giuseppina / Pintomalli, Letizia / Oteri, Rosaria / Calantoni, Valeria / Fiorillo, Maria Teresa / Caroleo, Maria Cristina / Curcio, Rosita / Dolce, Vincenza / Cione, Erika / Minchella, Pasquale

Biomedicines

2022 Band 10, Heft 8

Abstract: The rapid emergence and worldwide detection of the SARS-CoV-2 Omicron variant underscore the importance of robust genomic surveillance systems and prompt information sharing among global public health partners. The Omicron variant has rapidly replaced ... ...

Abstract	The rapid emergence and worldwide detection of the SARS-CoV-2 Omicron variant underscore the importance of robust genomic surveillance systems and prompt information sharing among global public health partners. The Omicron variant has rapidly replaced the Delta variant as a dominating SARS-CoV-2 variant because of natural selection, favoring the variant with higher infectivity and stronger vaccine breakthrough capability. The Omicron variant is also known as B.1.1.529. It has four sub-variants, indicated as BA.1, BA.2, BA.3 and BA.4. Among them, BA.1 is the currently prevailing sub-variant, and BA.2 has been found to be able to alarmingly re-infect patients initially infected by Omicron BA.1. The BA.3 sub-variant is a combination of mutations of BA.1 and BA.2, especially in the spike protein. Today, the BA.4 variant is emerging, which is herein described, and it was the first detected in Italy. Via bioinformatic analysis, we are reporting that the BA.4 that was identified harbors a new mutation, specifically a deletion in the ORF1ab gene, corresponding to KSF141_del in non-structural protein 1 (nsp1), a critical virulence factor able to suppress host translation. The bioinformatics comparison analysis with the other three sub-variants reveals that the deletion was not present before and was never reported until now. Therefore, we can speculate that Omicron BA.4 will become a new dominating "variant of concern" and may also break vaccine protection. Moreover, we show that other proteins are mutated in the BA.4. In particular, seven mutations are recognized in the nucleocapsid (N) protein, and the capability of five different types of rapid antigenic tests are used to identify it.
Sprache	Englisch
Erscheinungsdatum	2022-07-30
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines10081839
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Multimodal imaging of Hypotrichosis with juvenile macular dystrophy: a case report.

BMC ophthalmology

2021 Band 21, Heft 1, Seite(n) 284

Abstract: Background: To report the first Italian case of hypotrichosis with juvenile macular dystrophy complicated by macular neovascularization diagnosed through multimodal imaging.: Case presentation: An 11-year-old boy was referred to our Institution for ... ...

Abstract	Background: To report the first Italian case of hypotrichosis with juvenile macular dystrophy complicated by macular neovascularization diagnosed through multimodal imaging. Case presentation: An 11-year-old boy was referred to our Institution for bilateral maculopathy of unknown origin. Multimodal imaging helps the diagnosis of Juvenile Macular Dystrophy with Hypotrichosis (HJMD). Fundus examination showed several alterations of the retinal pigment epithelium and circular pigmented area of chorioretinal atrophy. Structural spectral domain optical coherence tomography (OCT) showed some backscattering phenomenon with several alterations of retinal pigment epithelium and photoreceptor layer in both eyes. Moreover, OCT showed hyperreflective lesion beneath the neuroepithelium in left eye. OCT angiography (OCT-A) revealed a pathologic neovascular network in choriocapillaris plexus, probably the result of a fibrovascular membrane. Multifocal electroretinograms (MfERGs) showed functional alterations in 12.22° of the central retina. In order to confirm the suspicion of HJMD, the child and both parents underwent genetic testing. Both parents resulted to be heterozygous healthy carriers of a single variation. Conclusion: Multimodal imaging, in particular OCT-A, is a useful aid, along to clinical findings and genetics, for the diagnosis of inherited retinal dystrophies.
Mesh-Begriff(e)	Child ; Fluorescein Angiography ; Humans ; Hypotrichosis ; Macular Degeneration ; Male ; Multimodal Imaging ; Retinal Dystrophies/diagnosis ; Retinal Dystrophies/genetics ; Retinal Pigment Epithelium ; Tomography, Optical Coherence
Sprache	Englisch
Erscheinungsdatum	2021-07-23
Erscheinungsland	England
Dokumenttyp	Case Reports ; Journal Article
ZDB-ID	2050436-6
ISSN	1471-2415 ; 1471-2415
ISSN (online)	1471-2415
ISSN	1471-2415
DOI	10.1186/s12886-021-02037-8
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Human NK Cell Subsets in Pregnancy and Disease: Toward a New Biological Complexity.

Cristiani, Costanza Maria / Palella, Eleonora / Sottile, Rosa / Tallerico, Rossana / Garofalo, Cinzia / Carbone, Ennio

Frontiers in immunology

2016 Band 7, Seite(n) 656

Abstract: In humans, NK cells are mainly identified by the surface expression levels of CD56 and CD16, which differentiate between five functionally different NK cell subsets. However, nowadays NK cells are considered as a more heterogeneous population formed by ... ...

Abstract	In humans, NK cells are mainly identified by the surface expression levels of CD56 and CD16, which differentiate between five functionally different NK cell subsets. However, nowadays NK cells are considered as a more heterogeneous population formed by various subsets differing in function, surface phenotype, and anatomic localization. In human CMV- and hantaviruses-infected subjects, an increased frequency of a NKG2A
Sprache	Englisch
Erscheinungsdatum	2016
Erscheinungsland	Switzerland
Dokumenttyp	Review ; Journal Article
ZDB-ID	2606827-8
ISSN	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2016.00656
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: A novel

Contrò, Gianluca / Tallerico, Rossana / Dattilo, Vincenzo / Fabiani, Fernanda / Enzo, Maria Vittoria / Hladnik, Uros / Dastoli, Stefano / Nisticò, Steven Paul / Colao, Emma / Perrotti, Nicola / Iuliano, Rodolfo

Human genome variation

2019 Band 6, Seite(n) 30

Abstract: Pseudoxanthoma elasticum is an autosomal recessive heritable disorder caused by mutations ... ...

Abstract	Pseudoxanthoma elasticum is an autosomal recessive heritable disorder caused by mutations in
Sprache	Englisch
Erscheinungsdatum	2019-06-20
Erscheinungsland	England
Dokumenttyp	Journal Article
ISSN	2054-345X
ISSN	2054-345X
DOI	10.1038/s41439-019-0062-x
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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