Result 1 - 10 of total 128
Radiat. res
| Keywords | covid19 |
|---|---|
| Publisher | WHO |
| Document type | Article |
| Note | WHO #Covidence: #154711 |
| Database | COVID19 |
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2020 Volume 193, Issue 6, Page(s) 505
| MeSH term(s) | Animals ; Antioxidants ; Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Mice ; Pandemics ; Pneumonia, Viral ; Radiation-Protective Agents ; SARS-CoV-2 ; Whole-Body Irradiation |
|---|---|
| Chemical Substances | Antioxidants ; Radiation-Protective Agents |
| Keywords | covid19 |
| Language | English |
| Publishing date | 2020-04-30 |
| Publishing country | United States |
| Document type | Letter ; Comment |
| ZDB-ID | 80322-4 |
| ISSN | 1938-5404 ; 0033-7587 |
| ISSN (online) | 1938-5404 |
| ISSN | 0033-7587 |
| DOI | 10.1667/RADE-20-000PC |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Ue I Zs.275: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
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Radiat Res
| Keywords | covid19 |
|---|---|
| Publisher | WHO |
| Document type | Article |
| Note | WHO #Covidence: #154711 |
| Database | COVID19 |
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.
Alzheimer's & dementia : the journal of the Alzheimer's Association
2023 Volume 19, Issue 11, Page(s) 5209–5231
Abstract: Microbial infections of the brain can lead to dementia, and for many decades microbial infections have been implicated in Alzheimer's disease (AD) pathology. However, a causal role for infection in AD remains contentious, and the lack of standardized ... ...
| Abstract | Microbial infections of the brain can lead to dementia, and for many decades microbial infections have been implicated in Alzheimer's disease (AD) pathology. However, a causal role for infection in AD remains contentious, and the lack of standardized detection methodologies has led to inconsistent detection/identification of microbes in AD brains. There is a need for a consensus methodology; the Alzheimer's Pathobiome Initiative aims to perform comparative molecular analyses of microbes in post mortem brains versus cerebrospinal fluid, blood, olfactory neuroepithelium, oral/nasopharyngeal tissue, bronchoalveolar, urinary, and gut/stool samples. Diverse extraction methodologies, polymerase chain reaction and sequencing techniques, and bioinformatic tools will be evaluated, in addition to direct microbial culture and metabolomic techniques. The goal is to provide a roadmap for detecting infectious agents in patients with mild cognitive impairment or AD. Positive findings would then prompt tailoring of antimicrobial treatments that might attenuate or remit mounting clinical deficits in a subset of patients. |
|---|---|
| MeSH term(s) | Humans ; Alzheimer Disease/pathology ; Consensus ; Cognitive Dysfunction/pathology ; Brain/pathology |
| Language | English |
| Publishing date | 2023-06-07 |
| Publishing country | United States |
| Document type | Journal Article ; Review |
| ZDB-ID | 2211627-8 |
| ISSN | 1552-5279 ; 1552-5260 |
| ISSN (online) | 1552-5279 |
| ISSN | 1552-5260 |
| DOI | 10.1002/alz.13076 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 6316: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
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| Zs.MO 540: Show issues |
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Healthcare (Basel, Switzerland)
2022 Volume 10, Issue 5
Abstract: Health care is uncertain, dynamic, and fast growing. With digital technologies set to revolutionise the industry, hospital capacity optimisation and planning have never been more relevant. The purposes of this article are threefold. The first is to ... ...
| Abstract | Health care is uncertain, dynamic, and fast growing. With digital technologies set to revolutionise the industry, hospital capacity optimisation and planning have never been more relevant. The purposes of this article are threefold. The first is to identify the current state of the art, to summarise/analyse the key achievements, and to identify gaps in the body of research. The second is to synthesise and evaluate that literature to create a holistic framework for understanding hospital capacity planning and optimisation, in terms of physical elements, process, and governance. Third, avenues for future research are sought to inform researchers and practitioners where they should best concentrate their efforts. In conclusion, we find that prior research has typically focussed on individual parts, but the hospital is one body that is made up of many interdependent parts. It is also evident that past attempts considering entire hospitals fail to incorporate all the detail that is necessary to provide solutions that can be implemented in the real world, across strategic, tactical and operational planning horizons. A holistic approach is needed that includes ancillary services, equipment medicines, utilities, instrument trays, supply chain and inventory considerations. |
|---|---|
| Language | English |
| Publishing date | 2022-04-29 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Review |
| ZDB-ID | 2721009-1 |
| ISSN | 2227-9032 |
| ISSN | 2227-9032 |
| DOI | 10.3390/healthcare10050826 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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2024 Volume 24, Issue 1, Page(s) 449
Abstract: Introduction: Understanding of the needs of people with stroke at hospital discharge and in the first six-months is limited. This study aim was to profile and document the needs of people with stroke at hospital discharge to home and thereafter.: ... ...
| Abstract | Introduction: Understanding of the needs of people with stroke at hospital discharge and in the first six-months is limited. This study aim was to profile and document the needs of people with stroke at hospital discharge to home and thereafter. Methods: A prospective cohort study recruiting individuals with stroke, from three hospitals, who transitioned home, either directly, through rehabilitation, or with early supported discharge teams. Their outcomes (global-health, cognition, function, quality of life, needs) were described using validated questionnaires and a needs survey, at 7-10 days, and at 3-, and 6-months, post-discharge. Results: 72 patients were available at hospital discharge; mean age 70 (SD 13); 61% female; median NIHSS score of 4 (IQR 0-20). 62 (86%), 54 (75%), and 45 (63%) individuals were available respectively at each data collection time-point. Perceived disability was considerable at hospital discharge (51% with mRS ≥ 3), and while it improved at 3-months, it increased thereafter (35% with mRS ≥ 3 at 6-months). Mean physical health and social functioning were "fair" at hospital discharge and ongoing; while HR-QOL, although improved over time, remained impaired at 6-months (0.69+/-0.28). At 6-months cognitive impairment was present in 40%. Unmet needs included involvement in transition planning and care decisions, with ongoing rehabilitation, information, and support needs. The median number of unmet needs at discharge to home was four (range:1-9), and three (range:1-7) at 6-months. Conclusion: Stroke community reintegration is challenging for people with stroke and their families, with high levels of unmet need. Profiling outcomes and unmet needs for people with stroke at hospital-to-home transition and onwards are crucial for shaping the development of effective support interventions to be delivered at this juncture. Isrctn registration: 02/08/2022; ISRCTN44633579. |
|---|---|
| MeSH term(s) | Humans ; Female ; Aged ; Male ; Stroke Rehabilitation ; Quality of Life ; Prospective Studies ; Aftercare ; Patient Discharge ; Stroke/therapy ; Stroke/psychology |
| Language | English |
| Publishing date | 2024-04-10 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 2050434-2 |
| ISSN | 1472-6963 ; 1472-6963 |
| ISSN (online) | 1472-6963 |
| ISSN | 1472-6963 |
| DOI | 10.1186/s12913-024-10820-8 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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2020 Volume 11, Page(s) 594520
Abstract: Helminths, including nematodes, cestodes and trematodes, are complex parasitic organisms that infect at least one billion people globally living in extreme poverty. Helminthic infections are associated with severe morbidity particularly in young children ...
| Abstract | Helminths, including nematodes, cestodes and trematodes, are complex parasitic organisms that infect at least one billion people globally living in extreme poverty. Helminthic infections are associated with severe morbidity particularly in young children who often harbor the highest burden of disease. While each helminth species completes a distinct life cycle within the host, several helminths incite significant lung disease. This impact on the lungs occurs either directly from larval migration and host immune activation or indirectly from a systemic inflammatory immune response. The impact of helminths on the pulmonary immune response involves a sophisticated orchestration and activation of the host innate and adaptive immune cells. The consequences of activating pulmonary host immune responses are variable with several helminthic infections leading to severe, pulmonary compromise while others providing immune tolerance and protection against the development of pulmonary diseases. Further delineation of the convoluted interface between helminth infection and the pulmonary host immune responses is critical to the development of novel therapeutics that are critically needed to prevent the significant global morbidity caused by these parasites. |
|---|---|
| MeSH term(s) | Adaptive Immunity ; Animals ; Biomarkers ; Disease Susceptibility ; Helminthiasis/immunology ; Helminthiasis/metabolism ; Helminthiasis/parasitology ; Helminths/growth & development ; Helminths/immunology ; Host-Parasite Interactions/immunology ; Humans ; Immunity ; Immunity, Innate ; Immunomodulation ; Life Cycle Stages ; Lung Diseases, Parasitic/immunology ; Lung Diseases, Parasitic/metabolism ; Lung Diseases, Parasitic/parasitology ; Organ Specificity/immunology |
| Chemical Substances | Biomarkers |
| Keywords | covid19 |
| Language | English |
| Publishing date | 2020-10-20 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Research Support, N.I.H., Intramural ; Review |
| ZDB-ID | 2606827-8 |
| ISSN | 1664-3224 ; 1664-3224 |
| ISSN (online) | 1664-3224 |
| ISSN | 1664-3224 |
| DOI | 10.3389/fimmu.2020.594520 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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International journal of bipolar disorders
2017 Volume 5, Issue 1, Page(s) 34
Abstract: Background: Bipolar disorder (BD) and the anxiety disorders are highly comorbid. The present study sought to examine perfectionism and goal attainment values as potential mechanisms of known associations between anxiety, stress and BD symptomatology. ... ...
| Abstract | Background: Bipolar disorder (BD) and the anxiety disorders are highly comorbid. The present study sought to examine perfectionism and goal attainment values as potential mechanisms of known associations between anxiety, stress and BD symptomatology. Measures of perfectionism and goal attainment values were administered to 269 members of BD pedigrees, alongside measures of anxiety and stress, and BD mood symptoms. Regression analyses were used to determine whether perfectionism and goal attainment values were related to depressive and (hypo)manic symptoms; planned mediation models were then used to test the potential for perfectionism to mediate associations between anxiety/stress and BD symptoms. Results: Self-oriented perfectionism was associated with chronic depressive symptoms; socially-prescribed perfectionism was associated with chronic (hypo)manic symptoms. Self-oriented perfectionism mediated relationships between anxiety/stress and chronic depressive symptoms even after controlling for chronic hypomanic symptoms. Similarly, socially-prescribed perfectionism mediated associations between anxiety/stress and chronic hypomanic symptoms after controlling for chronic depressive symptoms. Goal attainment beliefs were not uniquely associated with chronic depressive or (hypo)manic symptoms. Conclusions: Cognitive styles of perfectionism may explain the co-occurrence of anxiety and stress symptoms and BD symptoms. Psychological interventions for anxiety and stress symptoms in BD might therefore address perfectionism in attempt to reduce depression and (hypo)manic symptoms in addition to appropriate pharmacotherapy. |
|---|---|
| Language | English |
| Publishing date | 2017-10-06 |
| Publishing country | Germany |
| Document type | Journal Article |
| ZDB-ID | 2732954-9 |
| ISSN | 2194-7511 |
| ISSN | 2194-7511 |
| DOI | 10.1186/s40345-017-0102-8 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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2009 Volume 25, Issue 2, Page(s) 96–98
| MeSH term(s) | Animals ; History, 20th Century ; Humans ; Hyperthermia, Induced/history ; Neoplasms/history ; Neoplasms/metabolism ; Neoplasms/therapy ; Neovascularization, Pathologic ; Oxygen/metabolism ; Oxygen Consumption |
|---|---|
| Chemical Substances | Oxygen (S88TT14065) |
| Language | English |
| Publishing date | 2009-04-02 |
| Publishing country | England |
| Document type | Comment ; Historical Article ; Journal Article |
| ZDB-ID | 632526-9 |
| ISSN | 1464-5157 ; 0265-6736 |
| ISSN (online) | 1464-5157 |
| ISSN | 0265-6736 |
| DOI | 10.1080/02656730902758700 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 2051: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
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2024
Abstract: Aim: To explore the views of neonatal intensive care nursing staff on the deliverability of a novel genetic point-of-care test detecting a genetic variant associated with antibiotic-induced ototoxicity.: Design: An interpretive, descriptive, ... ...
| Abstract | Aim: To explore the views of neonatal intensive care nursing staff on the deliverability of a novel genetic point-of-care test detecting a genetic variant associated with antibiotic-induced ototoxicity. Design: An interpretive, descriptive, qualitative interview study. Methods: Data were collected using semi-structured interviews undertaken between January and November 2020. Participants were neonatal intensive care nursing staff taking part in the Pharmacogenetics to Avoid Loss of Hearing trial. Results: Thematic analysis resulted in four themes: perceived clinical utility; the golden hour; point-of-care device; training and support. Recommendations were made to streamline the protocol and ongoing training and support were considered key to incorporating the test into routine care. Conclusion: Exploring the views of nurses involved in the delivery of the point-of-care test was essential in its implementation. By the study endpoint, all participants could see the value of routine clinical introduction of the point-of care test. Implications for the profession and/or patient care: Nurses are in a key position to support the delivery of point-of-care genetic testing into mainstream settings. This study has implications for the successful integration of other genetic point-of-care tests in acute healthcare settings. Impact: The study will help to tailor the training and support required for routine deployment of the genetic point-of-care test. The study has relevance for nurses involved in the development and delivery of genetic point-of-care tests in other acute hospital settings. Reporting method: This qualitative study adheres to the Standards for Reporting Qualitative Research EQUATOR guidelines and utilizes COREQ and SRQR checklists. Patient or public contribution: All staff working on the participating neonatal intensive care units were trained to use the genetic point-of-care test. All inpatients on the participating units were eligible to have testing via the point-of-care test. The Pharmacogenetics to Avoid Loss of Hearing Patient and Public Involvement and Engagement group provided valuable feedback. Trial and protocol registration: Registered within the University of Manchester. Ethics approval reference numbers: IRAS: 253102 REC reference: 19/NW/0400. Also registered with the ISRCTN ref: ISRCTN13704894. |
|---|---|
| Language | English |
| Publishing date | 2024-01-07 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 197634-5 |
| ISSN | 1365-2648 ; 0309-2402 |
| ISSN (online) | 1365-2648 |
| ISSN | 0309-2402 |
| DOI | 10.1111/jan.16045 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.B 1851: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
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