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Article ; Online: Letter by Chen and Liang Regarding Article, "Impact of Diabetes on Myocardial Fibrosis in Patients With Hypertension: The REMODEL Study".

Chen, Jun-Zhang / Liang, Bo

2023 Volume 16, Issue 11, Page(s) e016023

MeSH term(s)	Humans ; Cardiomyopathies ; Hypertension/diagnosis ; Hypertension/epidemiology ; Diabetes Mellitus/diagnosis ; Diabetes Mellitus/epidemiology ; Fibrosis
Language	English
Publishing date	2023-10-26
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2435045-X
ISSN	1942-0080 ; 1941-9651
ISSN (online)	1942-0080
ISSN	1941-9651
DOI	10.1161/CIRCIMAGING.123.016023
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Article: Single-base editing in IGF2 improves meat production and intramuscular fat deposition in Liang Guang Small Spotted pigs.

Duo, Tianqi / Liu, Xiaohong / Mo, Delin / Bian, Yu / Cai, Shufang / Wang, Min / Li, Ruiqiang / Zhu, Qi / Tong, Xian / Liang, Ziyun / Jiang, Weilun / Chen, Shiyi / Chen, Yaosheng / He, Zuyong

Journal of animal science and biotechnology

2023 Volume 14, Issue 1, Page(s) 141

Abstract: ... into porcine embryonic fibroblasts (PEFs) isolated from a male Liang Guang Small Spotted pig (LGSS), and single ...

Abstract	Background: Chinese indigenous pigs are popular with consumers for their juiciness, flavour and meat quality, but they have lower meat production. Insulin-like growth factor 2 (IGF2) is a maternally imprinted growth factor that promotes skeletal muscle growth by regulating cell proliferation and differentiation. A single nucleotide polymorphism (SNP) within intron 3 of porcine IGF2 disrupts a binding site for the repressor, zinc finger BED-type containing 6 (ZBED6), leading to up-regulation of IGF2 and causing major effects on muscle growth, heart size, and backfat thickness. This favorable mutation is common in Western commercial pig populations, but absent in most Chinese indigenous pig breeds. To improve meat production of Chinese indigenous pigs, we used cytosine base editor 3 (CBE3) to introduce IGF2-intron3-C3071T mutation into porcine embryonic fibroblasts (PEFs) isolated from a male Liang Guang Small Spotted pig (LGSS), and single-cell clones harboring the desired mutation were selected for somatic cell nuclear transfer (SCNT) to generate the founder line of IGF2 Results: We found the heterozygous progeny IGF2 Conclusions: We demonstrated the introduction of IGF2-intron3-C3071T in Chinese LGSS can improve both meat production and quality, and first identified the regulation of IMF deposition by IGF2 through SREBP1 via the PI3K-AKT/AMPK signaling pathways. Our study provides a further understanding of the biological functions of IGF2 and an example for improving porcine economic traits through precise base editing.
Language	English
Publishing date	2023-11-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2630162-3
ISSN	2049-1891 ; 1674-9782
ISSN (online)	2049-1891
ISSN	1674-9782
DOI	10.1186/s40104-023-00930-4
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Article ; Online: "Liu-Liang-Chung" syndrome with multiple congenital anomalies and the distinctive craniofacial features caused by dominant ZEB2 gene gain mutation.

Liu, Wei-Liang / Li, Fang / Chen, Wei / Liu, Lu / Cheng, Hai-Jian / He, Zhi-Xu / Ai, Rong

BMC pediatrics

2023 Volume 23, Issue 1, Page(s) 480

Abstract: ... gain mutation, which is recommended to be named "Liu-Liang-Chung" syndrome. We diagnose this novel ...

Abstract	Background: Contiguous gene gain syndrome including entire ZEB2 may be a novel syndrome. In the past, there were no easily distinct and recognizable features as a guide for precise clinical and genetic diagnosis of the syndrome. Case presentation: We report a novel case with the syndrome with a novel de novo 22.16 Mb duplication at 2q21.2-q24.1. The syndrome is characterized by multiple anomalies including the same typical craniofacial phenotype that is entirely different from Mowat-Wilson syndrome (MWS), and other quite similar features of MWS consisting of development delay, congenital heart disease, abdominal abnormalities, urogenital abnormalities, behavioral problems and so on, in which the distinctive craniofacial features can be more easily recognized. Conclusions: Contiguous gene gain syndrome including entire ZEB2 characterized with similar multiple congenital anomalies of MWS and the distinctive craniofacial features is mainly caused by large 2q22 repeats including ZEB2 leading to dominant singe ZEB2 gene gain mutation, which is recommended to be named "Liu-Liang-Chung" syndrome. We diagnose this novel syndrome to distinguish it from MWS. Some variable additional features in the syndrome including remarkable growth and development retardation and protruding ears were recognized for the first time.
MeSH term(s)	Humans ; Abnormalities, Multiple/genetics ; Mutation ; Hirschsprung Disease/diagnosis ; Hirschsprung Disease/genetics ; Phenotype ; Zinc Finger E-box Binding Homeobox 2/genetics
Chemical Substances	ZEB2 protein, human ; Zinc Finger E-box Binding Homeobox 2
Language	English
Publishing date	2023-09-21
Publishing country	England
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2041342-7
ISSN	1471-2431 ; 1471-2431
ISSN (online)	1471-2431
ISSN	1471-2431
DOI	10.1186/s12887-023-04314-5
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Article ; Online: Single-base editing in IGF2 improves meat production and intramuscular fat deposition in Liang Guang Small Spotted pigs

Tianqi Duo / Xiaohong Liu / Delin Mo / Yu Bian / Shufang Cai / Min Wang / Ruiqiang Li / Qi Zhu / Xian Tong / Ziyun Liang / Weilun Jiang / Shiyi Chen / Yaosheng Chen / Zuyong He

Journal of Animal Science and Biotechnology, Vol 14, Iss 1, Pp 1-

2023 Volume 19

Abstract: ... into porcine embryonic fibroblasts (PEFs) isolated from a male Liang Guang Small Spotted pig (LGSS), and single ...

Abstract	Abstract Background Chinese indigenous pigs are popular with consumers for their juiciness, flavour and meat quality, but they have lower meat production. Insulin-like growth factor 2 (IGF2) is a maternally imprinted growth factor that promotes skeletal muscle growth by regulating cell proliferation and differentiation. A single nucleotide polymorphism (SNP) within intron 3 of porcine IGF2 disrupts a binding site for the repressor, zinc finger BED-type containing 6 (ZBED6), leading to up-regulation of IGF2 and causing major effects on muscle growth, heart size, and backfat thickness. This favorable mutation is common in Western commercial pig populations, but absent in most Chinese indigenous pig breeds. To improve meat production of Chinese indigenous pigs, we used cytosine base editor 3 (CBE3) to introduce IGF2-intron3-C3071T mutation into porcine embryonic fibroblasts (PEFs) isolated from a male Liang Guang Small Spotted pig (LGSS), and single-cell clones harboring the desired mutation were selected for somatic cell nuclear transfer (SCNT) to generate the founder line of IGF2 T/T pigs. Results We found the heterozygous progeny IGF2 C/T pigs exhibited enhanced expression of IGF2, increased lean meat by 18%–36%, enlarged loin muscle area by 3%–17%, improved intramuscular fat (IMF) content by 18%–39%, marbling score by 0.75–1, meat color score by 0.53–1.25, and reduced backfat thickness by 5%–16%. The enhanced accumulation of intramuscular fat in IGF2 C/T pigs was identified to be regulated by the PI3K-AKT/AMPK pathway, which activated SREBP1 to promote adipogenesis. Conclusions We demonstrated the introduction of IGF2-intron3-C3071T in Chinese LGSS can improve both meat production and quality, and first identified the regulation of IMF deposition by IGF2 through SREBP1 via the PI3K-AKT/AMPK signaling pathways. Our study provides a further understanding of the biological functions of IGF2 and an example for improving porcine economic traits through precise base editing.
Keywords	CBE3 ; IGF2 ; Intramuscular fat ; Meat production ; PI3K-AKT/AMPK ; ZBED6 ; Animal culture ; SF1-1100 ; Veterinary medicine ; SF600-1100
Subject code	630 ; 500
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Altered default mode network causal connectivity patterns in autism spectrum disorder revealed by Liang information flow analysis.

Cong, Jing / Zhuang, Wenwen / Liu, Yunhong / Yin, Shunjie / Jia, Hai / Yi, Chanlin / Chen, Kai / Xue, Kaiqing / Li, Fali / Yao, Dezhong / Xu, Peng / Zhang, Tao

Human brain mapping

2023 Volume 44, Issue 6, Page(s) 2279–2293

Abstract: ... remains largely unclear. Here, we introduced the Liang information flow method, widely applied to climate ... our findings indicated that the Liang information flow method could serve as an important way to explore ...

Abstract	Autism spectrum disorder (ASD) is a pervasive developmental disorder with severe cognitive impairment in social communication and interaction. Previous studies have reported that abnormal functional connectivity patterns within the default mode network (DMN) were associated with social dysfunction in ASD. However, how the altered causal connectivity pattern within the DMN affects the social functioning in ASD remains largely unclear. Here, we introduced the Liang information flow method, widely applied to climate science and quantum mechanics, to uncover the brain causal network patterns in ASD. Compared with the healthy controls (HC), we observed that the interactions among the dorsal medial prefrontal cortex (dMPFC), ventral medial prefrontal cortex (vMPFC), hippocampal formation, and temporo-parietal junction showed more inter-regional causal connectivity differences in ASD. For the topological property analysis, we also found the clustering coefficient of DMN and the In-Out degree of anterior medial prefrontal cortex were significantly decreased in ASD. Furthermore, we found that the causal connectivity from dMPFC to vMPFC was correlated with the clinical symptoms of ASD. These altered causal connectivity patterns indicated that the DMN inter-regions information processing was perturbed in ASD. In particular, we found that the dMPFC acts as a causal source in the DMN in HC, whereas it plays a causal target in ASD. Overall, our findings indicated that the Liang information flow method could serve as an important way to explore the DMN causal connectivity patterns, and it also can provide novel insights into the nueromechanisms underlying DMN dysfunction in ASD.
MeSH term(s)	Humans ; Autism Spectrum Disorder/diagnostic imaging ; Brain Mapping/methods ; Default Mode Network ; Magnetic Resonance Imaging/methods ; Neural Pathways/diagnostic imaging ; Brain/diagnostic imaging
Language	English
Publishing date	2023-01-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1197207-5
ISSN	1097-0193 ; 1065-9471
ISSN (online)	1097-0193
ISSN	1065-9471
DOI	10.1002/hbm.26209
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Zs.A 4028: Show issues

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Article ; Online: Liang-Ge-San inhibits dengue virus serotype 2 infection by reducing caveolin1-induced cytoplasmic heat shock protein 70 translocation into the plasma membrane.

Chen, Xi / Yang, Jia-Bin / Cao, Hui-Hui / Fang, Xiao-Chuan / Liu, Shan-Hong / Zou, Li-Fang / Yu, Jian-Hai / Zuo, Jian-Ping / Zhao, Wei / Lu, Zi-Bin / Liu, Jun-Shan / Yu, Lin-Zhong

Phytomedicine : international journal of phytotherapy and phytopharmacology

2023 Volume 119, Page(s) 154977

Abstract: ... therapeutic drugs for DENV. Many Chinese heat-cleaning formulas, such as Liang-Ge-San (LGS), have been frequently ...

Abstract	Background: Dengue virus (DENV) is a major public health threat. However, there are no specific therapeutic drugs for DENV. Many Chinese heat-cleaning formulas, such as Liang-Ge-San (LGS), have been frequently used in the virus-induced diseases. The antiviral effect of LGS has not been reported yet. Purpose: In this study, the effect of LGS on the inhibition of dengue virus serotype 2 (DENV-2) was investigated and the relevant mechanism was explored. Methods: High-performance liquid chromatography was applied to analyze the chemical characterization of LGS. The in vitro antiviral activities of LGS against DENV-2 were evaluated by time-of-drug-addition assay. The binding of heat shock protein 70 (Hsp70) and envelope (E) protein or caveolin1 (Cav1) were analyzed by immunofluorescence and immunoprecipitation assays. Then the role of Cav1 in the anti-DENV-2 effects of LGS was further examined. DENV-2 infected Institute of Cancer Research suckling mice (n = 10) and AG129 mice (n = 8) were used to examine the protective effects of LGS. Results: It was found that geniposide, liquiritin, forsythenside A, forsythin, baicalin, baicalein, rhein, and emodin maybe the characteristic components of LGS. LGS inhibited the early stage of DENV-2 infection, decreased the expression levels of viral E and non-structural protein 1 (NS1) proteins. LGS also reduced E protein and Hsp70 binding and attenuated the translocation of Hsp70 from cytoplasm to the cell membrane. Moreover, LGS decreased the binding of Hsp70 to Cav1. Further study showed that the overexpression of Cav1 reversed LGS-mediated E protein and Hsp70 inhibition in the plasma membrane. In the in vivo study, LGS was highly effective in prolonging the survival time, reducing viral loads. Conclusion: This work demonstrates for the first time that LGS exerts anti-DENV-2 activity in vitro and in vivo. LGS decreases DENV-2-stimulated cytoplasmic Hsp70 translocation into the plasma membrane by Cav1 inhibition, thereby inhibiting the early stage of virus infection. These findings indicate that LGS may be a candidate for the treatment of DENV.
MeSH term(s)	Animals ; Mice ; Dengue Virus ; Dengue/drug therapy ; HSP70 Heat-Shock Proteins ; Serogroup ; Cell Membrane ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Cytoplasm/metabolism
Chemical Substances	HSP70 Heat-Shock Proteins ; Antiviral Agents
Language	English
Publishing date	2023-07-18
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2023.154977
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Zs.A 4115: Show issues

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Article ; Online: Caridina stellata, a new species of atyid shrimp (Decapoda, Caridea, Atyidae) with the male description of Caridina cavernicola Liang & Zhou, 1993 from Guangxi, China

Guo-Cai Guo / Qing-Hua Chen / Wen-Jian Chen / Chao-Huang Cai / Zhao-Liang Guo

ZooKeys, Vol 1104, Iss , Pp 177-

2022 Volume 201

Abstract: ... in the field. Liang & Zhou, 1993 described C. cavernicola from the Lenggu Cave, Du’an County, Guangxi ...

Abstract	Caridina stellata sp. nov. is described from streams in Guangxi, south-western China. The new species clearly belongs to “Caridina serrata group” of the genus and shows a morphological similarity with C. cantonensis Yu, 1938, C. serrata Stimpson, 1860 and C. pacbo Do et al. 2020. Caridina stellata is distinguished from congeners, based on differences in its male first pleopod and appendix masculina morphology, along with COI and 16S rRNA molecular evidence. The first pleopod endopod in male is rectangle, about 0.70 × length of exopod, about 3.7–3.9 × as long as proximally wide, inner margin concave, bearing nearly equal spine setae, outer margin bearing nearly equal long and dense spine setae; appendix interna well developed, arising from distal 1/5 of endopod, reaching to end of endopod, with cincinuli distally. The new species displays a unique and brightly coloured pattern and, therefore, can be easily recognised in the field. Liang & Zhou, 1993 described C. cavernicola from the Lenggu Cave, Du’an County, Guangxi. However, the description was based exclusively on two females. We have collected specimens of both sexes near the type locality and describe herein the previously unknown male and present morphological data on females. Data on the habitat, ecology and levels of threat of the two species are provided and suggest that they should be categorised as vulnerable (VU) under the current IUCN Criteria.
Keywords	Zoology ; QL1-991
Subject code	590
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	Pensoft Publishers
Document type	Article ; Online
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Article ; Online: Caridina stellata, a new species of atyid shrimp (Decapoda, Caridea, Atyidae) with the male description of Caridina cavernicola Liang & Zhou, 1993 from Guangxi, China

Guo, Guo-Cai / Chen, Qing-Hua / Chen, Wen-Jian / Cai, Chao-Huang / Guo, Zhao-Liang

ZooKeys. 2022 June 14, v. 1104 p.177-201

2022

Abstract: ... in the field. Liang & Zhou, 1993 described C. cavernicola from the Lenggu Cave, Du’an County, Guangxi ...

Abstract	AbstractCaridina stellata sp. nov. is described from streams in Guangxi, south-western China. The new species clearly belongs to “Caridina serrata group” of the genus and shows a morphological similarity with C. cantonensis Yu, 1938, C. serrata Stimpson, 1860 and C. pacboDo et al. 2020. Caridina stellata is distinguished from congeners, based on differences in its male first pleopod and appendix masculina morphology, along with COI and 16S rRNA molecular evidence. The first pleopod endopod in male is rectangle, about 0.70 × length of exopod, about 3.7–3.9 × as long as proximally wide, inner margin concave, bearing nearly equal spine setae, outer margin bearing nearly equal long and dense spine setae; appendix interna well developed, arising from distal 1/5 of endopod, reaching to end of endopod, with cincinuli distally. The new species displays a unique and brightly coloured pattern and, therefore, can be easily recognised in the field. Liang & Zhou, 1993 described C. cavernicola from the Lenggu Cave, Du’an County, Guangxi. However, the description was based exclusively on two females. We have collected specimens of both sexes near the type locality and describe herein the previously unknown male and present morphological data on females. Data on the habitat, ecology and levels of threat of the two species are provided and suggest that they should be categorised as vulnerable (VU) under the current IUCN Criteria.
Keywords	Decapoda ; habitats ; males ; new species ; shrimp ; China ; COI and 16S rRNA ; ecology ; habitat ; levels of threat ; south-western China
Language	English
Dates of publication	2022-0614
Size	p. 177-201.
Publishing place	Pensoft Publishers
Document type	Article ; Online
ZDB-ID	2445640-8
ISSN	1313-2970 ; 1313-2989
ISSN (online)	1313-2970
ISSN	1313-2989
DOI	10.3897/zookeys.1104.81836
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Article: Editing the cystine knot motif of MSTN enhances muscle development of Liang Guang Small Spotted pigs.

Peng, Ding-Wei / Li, Rui-Qiang / Zeng, Wu / Wang, Min / Shi, Xuan / Zeng, Jian-Hua / Liu, Xiao-Hong / Chen, Yao-Shen / He, Zu-Yong

Yi chuan = Hereditas

2021 Volume 43, Issue 3, Page(s) 261–270

Abstract: ... Accordingly, in this study, we used the CRISRP/Cas9 to edit the exon 3 of MSTN in the kidney cells of Liang ... which were then transferred to surrogate sows to finally obtain eight MSTN-edited Liang Guang Small Spotted ... hips of the heterozygotes of MSTN-edited Liang Guang Small Spotted pigs. H&E analysis showed ...

Abstract	Myostatin (MSTN) is a member of the transforming growth factor-β (TGF-β) family, and functions as an inhibitor of muscle growth. Disrupting the inhibitory effect of MSTN on growth can provide an effective way to increase the muscle yield of livestock and poultry. The cysteine knot motif of TGF-β can stabilize the structure of MSTN protein and plays an important regulatory role in the biological function of MSTN. Accordingly, in this study, we used the CRISRP/Cas9 to edit the exon 3 of MSTN in the kidney cells of Liang Guang Small Spotted pig (LPKCs), in order to disrupt the cysteine knot motif of MSTN and remove the inhibitory effect of MSTN on its target genes.MSTN-edited LPKCs were obtained through fluorescence-activated cell sorting (FACS) and used as donor cells for somatic cell nuclear transfer (SCNT) to generate cloned embryos, which were then transferred to surrogate sows to finally obtain eight MSTN-edited Liang Guang Small Spotted piglets. Among them, two survived to 10 days old. Genotyping revealed that these two piglets were gene edited heterozygotes with base deletion and substitution occurred within the coding sequence of C106 and C108 at the cystine knot motif of MSTN. These changes resulted in frameshift mutations, and conversion of C106 and C108 to other amino acids. More developments of muscles were observed at the shoulders and hips of the heterozygotes of MSTN-edited Liang Guang Small Spotted pigs. H&E analysis showed that the cross-sectional area (CSA) of myofiber inMSTN-edited pigs was significantly decreased, and the number of myofiber were significantly increased. Western blot analysis showed that the disruption of C106 and C108 did not affect the expression of MSTN protein, but significantly up-regulated the expression of its target genes such as Myf5, MyoD, Myogenin and other myogenic regulatory factors. In summary, the gene-edited pig model obtained in this study did not cause complete loss of MSTN expression, and could retain other biological functions of MSTN, thereby promoting muscle growth while minimizing the potential adverse effects on complete loss of MSTN in the Liang Guang Small Spotted pigs.
MeSH term(s)	Animals ; Animals, Genetically Modified ; CRISPR-Cas Systems ; Cystine Knot Motifs ; Female ; Muscle Development/genetics ; Myostatin/genetics ; Swine
Chemical Substances	Myostatin
Language	English
Publishing date	2021-03-17
Publishing country	China
Document type	Journal Article
ISSN	0253-9772
ISSN	0253-9772
DOI	10.16288/j.yczz.20-222
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Article: Exploration of the Potential Mechanism of Qi Yin San Liang San Decoction in the Treatment of EGFRI-Related Adverse Skin Reactions Using Network Pharmacology and

Wang, Yalei / Zhang, Yali / Ding, Chengcheng / Jia, Caixia / Zhang, Huawei / Peng, Tiantian / Cheng, Shuo / Chen, Weihang / Tan, Yan / Wang, Xu / Liu, Zhaoheng / Wei, Peng / Wang, Xue / Jiang, Miao / Hua, Qian

Frontiers in oncology

2022 Volume 12, Page(s) 790713

Abstract: ... quality of life of patients. Qi Yin San Liang San Decoction (QYSLS) comes from folk prescription and is ...

Abstract	Background: Adverse skin reactions are the most common side effects of epidermal growth factor receptor inhibitors (EGFRIs) in the treatment of cancer, significantly affecting the survival rate and quality of life of patients. Qi Yin San Liang San Decoction (QYSLS) comes from folk prescription and is currently used in the clinical treatment of adverse skin reactions caused by EGFRIs. However, its therapeutic mechanism remains unclear. Objectives: To explore the potential mechanism of QYSLS in the treatment of adverse skin reactions caused by EGFR inhibition using network pharmacology and experimental research. Methods: First, we verified the effectiveness of QYSLS Results: In the Conclusions: The results revealed that QYSLS effectively treats EGFRI-related adverse skin reactions through multi-target and multi-pathway mechanisms. Luteolin and quercetin may be the core active ingredients of QYSLS in the treatment of EGFRI-related adverse skin reactions, and their therapeutic effects are potentially mediated through PTGS2, CCL2, and MMP9 in the IL-17 and TNF signaling pathway.
Language	English
Publishing date	2022-03-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2022.790713
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