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  1. Article ; Online: Diagnosis, treatment, and potential causative mutations of cryptogenic plastic bronchitis.

    Bai, Jiuwu / Liang, Shuo / Lu, Haiwen / Xiong, Mengting / Shen, Lei / Yu, Dong / Li, Yuping / Zhang, Li / Gu, Ye / Wu, Chunyan / Jiang, Ping / Jiang, Sen / Jiang, Gening / Xu, Jinfu

    Chinese medical journal

    2023  Volume 136, Issue 4, Page(s) 497–498

    MeSH term(s) Humans ; Bronchitis/diagnosis ; Bronchitis/drug therapy ; Bronchitis/genetics ; Bronchoscopy ; Mutation/genetics ; Plastics
    Chemical Substances Plastics
    Language English
    Publishing date 2023-02-20
    Publishing country China
    Document type Letter
    ZDB-ID 127089-8
    ISSN 2542-5641 ; 0366-6999 ; 1002-0187
    ISSN (online) 2542-5641
    ISSN 0366-6999 ; 1002-0187
    DOI 10.1097/CM9.0000000000002119
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  2. Article ; Online: Diagnosis, treatment, and potential causative mutations of cryptogenic plastic bronchitis

    Jiuwu Bai / Shuo Liang / Haiwen Lu / Mengting Xiong / Lei Shen / Dong Yu / Yuping Li / Li Zhang / Ye Gu / Chunyan Wu / Ping Jiang / Sen Jiang / Gening Jiang / Jinfu Xu / Peifang Wei

    Chinese Medical Journal, Vol 136, Iss 4, Pp 497-

    2023  Volume 498

    Keywords Medicine ; R
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher Wolters Kluwer
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Comparison of traditional methods and high-throughput genetic sequencing in the detection of pathogens in pulmonary infectious diseases.

    Chen, Xianqiu / Cheng, Kebin / Sun, Xiaoli / Zhang, Yuan / Cao, Zu / Li, Jianxiong / Bai, Jiuwu / Lu, Haiwen / Gu, Shuyi / Zhang, Li / Xu, Jinfu / Jiang, Ping / Liang, Shuo

    Annals of translational medicine

    2021  Volume 9, Issue 8, Page(s) 702

    Abstract: Background: The major causes of pulmonary infections are various microorganisms. This study aimed to compare the positive rates of pathogenic microorganism DNA/RNA high-throughput genetic sequencing (PMseq), which is an emerging technique, with ... ...

    Abstract Background: The major causes of pulmonary infections are various microorganisms. This study aimed to compare the positive rates of pathogenic microorganism DNA/RNA high-throughput genetic sequencing (PMseq), which is an emerging technique, with traditional methods for pulmonary disease detection, and to investigate the differences in different sample types.
    Methods: Bronchoalveolar lavage fluid (BALF) and venous blood samples from 104 patients were collected for detection.
    Results: The positive rates of PMseq in BALF and venous blood were both significantly higher than those of traditional methods in the same sample (P<0.001). For BALF, the detection sensitivities were 96.9% for non-febrile patients and 100% for febrile patients. For venous blood, the detection sensitivities were 50.0% for non-febrile patients and 81.3% for febrile patients. There was no statistical difference in the sensitivity of venous blood samples with or without fever (P=0.075). For patients without fever, the sensitivity of BALF was much higher than venous blood samples (P<0.001). In patients with fever, there were no significant differences between different samples.
    Conclusions: This study showed that PMseq has a higher positive rate for the detection of pulmonary diseases. For patients without fever, it is recommended to use BALF instead of venous blood samples because of the higher sensitivity. However, for patients with fever, venous blood samples can be used when bronchoalveolar lavage is inconvenient.
    Language English
    Publishing date 2021-04-27
    Publishing country China
    Document type Journal Article
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm-21-1322
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  4. Article: Castleman's disease presenting in the lungs: A report of two cases.

    Cao, Weijun / Liang, Shuo / Liu, Jinming / Bai, Jiuwu / Li, Huiping

    Oncology letters

    2015  Volume 10, Issue 2, Page(s) 1041–1043

    Abstract: Castleman's disease (CD) is a rare disease that most commonly occurs in the mediastinum. The lung is a rare site in which CD may occur. The current study reported 2 cases of CD localized in the lungs. Computed tomography imaging identified a high-density ...

    Abstract Castleman's disease (CD) is a rare disease that most commonly occurs in the mediastinum. The lung is a rare site in which CD may occur. The current study reported 2 cases of CD localized in the lungs. Computed tomography imaging identified a high-density mass in the lungs of the two patients. Biopsy and pathological examinations indicated that one case presented features of two CD types (hyaline-vascular and plasma cell types), while the other case suffered from multicentric CD. The present study highlighted the typical clinical features of CD in the lungs. In addition, it is proposed that a diagnosis of CD should be considered for certain patients with masses in the lungs, and a biopsy should be performed to facilitate diagnosis and treatment.
    Language English
    Publishing date 2015-06-10
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 2573196-8
    ISSN 1792-1082 ; 1792-1074
    ISSN (online) 1792-1082
    ISSN 1792-1074
    DOI 10.3892/ol.2015.3354
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  5. Article: The role of volatile organic compounds for assessing characteristics and severity of non-cystic fibrosis bronchiectasis: an observational study.

    Gu, Shu-Yi / Lu, Hai-Wen / Bai, Jiu-Wu / Yang, Jia-Wei / Mao, Bei / Yu, Li / Xu, Jin-Fu

    Frontiers in medicine

    2024  Volume 11, Page(s) 1345165

    Abstract: Background: Hypoxic conditions and : Methods: EBC samples were collected from stable bronchiectasis patients and analyzed using solid phase microextraction-gas chromatography-mass spectrometry (SPME-GCMS). The association of VOCs with bronchiectasis ... ...

    Abstract Background: Hypoxic conditions and
    Methods: EBC samples were collected from stable bronchiectasis patients and analyzed using solid phase microextraction-gas chromatography-mass spectrometry (SPME-GCMS). The association of VOCs with bronchiectasis patients' phenotypes including hypoxic conditions and
    Results: Levels of 10-heptadecenoic acid, heptadecanoic acid, longifolene, and decanol in the hypoxia group were higher compared to the normoxia group. Additionally, the levels of 13-octadecenoic acid, octadecenoic acid, phenol, pentadecanoic acid, and myristic acid were increased in
    Conclusion: The study provides evidence that specific VOCs in EBC are correlated with the severity of bronchiectasis, and 10-heptadecenoic acid is shown to be a predictive marker for hypoxia condition in bronchiectasis patients.
    Language English
    Publishing date 2024-04-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2024.1345165
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  6. Article ; Online: A New Scale to Assess the Severity and Prognosis of Pulmonary Alveolar Proteinosis.

    Bai, JiuWu / Xu, JinFu / Yang, WenLan / Gao, Beilan / Cao, Weijun / Liang, Shuo / Li, Huiping

    Canadian respiratory journal

    2016  Volume 2016, Page(s) 3412836

    Abstract: Background. Pulmonary Alveolar Proteinosis (PAP) is a syndrome characterized by pulmonary surfactant accumulation. Small proportion of PAP patients experienced spontaneous remission. Objective. The aim of this study was to assess the severity and ... ...

    Abstract Background. Pulmonary Alveolar Proteinosis (PAP) is a syndrome characterized by pulmonary surfactant accumulation. Small proportion of PAP patients experienced spontaneous remission. Objective. The aim of this study was to assess the severity and prognosis of PAP using various indexes. Methods. Characteristics, PaO2, lung function parameters, and HRCT score of 101 patients with PAP were retrospectively analyzed. Many indexes were explored and integrated into a scale. Results. PaO2 was lower among smokers than among never-smokers. PaO2 differed between each pair of patient groups stratified according to HRCT score or DLCO, % predicted, which differed between any two groups stratified according to PaO2. The PAP patients who died presented with more symptoms, a higher HRCT score, and lower DLCO, % predicted, than survivors. Smoking status, symptoms, PaO2, HRCT score, and DLCO, % predicted, were integrated into a scale (severity and prognosis score of PAP (SPSP)). SPSP correlated positively with PaO2, FVC, % predicted, FEV1, % predicted, and DLCO, % predicted, and negatively with HRCT score. The patients who died displayed a higher SPSP than survivors. Conclusion. Smoking status, symptoms, PaO2, HRCT score, and DLCO, % predicted, were integrated into a scale (SPSP) that can be used to assess the severity and prognosis of PAP to some degree.
    MeSH term(s) Adult ; China/epidemiology ; Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged ; Prognosis ; Pulmonary Alveolar Proteinosis/diagnosis ; Pulmonary Alveolar Proteinosis/mortality ; Retrospective Studies ; Severity of Illness Index
    Language English
    Publishing date 2016
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 1213103-9
    ISSN 1916-7245 ; 1198-2241
    ISSN (online) 1916-7245
    ISSN 1198-2241
    DOI 10.1155/2016/3412836
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    In stock of ZB MED Cologne/Königswinter

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  7. Article ; Online: Severe Pulmonary Hypertension Increased All-cause Mortality in Patients With Bronchiectasis.

    Gao, Yong-Hua / Zhu, Ya-Nan / Bai, Jiu-Wu / Liang, Shuo / Wang, Ling / Wang, Lan / Gong, Su-Gang / Zheng, Hui-Zhen / Xu, Jin-Fu

    Archivos de bronconeumologia

    2024  

    Language Spanish
    Publishing date 2024-03-23
    Publishing country Spain
    Document type Case Reports
    ZDB-ID 733126-5
    ISSN 1579-2129 ; 0300-2896
    ISSN (online) 1579-2129
    ISSN 0300-2896
    DOI 10.1016/j.arbres.2024.03.014
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  8. Article: Biochemical index and immunological function in the peripheral blood of patients with idiopathic pulmonary alveolar proteinosis.

    Bai, Jiuwu / Li, Huiping / Shi, Jingyun / Xu, Jinfu / Li, Xia / Cao, Weijun / Chu, Haiqing / Liu, Jinming / Gao, Beilan

    Biomedical reports

    2013  Volume 1, Issue 3, Page(s) 405–409

    Abstract: Idiopathic pulmonary alveolar proteinosis (PAP) has recently been recognized as a disease of impaired alveolar macrophage function caused by the neutralizing granulocyte-macrophage colony stimulating factor (GM-CSF) autoantibody. However, the change of ... ...

    Abstract Idiopathic pulmonary alveolar proteinosis (PAP) has recently been recognized as a disease of impaired alveolar macrophage function caused by the neutralizing granulocyte-macrophage colony stimulating factor (GM-CSF) autoantibody. However, the change of immunological function and biochemical index in the peripheral blood of patients with idiopathic PAP remains unclear. The clinical data of 29 patients with idiopathic PAP and 30 normal subjects were retrospectively analyzed. Biochemical indices, immunoglobulin and complement of all participants, and immunocytes in 19 patients and 30 normal subjects were evaluated. The peripheral blood of the patients showed a decrease in CD4
    Language English
    Publishing date 2013-02-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2763624-0
    ISSN 2049-9442 ; 2049-9434
    ISSN (online) 2049-9442
    ISSN 2049-9434
    DOI 10.3892/br.2013.66
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  9. Article ; Online: CYFRA21-1 is a more sensitive biomarker to assess the severity of pulmonary alveolar proteinosis.

    Bai, Jiu-Wu / Gu, Shui-Yi / Sun, Xiao-Li / Lu, Hai-Wen / Liang, Shuo / Xu, Jin-Fu

    BMC pulmonary medicine

    2022  Volume 22, Issue 1, Page(s) 2

    Abstract: Background: Serum lactate dehydrogenase (LDH), carcinoembryonic antigen (CEA) and CYFRA21-1 are the commonly used biomarkers to identify patients with autoimmune pulmonary alveolar proteinosis (APAP). However, it is not clear which of the biomarkers is ... ...

    Abstract Background: Serum lactate dehydrogenase (LDH), carcinoembryonic antigen (CEA) and CYFRA21-1 are the commonly used biomarkers to identify patients with autoimmune pulmonary alveolar proteinosis (APAP). However, it is not clear which of the biomarkers is more sensitive to the severity of the patient's condition.
    Methods: APAP patients numbering 151 were enrolled in this study. All patients' severity was assessed through the severity and prognosis score of PAP (SPSP). According to the respective laboratory upper limits of serum levels of LDH, CEA and CYFRA21-1, APAP patients were divided into higher and lower-level groups. Patients were divided into five groups based on SPSP. 88 patients had completed six months of follow-up. We calculated sensitivity, specificity, and critical point of LDH, CEA and CYFRA21-1 between APAP patients and normal control group, and between grade 1-2 and 3-5 through receiving operating characteristics (ROC) curve.
    Results: Serum LDH, CEA and CYFRA21-1 levels of patients with PAP were higher and distinctly related to PaO
    Conclusion: Serum CYFRA21-1 level was more sensitive in revealing the severity of APAP than LDH and CEA levels among mild to moderate forms of disease.
    MeSH term(s) Adult ; Aged ; Antigens, Neoplasm/blood ; Biomarkers/blood ; China ; Female ; Forced Expiratory Volume ; Humans ; Keratin-19/blood ; L-Lactate Dehydrogenase/blood ; Male ; Middle Aged ; Pulmonary Alveolar Proteinosis/blood ; Retrospective Studies ; Sensitivity and Specificity ; Severity of Illness Index
    Chemical Substances Antigens, Neoplasm ; Biomarkers ; Keratin-19 ; antigen CYFRA21.1 ; L-Lactate Dehydrogenase (EC 1.1.1.27)
    Language English
    Publishing date 2022-01-03
    Publishing country England
    Document type Comparative Study ; Journal Article
    ZDB-ID 2059871-3
    ISSN 1471-2466 ; 1471-2466
    ISSN (online) 1471-2466
    ISSN 1471-2466
    DOI 10.1186/s12890-021-01795-x
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  10. Article: Updated severity and prognosis score of pulmonary alveolar proteinosis: A multi-center cohort study in China.

    Bai, Jiu-Wu / Huang, Jian-Nan / Shi, Shen-Yun / Ge, Ai / Lu, Hai-Wen / Sun, Xiao-Li / Gu, Shu-Yi / Liang, Shuo / Cheng, Ke-Bin / Tian, Xin-Lun / Xiao, Yong-Long / Xu, Kai-Feng / Xu, Jin-Fu

    Frontiers in medicine

    2023  Volume 10, Page(s) 1058001

    Abstract: Background: The high-resolution computed tomography (HRCT) score is an important component of the severity and prognosis score of pulmonary alveolar proteinosis (SPSP). However, the HRCT score in SPSP only considers the extent of opacity, which is ... ...

    Abstract Background: The high-resolution computed tomography (HRCT) score is an important component of the severity and prognosis score of pulmonary alveolar proteinosis (SPSP). However, the HRCT score in SPSP only considers the extent of opacity, which is insufficient.
    Methods: We retrospectively evaluated HRCT scores for 231 patients with autoimmune pulmonary alveolar proteinosis (APAP) from three centers of the China Alliance for Rare Diseases. The SPSPII was created based on the overall density and extent, incorporating the SPSP. The severity of APAP patients was assessed using disease severity scores (DSS), SPSP, and SPSPII to determine the strengths and weaknesses of the different assessment methods. We then prospectively applied the SPSPII to patients before treatment, and the curative effect was assessed after 3 months.
    Results: The HRCT overall density and extent scores in our retrospective analysis were higher than the extent scores in all patients and every original extent score severity group, as well as higher related to arterial partial oxygen pressure (PaO
    Conclusion: The HRCT density and extent scores of patients with APAP were better than the extent score. The SPSPII score system based on smoking status, symptoms, PaO
    Trial registration: ClinicalTrial.gov, identifier: NCT04516577.
    Language English
    Publishing date 2023-02-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1058001
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