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Article ; Online: Experimental study on CO

Hu, Yanlong / Wang, Qiang / Hu, Dingkai / Zhang, Yingshuang / Furqan, Muhammad / Lu, Shijian

RSC advances

2024 Volume 14, Issue 5, Page(s) 3146–3157

Abstract: Monoethanolamines (MEAs) are widely used for ... ...

Abstract	Monoethanolamines (MEAs) are widely used for CO
Language	English
Publishing date	2024-01-19
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d3ra07193f
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Article ; Online: A review of metallurgical slags as catalysts in advanced oxidation processes for removal of refractory organic pollutants in wastewater.

Li, Xingyang / Liu, Hongwen / Zhang, Yingshuang / Mahlknecht, Jürgen / Wang, Chongqing

Journal of environmental management

2024 Volume 352, Page(s) 120051

Abstract: With the rapid growth of the metallurgical industry, there is a significant increase in the production of metallurgical slags. The waste slags pose significant challenges for their disposal because of complex compositions, low utilization rates, and ... ...

Abstract	With the rapid growth of the metallurgical industry, there is a significant increase in the production of metallurgical slags. The waste slags pose significant challenges for their disposal because of complex compositions, low utilization rates, and environmental toxicity. One promising approach is to utilize metallurgical slags as catalysts for treatment of refractory organic pollutants in wastewater through advanced oxidation processes (AOPs), achieving the objective of "treating waste with waste". This work provides a literature review of the source, production, and chemical composition of metallurgical slags, including steel slag, copper slag, electrolytic manganese residue, and red mud. It emphasizes the modification methods of metallurgical slags as catalysts and the application in AOPs for degradation of refractory organic pollutants. The reaction conditions, catalytic performance, and degradation mechanisms of organic pollutants using metallurgical slags are summarized. Studies have proved the feasibility of using metallurgical slags as catalysts for removing various pollutants by AOPs. The catalytic performance was significantly influenced by slags-derived catalysts, catalyst modification, and process factors. Future research should focus on addressing the safety and stability of catalysts, developing green and efficient modification methods, enhancing degradation efficiency, and implementing large-scale treatment of real wastewater. This work offers insights into the resource utilization of metallurgical slags and pollutant degradation in wastewater.
MeSH term(s)	Wastewater ; Environmental Pollutants ; Copper ; Hazardous Substances ; Metallurgy ; Oxidation-Reduction ; Water Pollutants, Chemical/analysis
Chemical Substances	Wastewater ; Environmental Pollutants ; Copper (789U1901C5) ; Hazardous Substances ; Water Pollutants, Chemical
Language	English
Publishing date	2024-01-22
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	184882-3
ISSN	1095-8630 ; 0301-4797
ISSN (online)	1095-8630
ISSN	0301-4797
DOI	10.1016/j.jenvman.2024.120051
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Article ; Online: The metabolism and transformation of casein-bound lactulosyllysine in vivo: Promoting dicarbonyl stress and the formation of advanced glycation end products accompanied by systemic inflammation.

Wu, Yuekun / Shi, Aiying / Li, Wanhua / Zhang, Jinhui / Lu, Yingshuang / Zhang, Yan / Wang, Shuo

Food chemistry

2024 Volume 444, Page(s) 138681

Abstract: Lactulosyllysine (LL) widely exists in thermally processed dairy products, while the metabolism and transformation of LL remain poorly understood. We aimed to elucidate the metabolic pathways of LL and its impact on body health by subjecting C57BL/6 mice ...

Abstract	Lactulosyllysine (LL) widely exists in thermally processed dairy products, while the metabolism and transformation of LL remain poorly understood. We aimed to elucidate the metabolic pathways of LL and its impact on body health by subjecting C57BL/6 mice to a short-term ll-fortified casein diet. Our findings indicated that casein-bound LL might be metabolized and transformed into 3-deoxyglucosone through fructosamine-3-kinase (FN3K) in vivo, which promoted α-dicarbonyl stress, ultimately leading to the formation of advanced glycation end products (AGEs) in various tissues/organs, accompanied by systemic inflammation. The levels of AGEs formation in tissues/organs at various stages of casein-bound LL intake exhibited dynamic changes, correlating with alterations in the expression of FN3K and α-dicarbonyl compounds metabolic detoxification enzymes. The negative effects induced by casein-bound LL cannot be fully reversed by switching to a standard diet for equal periods. Consumption of dairy products rich in LL raises concerns as a potential risk factor for healthy individuals.
MeSH term(s)	Mice ; Animals ; Glycation End Products, Advanced/metabolism ; Caseins/metabolism ; Mice, Inbred C57BL ; Glycosylation ; Inflammation
Chemical Substances	Glycation End Products, Advanced ; Caseins
Language	English
Publishing date	2024-02-05
Publishing country	England
Document type	Journal Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2024.138681
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Article ; Online: Dietary salt promotes cognition impairment through GLP-1R/mTOR/p70S6K signaling pathway.

Yang, Xu / Liu, Shu / Wang, Chuanling / Fan, Haixia / Zou, Qian / Pu, Yingshuang / Cai, Zhiyou

Scientific reports

2024 Volume 14, Issue 1, Page(s) 7970

Abstract: Dietary salt has been associated with cognitive impairment in mice, possibly related to damaged synapses and tau hyperphosphorylation. However, the mechanism underlying how dietary salt causes cognitive dysfunction remains unclear. In our study, either a ...

Abstract	Dietary salt has been associated with cognitive impairment in mice, possibly related to damaged synapses and tau hyperphosphorylation. However, the mechanism underlying how dietary salt causes cognitive dysfunction remains unclear. In our study, either a high-salt (8%) or normal diet (0.5%) was used to feed C57BL/6 mice for three months, and N2a cells were cultured in normal medium, NaCl medium (80 mM), or NaCl (80 mM) + Liraglutide (200 nM) medium for 48 h. Cognitive function in mice was assessed using the Morris water maze and shuttle box test, while anxiety was evaluated by the open field test (OPT). Western blotting (WB), immunofluorescence, and immunohistochemistry were utilized to assess the level of Glucagon-like Peptide-1 receptor (GLP-1R) and mTOR/p70S6K pathway. Electron microscope and western blotting were used to evaluate synapse function and tau phosphorylation. Our findings revealed that a high salt diet (HSD) reduced the level of synaptophysin (SYP) and postsynaptic density 95 (PSD95), resulting in significant synaptic damage. Additionally, hyperphosphorylation of tau at different sites was detected. The C57BL/6 mice showed significant impairment in learning and memory function compared to the control group, but HSD did not cause anxiety in the mice. In addition, the level of GLP-1R and autophagy flux decreased in the HSD group, while the level of mTOR/p70S6K was upregulated. Furthermore, liraglutide reversed the autophagy inhibition of N2a treated with NaCl. In summary, our study demonstrates that dietary salt inhibits the GLP-1R/mTOR/p70S6K pathway to inhibit autophagy and induces synaptic dysfunction and tau hyperphosphorylation, eventually impairing cognitive dysfunction.
MeSH term(s)	Mice ; Animals ; Liraglutide/pharmacology ; Sodium Chloride, Dietary/adverse effects ; Glucagon-Like Peptide-1 Receptor/metabolism ; Sodium Chloride/pharmacology ; Ribosomal Protein S6 Kinases, 70-kDa/metabolism ; Mice, Inbred C57BL ; Signal Transduction ; Cognitive Dysfunction/etiology ; Cognitive Dysfunction/metabolism ; TOR Serine-Threonine Kinases/metabolism ; Cognition
Chemical Substances	Liraglutide (839I73S42A) ; Sodium Chloride, Dietary ; Glucagon-Like Peptide-1 Receptor ; Sodium Chloride (451W47IQ8X) ; Ribosomal Protein S6 Kinases, 70-kDa (EC 2.7.11.1) ; TOR Serine-Threonine Kinases (EC 2.7.11.1)
Language	English
Publishing date	2024-04-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-57998-9
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Article ; Online: HPLC and LC-MS/MS-Based Quantitative Characterization of Related Substances Associated with Sotalol Hydrochloride.

Zhu, Pengyan / Shen, Xiaojing / Wang, Xinting / Liu, Xinlan / Zhang, Yingshuang / Wang, Ke / Gao, Wenfen / Wang, Xuanjun / Yuan, Wenjuan

Molecules (Basel, Switzerland)

2024 Volume 29, Issue 3

Abstract: In total, three related substances (RS) associated with sotalol hydrochloride (STHCl) were herein identified with a novel gradient high-performance liquid chromatography (HPLC) protocol. Further characterization of these substances was then performed via ...

Abstract	In total, three related substances (RS) associated with sotalol hydrochloride (STHCl) were herein identified with a novel gradient high-performance liquid chromatography (HPLC) protocol. Further characterization of these substances was then performed via liquid chromatography-mass spectroscopy (LC-MS/MS) and nuclear magnetic resonance (NMR) approaches. For these analyses, commercial STHCl samples were used for quantitative HPLC studies and the degradation of STHCl under acidic (1M HCl), alkaline (1M NaOH), oxidative (30% H
MeSH term(s)	Chromatography, High Pressure Liquid/methods ; Chromatography, Liquid/methods ; Sotalol/pharmacology ; Tandem Mass Spectrometry/methods ; Hydrogen Peroxide ; Liquid Chromatography-Mass Spectrometry ; Drug Stability ; Hydrolysis ; Oxidation-Reduction ; Photolysis
Chemical Substances	Sotalol (A6D97U294I) ; Hydrogen Peroxide (BBX060AN9V)
Language	English
Publishing date	2024-01-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules29030588
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Article ; Online: MdMAPKKK1 Regulates Apple Resistance to

Wang, Nan / Liu, Yingshuang / Dong, Chaohua / Zhang, Yugang / Bai, Suhua

International journal of molecular sciences

2022 Volume 23, Issue 8

Abstract: Plant MAPK cascade performs a critical role in the regulation of plant immunity and disease resistance. Although the function of MAPK cascade in immunity regulation is partially conserved between different species, the mechanism varies in different host ... ...

Abstract	Plant MAPK cascade performs a critical role in the regulation of plant immunity and disease resistance. Although the function of MAPK cascade in immunity regulation is partially conserved between different species, the mechanism varies in different host and pathogen combinations. To date, the MAPK cascade function of woody plants in the regulation of disease resistance has seldom been reported. Here, we present evidence to show that apple
MeSH term(s)	Ascomycota/physiology ; Disease Resistance/genetics ; Malus/metabolism ; Plant Diseases/genetics ; Plant Immunity/genetics
Language	English
Publishing date	2022-04-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23084415
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Article ; Online: Confined liquid crystallization governed by electric field for API crystal polymorphism screening and massive preparation.

Yuan, Zhijie / Wang, Lingfeng / Wu, Mengyuan / Niu, Yuchao / Meng, Yingshuang / Ruan, Xuehua / He, Gaohong / Jiang, Xiaobin

Journal of colloid and interface science

2024 Volume 664, Page(s) 74–83

Abstract: Active pharmaceutical ingredients (APIs) crystal preparation is a significant issue for the pharmaceutical development attributed to the effect on anti-inflammatory, anti-bacteria, and anti-viral, etc. While, the massive preparation of API crystal with ... ...

Abstract	Active pharmaceutical ingredients (APIs) crystal preparation is a significant issue for the pharmaceutical development attributed to the effect on anti-inflammatory, anti-bacteria, and anti-viral, etc. While, the massive preparation of API crystal with high polymorphism selectivity is still a pendent challenge. Here, we firstly proposed a criterion according to the molecular aggregation, molecular orientation, and hydrogen bond energy between INA molecules from molecular dynamics (MD) simulations, which predicted the hydrogen bond architecture in crystal under different electric fields, hinting the recognition of crystal polymorphism. Then, an electric field governing confined liquid crystallization was constructed to achieve the INA crystal polymorphism screening relying on the criterion. Further, magnifying confined liquid volume by 5000 times from 1.0 μL to 5.0 mL realized the massive preparation of INA crystal with high polymorphic purity (>98.4%), giving a unique pathway for crystal engineering and pharmaceutical industry on the development of innovative and generic API based drugs.
Language	English
Publishing date	2024-03-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2024.02.215
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Article ; Online: A clean and efficient flotation towards recovery of hazardous polyvinyl chloride and polycarbonate microplastics through selective aluminum coating: Process, mechanism, and optimization.

Jiang, Hongru / Zhang, Yingshuang / Wang, Chongqing / Wang, Hui

Journal of environmental management

2021 Volume 299, Page(s) 113626

Abstract: Polyvinyl chloride (PVC) and polycarbonate (PC) microplastics are major sources of hazardous chlorine and bisphenol A, threatening the ecosystem and environment. Plastic recycling can control the source of microplastics pollution, but the recycling of ... ...

Abstract	Polyvinyl chloride (PVC) and polycarbonate (PC) microplastics are major sources of hazardous chlorine and bisphenol A, threatening the ecosystem and environment. Plastic recycling can control the source of microplastics pollution, but the recycling of PVC and PC will be prevented by invalid separation. We established a novel and clean flotation method to separate PVC and PC microplastics by using aluminum coating. Trace amounts of Al(OH)
MeSH term(s)	Aluminum ; Ecosystem ; Microplastics ; Plastics ; Polycarboxylate Cement ; Polyvinyl Chloride ; Refuse Disposal
Chemical Substances	Microplastics ; Plastics ; Polycarboxylate Cement ; polycarbonate (25766-59-0) ; Polyvinyl Chloride (9002-86-2) ; Aluminum (CPD4NFA903)
Language	English
Publishing date	2021-09-03
Publishing country	England
Document type	Journal Article
ZDB-ID	184882-3
ISSN	1095-8630 ; 0301-4797
ISSN (online)	1095-8630
ISSN	0301-4797
DOI	10.1016/j.jenvman.2021.113626
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Article ; Online: Metabolomics Analysis and Diagnosis of Lung Cancer: Insights from Diverse Sample Types.

Liang, Simin / Cao, Xiujun / Wang, Yingshuang / Leng, Ping / Wen, Xiaoxia / Xie, Guojing / Luo, Huaichao / Yu, Rong

International journal of medical sciences

2024 Volume 21, Issue 2, Page(s) 234–252

Abstract: Lung cancer is a highly fatal disease that poses a significant global health burden. The absence of characteristic clinical symptoms frequently results in the diagnosis of most patients at advanced stages of lung cancer. Although low-dose computed ... ...

Abstract	Lung cancer is a highly fatal disease that poses a significant global health burden. The absence of characteristic clinical symptoms frequently results in the diagnosis of most patients at advanced stages of lung cancer. Although low-dose computed tomography (LDCT) screening has become increasingly prevalent in clinical practice, its high rate of false positives continues to present a significant challenge. In addition to LDCT screening, tumor biomarker detection represents a critical approach for early diagnosis of lung cancer; unfortunately, no tumor marker with optimal sensitivity and specificity is currently available. Metabolomics has recently emerged as a promising field for developing novel tumor biomarkers. In this paper, we introduce metabolic pathways, instrument platforms, and a wide variety of sample types for lung cancer metabolomics. Specifically, we explore the strengths, limitations, and distinguishing features of various sample types employed in lung cancer metabolomics research. Additionally, we present the latest advances in lung cancer metabolomics research that utilize diverse sample types. We summarize and enumerate research studies that have investigated lung cancer metabolomics using different metabolomic sample types. Finally, we provide a perspective on the future of metabolomics research in lung cancer. Our discussion of the potential of metabolomics in developing new tumor biomarkers may inspire further study and innovation in this dynamic field.
MeSH term(s)	Humans ; Lung Neoplasms/diagnosis ; Lung Neoplasms/metabolism ; Metabolomics/methods ; Biomarkers, Tumor/metabolism ; Sensitivity and Specificity ; Tomography, X-Ray Computed
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2024-01-01
Publishing country	Australia
Document type	Journal Article ; Review
ZDB-ID	2151424-0
ISSN	1449-1907 ; 1449-1907
ISSN (online)	1449-1907
ISSN	1449-1907
DOI	10.7150/ijms.85704
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Article ; Online: The Promotional Effect of Na on Ru for pH-Universal Hydrogen Evolution Reactions

Bingxin Guo / Chengfei Zhao / Yingshuang Zhou / Junjie Guo / Zhongzhe Wei / Jing Wang

Catalysts, Vol 13, Iss 552, p

2023 Volume 552

Abstract: Alkali metals, as ideal electron donors, can effectively regulate the valence state distribution of the host metals. Nevertheless, no studies have reported the application of alkali metal promoters in the hydrogen evolution reaction (HER). Here, we ... ...

Abstract	Alkali metals, as ideal electron donors, can effectively regulate the valence state distribution of the host metals. Nevertheless, no studies have reported the application of alkali metal promoters in the hydrogen evolution reaction (HER). Here, we designed an efficient and wide pH-universal hydrogen evolution catalyst that utilizes alkali metal to control the valence, size, and dispersion of Ru NPs. The experimental results reveal that the alkali metal additives contribute to the dispersion and stabilization of metallic Ru. More importantly, the interaction between Na and Ru regulates the distribution of Ru valence states and helps to form more active components of Ru 0 . Additionally, NaCl functioned as an in situ template to assist the construction of a porous carbon skeleton promotes mass transfer and exposes more active sites, further promoting the synergistic effect of Ru and Na. As a result, the optimal Ru 0.3 /C−800 delivers high efficiency for HER with an overpotential as low as 29 mV in 1.0 M KOH and 83 mV in 0.5 M H 2 SO 4 under 10 mA cm −2 . Particularly, the catalytic performance of Ru 0.3 /C−800 even outbalanced that of commercial Pt/C in an alkaline medium. This rational construction strategy opens up new avenues for obtaining superior pH-universal electrocatalysts.
Keywords	alkali metal ; Ru based ; hydrogen evolution reaction ; wide-range pH ; promotional effect ; Chemical technology ; TP1-1185 ; Chemistry ; QD1-999
Subject code	540
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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