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  1. Article ; Online: When Someone Should Do Something About This: How a Cryptococcal Clinical Trialist Became Involved With the Coronavirus Disease 2019 Pandemic.

    Boulware, David R

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2023  

    Language English
    Publishing date 2023-11-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciad648
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    Zs.A 1505: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 480: Show issues

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  2. Article ; Online: Timing of Antiretroviral Therapy in Cryptococcal Meningitis: What We Can (and Cannot) Learn From Observational Data.

    Boulware, David R / Jarvis, Joseph N

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2023  Volume 77, Issue 1, Page(s) 74–76

    MeSH term(s) Humans ; Meningitis, Cryptococcal/drug therapy ; Meningitis, Cryptococcal/complications ; HIV ; Cohort Studies ; Developed Countries ; HIV Infections/complications ; HIV Infections/drug therapy ; Anti-Retroviral Agents/therapeutic use
    Chemical Substances Anti-Retroviral Agents
    Language English
    Publishing date 2023-03-08
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciad123
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    Zs.A 1505: Show issues Location:
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  3. Article ; Online: Fluvoxamine for the treatment of COVID-19.

    Boulware, David R / Abassi, Mahsa

    The Lancet. Global health

    2022  Volume 10, Issue 3, Page(s) e329

    MeSH term(s) Fluvoxamine/therapeutic use ; Humans ; SARS-CoV-2 ; COVID-19 Drug Treatment
    Chemical Substances Fluvoxamine (O4L1XPO44W)
    Language English
    Publishing date 2022-05-03
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2723488-5
    ISSN 2214-109X ; 2214-109X
    ISSN (online) 2214-109X
    ISSN 2214-109X
    DOI 10.1016/S2214-109X(21)00590-8
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  4. Article ; Online: Ongoing Need for Clinical Trials and Contemporary End Points for Outpatient COVID-19.

    Lee, Todd C / Boulware, David R

    Annals of internal medicine

    2022  Volume 176, Issue 1, Page(s) 137–138

    MeSH term(s) Humans ; COVID-19/therapy ; Longitudinal Studies ; Outpatients ; Clinical Trials as Topic ; Health Services Needs and Demand
    Language English
    Publishing date 2022-11-29
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/M22-3317
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  5. Article ; Online: Technical procedures and REDCap tools for internet-based clinical trials.

    Bangdiwala, Ananta S / Boulware, David R

    Contemporary clinical trials

    2022  Volume 114, Page(s) 106660

    Abstract: In March of 2020 our team of researchers developed and opened three clinical trials to investigate hydroxychloroquine as prophylaxis or treatment for the coronavirus disease 2019 (COVID-19). We simultaneously built corresponding Research Electronic Data ... ...

    Abstract In March of 2020 our team of researchers developed and opened three clinical trials to investigate hydroxychloroquine as prophylaxis or treatment for the coronavirus disease 2019 (COVID-19). We simultaneously built corresponding Research Electronic Data Capture (REDCap) projects for these low-touch, remote trials that relied on participant-reported data. REDCap has built-in features that support pragmatic, internet-based studies, and REDCap is flexible enough to allow creative solutions for specific trials. We describe challenges, choices, and suggestions based on our experience with REDCap for our COVID-19 trials.
    MeSH term(s) COVID-19 ; Clinical Trials as Topic ; Humans ; Hydroxychloroquine/therapeutic use ; Internet ; Research Design
    Chemical Substances Hydroxychloroquine (4QWG6N8QKH)
    Language English
    Publishing date 2022-01-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2182176-8
    ISSN 1559-2030 ; 1551-7144
    ISSN (online) 1559-2030
    ISSN 1551-7144
    DOI 10.1016/j.cct.2021.106660
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    Zs.A 1581: Show issues Location:
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  6. Article: Prospective Cohort of Fluvoxamine for Early Treatment of Coronavirus Disease 19.

    Seftel, David / Boulware, David R

    Open forum infectious diseases

    2021  Volume 8, Issue 2, Page(s) ofab050

    Abstract: We report a real-world experience using fluvoxamine for coronavirus disease 19 (COVID-19) in a prospective cohort in the setting of a mass outbreak. Overall, 65 persons opted to receive fluvoxamine (50 mg twice daily) and 48 declined. Incidence of ... ...

    Abstract We report a real-world experience using fluvoxamine for coronavirus disease 19 (COVID-19) in a prospective cohort in the setting of a mass outbreak. Overall, 65 persons opted to receive fluvoxamine (50 mg twice daily) and 48 declined. Incidence of hospitalization was 0% (0 of 65) with fluvoxamine and 12.5% (6 of 48) with observation alone. At 14 days, residual symptoms persisted in 0% (0 of 65) with fluvoxamine and 60% (29 of 48) with observation.
    Language English
    Publishing date 2021-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofab050
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  7. Article ; Online: Complex Decisions in HIV-Related Cryptococcosis: Addressing Second Episodes of Cryptococcal Meningitis.

    Musubire, Abdu / Kagimu, Enock / Mugabi, Timothy / Meya, David B / Boulware, David R / Bahr, Nathan C

    Current HIV/AIDS reports

    2024  Volume 21, Issue 2, Page(s) 75–85

    Abstract: Purpose of review: This review highlights the difficulties in diagnosing and treating persons with a prior history of cryptococcal meningitis who improve but suffer from a recurrence of symptoms. This scenario is well known to those who frequently care ... ...

    Abstract Purpose of review: This review highlights the difficulties in diagnosing and treating persons with a prior history of cryptococcal meningitis who improve but suffer from a recurrence of symptoms. This scenario is well known to those who frequently care for patients with cryptococcal meningitis but is not well understood. We highlight major gaps in knowledge.
    Recent findings: We recently summarized our experience with 28 persons with paradoxical immune reconstitution inflammatory syndrome (IRIS) and 81 persons with microbiological relapse. CD4 count and cerebrospinal fluid white blood cell count were higher in IRIS than relapse but neither was reliable enough to routinely differentiate these conditions. Second-episode cryptococcal meningitis remains a difficult clinical scenario as cryptococcal antigen, while excellent for initial diagnosis has no value in differentiating relapse of infection from other causes of recurrent symptoms. Updated research definitions are proposed and rapid, accurate diagnostic tests are urgently needed.
    MeSH term(s) Humans ; Meningitis, Cryptococcal/diagnosis ; Meningitis, Cryptococcal/drug therapy ; Meningitis, Cryptococcal/microbiology ; HIV Infections/complications ; HIV Infections/drug therapy ; Cryptococcosis/complications ; Cryptococcosis/diagnosis ; CD4 Lymphocyte Count ; Immune Reconstitution Inflammatory Syndrome/diagnosis ; Immune Reconstitution Inflammatory Syndrome/drug therapy ; Immune Reconstitution Inflammatory Syndrome/etiology ; Recurrence
    Language English
    Publishing date 2024-02-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2151206-1
    ISSN 1548-3576 ; 1548-3568
    ISSN (online) 1548-3576
    ISSN 1548-3568
    DOI 10.1007/s11904-024-00691-3
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    Zs.A 5920: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Hydroxychloroquine in Nonhospitalized Adults With Early COVID-19.

    Skipper, Caleb P / Boulware, David R

    Annals of internal medicine

    2021  Volume 174, Issue 3, Page(s) 434–435

    MeSH term(s) Adult ; COVID-19/drug therapy ; Coronavirus Infections ; Humans ; Hydroxychloroquine/therapeutic use ; SARS-CoV-2
    Chemical Substances Hydroxychloroquine (4QWG6N8QKH)
    Language English
    Publishing date 2021-03-15
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/L20-1426
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Strategies for Expediting Clinical Trials in the Next Public Health Emergency.

    Titanji, Boghuma K / Boulware, David R / Bender Ignacio, Rachel A

    JAMA health forum

    2023  Volume 4, Issue 9, Page(s) e233191

    MeSH term(s) Public Health ; Clinical Trials as Topic
    Language English
    Publishing date 2023-09-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2689-0186
    ISSN (online) 2689-0186
    DOI 10.1001/jamahealthforum.2023.3191
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  10. Article: Randomized trial of mechanotherapy for the treatment of stress urinary incontinence in women.

    Nakib, Nissrine / Sutherland, Suzette / Hallman, Kevin / Mianulli, Marcus / R Boulware, David

    Therapeutic advances in urology

    2024  Volume 16, Page(s) 17562872241228023

    Abstract: Background: Stress urinary incontinence (SUI) presents as unintentional urine leakage associated with activities. It significantly affects quality of life (QoL) and is the most common type of incontinence in women. Current treatment options, ... ...

    Abstract Background: Stress urinary incontinence (SUI) presents as unintentional urine leakage associated with activities. It significantly affects quality of life (QoL) and is the most common type of incontinence in women. Current treatment options, particularly non-surgical therapies, are lacking.
    Objective: To assess the efficacy of mechanotherapy provided by the Flyte
    Design: This was a randomized, controlled, double-blinded trial.
    Materials and methods: Flyte is a repeat use device for conditioning and strengthening the pelvic floor muscles (PFMs). It provides two-part mechanotherapy. Part 1 is the stretching and preloading of the PFM from the internal wand. Part 2 integrates mechanical pulses which elicit muscle cellular and tissue level responses that trigger cellular regeneration, improve neuromuscular facilitation and motor learning. Subjects used the device for 5 min/day for 12 weeks. Subjects (144) were randomized and evaluated at 6 and 12 weeks. Arm A (72) received both Part 1 and Part 2 mechanotherapy for 12 weeks, whereas Arm B (72) received Part 1 therapy for 6 weeks, then crossed over to full therapy. Mean age was 50, 49, respectively, prior pelvic/abdominal surgery 26%, 46%, and previous incontinence treatments 13%, 22%. The primary endpoint was 24-h pad weight (24-HR PW) at 6 weeks. Secondary endpoints were 24-HR PW at 12 weeks and QoL [International Consultation on Incontinence Questionnaire (ICIQ), Urinary Incontinence Quality of Life (IQOL)].
    Results: Part 1 therapy had a greater than anticipated therapeutic effect. Thus, the study was underpowered to identify differences between study arms. Therefore, data were pooled to assess the effects of mechanotherapy. Twenty four-HR PW was significantly reduced at 6 weeks (
    Conclusion: Two-part mechanotherapy significantly improved 24-HR PW and QoL across all severities of SUI. Improvements were noted in as little as 2 weeks and appeared to be sustained through 2-year follow up.
    Trial registration: Registered on ClinTrials.gov (NCT02954042).
    Language English
    Publishing date 2024-02-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2492591-3
    ISSN 1756-2880 ; 1756-2872
    ISSN (online) 1756-2880
    ISSN 1756-2872
    DOI 10.1177/17562872241228023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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