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  1. Article ; Online: Bias of Attentional Oscillations in Individuals with Subthreshold Depression: Evidence from a Pre-Cueing Facial Expression Judgment Task.

    Wu, Wenfeng / Huang, Xiaojiaqi / Qi, Xin / Lu, Yongbiao

    International journal of environmental research and public health

    2022  Volume 19, Issue 21

    Abstract: ... ...

    Abstract Background
    MeSH term(s) Humans ; Facial Expression ; Cues ; Judgment ; Depression ; Attention/physiology ; Bias
    Language English
    Publishing date 2022-11-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph192114559
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  2. Article: Comprehensive analysis of prognostic value, immune implication and biological function of CPNE1 in clear cell renal cell carcinoma.

    Zhou, Haiting / He, Yi / Huang, Yongbiao / Li, Rui / Zhang, Hao / Xia, Xiaohui / Xiong, Huihua

    Frontiers in cell and developmental biology

    2023  Volume 11, Page(s) 1157269

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-04-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2023.1157269
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A comprehensive investigation on the receptor BSG expression reveals the potential risk of healthy individuals and cancer patients to 2019-nCoV infection.

    Huang, Yongbiao / Zhou, Haiting / Wang, Yuan / Xiao, Lingyan / Qin, Wan / Li, Long

    Aging

    2024  Volume 16, Issue 6, Page(s) 5412–5434

    Abstract: Background: Coronavirus disease-2019 (COVID-19) pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a newly emerging coronavirus. BSG (basigin) is involved in the tumorigenesis of multiple tumors and recently emerged as a ...

    Abstract Background: Coronavirus disease-2019 (COVID-19) pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a newly emerging coronavirus. BSG (basigin) is involved in the tumorigenesis of multiple tumors and recently emerged as a novel viral entry receptor for SARS-CoV-2. However, its expression profile in normal individuals and cancer patients are still unclear.
    Methods: We performed a comprehensive analysis of the expression and distribution of BSG in normal tissues, tumor tissues, and cell lines via bioinformatics analysis and experimental verification. In addition, we investigated the expression of BSG and its isoforms in multiple malignancies and adjacent normal tissues, and explored the prognostic values across pan-cancers. Finally, we conducted function analysis for co-expressed genes with BSG.
    Results: We found BSG was highly conserved in different species, and was ubiquitously expressed in almost all normal tissues and significantly increased in some types of cancer tissues. Moreover, BSG at mRNA expression level was higher than ACE2 in normal lung tissues, and lung cancer tissues. High expression of BSG indicated shorter overall survival (OS) in multiple tumors. The Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses indicated that BSG is mostly enriched in genes for mitochondria electron transport, oxidoreduction-driven active transmembrane transporter activity, mitochondrial inner membrane, oxidative phosphorylation, and genes involving COVID-19.
    Conclusions: Our present work emphasized the value of targeting BSG in the treatment of COVID-19 and cancer, and also provided several novel insights for understanding the SARS-CoV-2 pandemic.
    MeSH term(s) Humans ; COVID-19/genetics ; COVID-19/pathology ; Gene Expression ; Lung/pathology ; Lung Neoplasms/pathology ; SARS-CoV-2
    Chemical Substances BSG protein, human
    Language English
    Publishing date 2024-03-13
    Publishing country United States
    Document type Journal Article
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.205655
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Phase separation of S-RNase promotes self-incompatibility in Petunia hybrida.

    Tian, Huayang / Zhang, Hongkui / Huang, Huaqiu / Zhang, Yu'e / Xue, Yongbiao

    Journal of integrative plant biology

    2023  

    Abstract: Self-incompatibility (SI) is an intraspecific reproductive barrier widely present in angiosperms. The SI system with the broadest occurrence in angiosperms is based on an S-RNase linked to a cluster of multiple S-locus F-box (SLF) genes found in the ... ...

    Abstract Self-incompatibility (SI) is an intraspecific reproductive barrier widely present in angiosperms. The SI system with the broadest occurrence in angiosperms is based on an S-RNase linked to a cluster of multiple S-locus F-box (SLF) genes found in the Solanaceae, Plantaginaceae, Rosaceae, and Rutaceae. Recent studies reveal that non-self S-RNase is degraded by the Skip Cullin F-box (SCF)
    Language English
    Publishing date 2023-11-14
    Publishing country China (Republic : 1949- )
    Document type Journal Article
    ZDB-ID 2130095-1
    ISSN 1744-7909 ; 1672-9072
    ISSN (online) 1744-7909
    ISSN 1672-9072
    DOI 10.1111/jipb.13584
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  5. Article ; Online: Bias of Attentional Oscillations in Individuals with Subthreshold Depression

    Wenfeng Wu / Xiaojiaqi Huang / Xin Qi / Yongbiao Lu

    International Journal of Environmental Research and Public Health, Vol 19, Iss 14559, p

    Evidence from a Pre-Cueing Facial Expression Judgment Task

    2022  Volume 14559

    Abstract: Background : Study results regarding attentional bias in depressed individuals are inconsistent. Recent studies have found that attention is a discrete process, alternating between periods of either enhanced or diminished attention sensitivity. Whether a ...

    Abstract Background : Study results regarding attentional bias in depressed individuals are inconsistent. Recent studies have found that attention is a discrete process, alternating between periods of either enhanced or diminished attention sensitivity. Whether a visual target can be detected depends on when it occurs relative to these oscillation rhythms. We infer that the inconsistency of attentional bias may be related to the abnormality of attentional oscillations in depressed individuals. Methods : A pre-cueing attentional task was used. We set 48 levels of stimulus onset asynchrony (SOA) between cues and targets and measured the response time (RT) of participants, as well as their EEG signals. Results : The RTs showed patterns of behavioral oscillations. Repeated-measure ANOVA indicated that subthreshold depressed participants had significantly higher RTs for negative expressions than for neutral but significantly lower RTs for positive than for neutral. The frequency analysis indicated that the RT oscillational frequency of subthreshold depressed participants to negative/positive expressions was different from that to neutral. The EEG time–frequency analysis showed that when faced with negative expressions, the intensity of the neural alpha oscillatory power of subthreshold depressed participants was significantly lower than that of normal controls. When faced with positive expressions, the intensity of neural alpha oscillatory power was significantly higher than that of normal controls. Conclusion : Compared to normal persons, subthreshold depressed individuals may have biases in both the amplitude and frequency of attentional oscillations. These attentional biases correspond to the intensity of their neural alpha wave rhythms.
    Keywords attentional oscillation ; attentional bias ; alpha neural rhythms ; subthreshold depression ; Medicine ; R
    Subject code 150
    Language English
    Publishing date 2022-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Integrative Analysis Constructs an Extracellular Matrix-Associated Gene Signature for the Prediction of Survival and Tumor Immunity in Lung Adenocarcinoma.

    Xiao, Lingyan / Li, Qian / Huang, Yongbiao / Fan, Zhijie / Qin, Wan / Liu, Bo / Yuan, Xianglin

    Frontiers in cell and developmental biology

    2022  Volume 10, Page(s) 835043

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2022-04-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2022.835043
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  7. Article ; Online: Carbon-Iodine Polydiacetylene Nanofibers for Image-Guided Radiotherapy and Tumor-Microenvironment-Enhanced Radiosensitization.

    Yin, Mingming / Yuan, Ye / Huang, Yongbiao / Liu, Xiaoming / Meng, Fanling / Luo, Liang / Tian, Sidan / Liu, Bo

    ACS nano

    2024  Volume 18, Issue 11, Page(s) 8325–8336

    Abstract: Radiotherapy is a mainstay treatment used in clinics for locoregional therapy, although it still represents a great challenge to improve the sensitivity and accuracy of radiotherapy for tumors. Here, we report the conjugated polymer, ... ...

    Abstract Radiotherapy is a mainstay treatment used in clinics for locoregional therapy, although it still represents a great challenge to improve the sensitivity and accuracy of radiotherapy for tumors. Here, we report the conjugated polymer, polydiiododiacetylene (PIDA), with an iodine content of 84 wt %, as a highly effective computed tomography (CT) contrast agent and tumor microenvironment-responsive radiosensitizer. PIDA exhibited several key properties that contribute to the improvement of precision radiotherapy. The integrated PIDA nanofibers confined within the tumor envelope demonstrated amplified CT intensity and prolonged retention, providing an accurate calculation of dose distribution and precise radiation delivery for CT image-guided radiotherapy. Therefore, our strategy pioneers PIDA nanofibers as a bridge to cleverly connect a fiducial marker to guide accurate radiotherapy and a radiosensitizer to improve tumor sensitivity, thereby minimizing potential damage to surrounding tissues and facilitating on-demand therapeutic intervention in tumors.
    MeSH term(s) Humans ; Radiotherapy, Image-Guided ; Carbon ; Nanofibers ; Tumor Microenvironment ; Radiation-Sensitizing Agents/pharmacology ; Radiation-Sensitizing Agents/therapeutic use ; Neoplasms ; Polyacetylene Polymer
    Chemical Substances polydiacetylene (27987-87-7) ; Carbon (7440-44-0) ; Radiation-Sensitizing Agents ; Polyacetylene Polymer
    Language English
    Publishing date 2024-03-06
    Publishing country United States
    Document type Journal Article
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.3c12623
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  8. Article ; Online: Comprehensive analysis of prognostic value, immune implication and biological function of CPNE1 in clear cell renal cell carcinoma

    Haiting Zhou / Yi He / Yongbiao Huang / Rui Li / Hao Zhang / Xiaohui Xia / Huihua Xiong

    Frontiers in Cell and Developmental Biology, Vol

    2023  Volume 11

    Abstract: Background: Elevated expression of Copine-1 (CPNE1) has been proved in various cancers; however, the underlying mechanisms by which it affects clear cell renal cell carcinoma (ccRCC) are unclear.Methods: In this study, we applied multiple bioinformatic ... ...

    Abstract Background: Elevated expression of Copine-1 (CPNE1) has been proved in various cancers; however, the underlying mechanisms by which it affects clear cell renal cell carcinoma (ccRCC) are unclear.Methods: In this study, we applied multiple bioinformatic databases to analyze the expression and clinical significance of CPNE1 in ccRCC. Co-expression analysis and functional enrichment analysis were investigated by LinkedOmics, cBioPortal and Metascape. The relationships between CPNE1 and tumor immunology were explored using ESTIMATE and CIBERSORT method. In vitro experiments, CCK-8, wound healing, transwell assays and western blotting were conducted to investigate the effects of gain- or loss-of-function of CPNE1 in ccRCC cells.Results: The expression of CPNE1 was notably elevated in ccRCC tissues and cells, and significantly correlated with grade, invasion range, stage and distant metastasis. Kaplan–Meier and Cox regression analysis displayed that CPNE1 expression was an independent prognostic factor for ccRCC patients. Functional enrichment analysis revealed that CPNE1 and its co-expressed genes mainly regulated cancer-related and immune-related pathways. Immune correlation analysis showed that CPNE1 expression was significantly related to immune and estimate scores. CPNE1 expression was positively related to higher infiltrations of immune cells, such as CD8+ T cells, plasma cells and regulatory T cells, exhibited lower infiltrations of neutrophils. Meanwhile, elevated expression of CPNE1 was characterized by high immune infiltration levels, increased expression levels of CD8+ T cell exhaustion markers (CTLA4, PDCD1 and LAG3) and worse response to immunotherapy. In vitro functional studies demonstrated that CPNE1 promoted proliferation, migration and invasion of ccRCC cells through EGFR/STAT3 pathway.Conclusion: CPNE1 is a reliable clinical predictor for the prognosis of ccRCC and promotes proliferation and migration by activating EGFR/STAT3 signaling. Moreover, CPNE1 significantly correlates with immune ...
    Keywords CPNE1 ; prognosis ; immune infiltration ; renal cell carcinoma ; EGFR/STAT3 ; Biology (General) ; QH301-705.5
    Subject code 616 ; 570
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: The application and research progress of anti-angiogenesis therapy in tumor immunotherapy.

    Tu, Jingyao / Liang, Hang / Li, Chunya / Huang, Yongbiao / Wang, Ziqi / Chen, Xinyi / Yuan, Xianglin

    Frontiers in immunology

    2023  Volume 14, Page(s) 1198972

    Abstract: Tumor immunotherapy, as the focus of scientific research and clinical tumor treatment in recent years, has received extensive attention. Due to its remarkable curative effect and fewer side effects than traditional treatments, it has significant clinical ...

    Abstract Tumor immunotherapy, as the focus of scientific research and clinical tumor treatment in recent years, has received extensive attention. Due to its remarkable curative effect and fewer side effects than traditional treatments, it has significant clinical benefits for the treatment of various advanced cancers and can improve cancer patient survival in the long term. Currently, most patients cannot benefit from immunotherapy, and some patients may experience tumor recurrence and drug resistance even if they achieve remission overcome. Numerous studies have shown that the abnormal angiogenesis state of tumors can lead to immunosuppressive tumor microenvironment, which affects the efficacy of immunotherapy. Actually, to improve the efficacy of immunotherapy, the application of anti-angiogenesis drugs to normalize abnormal tumor vessel has been widely confirmed in basic and clinical research. This review not only discusses the risk factors, mechanisms, and effects of abnormal and normalized tumor angiogenesis state on the immune environment, but summarizes the latest progress of immunotherapy combined with anti-angiogenic therapy. We hope this review provides an applied reference for anti-angiogenesis drugs and synergistic immunotherapy therapy.
    MeSH term(s) Humans ; Neoplasms/pathology ; Neovascularization, Pathologic ; Immunotherapy ; Angiogenesis Inhibitors/pharmacology ; Tumor Microenvironment
    Chemical Substances Angiogenesis Inhibitors
    Language English
    Publishing date 2023-06-02
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1198972
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Ischemic Stroke and Intraventricular Hemorrhage in Moyamoya Syndrome Associated With Graves' Disease: A Case Report.

    Huang, Mufang / Tang, Siqiang / Zou, Yongbiao / Yang, Ge / Nan, Yuyu / Li, Yanfang / Zhang, Chunhua

    The neurologist

    2023  Volume 28, Issue 1, Page(s) 42–45

    Abstract: Introduction: Moyamoya syndrome is commonly associated with sickle cell anemia, neurofibromatosis type 1, cranial therapeutic irradiation, and Down syndrome. However, it is rare for Moyamoya syndrome associated with Graves' disease.: Case report: ... ...

    Abstract Introduction: Moyamoya syndrome is commonly associated with sickle cell anemia, neurofibromatosis type 1, cranial therapeutic irradiation, and Down syndrome. However, it is rare for Moyamoya syndrome associated with Graves' disease.
    Case report: Here we report a case of Moyamoya syndrome associated with Graves' disease in a 19-year-old girl with sudden weakness of the right arm, progressive caries, and alopecia for 4 years. Brain magnetic resonance imaging revealed acute intraventricular hemorrhage and cerebral infarction of left middle cerebral artery territory and narrowing of the proximal portion of bilateral anterior and middle cerebral arteries.
    Conclusion: Acute cerebral infarction and intraventricular hemorrhage can occur simultaneously in Moyamoya syndrome associated with Graves' disease. Hydrocortisone, combined with prothiouracil medication, can correct thyroid dysfunction and improve neurological function. Caries may be the first symptom of Graves' disease.
    MeSH term(s) Female ; Humans ; Young Adult ; Adult ; Ischemic Stroke/complications ; Moyamoya Disease/complications ; Moyamoya Disease/diagnostic imaging ; Cerebral Hemorrhage/complications ; Cerebral Hemorrhage/diagnostic imaging ; Cerebral Infarction/etiology ; Intracranial Hemorrhages/complications ; Graves Disease/complications ; Graves Disease/diagnostic imaging
    Language English
    Publishing date 2023-01-01
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1361380-7
    ISSN 2331-2637 ; 1074-7931
    ISSN (online) 2331-2637
    ISSN 1074-7931
    DOI 10.1097/NRL.0000000000000428
    Database MEDical Literature Analysis and Retrieval System OnLINE

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