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  1. Book ; Thesis: Zur Bedeutung des unteren Handareals des Kleinhirns

    Reinold, Johanna

    eine Untersuchung bei Patienten mit akuten Kleinhirninfarkten

    2019  

    Institution Universität Duisburg-Essen
    Author's details vorgelegt von Johanna Reinhold
    Language German
    Size 91 Blätter, Illustrationen
    Publishing place Duisburg ; Essen
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität Duisburg-Essen, 2019
    HBZ-ID HT020385848
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: Systemische Entzündung, „Sickness Behavior“ und Erwartungsprozesse : Welche Rolle spielen Erwartungen bei entzündungsassoziierten Symptomen?

    Schmidt, Justine / Reinold, Johanna / Klinger, Regine / Benson, Sven

    Schmerz (Berlin, Germany)

    2021  Volume 36, Issue 3, Page(s) 166–171

    Abstract: Background: Systemic inflammation is accompanied by unspecific physical and psychological symptoms of sickness, including pain and affective symptoms. These symptoms (commonly called "sickness behavior") are mediated by the central nervous effects of ... ...

    Title translation Systemic inflammation, "sickness behavior" and expectations : What role do expectations play in inflammation-associated symptoms?
    Abstract Background: Systemic inflammation is accompanied by unspecific physical and psychological symptoms of sickness, including pain and affective symptoms. These symptoms (commonly called "sickness behavior") are mediated by the central nervous effects of immune messengers such as pro-inflammatory cytokines. While adaptive during acute inflammation, sickness symptoms can have detrimental effects on quality of life during chronic inflammation and may contribute to comorbidity in chronic pain conditions. Despite the high clinical relevance of sickness behavior, psychological interventions aiming to modulate sickness symptoms have hardly been investigated. One approach could be the use of expectation effects, since positive and negative expectations (placebo or nocebo effects) have been shown to have an influence on pain and affect-related symptoms.
    Objectives: Herein, we summarize immunological and psychobiological factors that contribute to pain in the context of sickness behavior, with a major focus on findings from experimental endotoxemia. Against this background, we discuss how expectations could help to improve immune-mediated sickness symptoms and outline potential psychological and psychobiological mechanisms underlying this putative effect.
    MeSH term(s) Chronic Disease ; Chronic Pain ; Humans ; Illness Behavior/physiology ; Inflammation ; Motivation ; Quality of Life
    Language German
    Publishing date 2021-10-29
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 625283-7
    ISSN 1432-2129 ; 0932-433X
    ISSN (online) 1432-2129
    ISSN 0932-433X
    DOI 10.1007/s00482-021-00602-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Implications of an HbA1c-based Diabetes Screening on Prevalence and Effect of Dysglycemia in Patients With COVID-19.

    Van Baal, Lukas / Reinold, Johanna / Benson, Sven / Diehl, Anke / Witzke, Oliver / Fuehrer, Dagmar / Tan, Susanne

    The Journal of clinical endocrinology and metabolism

    2022  Volume 108, Issue 3, Page(s) 697–705

    Abstract: Context: In patients with severe acute respiratory syndrome coronavirus type 2 infection, diabetes is associated with poor COVID-19 prognosis. However, case detection strategy is divergent and reported prevalence varies from 5% to 35%.: Objective: We ...

    Abstract Context: In patients with severe acute respiratory syndrome coronavirus type 2 infection, diabetes is associated with poor COVID-19 prognosis. However, case detection strategy is divergent and reported prevalence varies from 5% to 35%.
    Objective: We examined how far the choice of screening tools affects the detection rate of dysglycemia and in consequence the estimation of diagnosis-associated risk for moderate (mo) or severe (s) COVID-19.
    Methods: Non-intensive care unit inpatients with COVID-19 were screened systematically at admission for diabetes (D) and prediabetes (PreD) by glycated hemoglobin A1c (HbA1c) (A), random blood glucose (B), and known history (C) from November 1, 2020 to March 8, 2021. Dysglycemia rate and effect on COVID-19 outcome were analyzed in 2 screening strategies (ABC vs BC).
    Results: A total of 578 of 601 (96.2%) of admitted patients were screened and analyzed. In ABC, prevalence of D and PreD was 38.2% and 37.5%, respectively. D was significantly associated with an increased risk for more severe COVID-19 (adjusted odds ratio [aOR] [moCOVID-19]: 2.27, 95% CI, 1.16-4.46 and aOR [sCOVID-19]: 3.26, 95% CI, 1.56-6.38). Patients with PreD also presented more often with more severe COVID-19 than those with normoglycemia (aOR [moCOVID-19]: 1.76, 95% CI, 1.04-2.97 and aOR [sCOVID-19]: 2.41, 95% CI, 1.37-4.23). Screening with BC failed to identify only 96% of PreD (206/217) and 26.2% of D diagnosis (58/221) and missed associations of dysglycemia and COVID-19 severity.
    Conclusion: Pandemic conditions may hamper dysglycemia detection rate and in consequence the awareness of individual patient risk for COVID-19 severity. A systematic diabetes screening including HbA1c reduces underdiagnosis of previously unknown or new-onset dysglycemia, and enhances the quality of risk estimation and access of patients at risk to a diabetes-specific intervention.
    MeSH term(s) Humans ; Glycated Hemoglobin ; Prevalence ; COVID-19/complications ; COVID-19/diagnosis ; COVID-19/epidemiology ; Diabetes Mellitus/diagnosis ; Diabetes Mellitus/epidemiology ; Prediabetic State/diagnosis ; Prediabetic State/epidemiology
    Chemical Substances Glycated Hemoglobin
    Language English
    Publishing date 2022-10-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgac590
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The Fungal Gut Microbiome Exhibits Reduced Diversity and Increased Relative Abundance of Ascomycota in Severe COVID-19 Illness and Distinct Interconnected Communities in SARS-CoV-2 Positive Patients.

    Reinold, Johanna / Farahpour, Farnoush / Schoerding, Ann-Kathrin / Fehring, Christian / Dolff, Sebastian / Konik, Margarethe / Korth, Johannes / van Baal, Lukas / Buer, Jan / Witzke, Oliver / Westendorf, Astrid M / Kehrmann, Jan

    Frontiers in cellular and infection microbiology

    2022  Volume 12, Page(s) 848650

    Abstract: Clinical and experimental studies indicate that the bacterial and fungal gut microbiota modulates immune responses in distant organs including the lungs. Immune dysregulation is associated with severe SARS-CoV-2 infection, and several groups have ... ...

    Abstract Clinical and experimental studies indicate that the bacterial and fungal gut microbiota modulates immune responses in distant organs including the lungs. Immune dysregulation is associated with severe SARS-CoV-2 infection, and several groups have observed gut bacterial dysbiosis in SARS-CoV-2 infected patients, while the fungal gut microbiota remains poorly defined in these patients. We analyzed the fungal gut microbiome from rectal swabs taken prior to anti-infective treatment in 30 SARS-CoV-2 positive (21 non-severe COVID-19 and 9 developing severe/critical COVID-19 patients) and 23 SARS-CoV-2 negative patients by ITS2-sequencing. Pronounced but distinct interconnected fungal communities distinguished SARS-CoV-2 positive and negative patients. Fungal gut microbiota in severe/critical COVID-19 illness was characterized by a reduced diversity, richness and evenness and by an increase of the relative abundance of the Ascomycota phylum compared with non-severe COVID-19 illness. A dominance of a single fungal species with a relative abundance of >75% was a frequent feature in severe/critical COVID-19. The dominating fungal species were highly variable between patients even within the groups. Several fungal taxa were depleted in patients with severe/critical COVID-19.The distinct compositional changes of the fungal gut microbiome in SARS-CoV-2 infection, especially in severe COVID-19 illness, illuminate the necessity of a broader approach to investigate whether the differences in the fungal gut microbiome are consequences of SARS-CoV-2 infection or a predisposing factor for critical illness.
    MeSH term(s) Ascomycota ; Bacteria ; COVID-19 ; Dysbiosis ; Gastrointestinal Microbiome ; Humans ; Mycobiome ; SARS-CoV-2
    Language English
    Publishing date 2022-04-19
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2022.848650
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Implications of an HbA(1c)-based diabetes screening on prevalence and effect of dysglycemia in patients with COVID-19

    Van Baal, Lukas / Reinold, Johanna / Benson, Sven / Diehl, Anke / Witzke, Oliver / Fuehrer, Dagmar / Tan, Susanne

    Journal of Clinical Endocrinology and Metabolism

    2022  

    Abstract: Context: In patients with severe acute respiratory syndrome coronavirus type 2 infection, diabetes is associated with poor COVID-19 prognosis. However, case detection strategy is divergent and reported prevalence varies from 5% to 35%. Objective: We ... ...

    Title translation Auswirkungen eines HbA(1c)-basierten Diabetes-Screenings auf die Prävalenz und die Auswirkungen der Dysglykämie bei Patienten mit COVID-19. (DeepL)
    Abstract Context: In patients with severe acute respiratory syndrome coronavirus type 2 infection, diabetes is associated with poor COVID-19 prognosis. However, case detection strategy is divergent and reported prevalence varies from 5% to 35%. Objective: We examined how far the choice of screening tools affects the detection rate of dysglycemia and in consequence the estimation of diagnosis-associated risk for moderate (mo) or severe (s) COVID-19. Methods: Non-intensive care unit inpatients with COVID-19 were screened systematically at admission for diabetes (D) and prediabetes (PreD) by glycated hemoglobin A(1c) (HbA(1c)) (A), random blood glucose (B), and known history (C) from November 1, 2020 to March 8, 2021. Dysglycemia rate and effect on COVID-19 outcome were analyzed in 2 screening strategies (ABC vs BC). Results: A total of 578 of 601 (96.2%) of admitted patients were screened and analyzed. In ABC, prevalence of D and PreD was 38.2% and 37.5%, respectively. D was significantly associated with an increased risk for more severe COVID-19 (adjusted odds ratio [aOR] [moCOVID-19]: 2.27, 95% CI, 1.16-4.46 and aOR [sCOVID-19]: 3.26, 95% CI, 1.56-6.38). Patients with PreD also presented more often with more severe COVID-19 than those with normoglycemia (aOR [moCOVID-19]: 1.76, 95% CI, 1.04-2.97 and aOR [sCOVID-19]: 2.41, 95% CI, 1.37-4.23). Screening with BC failed to identify only 96% of PreD (206/217) and 26.2% of D diagnosis (58/221) and missed associations of dysglycemia and COVID-19 severity. Conclusion: Pandemic conditions may hamper dysglycemia detection rate and in consequence the awareness of individual patient risk for COVID-19 severity. A systematic diabetes screening including HbA(1c) reduces underdiagnosis of previously unknown or new-onset dysglycemia, and enhances the quality of risk estimation and access of patients at risk to a diabetes-specific intervention.
    Keywords At Risk Populations ; Blood Sugar ; Blutzucker ; COVID-19 ; Diabetes ; Epidemiologie ; Epidemiology ; Krankheitsschweregrad ; Risikofaktoren ; Risikogruppen ; Risk Factors ; Screening ; Severity (Disorders)
    Language English
    Document type Article
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgac590
    Database PSYNDEX

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  6. Article ; Online: A Pro-Inflammatory Gut Microbiome Characterizes SARS-CoV-2 Infected Patients and a Reduction in the Connectivity of an Anti-Inflammatory Bacterial Network Associates With Severe COVID-19.

    Reinold, Johanna / Farahpour, Farnoush / Fehring, Christian / Dolff, Sebastian / Konik, Margarethe / Korth, Johannes / van Baal, Lukas / Hoffmann, Daniel / Buer, Jan / Witzke, Oliver / Westendorf, Astrid M / Kehrmann, Jan

    Frontiers in cellular and infection microbiology

    2021  Volume 11, Page(s) 747816

    Abstract: The gut microbiota contributes to maintaining human health and regulating immune responses. Severe COVID-19 illness is associated with a dysregulated pro-inflammatory immune response. The effect of SARS-CoV-2 on altering the gut microbiome and the ... ...

    Abstract The gut microbiota contributes to maintaining human health and regulating immune responses. Severe COVID-19 illness is associated with a dysregulated pro-inflammatory immune response. The effect of SARS-CoV-2 on altering the gut microbiome and the relevance of the gut microbiome on COVID-19 severity needs to be clarified. In this prospective study, we analyzed the gut microbiome of 212 patients of a tertiary care hospital (117 patients infected with SARS-CoV-2 and 95 SARS-CoV-2 negative patients) using
    MeSH term(s) Anti-Inflammatory Agents ; COVID-19 ; Gastrointestinal Microbiome ; Humans ; Prospective Studies ; RNA, Ribosomal, 16S/genetics ; SARS-CoV-2
    Chemical Substances Anti-Inflammatory Agents ; RNA, Ribosomal, 16S
    Language English
    Publishing date 2021-11-17
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2021.747816
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Mediterranean Style Diet and Kidney Function Loss in Kidney Transplant Recipients.

    Gomes-Neto, António W / Osté, Maryse C J / Sotomayor, Camilo G / van den Berg, Else / Geleijnse, Johanna Marianna / Berger, Stefan P / Gans, Reinold O B / Bakker, Stephan J L / Navis, Gerjan J

    Clinical journal of the American Society of Nephrology : CJASN

    2020  Volume 15, Issue 2, Page(s) 238–246

    Abstract: Background and objectives: Despite improvement of short-term graft survival over recent years, long-term graft survival after kidney transplantation has not improved. Studies in the general population suggest the Mediterranean diet benefits kidney ... ...

    Abstract Background and objectives: Despite improvement of short-term graft survival over recent years, long-term graft survival after kidney transplantation has not improved. Studies in the general population suggest the Mediterranean diet benefits kidney function preservation. We investigated whether adherence to the Mediterranean diet is associated with kidney outcomes in kidney transplant recipients.
    Design, setting, participants, & measurements: We included 632 adult kidney transplant recipients with a functioning graft for ≥1 year. Dietary intake was inquired using a 177-item validated food frequency questionnaire. Adherence to the Mediterranean diet was assessed using a nine-point Mediterranean Diet Score. Primary end point of the study was graft failure and secondary end points included kidney function decline (doubling of serum creatinine or graft failure) and graft loss (graft failure or death with a functioning graft). Cox regression analyses were used to prospectively study the associations of the Mediterranean Diet Score with study end points.
    Results: During median follow-up of 5.4 (interquartile range, 4.9-6.0) years, 76 participants developed graft failure, 119 developed kidney function decline, and 181 developed graft loss. The Mediterranean Diet Score was inversely associated with all study end points (graft failure: hazard ratio [HR], 0.68; 95% confidence interval [95% CI], 0.50 to 0.91; kidney function decline: HR, 0.68; 95% CI, 0.55 to 0.85; and graft loss: HR, 0.74; 95% CI, 0.63 to 0.88 per two-point increase in Mediterranean Diet Score) independent of potential confounders. We identified 24-hour urinary protein excretion and time since transplantation to be an effect modifier, with stronger inverse associations between the Mediterranean Diet Score and kidney outcomes observed in participants with higher urinary protein excretion and participants transplanted more recently.
    Conclusions: Adherence to the Mediterranean diet is associated with better kidney function outcomes in kidney transplant recipients.
    MeSH term(s) Adult ; Aged ; Diet, Mediterranean ; Female ; Graft Survival ; Humans ; Kidney/physiopathology ; Kidney Diseases/etiology ; Kidney Diseases/mortality ; Kidney Diseases/physiopathology ; Kidney Diseases/prevention & control ; Kidney Transplantation/adverse effects ; Kidney Transplantation/mortality ; Male ; Middle Aged ; Patient Compliance ; Prospective Studies ; Protective Factors ; Risk Assessment ; Risk Factors ; Time Factors ; Treatment Outcome
    Language English
    Publishing date 2020-01-02
    Publishing country United States
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2226665-3
    ISSN 1555-905X ; 1555-9041
    ISSN (online) 1555-905X
    ISSN 1555-9041
    DOI 10.2215/CJN.06710619
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Fruit and Vegetable Intake and Risk of Posttransplantation Diabetes in Renal Transplant Recipients.

    Gomes-Neto, António W / Osté, Maryse C J / Sotomayor, Camilo G / V D Berg, Else / Geleijnse, Johanna M / Gans, Reinold O B / Bakker, Stephan J L / Navis, Gerjan J

    Diabetes care

    2019  Volume 42, Issue 9, Page(s) 1645–1652

    Abstract: Objective: Posttransplantation diabetes mellitus (PTDM) contributes to risk for cardiovascular morbidity and mortality in renal transplant recipients (RTRs). In the general population, consumption of a diet containing few fruits and vegetables ... ...

    Abstract Objective: Posttransplantation diabetes mellitus (PTDM) contributes to risk for cardiovascular morbidity and mortality in renal transplant recipients (RTRs). In the general population, consumption of a diet containing few fruits and vegetables predisposes to type 2 diabetes. The role of diet as a potential modifiable risk factor for PTDM has not been explored. Our focus was to investigate the prospective associations of fruit and vegetable intake with risk of PTDM in stable RTRs.
    Research design and methods: We included 472 adult RTRs who had a functioning graft ≥1 year. Fruit and vegetable intake was assessed by using a 177-item food frequency questionnaire. PTDM was defined according the American Diabetes Association's diagnostic criteria for diabetes.
    Results: During 5.2 years of follow-up, 52 RTRs (11%) developed PTDM. Fruit intake was not associated with PTDM (hazard ratio [HR] 0.90 [95% CI 0.79-1.03] per
    Conclusions: In this study vegetable intake, but not fruit intake, was associated with lower risk of PTDM in RTRs, likely largely through beneficial effects on key components of the metabolic syndrome. These findings further support accumulating evidence that supports a recommendation of higher vegetable intake by RTRs.
    MeSH term(s) Adult ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/etiology ; Diet/adverse effects ; Eating/physiology ; Female ; Follow-Up Studies ; Fruit/physiology ; Humans ; Kidney Transplantation/adverse effects ; Kidney Transplantation/rehabilitation ; Kidney Transplantation/statistics & numerical data ; Male ; Metabolic Syndrome/epidemiology ; Metabolic Syndrome/etiology ; Middle Aged ; Nutrition Surveys ; Prospective Studies ; Risk Factors ; Vegetables/physiology
    Language English
    Publishing date 2019-07-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 441231-x
    ISSN 1935-5548 ; 0149-5992
    ISSN (online) 1935-5548
    ISSN 0149-5992
    DOI 10.2337/dc19-0224
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Renal sulfate reabsorption in healthy individuals and renal transplant recipients.

    Post, Adrian / Minović, Isidor / van den Berg, Else / Eggersdorfer, Manfred L / Navis, Gerjan J / Geleijnse, Johanna M / Gans, Reinold O B / van Goor, Harry / Struck, Joachim / Franssen, Casper F M / Kema, Ido P / Bakker, Stephan J L

    Physiological reports

    2018  Volume 6, Issue 8, Page(s) e13670

    Abstract: Inorganic sulfate is essential for normal cellular function and its homeostasis is primarily regulated in the kidneys. However, little is known about renal sulfate handling in humans and particularly in populations with impaired kidney function such as ... ...

    Abstract Inorganic sulfate is essential for normal cellular function and its homeostasis is primarily regulated in the kidneys. However, little is known about renal sulfate handling in humans and particularly in populations with impaired kidney function such as renal transplant recipients (RTR). Hence, we aimed to assess sulfate reabsorption in kidney donors and RTR. Plasma and urinary sulfate were determined in 671 RTR and in 251 kidney donors. Tubular sulfate reabsorption (TSR) was defined as filtered load minus sulfate excretion and fractional sulfate reabsorption (FSR) was defined as 1-fractional excretion. Linear regression analyses were employed to explore associations of FSR with baseline parameters and to identify the determinants of FSR in RTR. Compared to kidney donors, RTR had significantly lower TSR (15.2 [11.2-19.5] vs. 20.3 [16.7-26.3] μmol/min), and lower FSR (0.56 [0.48-0.64] vs. 0.64 [0.57-0.69]) (all P < 0.001). Kidney donation reduced both TSR and FSR by circa 50% and 25% respectively (both P < 0.001). In RTR and donors, both TSR and FSR associated positively with renal function. In RTR, FSR was independently associated with urinary thiosulfate (β = -0.18; P = 0.002), growth hormone (β = 0.12; P = 0.007), the intakes of alcohol (β = -0.14; P = 0.002), methionine (β = -0.34; P < 0.001), cysteine (β = -0.41; P < 0.001), and vitamin D (β = -0.14; P = 0.009). In conclusion, TSR and FSR are lower in RTR compared to kidney donors and both associated with renal function. Additionally, FSR is determined by various dietary and metabolic factors. Future research should determine the mechanisms behind sulfate handling in humans and the prognostic value of renal sulfate reabsorption in RTR.
    MeSH term(s) Adult ; Aged ; Cross-Sectional Studies ; Female ; Healthy Volunteers ; Humans ; Kidney/metabolism ; Kidney Transplantation ; Male ; Middle Aged ; Renal Reabsorption/physiology ; Sulfates/metabolism ; Transplant Recipients
    Chemical Substances Sulfates
    Language English
    Publishing date 2018-04-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2724325-4
    ISSN 2051-817X ; 2051-817X
    ISSN (online) 2051-817X
    ISSN 2051-817X
    DOI 10.14814/phy2.13670
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Mediterranean style diet and kidney function loss in kidney transplant recipients

    Gomes-Neto, António W. / Osté, Maryse C.J. / Sotomayor, Camilo G. / van den Berg, Else / Geleijnse, Johanna Marianna / Berger, Stefan P. / Gans, Reinold O.B. / Bakker, Stephan J.L. / Navis, Gerjan J.

    Clinical Journal of the American Society of Nephrology

    2020  Volume 15, Issue 2

    Abstract: Background and objectives Despite improvement of short-term graft survival over recent years, long-term graft survival after kidney transplantation has not improved. Studies in the general population suggest the Mediterranean diet benefits kidney ... ...

    Abstract Background and objectives Despite improvement of short-term graft survival over recent years, long-term graft survival after kidney transplantation has not improved. Studies in the general population suggest the Mediterranean diet benefits kidney function preservation. We investigated whether adherence to the Mediterranean diet is associated with kidney outcomes in kidney transplant recipients. Design, setting, participants, & measurements We included 632 adult kidney transplant recipients with a functioning graft for ≥1 year. Dietary intake was inquired using a 177-item validated food frequency questionnaire. Adherence to the Mediterranean diet was assessed using a nine-point Mediterranean Diet Score. Primary end point of the study was graft failure and secondary end points included kidney function decline (doubling of serum creatinine or graft failure) and graft loss (graft failure or death with a functioning graft). Cox regression analyses were used to prospectively study the associations of the Mediterranean Diet Score with study end points. Results During median follow-up of 5.4 (interquartile range, 4.9–6.0) years, 76 participants developed graft failure, 119 developed kidney function decline, and 181 developed graft loss. The Mediterranean Diet Score was inversely associated with all study end points (graft failure: hazard ratio [HR], 0.68; 95% confidence interval [95% CI], 0.50 to 0.91; kidney function decline: HR, 0.68; 95% CI, 0.55 to 0.85; and graft loss: HR, 0.74; 95% CI, 0.63 to 0.88 per two-point increase in Mediterranean Diet Score) independent of potential confounders. We identified 24-hour urinary protein excretion and time since transplantation to be an effect modifier, with stronger inverse associations between the Mediterranean Diet Score and kidney outcomes observed in participants with higher urinary protein excretion and participants transplanted more recently. Conclusions Adherence to the Mediterranean diet is associated with better kidney function outcomes in kidney transplant ...
    Keywords Life Science
    Language English
    Publishing country nl
    Document type Article ; Online
    ZDB-ID 2226665-3
    ISSN 1555-9041
    ISSN 1555-9041
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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