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  1. Article: Interview: Der Vorstand der KBV, Andreas Köhler und Carl-Heinz Müller, zum Versorgungsstrukturgesetz

    Köhler, Andreas / Müller, Carl-Heinz

    Deutsches Ärzteblatt : Ausgabe A, Praxis-Ausgabe : niedergelassene Ärzte

    2011  Volume 108, Issue 30, Page(s) 1605

    Language German
    Document type Article
    ZDB-ID 1453475-7
    ISSN 0012-1207
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.103/2: Show issues Location:
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  2. Article: Interview: Andreas Köhler und Carl-Heinz Müller, Vorstände der KBV, über mehr Einfluss für die Regionen und ihre Ziele für die nächste Amtsperiode

    Köhler, Andreas / Müller, Carl-Heinz

    Deutsches Ärzteblatt : Ausgabe A, Praxis-Ausgabe : niedergelassene Ärzte

    2011  Volume 108, Issue 10, Page(s) 497

    Language German
    Document type Article
    ZDB-ID 1453475-7
    ISSN 0012-1207
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.103/2: Show issues Location:
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  3. Book: Feierliche Übergabe des Präsidentenamtes von Heinz Bethge an Benno Parthier / Deutsche Akademie der Naturforscher Leopoldina, Halle (Saale)

    Köhler, Werner

    am 30.06.1990 im Goethe-Theater zu Bad Lauchstädt

    (Nova acta Leopoldina ; N.F., Nr. 278 : Bd. 65)

    1990  

    Institution Deutsche Akademie der Naturforscher Leopoldina
    Author's details [Hrsg.: Werner Köhler]
    Series title Nova acta Leopoldina ; N.F., Nr. 278 : Bd. 65
    Collection
    Language German
    Size 41 S. : Ill.
    Publisher Barth
    Publishing place Leipzig
    Publishing country Germany
    Document type Book
    HBZ-ID HT003803883
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Ua VI Zs 1/20 -278- verfügbar in Königswinter Königswinter

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  4. Article: Interview: Die KBV-Vorstände Andreas Köhler und Carl-Heinz Müller zum Ärger um die Ambulanten Kodierrichtlinien

    Köhler, Andreas / Müller, Carl-Heinz

    Deutsches Ärzteblatt : Ausgabe A, Praxis-Ausgabe : niedergelassene Ärzte

    2010  Volume 107, Issue 50, Page(s) 2488

    Language German
    Document type Article
    ZDB-ID 1453475-7
    ISSN 0012-1207
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

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  5. Article ; Conference proceedings ; Online: LaxWO3 - Perovskite

    Kohler, Heinz

    A New Sensor Material for the Potentiometric Detection of Dissolved Oxygen

    2023  

    Abstract: The suitability of the La,WO3 -perovskites as electrode materials for potentiometric measurements of dissolved oxygen at room temperature or below is demonstrated by EMF data of a Lag 2WO3 ceramics. A model of potential formation is presented which ... ...

    Abstract The suitability of the La,WO3 -perovskites as electrode materials for potentiometric measurements of dissolved oxygen at room temperature or below is demonstrated by EMF data of a Lag 2WO3 ceramics. A model of potential formation is presented which explains the observed dependency of the EMF on the concentration of dissolved oxygen as well as on the solution acidity and on [WO,42-].
    Language English
    Publishing date 2023-12-06
    Publisher GBF Gesellschaft für Biotechnologische Forschung mbH, Braunschweig
    Publishing country de
    Document type Article ; Conference proceedings ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: The Impact of the Hybridoma Technology on the R&D of Idiotypic Antibodies.

    Kohler, Heinz

    Monoclonal antibodies in immunodiagnosis and immunotherapy

    2021  Volume 40, Issue 1, Page(s) 2–5

    Abstract: ... subsequently discussed. Although the use of the Milstein and Kohler hybridoma technology and subsequently ...

    Abstract The PubMed data set was scanned with the title and abstract term "Idiotype" followed by secondary searches with "Vaccine" and "Clinical trial." The retrieved references were analyzed from the period before and after hybridoma technology (1975). In 1963, Oudin and Kunkel discovered that antibodies against antibodies can be raised to identify determinants unique to an antibody termed idiotype or individual antigenic determinant. Two laboratories reported that anti-idiotypic antibodies can suppress specific antibody responses in mice. In 1974, Jerne proposed a network of idiotypes and anti-idiotypes and the functionality of the idiotype network was confirmed. This prompted the proposal of a symmetrical regulatory immune response. By 1989, the concept and the functional parameters of the immune idiotype network were established in the prehybridoma period. It was not until 1981 that monoclonal anti-idiotypic antibodies were used as tools to study the expression of idiotypic determinants on antibodies and to categorize functional properties in the immune network as network antigens in 1989. Hybridoma-generated monoclonal anti-idiotypic antibodies provided the tools to precisely identify different idiotypic regions on antibodies and test these as targets to induce network cascades. The initial distinction of Ab2s as alpha and beta were expanded to include gamma and delta. The initial concept of Ab2beta being an antigen internal image, used as vaccine, was challenged showing that targeting all idiotopes on B cell receptors can induce specific antibodies. After the discovery of the hybridoma technology a wave of idiotype topic publications occurred, that declined by 2015. In 1985, in this wave of reports on anti-idiotypes, their importance to vaccines dominated. These vaccines targeted in animal models parasite, bacterial, and viral diseases, and cancer. The reported data indicated a therapeutic response in inbred mice. The issue of idiotype matching between mouse haplotypes of vaccine origin and treated mice were raised. In 1995, the human clinical trials in different cancers using anti-Id vaccines were reported. Only one such vaccine received conditional approval in Argentina and Cuba, whereas the other trials failed in phase II and III. The reasons for this failure were subsequently discussed. Although the use of the Milstein and Kohler hybridoma technology and subsequently alternative methods to produce monoclonal animal and human antibodies created a new class of drugs, commonly referred as "Biological," it failed on the promise therapeutic of anti-Id vaccines.
    MeSH term(s) Animals ; Antibodies, Monoclonal ; Epitopes ; Hybridomas ; Immunoglobulin Idiotypes ; Mice ; Technology
    Chemical Substances Antibodies, Monoclonal ; Epitopes ; Immunoglobulin Idiotypes
    Language English
    Publishing date 2021-02-02
    Publishing country United States
    Document type Journal Article
    ISSN 2167-9436
    ISSN (online) 2167-9436
    DOI 10.1089/mab.2020.0044
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  7. Article ; Online: Impact of Photoluminescence Imaging Methodology on Transport Parameters in Semiconductors.

    Banappanavar, Gangadhar / Saxena, Rishabh / Bässler, Heinz / Köhler, Anna / Kabra, Dinesh

    The journal of physical chemistry letters

    2024  Volume 15, Issue 11, Page(s) 3109–3117

    Abstract: Triplet-triplet annihilation-induced delayed emission provides a pathway for investigating triplets via emission spectroscopy. This bimolecular annihilation depends directly on the transport properties of triplet excitons in disordered organic ... ...

    Abstract Triplet-triplet annihilation-induced delayed emission provides a pathway for investigating triplets via emission spectroscopy. This bimolecular annihilation depends directly on the transport properties of triplet excitons in disordered organic semiconductors. Photoluminescence (PL) imaging is a direct method for studying exciton and charge-carrier diffusivity. However, most of these studies neglect dispersive transport. Early time scale measurements using this technique can lead to an overestimation of the diffusion coefficient (
    Language English
    Publishing date 2024-03-12
    Publishing country United States
    Document type Journal Article
    ISSN 1948-7185
    ISSN (online) 1948-7185
    DOI 10.1021/acs.jpclett.4c00169
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Thermal Impact and the Relevance of Body Size and Activity on the Oxygen Consumption of a Terrestrial Snail,

    Zimmermann, Sascha / Gärtner, Ulrich / Ferreira, Gabriel S / Köhler, Heinz-R / Wharam, David

    Animals : an open access journal from MDPI

    2024  Volume 14, Issue 2

    Abstract: Metabolism, mainly driven by oxygen consumption, plays a key role in life, as it is one of the main ways to respond to extreme temperatures through internal processes. ...

    Abstract Metabolism, mainly driven by oxygen consumption, plays a key role in life, as it is one of the main ways to respond to extreme temperatures through internal processes.
    Language English
    Publishing date 2024-01-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani14020261
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Personalien - Laudatio - einmal anders Gedanken zum 65. Geburtstag von Karl-Heinz Gebhardt am 18.10.89

    Köhler, G.

    Zeitschrift für Klassische Homöopathie

    1989  Volume 33, Issue 05, Page(s) 222–223

    Language German
    Publishing date 1989-01-01
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 180129-6
    ISSN 1439-4308 ; 0935-0853 ; 0301-1402
    ISSN (online) 1439-4308
    ISSN 0935-0853 ; 0301-1402
    DOI 10.1055/s-2006-938341
    Database Thieme publisher's database

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  10. Article ; Online: Incidence of mental disorders in soldiers deployed to Afghanistan who have or have not experienced a life-threatening military incident-a quasi-experimental cohort study.

    Wesemann, Ulrich / Renner, Karl-Heinz / Rowlands, Katie / Köhler, Kai / Hüttermann, Nils / Himmerich, Hubertus

    Frontiers in public health

    2024  Volume 12, Page(s) 1357836

    Abstract: Introduction: There is very good international research on deployment-related mental disorders in military personnel. The incidence rates show a very wide range. A new strategy is therefore proposed in order to achieve better standardization and thus ... ...

    Abstract Introduction: There is very good international research on deployment-related mental disorders in military personnel. The incidence rates show a very wide range. A new strategy is therefore proposed in order to achieve better standardization and thus better comparability of the studies. In addition to a non-deployed comparison group, we propose to compare deployed soldiers with and without critical military incidents during the deployment. This additional distinction makes it possible to differentiate between the influencing variables of actual threat and general deployment stress.
    Methods: N
    Results: When comparing both groups, we found significantly higher 1-year incidence rates in the group with critical military incidents: 6.4% vs. 1.1% (OR 6.2) for post-traumatic stress disorder (PTSD); 7.0% vs. 1.1% (OR 6.5) for depression; and 15.9% vs. 2.8% (OR 6.6) for anxiety disorders. The 1-year incidence rate of mental multimorbidity (PTSD with anxiety or depression) was 4.8% vs. 0.4% (OR 12.0).
    Discussion: These results indicate that life-threatening military incidents during military deployment are important to mental health. As the different threat levels of the various missions are taken into account, additional predictors could be determined more precisely in further research.
    MeSH term(s) Humans ; Male ; Military Personnel/psychology ; Incidence ; Cohort Studies ; Afghanistan/epidemiology ; Stress Disorders, Post-Traumatic/epidemiology
    Language English
    Publishing date 2024-02-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2024.1357836
    Database MEDical Literature Analysis and Retrieval System OnLINE

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