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  1. Article: Plethora of adverse drug reactions in geriatric population receiving statin therapy for dyslipidaemia.

    Padhye, Mugdha R / Yadav, Nikhil S

    Journal of family medicine and primary care

    2022  Volume 11, Issue 7, Page(s) 3726–3729

    Abstract: Background: Hyperlipidemia plays a major role in the pathogenesis of cardiovascular diseases (CVD). Statins are considered to be the most efficacious drugs in the management of hyperlipidemia and this class of drugs is most commonly prescribed for the ... ...

    Abstract Background: Hyperlipidemia plays a major role in the pathogenesis of cardiovascular diseases (CVD). Statins are considered to be the most efficacious drugs in the management of hyperlipidemia and this class of drugs is most commonly prescribed for the treatment of hyperlipidemias. Although statin therapy has transformed the management of hyperlipidemia, it is associated with the skeletal muscle, neurological, and metabolic adverse effects. This study was conducted to evaluate the adverse effects of statin therapy in a geriatric population which may help in understanding whether these effects are dose-dependent.
    Methods: The study was conducted on 200 patients receiving statin therapy (atorvastatin and rosuvastatin) for hyperlipidemias. They were divided into four groups depending on the prescribed dose of atorvastatin and rosuvastatin. All study subjects were followed up for 6 months. The adverse effects reported by them during the statin therapy were documented and analyzed.
    Results: All patients reported adverse effects after the initiation of statin therapy. Headache and muscle symptoms were among the most commonly reported adverse effects. There was no serious adverse effect (SAE). None of the adverse effects led to the discontinuation of the statin therapy.
    Conclusion: The results of this study suggest that all patients receiving statin therapy experience one or more adverse effects during the therapy. The adverse effects were not found to be severe in the geriatric age group.
    Language English
    Publishing date 2022-07-22
    Publishing country India
    Document type Journal Article
    ZDB-ID 2735275-4
    ISSN 2278-7135 ; 2249-4863
    ISSN (online) 2278-7135
    ISSN 2249-4863
    DOI 10.4103/jfmpc.jfmpc_2205_21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Reconstructed diagnostic sensitivity and specificity of the RT-PCR test for COVID-19

    Padhye, Nikhil S

    medRxiv

    Abstract: Background. Real-time reverse transcription polymerase chain reaction (RT-PCR) targeting select genes of the SARS-CoV-2 RNA has been the main diagnostic tool in the global response to the COVID-19 pandemic. However, the diagnostic accuracy of the test ... ...

    Abstract Background. Real-time reverse transcription polymerase chain reaction (RT-PCR) targeting select genes of the SARS-CoV-2 RNA has been the main diagnostic tool in the global response to the COVID-19 pandemic. However, the diagnostic accuracy of the test has not been studied systematically outside of the laboratory setting. The aim of this study is to provide estimates of the diagnostic sensitivity and specificity of the RT-PCR test developed by China CDC. Methods. The study design is a secondary analysis of published findings on 1014 patients in Wuhan, China, of whom 601 tested positive and 413 were negative for COVID-19. Sensitivity and specificity were reconstructed using a Bayesian approach from probabilistic knowledge of the diagnostic errors. Predictive values of the test were calculated, resulting in estimates for the number of confirmatory tests that are needed for establishing the presence or absence of COVID-19, depending on the prior probability of a patient having the disease. Results. The sensitivity of the RT-PCR diagnostic test was estimated to be 0.777 (95% CI: 0.715, 0.849), while the specificity was 0.988 (95% CI: 0.933, 1.000). The confidence intervals include sampling error in addition to the error due to probabilistic knowledge of the data. Discussion. The Chinese version of the RT-PCR test had a conspicuous rate of false negative results, likely missing between 15% and 29% of patients with COVID-19. For a patient with a prior probability of COVID-19 greater than 18%, at least two negative test results would be needed to lower the chances of COVID-19 below 5%. Caution is advised in generalizing these findings to other versions of the RT-PCR test that are being used in diverse geographic regions.
    Keywords covid19
    Language English
    Publishing date 2020-04-29
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2020.04.24.20078949
    Database COVID19

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  3. Book ; Online: Dilatational-Plasticity Opens a New Mechanistic Pathway for Macromolecular Transport Across Polymeric Interfaces Yielding Solid-State Bonding

    Padhye, Nikhil / Vallabh, Ajay

    2022  

    Abstract: Bonding between polymeric interfaces is encountered widely in several industrial applications. Many of these bonding processes rely on time-consuming and temperature-dependent classical mechanism of polymer interdiffusion via reptation in a melt state. ... ...

    Abstract Bonding between polymeric interfaces is encountered widely in several industrial applications. Many of these bonding processes rely on time-consuming and temperature-dependent classical mechanism of polymer interdiffusion via reptation in a melt state. Here, for the first time, we report a new mechanistic pathway for achieving solid-state polymer bonding by triggering rapid macromolecular acceleration through mechanical deformation. Large-scale molecular simulations reveal that active plastic deformation in glassy polymers, at temperatures well-below the bulk (and surface) glass transition temperatures, is sufficient to cause segmental translations of the polymer chains that lead to interfacial interpenetrations, and formation of new entanglements. The underlying mechanistic basis for this new type of bonding is identified as enhanced molecular-scale dilatations (or densifications) in conjunction with accelerated molecular mobility during plastic deformation. The reported mechanistic insights open promising avenues for designing new bonding technologies or material systems, and transformation of the existing ones to achieve quick and energetically less intensive bonding.
    Keywords Condensed Matter - Soft Condensed Matter ; Condensed Matter - Materials Science
    Subject code 540
    Publishing date 2022-05-08
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Pressure Injury Link to Entropy of Abdominal Temperature.

    Padhye, Nikhil / Rios, Denise / Fay, Vaunette / Hanneman, Sandra K

    Entropy (Basel, Switzerland)

    2022  Volume 24, Issue 8

    Abstract: This study examined the association between pressure injuries and complexity of abdominal temperature measured in residents of a nursing facility. The temperature served as a proxy measure for skin thermoregulation. Refined multiscale sample entropy and ... ...

    Abstract This study examined the association between pressure injuries and complexity of abdominal temperature measured in residents of a nursing facility. The temperature served as a proxy measure for skin thermoregulation. Refined multiscale sample entropy and bubble entropy were used to measure the irregularity of the temperature time series measured over two days at 1-min intervals. Robust summary measures were derived for the multiscale entropies and used in predictive models for pressure injuries that were built with adaptive lasso regression and neural networks. Both types of entropies were lower in the group of participants with pressure injuries (n=11) relative to the group of non-injured participants (n=15). This was generally true at the longer temporal scales, with the effect peaking at scale τ=22 min for sample entropy and τ=23 min for bubble entropy. Predictive models for pressure injury on the basis of refined multiscale sample entropy and bubble entropy yielded 96% accuracy, outperforming predictions based on any single measure of entropy. Combining entropy measures with a widely used risk assessment score led to the best prediction accuracy. Complexity of the abdominal temperature series could therefore serve as an indicator of risk of pressure injury.
    Language English
    Publishing date 2022-08-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2014734-X
    ISSN 1099-4300 ; 1099-4300
    ISSN (online) 1099-4300
    ISSN 1099-4300
    DOI 10.3390/e24081127
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Validation of Self-Reported Attachment Classification Among Racially and Ethnically Diverse Parents of Young Children.

    Cain, Cary M / Mandell, Dorothy J / Padhye, Nikhil S / Rozmus, Cathy L

    Nursing research

    2022  Volume 72, Issue 2, Page(s) 150–157

    Abstract: Background: The Attachment Style Questionnaire (ASQ) was developed to measure individual differences in insecure adult attachment and was suitable for populations that may have minimal or no experience in romantic relationships. The measure was ... ...

    Abstract Background: The Attachment Style Questionnaire (ASQ) was developed to measure individual differences in insecure adult attachment and was suitable for populations that may have minimal or no experience in romantic relationships. The measure was previously validated on homogenous populations.
    Objectives: The purpose of this study was to verify construct validity and internal consistency of the ASQ among an ethnically and racially diverse sample of caregivers of young children ages birth to 3 years.
    Methods: Using a cross-sectional design, we examined the psychometric properties of the ASQ. A racially and ethnically diverse sample of caregivers of young children (birth to 3 years old) completed the 40-item measure. Factor analyses and internal consistency analyses were conducted.
    Results: Confirmatory factor analyses showed that the previously published factor structures were not a good fit for this diverse sample. Exploratory factor analysis with promax rotation revealed a four-factor solution among 16 items, including relationship anxiety, relationships as secondary, discomfort with closeness, and relationship distrust. Adequate internal consistency was noted for the factors, and structural invariance was confirmed across Hispanic and non-Hispanic ethnicities.
    Discussion: Nurse scientists and practitioners should take caution when using or developing indices based on previous research. There should be consideration of structural stability and replication across the intended population.
    MeSH term(s) Adult ; Humans ; Child ; Child, Preschool ; Self Report ; Cross-Sectional Studies ; Reproducibility of Results ; Parents ; Surveys and Questionnaires ; Psychometrics ; Factor Analysis, Statistical
    Language English
    Publishing date 2022-12-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80332-7
    ISSN 1538-9847 ; 0029-6562
    ISSN (online) 1538-9847
    ISSN 0029-6562
    DOI 10.1097/NNR.0000000000000634
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    Zs.A 697: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  6. Article ; Online: Digital image post processing techniques for taxonomic publications with reference to insects

    Nikhil Joshi / Hemant Ghate / Sameer Padhye

    Journal of Threatened Taxa, Vol 12, Iss 1, Pp 15173-

    2020  Volume 15180

    Abstract: There exists substantial literature for capturing digital images of insect specimens for taxonomy purposes but very few papers are available on post processing of these images. We present a few techniques for editing digital images of insects using Adobe® ...

    Abstract There exists substantial literature for capturing digital images of insect specimens for taxonomy purposes but very few papers are available on post processing of these images. We present a few techniques for editing digital images of insects using Adobe® Photoshop® which can be performed in a relatively short amount of time. The results clearly show that techniques using a combination of options like Curves, Dodge/Burn, Hue/Saturation and Lab Color mode in the software, enhance the quality of the original image without changing any taxonomic information. These methods applied in different combinations can be used for taxonomy of any insect taxon. We also caution the readers of the abuse of such techniques in context of taxonomy.
    Keywords adobe® photoshop® ; beetles ; insects ; lab color ; purple fringing ; Ecology ; QH540-549.5 ; General. Including nature conservation ; geographical distribution ; QH1-199.5
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher Wildlife Information Liaison Development Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Associations Between the COVID-19 Pandemic and New Nurses' Transition to Practice Outcomes: A Multi-site, Longitudinal Study.

    Djukic, Maja / Padhye, Nikhil / Ke, Zhichun / Yu, Erica / McVey, Caitlin / Manuel, Warisara / Short, Yashamika / Pine, Rosemary / Caligone, Shamail

    Journal of nursing regulation

    2023  Volume 14, Issue 1, Page(s) 42–49

    Abstract: Background: The transition between nursing school and nursing practice has been well studied and recognized as a turbulent time for new nurses. Existing literature suggests that transition to practice (TTP) programs can successfully support new nurses ... ...

    Abstract Background: The transition between nursing school and nursing practice has been well studied and recognized as a turbulent time for new nurses. Existing literature suggests that transition to practice (TTP) programs can successfully support new nurses through this challenging period. However, TTP program outcomes have not been studied related to the COVID-19 pandemic, which altered TTP experiences for many new nurses by limiting their access to clinical sites for hands-on patient care experience and shifting delivery of nursing education and TTP programs from in-person to virtual environments.
    Purpose: The purpose of this study was to analyze the associations between TTP outcomes and the COVID-19 pandemic.
    Methods: This was a retrospective correlational, longitudinal study using secondary analysis of Vizient /AACN Nurse Residency Program survey data from the Casey-Fink Graduate Nurse Experience Survey and the Nurse Resident Progression Survey. Self-reported data from new nurses in Southeast Texas who participated in a standardized TTP program before the COVID-19 pandemic (2017-2019) were compared with self-reported data from nurses who participated in the TTP program during the pandemic (2020 and 2021).
    Results: A total of 2,673 nurses participated in this study. When adjusting for demographic composition of the cohorts, statistically significant differences (
    Conclusion: Our findings provide new information on the impact of the COVID-19 pandemic on new nurses' participating in a standardized TTP program. The results indicate that patient safety and commitment to staying employed in the organization and the nursing profession should be priority improvement areas for employers and TTP program staff as they work to support new nurses' TTP in a pandemic.
    Language English
    Publishing date 2023-04-05
    Publishing country United States
    Document type Journal Article
    ISSN 2155-8256
    ISSN 2155-8256
    DOI 10.1016/S2155-8256(23)00067-4
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  8. Article ; Online: Effect of self-monitoring clusters on weight and hemoglobin A1c.

    Padhye, Nikhil S / Jing Wang

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

    2017  Volume 2016, Page(s) 275–278

    Abstract: We investigated whether participants with higher adherence to smartphone or paper-based self-monitoring of diet, physical activity, blood glucose, and body weight have a beneficial impact on their body weight and hemoglobin A1c measures over a 3-month ... ...

    Abstract We investigated whether participants with higher adherence to smartphone or paper-based self-monitoring of diet, physical activity, blood glucose, and body weight have a beneficial impact on their body weight and hemoglobin A1c measures over a 3-month period. Data were combined from two intervention studies that recruited overweight or obese participants with type 2 diabetes. Three clusters of adherence to self-monitoring were identified. Participants in a cluster with high adherence to self-monitoring of diet and moderate adherence to glucose self-monitoring were found to have the biggest reductions in weight and hemoglobin A1c, as compared to clusters with either high or low adherence to self-monitoring of all four factors.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Blood Glucose/analysis ; Blood Glucose Self-Monitoring/methods ; Body Weight ; Diabetes Mellitus, Type 2/blood ; Exercise ; Female ; Glycated Hemoglobin A/analysis ; Humans ; Male ; Middle Aged ; Obesity ; Overweight ; Patient Compliance ; Young Adult
    Chemical Substances Blood Glucose ; Glycated Hemoglobin A
    Language English
    Publishing date 2017-03-08
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial
    ISSN 2694-0604
    ISSN (online) 2694-0604
    DOI 10.1109/EMBC.2016.7590693
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  9. Article ; Online: Sex, race, ADHD, and prior concussions as predictors of concussion recovery in adolescents.

    Aggarwal, Seema S / Ott, Summer D / Padhye, Nikhil S / Schulz, Paul E

    Brain injury

    2020  Volume 34, Issue 6, Page(s) 809–817

    Abstract: Objective: Concussions in adolescents are a growing public health concern as the popularity of high school sports increases. The aim of this study was to identify clinical (e.g., prior concussion, migraine history, learning disabilities/attention ... ...

    Abstract Objective: Concussions in adolescents are a growing public health concern as the popularity of high school sports increases. The aim of this study was to identify clinical (e.g., prior concussion, migraine history, learning disabilities/attention deficit hyperactivity disorders [ADHD]) and demographic factors (e.g., sex, race, health insurance, mechanism of injury/sport, education) that predict concussion recovery times.
    Design: In a retrospective cohort study of adolescents 13-19 years old evaluated for an acute concussion (≤ 10 days from injury), recovery times were calculated from the date of concussive injury to the date of clearance to return to play or normal activities.
    Results: The sample (N = 227) was primarily male (75%), and the median age was 15 years. Predictors of protracted recovery were ADHD (hazard ratio [HR] =.449, 95% confidence interval [CI] =.272-.741,
    Conclusions: Further research is needed to examine the role of sex, race, ADHD, and concussion history on concussion outcomes.
    MeSH term(s) Adolescent ; Athletic Injuries/complications ; Athletic Injuries/epidemiology ; Attention Deficit Disorder with Hyperactivity/epidemiology ; Attention Deficit Disorder with Hyperactivity/etiology ; Brain Concussion/epidemiology ; Female ; Humans ; Infant, Newborn ; Learning Disabilities ; Male ; Retrospective Studies
    Language English
    Publishing date 2020-03-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 639115-1
    ISSN 1362-301X ; 0269-9052
    ISSN (online) 1362-301X
    ISSN 0269-9052
    DOI 10.1080/02699052.2020.1740942
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2242: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Animal-Assisted Activity in Critically Ill Older Adults: A Randomized Pilot and Feasibility Trial.

    Branson, Sandy / Boss, Lisa / Hamlin, Shannan / Padhye, Nikhil S

    Biological research for nursing

    2020  Volume 22, Issue 3, Page(s) 412–417

    Abstract: Background: Limited evidence suggests the efficacy of animal-assisted activities (AAA) in improving biobehavioral stress responses in older patients in intensive care units (ICUs).: Objectives: To assess the feasibility of an AAA (dog) intervention ... ...

    Abstract Background: Limited evidence suggests the efficacy of animal-assisted activities (AAA) in improving biobehavioral stress responses in older patients in intensive care units (ICUs).
    Objectives: To assess the feasibility of an AAA (dog) intervention for improving biobehavioral stress response, measured by self-reported stress and anxiety and salivary cortisol, C-reactive protein, and interleukin-1β in older ICU patients, we examined enrollment, attrition, completion, data collection, and biobehavioral stress responses.
    Methods: ICU patients ≥60 years old were randomly assigned to a 10-min AAA intervention or control/usual ICU care. Attitudes toward pets were assessed before the intervention. Self-reported stress and anxiety and salivary stress biomarkers were collected before and after the intervention and the usual care condition.
    Results: The majority of patients were ineligible due to lack of decisional capacity, younger age, inability to provide saliva specimens, or critical illness. Though 15 participants were randomly allocated (AAA = 9; control = 6), only 10 completed the study. All participants completed the questionnaires; however, saliva specimens were significantly limited by volume. AAA was associated with decreases in stress and anxiety. Biomarker results were variable and revealed no specific trends associated with stress responses.
    MeSH term(s) Aged ; Aged, 80 and over ; Animal Assisted Therapy/methods ; Animals ; Critical Illness/psychology ; Critical Illness/therapy ; Dogs ; Feasibility Studies ; Female ; Frail Elderly/psychology ; Humans ; Intensive Care Units/statistics & numerical data ; Male ; Middle Aged ; Pilot Projects ; Random Allocation ; Stress, Psychological/therapy ; Surveys and Questionnaires
    Language English
    Publishing date 2020-04-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2145107-2
    ISSN 1552-4175 ; 1099-8004
    ISSN (online) 1552-4175
    ISSN 1099-8004
    DOI 10.1177/1099800420920719
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    Zs.A 5946: Show issues Location:
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