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Article ; Online: Dengue: updates for dermatologists on the world's fastest-growing vector-borne disease.

Braun, Mitchell / Andersen, Louise K / Norton, Scott A / Coates, Sarah J

2023 Volume 62, Issue 9, Page(s) 1110–1120

Abstract: Dengue is the world's fastest-growing vector borne disease and has significant epidemic potential in suitable climates. Recent disease models incorporating climate change scenarios predict geographic expansion across the globe, including parts of the ... ...

Abstract	Dengue is the world's fastest-growing vector borne disease and has significant epidemic potential in suitable climates. Recent disease models incorporating climate change scenarios predict geographic expansion across the globe, including parts of the United States and Europe. It will be increasingly important in the next decade for dermatologists to become familiar with dengue, as it commonly manifests with rashes, which can be used to aid diagnosis. In this review, we discuss dengue for general dermatologists, specifically focusing on its cutaneous manifestations, epidemiology, diagnosis, treatment, and prevention. As dengue continues to spread in both endemic and new locations, dermatologists may have a larger role in the timely diagnosis and management of this disease.
MeSH term(s)	Humans ; Dengue/diagnosis ; Dengue/epidemiology ; Dengue/therapy ; Dermatologists ; Europe ; Climate Change ; Exanthema
Language	English
Publishing date	2023-06-12
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	412254-9
ISSN	1365-4632 ; 0011-9059 ; 1461-1244
ISSN (online)	1365-4632
ISSN	0011-9059 ; 1461-1244
DOI	10.1111/ijd.16739
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Article: Local and systemic responses to repeated gluteal muscle microbiopsies in mature sedentary horses.

Artman, Jessica L / Wesolowski, Lauren T / Semanchik, Pier L / Isles, JadaLea K / Norton, Sharon A / White-Springer, Sarah H

Journal of equine veterinary science

2024 Volume 136, Page(s) 105070

Abstract: We aimed to test the hypothesis that repeated muscle collections would impact mitochondrial function, antioxidant status, and markers of inflammation and muscle damage. Twenty-six horses (8 geldings, 18 mares; mean ± SD 9.5 ± 3.5 y) had gluteus medius ... ...

Abstract	We aimed to test the hypothesis that repeated muscle collections would impact mitochondrial function, antioxidant status, and markers of inflammation and muscle damage. Twenty-six horses (8 geldings, 18 mares; mean ± SD 9.5 ± 3.5 y) had gluteus medius muscle biopsy samples collected at: 0 and 24h (n=7); 0 and 6h (n = 6); 0, 6, and 12h (n=7); or 0, 6, 12, and 24h (n=6). Blood was collected from all horses every 6h for 72h, starting 24h prior to the 0h muscle collection. Data were analyzed using mixed linear models. Muscle integrative (per mg tissue) electron transfer capacity of complex II decreased (P=0.004) and intrinsic (relative to citrate synthase (CS) activity) LEAK increased (P<0.03) from 0 to 6h but both returned to 0h levels by 12h. Activity of CS was greater at 0 than 12 and 24h (P≤0.02). Serum creatine kinase (CK) activity was similar from -24 through 0h but increased in all horses at 6h and remained elevated through 48h (P<0.05) though not above reference ranges. Whole blood superoxide dismutase activity fluctuated throughout the 72-h collection period (P=0.03) and serum cortisol concentration displayed a circadian pattern (P<0.0001) but neither were altered by muscle collections. No other variable, including muscle mitochondrial capacities and function, blood and muscle antioxidant status and concentrations of select cytokines, and serum amyloid A, differed by time or muscle collection. Repeated gluteal collections had limited short-term or no effect on physiological markers in unstressed, mature horses except serum CK activity, which should be interpreted with caution during repeated tissue collections.
Language	English
Publishing date	2024-04-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2102631-2
ISSN	1542-7412 ; 0737-0806
ISSN (online)	1542-7412
ISSN	0737-0806
DOI	10.1016/j.jevs.2024.105070
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Article: Descriptive Epidemiology of Pathogens Associated with Acute Respiratory Infection in a Community-Based Study of K-12 School Children (2015-2023).

Bell, Cristalyne / Goss, Maureen / Norton, Derek / Barlow, Shari / Temte, Emily / He, Cecilia / Hamer, Caroline / Walters, Sarah / Sabry, Alea / Johnson, Kelly / Chen, Guanhua / Uzicanin, Amra / Temte, Jonathan

Pathogens (Basel, Switzerland)

2024 Volume 13, Issue 4

Abstract: School-based outbreaks often precede increased incidence of acute respiratory infections in the greater community. We conducted acute respiratory infection surveillance among children to elucidate commonly detected pathogens in school settings and their ... ...

Abstract	School-based outbreaks often precede increased incidence of acute respiratory infections in the greater community. We conducted acute respiratory infection surveillance among children to elucidate commonly detected pathogens in school settings and their unique characteristics and epidemiological patterns. The ORegon CHild Absenteeism due to Respiratory Disease Study (ORCHARDS) is a longitudinal, laboratory-supported, school-based, acute respiratory illness (ARI) surveillance study designed to evaluate the utility of cause-specific student absenteeism monitoring for early detection of increased activity of influenza and other respiratory viruses in schools from kindergarten through 12th grade. Eligible participants with ARIs provided demographic, epidemiologic, and symptom data, along with a nasal swab or oropharyngeal specimen. Multipathogen testing using reverse-transcription polymerase chain reaction (RT-PCR) was performed on all specimens for 18 respiratory viruses and 2 atypical bacterial pathogens (
Language	English
Publishing date	2024-04-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens13040340
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Article ; Online: Acceptability of 'as needed' biologic therapy in psoriasis: insights from a multi-stakeholder mixed methods study.

Gleeson, David / Naveed, Maneeha / Moorhead, Lucy / McAteer, Helen / Sewell, Georgia / McGuire, Arlene / Weinman, John / Barker, Jonathan N W N / Norton, Sam / Chapman, Sarah C E / Smith, Catherine H / Mahil, Satveer K

The British journal of dermatology

2024

Abstract: Objectives: Biologic therapies have led to increasing numbers of patients with psoriasis who have clear or nearly clear skin. Current practice is that biologic therapy is continued indefinitely in these patients, contributing to a substantial long-term ... ...

Abstract	Objectives: Biologic therapies have led to increasing numbers of patients with psoriasis who have clear or nearly clear skin. Current practice is that biologic therapy is continued indefinitely in these patients, contributing to a substantial long-term drug and healthcare burden. 'As needed' biologic therapy in psoriasis may address this, however our understanding of patient and clinician perceptions of this strategy is limited. Methods: We first conducted UK-wide online scoping surveys of patients with psoriasis and dermatology clinicians to explore their views on 'as needed' biologic therapy. Using topic guides informed by these survey findings, we then carried out qualitative focus groups with patients and clinicians. Themes were identified using reflexive thematic analysis. Results: Of 67 patients and 27 clinicians completing the scoping surveys, 67% (43/64) and 78% (21/27), respectively, supported the use of 'as needed' biologic therapy. Respondents highlighted advantages such as a reduction in healthcare burden and greater ownership of care. Challenges included logistics of 'as needed' drug provision and potential risks of disease flare and drug immunogenicity. Focus groups comprised 15 patients with psoriasis (9 female [60%], average disease duration 32 years [range 9-64 years]) and 9 dermatology clinicians (8 female [89%], average dermatology experience 20 years [range 8-33 years]). Both patients and clinicians felt that an 'as needed' treatment approach will deliver a reduction in treatment burden and present an opportunity for patient-led ownership of care. Both groups highlighted the importance of ensuring ongoing access to medication and discussing the potential impact of psoriasis recurrence. Patient preferences were influenced by their lived experiences, particularly previous difficulties with medication delivery logistics and establishing disease control. Clinician perspectives were informed by personal experience of their patients adapting their own dosing schedules. Clinicians highlighted the importance of targeted patient selection for an 'as needed' approach, ongoing disease monitoring, and prompt re-access to medications upon psoriasis recurrence. Conclusion: These data indicate that 'as needed' biologic therapy in psoriasis is acceptable for both patients and clinicians. Formal assessment of clinical effectiveness and cost effectiveness is warranted, to enable the real-world potential of this approach to be realised.
Language	English
Publishing date	2024-02-17
Publishing country	England
Document type	Journal Article
ZDB-ID	80076-4
ISSN	1365-2133 ; 0007-0963
ISSN (online)	1365-2133
ISSN	0007-0963
DOI	10.1093/bjd/ljae068
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Article: The burden of size and growth for the juveniles of large mammalian herbivores: Structural and functional constraints in the feeding biology of juveniles relative to adults in red kangaroos,

Dawson, Terence J / Norton, Melinda A / Rodoreda, Suzette / Abbott, Sarah K / McLeod, Steven R

Ecology and evolution

2021 Volume 11, Issue 13, Page(s) 9062–9078

Abstract: Juvenile mammals in their postweaning developmental stages face many challenges in transitioning to adulthood. Among large grazing species such as ruminant bovids and cervids, an overarching challenge is acquiring and processing sufficient nutrients to ... ...

Abstract	Juvenile mammals in their postweaning developmental stages face many challenges in transitioning to adulthood. Among large grazing species such as ruminant bovids and cervids, an overarching challenge is acquiring and processing sufficient nutrients to survive and grow, with a gut that may not yet be fully developed. Marsupial kangaroos of Australia face similar challenges; they also digest vegetation by fermentation in a large foregut. In red kangaroos,
Language	English
Publishing date	2021-06-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2635675-2
ISSN	2045-7758
ISSN	2045-7758
DOI	10.1002/ece3.7750
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Article: Defining coastal resilience in the Great Lakes: a systematic review and critical comparison

Dobie, Sarah / Doran, Patrick J. / Norton, Richard K. / Hughes, Sara / Goode, Maeghen J.

Journal of Great Lakes research. 2022 Aug. 01,

2022

Abstract: There are many definitions of resilience, and a growing body of literature suggests that how resilience is defined may have significant consequences for planning and policy making outcomes. In the Great Lakes Region, resilience is gaining increasing ... ...

Abstract	There are many definitions of resilience, and a growing body of literature suggests that how resilience is defined may have significant consequences for planning and policy making outcomes. In the Great Lakes Region, resilience is gaining increasing attention from planners and policy makers in response to more frequent disruptions to social-ecological systems and built environments from coastal hazards. There has not yet been extensive research into how resilience is being defined in practice and how these definitions can affect geographies of risk and resilience and contribute to varying ecological, social, cultural, political, and economic outcomes. In this paper, we analyzed how stakeholders engaged in natural resource management activities within the Laurentian Great Lakes coastal environment define resilience and discuss the implications for planning and policy making through a critical geography and critical space lens. We systematically reviewed gray literature published by these stakeholders to document definitions of resilience. We then applied a 5Ws +H of resilience framework—resilience for whom, what, where, when, why, and how—to develop descriptive statistics and qualitatively analyze the definitions, considering the potential implications for ongoing regional planning and policy making efforts. Our analysis revealed a large degree of variation in the definitions, although we note two distinct gaps. We discuss how these gaps could affect ongoing regional planning and policy making efforts, and we lay out four research needs to inform planning and policy making going forward.
Keywords	descriptive statistics ; geography ; issues and policy ; natural resource management ; politics ; research ; risk ; stakeholders ; systematic review
Language	English
Dates of publication	2022-0801
Publishing place	Elsevier B.V.
Document type	Article
Note	Pre-press version
ZDB-ID	2163239-X
ISSN	0380-1330 ; 0380-1330
ISSN (online)	0380-1330
ISSN	0380-1330
DOI	10.1016/j.jglr.2022.08.001
Database	NAL-Catalogue (AGRICOLA)

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Article: Phallus preservation and reconstruction: 5-year outcomes of national penile cancer centralisation in the Republic of Ireland.

Hogan, Donnacha / Norton, Sarah M / Patterson, Kenneth / Murphy, Adrian / O'Neill, Brian / Daly, Padraig / Cullen, Ivor M

The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland

2024

Abstract: Introduction: Penile cancer is a rare urological malignancy with an age-standardised incidence of 0.8 per 100,000 person-years [1]. Given this low incidence it has been suggested that centralised care may improve patient outcomes in relation to phallus ... ...

Abstract	Introduction: Penile cancer is a rare urological malignancy with an age-standardised incidence of 0.8 per 100,000 person-years [1]. Given this low incidence it has been suggested that centralised care may improve patient outcomes in relation to phallus sparing surgery and nodal assessment [2]. We aim to assess the outcomes after 5-years of national centralisation of penile cancer care. Methods: A retrospective analysis of prospectively collected data was performed. All patients undergoing penile cancer surgery from January 2018 to December 2022 following centralisation of care were included. The primary outcome was proportion of phallus sparing procedures performed. Secondary outcomes were patient characteristics, histologic outcomes and procedures performed. Results: 124 patients underwent surgery in the study period. Mean age was 64.49 (±13.87). Overall, 82.3% of patients underwent phallus sparing surgery. This remained stable over the 5-year period from 2018 to 2022 at 92%, 85%, 76%, 79% and 78% respectively (p = 0.534). 62.7% had reconstruction performed, including split-thickness skin graft neoglans formation, (57.8% [n = 37]), preputial flap (32.8% [n = 21]), glans resurfacing (4.7% [n = 3]), shaft advancement flap (1.6% [n = 1]), penile shaft skin graft (1.6% [n = 1]), and partial penectomy with urethral centralisation (1.6% [n = 1]). Phallus preservation was not affected by positive nodal status (OR 0.75 [95% CI 0.249-2.266], p = 0.564) or T-stage ≥1b (OR 0.51 [95% CI 0.153-1.711], p = 0.276). There has been a significant reduction in Nx nodal status from 64% in 2017 to 15% in 2021 (p = 0.009). Conclusion: Centralisation of treatment for rare malignancies such as penile cancer may improve oncologic outcomes and rates of phallus preservation. This study has shown centralisation to has a high rate of phallus preservation. Further long-term analysis of outcomes in Ireland is required.
Language	English
Publishing date	2024-04-13
Publishing country	Scotland
Document type	Journal Article
ZDB-ID	2102927-1
ISSN	1479-666X
ISSN	1479-666X
DOI	10.1016/j.surge.2024.04.002
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Article ; Online: Understanding Preterm Birth in Pregnancies Complicated by Nonimmune Hydrops Fetalis.

Swanson, Kate / Norton, Mary E / Downum, Sarah L / Gonzalez-Velez, Juan M / Sparks, Teresa N

American journal of perinatology

2023 Volume 40, Issue 9, Page(s) 917–922

Abstract: Objective: Nonimmune hydrops fetalis (NIHF) is associated with poor perinatal outcomes including preterm birth (PTB). However, the frequency and causes of PTB in this population are not well understood. We hypothesized that NIHF frequently results in ... ...

Abstract	Objective: Nonimmune hydrops fetalis (NIHF) is associated with poor perinatal outcomes including preterm birth (PTB). However, the frequency and causes of PTB in this population are not well understood. We hypothesized that NIHF frequently results in PTB due to medically indicated delivery for fetal distress. Study design: This was a secondary analysis of a prospectively enrolled cohort of pregnancies with NIHF that underwent exome sequencing if standard testing was nondiagnostic. The primary outcome was frequency of PTB at <37 weeks' gestation. Secondary outcomes were reasons for PTB, fetal predictors of PTB, and frequency of neonatal death following PTB. Results: Fifty-six cases were included, with a median gestational age at delivery of 32.8 weeks (interquartile range [IQR]: 30.3-35.0). Overall, 86% (48/56) were delivered preterm. Among 48 PTBs, 18 (38%) were spontaneous, 9 (19%) were medically indicated for maternal indications (primarily preeclampsia), and 21 (44%) were medically indicated for fetal indications (nonreassuring antenatal testing or worsening effusions). Neither fetal genetic diagnosis nor polyhydramnios was associated with PTB. Conclusion: More than four-fifths of pregnancies with NIHF result in PTB, often due to nonreassuring fetal status. These data are informative for counseling patients and for developing strategies to reduce PTB in pregnancies with NIHF. Key points: · Pregnancies complicated by nonimmune hydrops fetalis often result in preterm birth.. · Preterm birth in these cases is most often medically indicated for fetal benefit.. · Fetal genetic conditions and polyhydramnios may be associated with preterm birth in cases of NIHF..
MeSH term(s)	Pregnancy ; Infant, Newborn ; Humans ; Female ; Infant ; Hydrops Fetalis/etiology ; Premature Birth/epidemiology ; Premature Birth/etiology ; Polyhydramnios/epidemiology ; Retrospective Studies ; Fetal Diseases ; Parturition ; Fetal Distress/complications
Language	English
Publishing date	2023-01-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	605671-4
ISSN	1098-8785 ; 0735-1631
ISSN (online)	1098-8785
ISSN	0735-1631
DOI	10.1055/a-2008-2495
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Article ; Online: The importance of living well now and relationships: A qualitative study of the barriers and enablers to engaging frail elders with advance care planning.

Combes, Sarah / Gillett, Karen / Norton, Christine / Nicholson, Caroline Jane

Palliative medicine

2021 Volume 35, Issue 6, Page(s) 1137–1147

Abstract: Background: The population of frail elders is growing, and due to their vulnerability to sudden deterioration, advance care planning is particularly important. However, advance care planning is uncommon for multiple reasons, some of which are linked to ... ...

Abstract	Background: The population of frail elders is growing, and due to their vulnerability to sudden deterioration, advance care planning is particularly important. However, advance care planning is uncommon for multiple reasons, some of which are linked to the perceptions of frail elders and their families. Aim: To explore the barriers and enablers to advance care planning engagement with frail elders. Design: Qualitative in-depth interviews with thematic analysis. Setting/participants: Purposive sample of 10 frail elders and 8 nominated family members using a community-based older persons' service run by a large urban UK hospice. Frail elders had capacity, were ⩾65 (median 85, range 71-95), scored 6 or 7 (median 6.5) on the Clinical Frailty Scale, and 70% were female. Results: Key barriers were: Conclusions: Essential enablers for frail elders are understanding what advance care planning is and why it may be relevant to them. For professionals, enablers include recognising the importance of living well now and relational decision-making. To further support advance care planning, recommendations include early engagement and re-conceptualising advance care planning as an ongoing process which encompasses current and future care. Further research is needed in different cultures and care contexts.
MeSH term(s)	Advance Care Planning ; Aged ; Aged, 80 and over ; Communication ; Family ; Female ; Frail Elderly ; Humans ; Qualitative Research
Language	English
Publishing date	2021-05-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639247-7
ISSN	1477-030X ; 0269-2163
ISSN (online)	1477-030X
ISSN	0269-2163
DOI	10.1177/02692163211013260
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Article ; Online: Reporting of Patient Experience Data on Health Systems' Websites and Commercial Physician-Rating Websites: Mixed-Methods Analysis.

Lagu, Tara / Norton, Caroline M / Russo, Lindsey M / Priya, Aruna / Goff, Sarah L / Lindenauer, Peter K

Journal of medical Internet research

2019 Volume 21, Issue 3, Page(s) e12007

Abstract: Background: Some hospitals' and health systems' websites report physician-level ratings and comments drawn from the Consumer Assessment of Healthcare Providers and Systems surveys.: Objective: The aim was to examine the prevalence and content of ... ...

Abstract	Background: Some hospitals' and health systems' websites report physician-level ratings and comments drawn from the Consumer Assessment of Healthcare Providers and Systems surveys. Objective: The aim was to examine the prevalence and content of health system websites reporting these data and compare narratives from these sites to narratives from commercial physician-rating sites. Methods: We identified health system websites active between June 1 and 30, 2016, that posted clinician reviews. For 140 randomly selected clinicians, we extracted the number of star ratings and narrative comments. We conducted a qualitative analysis of a random sample of these physicians' narrative reviews and compared these to a random sample of reviews from commercial physician-rating websites. We described composite quantitative scores for sampled physicians and compared the frequency of themes between reviews drawn from health systems' and commercial physician-rating websites. Results: We identified 42 health systems that published composite star ratings (42/42, 100%) or narratives (33/42, 79%). Most (27/42, 64%) stated that they excluded narratives deemed offensive. Of 140 clinicians, the majority had composite scores listed (star ratings: 122/140, 87.1%; narrative reviews: 114/140, 81.4%), with medians of 110 star ratings (IQR 42-175) and 25.5 (IQR 13-48) narratives. The rating median was 4.8 (IQR 4.7-4.9) out of five stars, and no clinician had a score less than 4.2. Compared to commercial physician-rating websites, we found significantly fewer negative comments on health system websites (35.5%, 76/214 vs 12.8%, 72/561, respectively; P<.001). Conclusions: The lack of variation in star ratings on health system sites may make it difficult to differentiate between clinicians. Most health systems report that they remove offensive comments, and we notably found fewer negative comments on health system websites compared to commercial physician-rating sites.
MeSH term(s)	Female ; Humans ; Internet ; Male ; Patient Satisfaction/statistics & numerical data ; Physicians ; Research Design ; Social Networking ; Surveys and Questionnaires
Language	English
Publishing date	2019-03-27
Publishing country	Canada
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2028830-X
ISSN	1438-8871 ; 1438-8871
ISSN (online)	1438-8871
ISSN	1438-8871
DOI	10.2196/12007
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