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Article ; Online: A Randomized Trial of Instructor-Led Training Versus Video Lesson in Training Health Care Providers in Proper Donning and Doffing of Personal Protective Equipment.

Christensen, Liva / Rasmussen, Charlotte Schang / Benfield, Thomas / Franc, Jeffrey Michael

Disaster medicine and public health preparedness

2020 Volume 14, Issue 4, Page(s) 514–520

Abstract: Objective: This study compared live instructor-led training with video-based instruction in personal protective equipment (PPE) donning and doffing. It assessed the difference in performance between (1) attending 1 instructor-led training session in ... ...

Abstract	Objective: This study compared live instructor-led training with video-based instruction in personal protective equipment (PPE) donning and doffing. It assessed the difference in performance between (1) attending 1 instructor-led training session in donning and doffing PPE at 1 month prior to assessment, and (2) watching training videos for 1 month. Methods: This randomized controlled trial pilot study divided 21 medical students and junior doctors into 2 groups. Control group participants attended 1 instructor-led training session. Video group participants watched training videos demonstrating the same procedures, which they could freely watch again at home. After 1 month, a doctor performed a blind evaluation of performance using checklists. Results: Nineteen participants were assessed after 1 month. The mean donning score was 84.8/100 for the instructor-led group and 88/100 for the video group; mean effect size was 3.2 (95% CI: -7.5 to 9.5). The mean doffing score was 79.1/100 for the instructor-led group and 73.9/100 for the video group; mean effect size was 5.2 (95% CI: -7.6 to 18). Conclusion: Our study found no significant difference in donning and doffing scores between instructor-led and video lessons. Video training could be a fast and resource-efficient method of training in PPE donning and doffing in responding to the COVID-19 pandemic.
MeSH term(s)	Health Personnel/education ; Health Personnel/psychology ; Health Personnel/statistics & numerical data ; Humans ; Pandemics/prevention & control ; Pandemics/statistics & numerical data ; Personal Protective Equipment ; Pilot Projects ; Teaching/classification ; Teaching/standards ; Teaching/statistics & numerical data
Keywords	covid19
Language	English
Publishing date	2020-03-30
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2375268-3
ISSN	1938-744X ; 1935-7893
ISSN (online)	1938-744X
ISSN	1935-7893
DOI	10.1017/dmp.2020.56
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Acute concomitant glucose-dependent insulinotropic polypeptide receptor antagonism during glucagon-like peptide 1 receptor agonism does not affect appetite, resting energy expenditure or food intake in patients with type 2 diabetes and overweight/obesity.

Stensen, Signe / Krogh, Liva L / Sparre-Ulrich, Alexander H / Dela, Flemming / Hartmann, Bolette / Vilsbøll, Tina / Holst, Jens J / Rosenkilde, Mette M / Christensen, Mikkel B / Gasbjerg, Laerke S / Knop, Filip K

Diabetes, obesity & metabolism

2022 Volume 24, Issue 9, Page(s) 1882–1887

MeSH term(s)	Appetite ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Eating ; Energy Metabolism ; Gastric Inhibitory Polypeptide/metabolism ; Glucagon-Like Peptide 1 ; Glucagon-Like Peptide-1 Receptor ; Humans ; Incretins ; Obesity/complications ; Obesity/drug therapy ; Overweight/complications ; Overweight/drug therapy ; Receptors, Gastrointestinal Hormone
Chemical Substances	Glucagon-Like Peptide-1 Receptor ; Incretins ; Receptors, Gastrointestinal Hormone ; Gastric Inhibitory Polypeptide (59392-49-3) ; Glucagon-Like Peptide 1 (89750-14-1) ; gastric inhibitory polypeptide receptor (D6H00MV7K8)
Language	English
Publishing date	2022-06-20
Publishing country	England
Document type	Research Support, Non-U.S. Gov't ; Journal Article
ZDB-ID	1454944-x
ISSN	1463-1326 ; 1462-8902
ISSN (online)	1463-1326
ISSN	1462-8902
DOI	10.1111/dom.14736
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A Randomized Trial of Instructor-Led Training Versus Video Lesson in Training Health Care Providers in Proper Donning and Doffing of Personal Protective Equipment

Christensen, Liva / Rasmussen, Charlotte Schang / Benfield, Thomas / Franc, Jeffrey Michael

Disaster Medicine and Public Health Preparedness

2020 , Page(s) 1–7

Abstract: ABSTRACT Objective: This study compared live instructor-led training with video-based instruction in personal protective equipment (PPE) donning and doffing. It assessed the difference in performance between (1) attending 1 instructor-led training ... ...

Abstract	ABSTRACT Objective: This study compared live instructor-led training with video-based instruction in personal protective equipment (PPE) donning and doffing. It assessed the difference in performance between (1) attending 1 instructor-led training session in donning and doffing PPE at 1 month prior to assessment, and (2) watching training videos for 1 month. Methods: This randomized controlled trial pilot study divided 21 medical students and junior doctors into 2 groups. Control group participants attended 1 instructor-led training session. Video group participants watched training videos demonstrating the same procedures, which they could freely watch again at home. After 1 month, a doctor performed a blind evaluation of performance using checklists. Results: Nineteen participants were assessed after 1 month. The mean donning score was 84.8/100 for the instructor-led group and 88/100 for the video group; mean effect size was 3.2 (95% CI: -7.5 to 9.5). The mean doffing score was 79.1/100 for the instructor-led group and 73.9/100 for the video group; mean effect size was 5.2 (95% CI: -7.6 to 18). Conclusion: Our study found no significant difference in donning and doffing scores between instructor-led and video lessons. Video training could be a fast and resource-efficient method of training in PPE donning and doffing in responding to the COVID-19 pandemic.
Keywords	Public Health, Environmental and Occupational Health ; covid19
Language	English
Publisher	Cambridge University Press (CUP)
Publishing country	uk
Document type	Article ; Online
ZDB-ID	2375268-3
ISSN	1938-744X ; 1935-7893
ISSN (online)	1938-744X
ISSN	1935-7893
DOI	10.1017/dmp.2020.56
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: A Randomized Trial of Instructor-led Training versus Video Lesson in Training Health Care Providers in Proper Donning and Doffing of Personal Protective Equipment

Christensen, Liva / Rasmussen, Charlotte Schang / Benfield, Thomas / Franc, Jeffrey Michael

Disaster Med Public Health Prep

Abstract: OBJECTIVE: This study compared live instructor-led training in Personal Protective Equipment (PPE) donning and doffing with video-based instruction. It assessed the difference in performance between (i) attending one instructor-led training session in ... ...

Abstract	OBJECTIVE: This study compared live instructor-led training in Personal Protective Equipment (PPE) donning and doffing with video-based instruction. It assessed the difference in performance between (i) attending one instructor-led training session in donning and doffing PPE one month prior to assessment, and (ii) watching training videos over the month. METHODS: This randomized controlled trial pilot study divided 21 medical students and junior doctors into 2 groups. Control group participants attended one instructor-led training session. Video group participants watched training videos demonstrating the same procedures, which they could freely watch again at home. After one month, a doctor performed a blind evaluation of performance using checklists. RESULTS: 19 participants were assessed after one month. The mean donning score was 84.8/100 for the instructor-led group and 88/100 for the video group; mean effect size 3,2 (95%CI: -7,5 to 9,5). The mean doffing score was 79.1/100 for the instructor group and 73.9/100 for the video group; mean effect size 5,2 (95%CI: -7,6 to 18). CONCLUSION: Our study found no significant difference in donning and doffing score between instructor-led and video lessons. Video training could be a fast and resource-efficient method of training in PPE donning and doffing in responding to the COVID-19 pandemic.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #17725
Database	COVID19

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Article ; Online: Effects of endogenous GIP in patients with type 2 diabetes.

Stensen, Signe / Gasbjerg, Lærke S / Krogh, Liva L / Skov-Jeppesen, Kirsa / Sparre-Ulrich, Alexander H / Jensen, Mette H / Dela, Flemming / Hartmann, Bolette / Vilsbøll, Tina / Holst, Jens J / Rosenkilde, Mette M / Christensen, Mikkel B / Knop, Filip K

European journal of endocrinology

2021 Volume 185, Issue 1, Page(s) 33–45

Abstract: Objective: The insulinotropic effect of exogenous, intravenously infused glucose-dependent insulinotropic polypeptide (GIP) is impaired in patients with type 2 diabetes. We evaluated the effects of endogenous GIP in relation to glucose and bone ... ...

Abstract	Objective: The insulinotropic effect of exogenous, intravenously infused glucose-dependent insulinotropic polypeptide (GIP) is impaired in patients with type 2 diabetes. We evaluated the effects of endogenous GIP in relation to glucose and bone metabolism in patients with type 2 diabetes using a selective GIP receptor antagonist and hypothesized that the effects of endogenous GIP were preserved. Design: A randomized, double-blinded, placebo-controlled, crossover study. Methods: Ten patients with overweight/obesity and type 2 diabetes (mean±s.d.; HbA1c 52 ± 11 mmol/mol; BMI 32.5 ± 4.8 kg/m2) were included. We infused a selective GIP receptor antagonist, GIP(3-30)NH2 (1200 pmol/kg/min), or placebo (saline) during two separate, 230-min, standardized, liquid mixed meal tests followed by a meal ad libitum. Subcutaneous adipose tissue biopsies were analyzed. Results: Compared with placebo, GIP(3-30)NH2 reduced postprandial insulin secretion (Δbaseline-subtracted area under the curve (bsAUC)C-peptide% ± s.e.m.; -14 ± 6%, P = 0.021) and peak glucagon (Δ% ± s.e.m.; -11 ± 6%, P = 0.046) but had no effect on plasma glucose (P = 0.692). Suppression of bone resorption (assessed by circulating carboxy-terminal collagen crosslinks (CTX)) was impaired during GIP(3-30)NH2 infusion compared with placebo (ΔbsAUCCTX; ±s.e.m.; -4.9 ± 2 ng/mL × min, P = 0.005) corresponding to a ~50% reduction. Compared with placebo, GIP(3-30)NH2 did not affect plasma lipids, meal consumption ad libitum or adipose tissue triglyceride content. Conclusions: Using a selective GIP receptor antagonist during a meal, we show that endogenous GIP increases postprandial insulin secretion with little effect on postprandial glycaemia but is important for postprandial bone homeostasis in patients with type 2 diabetes.
MeSH term(s)	Adult ; Aged ; Blood Glucose/drug effects ; Blood Glucose/metabolism ; Bone Resorption/metabolism ; Collagen Type I/drug effects ; Collagen Type I/metabolism ; Cross-Over Studies ; Diabetes Mellitus, Type 2/metabolism ; Double-Blind Method ; Feeding Behavior/drug effects ; Gastric Inhibitory Polypeptide/metabolism ; Gastric Inhibitory Polypeptide/pharmacology ; Humans ; Insulin Secretion/drug effects ; Insulin Secretion/physiology ; Male ; Middle Aged ; Obesity/metabolism ; Peptide Fragments/pharmacology ; Peptides/drug effects ; Peptides/metabolism ; Postprandial Period ; Random Allocation ; Receptors, Gastrointestinal Hormone/antagonists & inhibitors ; Subcutaneous Fat/drug effects ; Subcutaneous Fat/metabolism ; Triglycerides/metabolism
Chemical Substances	Blood Glucose ; Collagen Type I ; Peptide Fragments ; Peptides ; Receptors, Gastrointestinal Hormone ; Triglycerides ; collagen type I trimeric cross-linked peptide ; gastric inhibitory polypeptide (3-30)-amide ; Gastric Inhibitory Polypeptide (59392-49-3) ; gastric inhibitory polypeptide receptor (D6H00MV7K8)
Language	English
Publishing date	2021-05-21
Publishing country	England
Document type	Journal Article
ZDB-ID	1183856-5
ISSN	1479-683X ; 0804-4643
ISSN (online)	1479-683X
ISSN	0804-4643
DOI	10.1530/EJE-21-0135
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Article ; Online: No Acute Effects of Exogenous Glucose-Dependent Insulinotropic Polypeptide on Energy Intake, Appetite, or Energy Expenditure When Added to Treatment With a Long-Acting Glucagon-Like Peptide 1 Receptor Agonist in Men With Type 2 Diabetes.

Bergmann, Natasha C / Gasbjerg, Lærke S / Heimbürger, Sebastian M / Krogh, Liva S L / Dela, Flemming / Hartmann, Bolette / Holst, Jens J / Jessen, Lene / Christensen, Mikkel B / Vilsbøll, Tina / Lund, Asger / Knop, Filip K

Diabetes care

2020 Volume 43, Issue 3, Page(s) 588–596

Abstract: Objective: Dual incretin receptor agonists in clinical development have shown reductions in body weight and hemoglobin A: Research design and methods: In a randomized, double-blind design, men with type 2 diabetes (: Results: Energy intake was ... ...

Abstract	Objective: Dual incretin receptor agonists in clinical development have shown reductions in body weight and hemoglobin A Research design and methods: In a randomized, double-blind design, men with type 2 diabetes ( Results: Energy intake was similar during GIP and placebo infusion (648 ± 74 kcal vs. 594 ± 55 kcal, respectively; Conclusions: In patients with type 2 diabetes, GIP infusion on top of treatment with metformin and a long-acting GLP-1R agonist did not affect energy intake, appetite, or energy expenditure but increased plasma glucose compared with placebo. These results indicate no acute beneficial effects of combining GIP and GLP-1.
MeSH term(s)	Adult ; Aged ; Appetite/drug effects ; Delayed-Action Preparations/administration & dosage ; Delayed-Action Preparations/pharmacology ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/metabolism ; Double-Blind Method ; Drug Administration Schedule ; Drug Therapy, Combination ; Energy Intake/drug effects ; Energy Metabolism/drug effects ; Gastric Inhibitory Polypeptide/administration & dosage ; Gastric Inhibitory Polypeptide/pharmacology ; Glucagon/blood ; Glucagon-Like Peptide 1/administration & dosage ; Glucagon-Like Peptide 1/analogs & derivatives ; Glucagon-Like Peptide 1/pharmacology ; Glucagon-Like Peptide-1 Receptor/agonists ; Glycated Hemoglobin A/drug effects ; Glycated Hemoglobin A/metabolism ; Humans ; Insulin/blood ; Male ; Middle Aged
Chemical Substances	Delayed-Action Preparations ; Glucagon-Like Peptide-1 Receptor ; Glycated Hemoglobin A ; Insulin ; Gastric Inhibitory Polypeptide (59392-49-3) ; Glucagon-Like Peptide 1 (89750-14-1) ; Glucagon (9007-92-5)
Language	English
Publishing date	2020-01-16
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	441231-x
ISSN	1935-5548 ; 0149-5992
ISSN (online)	1935-5548
ISSN	0149-5992
DOI	10.2337/dc19-0578
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Article: Evaluation of the Clinical and Economic Effects of a Primary Care Anchored, Collaborative, Electronic Health Lifestyle Coaching Program in Denmark: Protocol for a Two-Year Randomized Controlled Trial.

Brandt, Carl J / Christensen, Jeanette Reffstrup / Lauridsen, Jørgen T / Nielsen, Jesper Bo / Søndergaard, Jens / Sortsø, Camilla

JMIR research protocols

2020 Volume 9, Issue 6, Page(s) e19172

Abstract: ... Lifestyle change InterVention and eHealth Application [LIVA] 2.0) in obese participants with and ... A: Methods: We conduct a multicenter trial with a 1-year intervention and 1-year retention. LIVA 2.0 is ... data from the LIVA 2.0 platform are combined with clinical measurements, questionnaires, and ...

Abstract	Background: Obesity is linked to a number of chronic health conditions, such as type 2 diabetes, heart disease, and cancer, and weight loss interventions are often expensive. Recent systematic reviews concluded that app and web-based interventions can improve lifestyle behaviors and weight loss at a reasonable cost, but long-term sustainability needs to be demonstrated. Objective: This study protocol is for a 2-year randomized controlled trial that aims to evaluate the clinical and economic effects of a primary care, anchored, collaborative, electronic health (eHealth) lifestyle coaching program (long-term Lifestyle change InterVention and eHealth Application [LIVA] 2.0) in obese participants with and without type 2 diabetes. The program's primary outcome is weight loss. Its secondary outcome is the hemoglobin A Methods: We conduct a multicenter trial with a 1-year intervention and 1-year retention. LIVA 2.0 is implemented in municipalities within administrative regions in Denmark, specifically eight municipalities located within the Region of Southern Denmark and two municipalities located within the Capital Region of Denmark. The participants are assessed at baseline and at 6-, 12-, and 24-month follow-ups. Individual data from the LIVA 2.0 platform are combined with clinical measurements, questionnaires, and participants' usage of municipality and health care services. The participants have a BMI ≥30 but ≤45 kg/m2, and 50% of the participants have type 2 diabetes. The participants are randomized in an approximately 60:40 manner, and based on sample size calculations on weight loss and intention-to-treat statistics, 200 participants are randomized to an intervention group and 140 are randomized to a control group. The control group is offered the conventional preventive program of the municipality, and it is compared to the intervention group, which follows the LIVA 2.0 in addition to the conventional preventive program. Results: The first baseline assessments have been carried out in March 2018, and the 2-year follow-up will be carried out between March 2020 and April 2021. The hypothesis is that the trial results will demonstrate decreased body weight and that the number of patients who show normalization of their HbA Conclusions: This is the first time that an app and web-based eHealth lifestyle coaching program implemented in Danish municipalities will be clinically and economically evaluated. If the LIVA 2.0 eHealth lifestyle coaching program is proven to be effective, there is great potential for decreasing the rates of obesity, diabetes, and related chronic diseases. Trial registration: ClinicalTrials.gov NCT03788915; https://clinicaltrials.gov/ct2/show/NCT03788915. International registered report identifier (irrid): DERR1-10.2196/19172.
Language	English
Publishing date	2020-06-25
Publishing country	Canada
Document type	Journal Article
ZDB-ID	2719222-2
ISSN	1929-0748
ISSN	1929-0748
DOI	10.2196/19172
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Article ; Online: Long-term weight loss in a 24-month primary care-anchored telehealth lifestyle coaching program: Randomized controlled trial.

Christensen, Jeanette R / Hesseldal, Laura / Olesen, Thomas B / Olsen, Michael H / Jakobsen, Pernille R / Laursen, Ditte H / Lauridsen, Jørgen T / Nielsen, Jesper B / Søndergaard, Jens / Brandt, Carl J

Journal of telemedicine and telecare

2022 Volume 28, Issue 10, Page(s) 764–770

Abstract: ... lifestyle-coaching program (Liva) leads to long-term (24 months) weight loss compared to usual care ...

Abstract	Long-term weight loss can reduce the risk of type 2 diabetes for people living with obesity and reduce complications for patients diagnosed with type 2 diabetes. We investigated whether a telehealth lifestyle-coaching program (Liva) leads to long-term (24 months) weight loss compared to usual care. In a randomized controlled trial,
MeSH term(s)	Humans ; Diabetes Mellitus, Type 2/prevention & control ; Mentoring ; COVID-19 ; Weight Loss ; Telemedicine/methods ; Life Style ; Obesity/therapy ; Primary Health Care
Language	English
Publishing date	2022-11-09
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	1340281-x
ISSN	1758-1109 ; 1357-633X
ISSN (online)	1758-1109
ISSN	1357-633X
DOI	10.1177/1357633X221123411
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Article ; Online: Evaluation of the Clinical and Economic Effects of a Primary Care Anchored, Collaborative, Electronic Health Lifestyle Coaching Program in Denmark

Brandt, Carl J / Christensen, Jeanette Reffstrup / Lauridsen, Jørgen T / Nielsen, Jesper Bo / Søndergaard, Jens / Sortsø, Camilla

JMIR Research Protocols, Vol 9, Iss 6, p e

Protocol for a Two-Year Randomized Controlled Trial

2020 Volume 19172

Abstract: ... Lifestyle change InterVention and eHealth Application [LIVA] 2.0) in obese participants with and ... sustainability. MethodsWe conduct a multicenter trial with a 1-year intervention and 1-year retention. LIVA 2.0 ... Individual data from the LIVA 2.0 platform are combined with clinical measurements, questionnaires, and ...

Abstract	BackgroundObesity is linked to a number of chronic health conditions, such as type 2 diabetes, heart disease, and cancer, and weight loss interventions are often expensive. Recent systematic reviews concluded that app and web-based interventions can improve lifestyle behaviors and weight loss at a reasonable cost, but long-term sustainability needs to be demonstrated. ObjectiveThis study protocol is for a 2-year randomized controlled trial that aims to evaluate the clinical and economic effects of a primary care, anchored, collaborative, electronic health (eHealth) lifestyle coaching program (long-term Lifestyle change InterVention and eHealth Application [LIVA] 2.0) in obese participants with and without type 2 diabetes. The program’s primary outcome is weight loss. Its secondary outcome is the hemoglobin A1c (HbA1c) level, and its tertiary outcomes are retention rate, quality of life (QOL), and cost effectiveness. Analytically, the focus is on associations of participant characteristics with outcomes and sustainability. MethodsWe conduct a multicenter trial with a 1-year intervention and 1-year retention. LIVA 2.0 is implemented in municipalities within administrative regions in Denmark, specifically eight municipalities located within the Region of Southern Denmark and two municipalities located within the Capital Region of Denmark. The participants are assessed at baseline and at 6-, 12-, and 24-month follow-ups. Individual data from the LIVA 2.0 platform are combined with clinical measurements, questionnaires, and participants’ usage of municipality and health care services. The participants have a BMI ≥30 but ≤45 kg/m2, and 50% of the participants have type 2 diabetes. The participants are randomized in an approximately 60:40 manner, and based on sample size calculations on weight loss and intention-to-treat statistics, 200 participants are randomized to an intervention group and 140 are randomized to a control group. The control group is offered the conventional preventive program of the municipality, and ...
Keywords	Medicine ; R ; Computer applications to medicine. Medical informatics ; R858-859.7
Subject code	796
Language	English
Publishing date	2020-06-01T00:00:00Z
Publisher	JMIR Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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