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  1. Book: Integrative pancreatic intervention therapy

    Li, Maoquan / Lu, Ligong / Xiao, Yueyong / Fu, Deliang / Zhang, Haijun

    a holistic approach

    2021  

    Author's details editor in chief Maoquan Li ; edited by Ligong Lu, Yueyong Xiao, Deliang Fu, Haijun Zhang
    Keywords Pancreas/Diseases/Treatment
    Subject code 616.3706
    Language English
    Size xxii, 599 Seiten, Illustrationen, 28 cm
    Publisher Elsevier
    Publishing place Amsterdam
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT020584530
    ISBN 978-0-12-819402-7 ; 9780128194034 ; 0-12-819402-2 ; 0128194030
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2020 A 1385 available for loan (reading room) Lesesaal EG

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  2. Article: Ewing's sarcoma/primitive neuroectodermal tumor (ES/PNET) of the bladder in an adolescent: a case description.

    Tan, Jingyi / Liang, Jie / Lu, Ligong

    Quantitative imaging in medicine and surgery

    2023  Volume 13, Issue 4, Page(s) 2758–2762

    Language English
    Publishing date 2023-02-07
    Publishing country China
    Document type Journal Article
    ZDB-ID 2653586-5
    ISSN 2223-4306 ; 2223-4292
    ISSN (online) 2223-4306
    ISSN 2223-4292
    DOI 10.21037/qims-22-867
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Refining taxonomic identification of microalgae through molecular and genetic evolution: a case study of

    Zheng, Danlin / Zou, Ligong / Zou, Jian / Li, Qun / Lu, Songhui

    Microbiology spectrum

    2024  , Page(s) e0236723

    Abstract: Species delimitation based on lineage definition has become increasingly popular. However, these methods have been limited, especially for species that lack genomic data and are morphologically similar. The trickiest part for the species identification ... ...

    Abstract Species delimitation based on lineage definition has become increasingly popular. However, these methods have been limited, especially for species that lack genomic data and are morphologically similar. The trickiest part for the species identification is that the interspecific and intraspecific boundaries are vague. Taking
    Language English
    Publishing date 2024-04-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.02367-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The NLRP3 molecule is responsible for mediating the pyroptosis of intestinal mucosa cells and plays a crucial role in salmonellosis enteritis in chicks.

    Liu, Zhe / Du, Juan / Wang, Yanhong / Song, Haoyu / Lu, Ligong / Wu, Rui / Jin, Chenghao

    Molecular immunology

    2024  Volume 168, Page(s) 47–50

    Abstract: Salmonella enteritis in poultry can result in reduced immune function, decreased growth rate, and increased mortality. Many farm salmonella strains have developed severe drug resistance and are less susceptible to multiple antibiotics. In the post- ... ...

    Abstract Salmonella enteritis in poultry can result in reduced immune function, decreased growth rate, and increased mortality. Many farm salmonella strains have developed severe drug resistance and are less susceptible to multiple antibiotics. In the post-antibiotic era, it is of great significance to identify the mechanism of salmonella-induced enteritis in chicks to protect their health and ensure food safety. This article will elucidate the activation mechanism of NOD-like receptor protein 3 (NLRP3) inflammasomes in Salmonella enteritis and review the research on interventions targeting NLRP3 inflammasomes.
    MeSH term(s) Enteritis/veterinary ; Inflammasomes/metabolism ; Intestinal Mucosa/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; NLR Proteins ; Pyroptosis ; Salmonella Infections/genetics ; Salmonella Infections/metabolism ; Salmonella typhimurium ; Animals ; Chickens/metabolism ; Chickens/microbiology
    Chemical Substances Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; NLR Proteins
    Language English
    Publishing date 2024-02-29
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 424427-8
    ISSN 1872-9142 ; 0161-5890
    ISSN (online) 1872-9142
    ISSN 0161-5890
    DOI 10.1016/j.molimm.2024.02.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 166: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: COVID-19 Emergencies in East Asian Countries: Experiences and Challenges.

    Jin, Hao / Lu, Ligong / Liu, Junwei / Cui, Min

    Asia-Pacific journal of public health

    2021  Volume 33, Issue 4, Page(s) 461–462

    Language English
    Publishing date 2021-03-18
    Publishing country China
    Document type Letter
    ZDB-ID 1025444-4
    ISSN 1941-2479 ; 1010-5395
    ISSN (online) 1941-2479
    ISSN 1010-5395
    DOI 10.1177/10105395211001658
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2802: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: SPOP point mutations regulate substrate preference and affect its function.

    Deng, Yanran / Ding, Wenhao / Ma, Kaize / Zhan, Meixiao / Sun, Li / Zhou, Zizhang / Lu, Ligong

    Cell death & disease

    2024  Volume 15, Issue 2, Page(s) 172

    Abstract: The adaptor SPOP recruits substrates to CUL3 E3 ligase for ubiquitination and degradation. Structurally, SPOP harbors a MATH domain for substrate recognition, and a BTB domain responsible for binding CUL3. Reported point mutations always occur in SPOP's ... ...

    Abstract The adaptor SPOP recruits substrates to CUL3 E3 ligase for ubiquitination and degradation. Structurally, SPOP harbors a MATH domain for substrate recognition, and a BTB domain responsible for binding CUL3. Reported point mutations always occur in SPOP's MATH domain and are through to disrupt affinities of SPOP to substrates, thereby leading to tumorigenesis. In this study, we identify the tumor suppressor IRF2BP2 as a novel substrate of SPOP. SPOP enables to attenuate IRF2BP2-inhibited cell proliferation and metastasis in HCC cells. However, overexpression of wild-type SPOP alone suppresses HCC cell proliferation and metastasis. In addition, a HCC-derived mutant, SPOP-M35L, shows an increased affinity to IRF2BP2 in comparison with wild-type SPOP. SPOP-M35L promotes HCC cell proliferation and metastasis, suggesting that M35L mutation possibly reprograms SPOP from a tumor suppressor to an oncoprotein. Taken together, this study uncovers mutations in SPOP's MATH lead to distinct functional consequences in context-dependent manners, rather than simply disrupting its interactions with substrates, raising a noteworthy concern that we should be prudent to select SPOP as therapeutic target for cancers.
    MeSH term(s) Humans ; Repressor Proteins/metabolism ; Point Mutation ; Nuclear Proteins/metabolism ; Carcinoma, Hepatocellular ; Cullin Proteins/metabolism ; Liver Neoplasms ; Ubiquitination
    Chemical Substances Repressor Proteins ; Nuclear Proteins ; Cullin Proteins ; SPOP protein, human
    Language English
    Publishing date 2024-02-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2541626-1
    ISSN 2041-4889 ; 2041-4889
    ISSN (online) 2041-4889
    ISSN 2041-4889
    DOI 10.1038/s41419-024-06565-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A duplex real-time NASBA assay targeting a serotype-specific gene for rapid detection of viable

    Zhai, Ligong / Liu, Hongxia / Li, Junjie / Lu, Zhaoxin / Bie, Xiaomei

    Canadian journal of microbiology

    2022  Volume 68, Issue 4, Page(s) 259–268

    Abstract: Salmonella ... ...

    Abstract Salmonella enterica
    MeSH term(s) Animals ; Food Microbiology ; Salmonella/genetics ; Salmonella paratyphi A/genetics ; Salmonella paratyphi C/genetics ; Self-Sustained Sequence Replication ; Serogroup
    Language English
    Publishing date 2022-01-13
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 280534-0
    ISSN 1480-3275 ; 0008-4166
    ISSN (online) 1480-3275
    ISSN 0008-4166
    DOI 10.1139/cjm-2021-0054
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 85: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Cancer diagnosis and treatment platform based on manganese-based nanomaterials.

    Fei, Jia / Liu, Yanyan / Zeng, Ya / Yang, Mingqi / Chen, Shanshan / Duan, Xiaobing / Lu, Ligong / Chen, Muhe

    Frontiers in bioengineering and biotechnology

    2024  Volume 12, Page(s) 1363569

    Abstract: Cancer is a leading cause of death worldwide, and the development of new diagnostic and treatment methods is crucial. Manganese-based nanomaterials (MnNMs) have emerged as a focal point in the field of cancer diagnosis and treatment due to their ... ...

    Abstract Cancer is a leading cause of death worldwide, and the development of new diagnostic and treatment methods is crucial. Manganese-based nanomaterials (MnNMs) have emerged as a focal point in the field of cancer diagnosis and treatment due to their multifunctional properties. These nanomaterials have been extensively explored as contrast agents for various imaging technologies such as magnetic resonance imaging (MRI), photoacoustic imaging (PAI), and near-infrared fluorescence imaging (NIR-FL). The use of these nanomaterials has significantly enhanced the contrast for precise tumor detection and localization. Moreover, MnNMs have shown responsiveness to the tumor microenvironment (TME), enabling innovative approaches to cancer treatment. This review provides an overview of the latest developments of MnNMs and their potential applications in tumor diagnosis and therapy. Finally, potential challenges and prospects of MnNMs in clinical applications are discussed. We believe that this review would serve as a valuable resource for guiding further research on the application of manganese nanomaterials in cancer diagnosis and treatment, addressing the current limitations, and proposing future research directions.
    Language English
    Publishing date 2024-03-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2024.1363569
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Drug resistance mechanism of kinase inhibitors in the treatment of hepatocellular carcinoma.

    Jiang, Lei / Li, Luan / Liu, Yongzhuang / Lu, Ligong / Zhan, Meixiao / Yuan, Shengtao / Liu, Yanyan

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1097277

    Abstract: Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer, and it usually occurs following chronic liver disease. Although some progress has been made in the treatment of HCC, the prognosis of patients with advanced HCC is not ... ...

    Abstract Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer, and it usually occurs following chronic liver disease. Although some progress has been made in the treatment of HCC, the prognosis of patients with advanced HCC is not optimistic, mainly because of the inevitable development of drug resistance. Therefore, multi-target kinase inhibitors for the treatment of HCC, such as sorafenib, lenvatinib, cabozantinib, and regorafenib, produce small clinical benefits for patients with HCC. It is necessary to study the mechanism of kinase inhibitor resistance and explore possible solutions to overcome this resistance to improve clinical benefits. In this study, we reviewed the mechanisms of resistance to multi-target kinase inhibitors in HCC and discussed strategies that can be used to improve treatment outcomes.
    Language English
    Publishing date 2023-02-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1097277
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Progress and Challenges in Tumor Ferroptosis Treatment Strategies: A Comprehensive Review of Metal Complexes and Nanomedicine.

    Su, Yanhong / Liu, Bing / Wang, Binghan / Chan, Leung / Xiong, Chan / Lu, Ligong / Zhang, Xuanjun / Zhan, Meixiao / He, Weiling

    Small (Weinheim an der Bergstrasse, Germany)

    2024  , Page(s) e2310342

    Abstract: Ferroptosis is a new form of regulated cell death featuring iron-dependent lipid peroxides accumulation to kill tumor cells. A growing body of evidence has shown the potential of ferroptosis-based cancer therapy in eradicating refractory malignancies ... ...

    Abstract Ferroptosis is a new form of regulated cell death featuring iron-dependent lipid peroxides accumulation to kill tumor cells. A growing body of evidence has shown the potential of ferroptosis-based cancer therapy in eradicating refractory malignancies that are resistant to apoptosis-based conventional therapies. In recent years, studies have reported a number of ferroptosis inducers that can increase the vulnerability of tumor cells to ferroptosis by regulating ferroptosis-related signaling pathways. Encouraged by the rapid development of ferroptosis-driven cancer therapies, interdisciplinary fields that combine ferroptosis, pharmaceutical chemistry, and nanotechnology are focused. First, the prerequisites and metabolic pathways for ferroptosis are briefly introduced. Then, in detail emerging ferroptosis inducers designed to boost ferroptosis-induced tumor therapy, including metal complexes, metal-based nanoparticles, and metal-free nanoparticles are summarized. Subsequently, the application of synergistic strategies that combine ferroptosis with apoptosis and other regulated cell death for cancer therapy, with emphasis on the use of both cuproptosis and ferroptosis to induce redox dysregulation in tumor and intracellular bimetallic copper/iron metabolism disorders during tumor treatment is discussed. Finally, challenges associated with clinical translation and potential future directions for potentiating cancer ferroptosis therapies are highlighted.
    Language English
    Publishing date 2024-01-14
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2168935-0
    ISSN 1613-6829 ; 1613-6810
    ISSN (online) 1613-6829
    ISSN 1613-6810
    DOI 10.1002/smll.202310342
    Database MEDical Literature Analysis and Retrieval System OnLINE

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