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  1. Article ; Online: Sertoli-Leydig cell tumor of ovary in children: A report of two cases, including retiform variant.

    Sarkar, Piyabi / Sengupta, Moumita / Chatterjee, Uttara / Ghosh, Dipak

    Indian journal of pathology & microbiology

    2021  Volume 64, Issue 3, Page(s) 559–562

    Abstract: Sertoli-Leydig cell tumors (SLCTs) are rare and heterogeneous group of ovarian neoplasms which belong to the sex cord-stromal category of tumors. SLCTs are classified into well, intermediate, and poorly differentiated types. Retiform growth pattern and ... ...

    Abstract Sertoli-Leydig cell tumors (SLCTs) are rare and heterogeneous group of ovarian neoplasms which belong to the sex cord-stromal category of tumors. SLCTs are classified into well, intermediate, and poorly differentiated types. Retiform growth pattern and heterologous elements are commonly found in moderately and poorly differentiated tumors. SLCTs are usually encountered in the third decade of life and patients most often present with virilization. Here, we report two cases of SLCTs of the ovary, both in 2-year-old girls without any hormonal symptoms. The first case was a retiform variant of Sertoli-Leydig cell tumor and the second was a well-differentiated SLCT. Because of its wide spectrum of morphology, several tumors enter in the differential diagnosis and the presence of heterologous elements further complicates the diagnosis. Here, we have described the morphological characteristics of these tumors and discussed their differential diagnoses. SF-1, WT1, and α-inhibin are useful immunostains in establishing the diagnosis and differentiating these from the more the common ovarian germ cell tumors in children.
    MeSH term(s) Child, Preschool ; Diagnosis, Differential ; Female ; Humans ; Ovarian Neoplasms/diagnostic imaging ; Ovarian Neoplasms/pathology ; Ovary/pathology ; Sertoli-Leydig Cell Tumor/classification ; Sertoli-Leydig Cell Tumor/diagnostic imaging ; Sertoli-Leydig Cell Tumor/pathology ; Tomography, X-Ray Computed ; Ultrasonography
    Language English
    Publishing date 2021-07-23
    Publishing country India
    Document type Case Reports
    ZDB-ID 197621-7
    ISSN 0974-5130 ; 0377-4929
    ISSN (online) 0974-5130
    ISSN 0377-4929
    DOI 10.4103/IJPM.IJPM_443_20
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  2. Article: Association of Coronary Heart Disease and CRP - as a Noble Marker of Inflammation - A Case Control Study.

    Sarkar, Narayan Chandra / Sarkar, Piyabi / Sarkar, Pubali / Das, Suranjita

    The Journal of the Association of Physicians of India

    2019  Volume 67, Issue 10, Page(s) 54–56

    Abstract: Background: Attention has increasingly turned towards the role of factors, such as inflammation in the development of atherosclerosis and CHD. C-reactive protein (CRP) has emerged as one of the most important novel inflammatory marker. Subsequent risk ... ...

    Abstract Background: Attention has increasingly turned towards the role of factors, such as inflammation in the development of atherosclerosis and CHD. C-reactive protein (CRP) has emerged as one of the most important novel inflammatory marker. Subsequent risk modification and treatment strategies of CHD keeping on pointer towards inflammation may be the appropriate approach.
    Aim: The aim of this study was to determine the association of CHD with CRP, a sensitive marker of inflammation.
    Material and methods: This is a case control study amongst 300 subjects (150 cases and 150 controls), conducted in the Department of Cardiology at Sri Aurobindo Medical College and P.G Institute, Indore, M.P. Subjects with definite diagnosis of CHD established by coronary angiography (CAG) was taken as cases, subjects matched with age, gender with no conventional risk factor and past history of CHD from the relatives and accompanying persons were enlisted as controls.
    Results: Estimation of CRP reveals ≥0.6 mg/dl in 88(58.7%) subjects out of 150, compared to 26 (17.3%) control subjects out of 150 which is statistically significant (p value<0.0001) (OR=6.7).
    Conclusion: CRP as a noble marker of inflammation was significantly higher in subjects of CHD and thus supported adequately the hypothesis of an activation of inflammatory cascade for coronary atheromatous plaque formation and causation of CHD.
    MeSH term(s) Biomarkers/metabolism ; C-Reactive Protein/metabolism ; Case-Control Studies ; Coronary Disease/metabolism ; Humans ; Inflammation/metabolism ; Risk Factors
    Chemical Substances Biomarkers ; C-Reactive Protein (9007-41-4)
    Language English
    Publishing date 2019-05-25
    Publishing country India
    Document type Journal Article
    ZDB-ID 800766-4
    ISSN 0004-5772
    ISSN 0004-5772
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  3. Article ; Online: A Rare Case of Juvenile Systemic Lupus Erythematosus with Disseminated Histoplasmosis.

    Sarkar, Piyabi / Basu, Keya / Mallick Sinha, Mamata Guha

    Indian journal of dermatology

    2016  Volume 61, Issue 6, Page(s) 700

    Abstract: Histoplasmosis is a systemic fungal infection caused by dimorphic fungus, ...

    Abstract Histoplasmosis is a systemic fungal infection caused by dimorphic fungus,
    Language English
    Publishing date 2016-11
    Publishing country India
    Document type Journal Article
    ZDB-ID 416069-1
    ISSN 1998-3611 ; 0019-5154
    ISSN (online) 1998-3611
    ISSN 0019-5154
    DOI 10.4103/0019-5154.193710
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Medullomyoblastoma: A report of two cases.

    Sarkar, Piyabi / Halder, Aniket / Arun, Indu / Chatterjee, Uttara / Chatterjee, Sandip

    Neurology India

    2017  Volume 65, Issue 3, Page(s) 647–650

    MeSH term(s) Brain/diagnostic imaging ; Cerebellar Neoplasms/diagnostic imaging ; Child ; Child, Preschool ; Female ; Fourth Ventricle/diagnostic imaging ; Humans ; Magnetic Resonance Imaging ; Male ; Medulloblastoma/diagnostic imaging ; Tomography, X-Ray Computed
    Language English
    Publishing date 2017-05-06
    Publishing country India
    Document type Case Reports ; Letter
    ZDB-ID 415522-1
    ISSN 1998-4022 ; 0028-3886
    ISSN (online) 1998-4022
    ISSN 0028-3886
    DOI 10.4103/neuroindia.NI_181_16
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Medullomyoblastoma

    Piyabi Sarkar / Aniket Halder / Indu Arun / Uttara Chatterjee / Sandip Chatterjee

    Neurology India, Vol 65, Iss 3, Pp 647-

    A report of two cases

    2017  Volume 650

    Keywords Neurology. Diseases of the nervous system ; RC346-429 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571 ; Internal medicine ; RC31-1245 ; Medicine ; R
    Language English
    Publishing date 2017-01-01T00:00:00Z
    Publisher Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: A rare case of juvenile systemic lupus erythematosus with disseminated histoplasmosis

    Piyabi Sarkar / Keya Basu / Mamata Guha Mallick (Sinha)

    Indian Journal of Dermatology, Vol 61, Iss 6, Pp 700-

    2016  Volume 700

    Abstract: Histoplasmosis is a systemic fungal infection caused by dimorphic fungus, Histoplasma capsulatum. Immunocompetent individuals usually have self-limiting or localized disease whereas immunocompromised individuals develop disseminated disease. The ... ...

    Abstract Histoplasmosis is a systemic fungal infection caused by dimorphic fungus, Histoplasma capsulatum. Immunocompetent individuals usually have self-limiting or localized disease whereas immunocompromised individuals develop disseminated disease. The occurrence of progressive disseminated histoplasmosis in juvenile systemic lupus erythematosus is extremely rare with only one reported case in literature showing such association. Therefore, we report a case of severe opportunistic fungal infection caused by Histoplasma in a 13-year-old girl who was diagnosed with juvenile lupus erythematosus, subsequently developed septic shock and died of the disease despite of aggressive antifungal therapy.
    Keywords Disseminated histoplasmosis ; juvenile systemic lupus erythematosus ; rare ; Medicine ; R ; Dermatology ; RL1-803
    Language English
    Publishing date 2016-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Soft-tissue amyloidoma with associated plasmacytoma

    Bibhas Saha Dalal / Piyabi Sarkar / Namrata Maity / Sayed Mahmood Nadeem

    Indian Journal of Pathology and Microbiology, Vol 59, Iss 4, Pp 535-

    2016  Volume 537

    Abstract: Soft tissue amyloidoma with features similar to plasmacytoma, in absence of systemic amyloidosis, is an extremely rare finding. We hereby report the case of a 77 year old man who presented with a painless, nodular swelling on chest wall, diagnosed as ... ...

    Abstract Soft tissue amyloidoma with features similar to plasmacytoma, in absence of systemic amyloidosis, is an extremely rare finding. We hereby report the case of a 77 year old man who presented with a painless, nodular swelling on chest wall, diagnosed as soft tissue amyloidoma with plasma cell infiltration. Congo red staining was done to prove the presence of amyloid which showed characteristic "apple-green" birefringence on polarized microscopy. The plasma cells were monoclonal in origin as demonstrated by serum protein and immunofixation electrophoresis. To the best of our knowledge, this is the second such reported case. However close follow up is required, as this patient may develop multiple myeloma in future.
    Keywords Extramedullary plasmacytoma ; soft-tissue amyloidoma ; rare ; Pathology ; RB1-214 ; Medicine ; R ; Microbiology ; QR1-502 ; Science ; Q
    Language English
    Publishing date 2016-01-01T00:00:00Z
    Publisher Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Soft-tissue amyloidoma with associated plasmacytoma.

    Dalal, Bibhas Saha / Sarkar, Piyabi / Maity, Namrata / Nadeem, Sayed Mahmood

    Indian journal of pathology & microbiology

    2016  Volume 59, Issue 4, Page(s) 535–537

    Abstract: Soft tissue amyloidoma with features similar to plasmacytoma, in absence of systemic amyloidosis, is an extremely rare finding. We hereby report the case of a 77 year old man who presented with a painless, nodular swelling on chest wall, diagnosed as ... ...

    Abstract Soft tissue amyloidoma with features similar to plasmacytoma, in absence of systemic amyloidosis, is an extremely rare finding. We hereby report the case of a 77 year old man who presented with a painless, nodular swelling on chest wall, diagnosed as soft tissue amyloidoma with plasma cell infiltration. Congo red staining was done to prove the presence of amyloid which showed characteristic "apple-green" birefringence on polarized microscopy. The plasma cells were monoclonal in origin as demonstrated by serum protein and immunofixation electrophoresis. To the best of our knowledge, this is the second such reported case. However close follow up is required, as this patient may develop multiple myeloma in future.
    MeSH term(s) Aged ; Amyloidosis/complications ; Amyloidosis/diagnosis ; Amyloidosis/pathology ; Biomarkers, Tumor/analysis ; Blood Proteins/analysis ; Electrophoresis ; Histocytochemistry ; Humans ; Male ; Microscopy ; Plasmacytoma/complications ; Plasmacytoma/diagnosis ; Plasmacytoma/pathology ; Soft Tissue Neoplasms/complications ; Soft Tissue Neoplasms/diagnosis ; Soft Tissue Neoplasms/pathology ; Thorax/pathology
    Chemical Substances Biomarkers, Tumor ; Blood Proteins
    Language English
    Publishing date 2016-10
    Publishing country India
    Document type Case Reports
    ZDB-ID 197621-7
    ISSN 0974-5130 ; 0377-4929
    ISSN (online) 0974-5130
    ISSN 0377-4929
    DOI 10.4103/0377-4929.191821
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  9. Article: Correlations of aldehyde dehydrogenase-1 (ALDH1) expression with traditional prognostic parameters and different molecular subtypes of breast carcinoma.

    Sarkar, Piyabi / Basu, Keya / Sarkar, Pubali / Chatterjee, Uttara / Mukhopadhyay, Madhumita / Choudhuri, Manoj Kumar / Srakar, Diptendra Kumar

    Clujul medical (1957)

    2018  Volume 91, Issue 2, Page(s) 181–187

    Abstract: Background and aim: Breast cancer, a heterogeneous disease, is the most common cause of cancer-related death in women worldwide. Despite considerable developments in treatment modalities, a subset of patients with advanced-stage breast carcinoma display ...

    Abstract Background and aim: Breast cancer, a heterogeneous disease, is the most common cause of cancer-related death in women worldwide. Despite considerable developments in treatment modalities, a subset of patients with advanced-stage breast carcinoma display poor prognosis. Breast cancer heterogeneity and risk of recurrence could be explained with the help of cancer stem cell hypothesis. Stem cells have the capacity to self-renew and differentiate into multiple cell types. Aldehyde dehydrogenase-1 (ALDH1), an enzyme responsible for the oxidation of intracellular aldehydes, contributes to normal and tumor stem cell differentiation. Invasion and metastasis in breast cancer are found to be mediated by a subpopulation of tumor cells which exhibit stem cell-like features and express ALDH1.
    Study design: This was a cross-sectional observational study.
    Methods: A total of 62 patients with breast carcinoma undergoing mastectomy were included in this study. The tumors were classified into molecular subtypes by assessing immunohistochemical (IHC) expression of ER, PgR, HER2 and Ki-67 according to St. Gallen Consensus Conference 2013. ALDH1 expression was studied by IHC and correlated with clinicoathological parameters.
    Statistical analysis: Statistical analysis was done using Graph Pad software (Prism 5 version) for Windows 7. A p-value <0.05 was considered statistically significant.
    Results and analysis: Out of 62 tumors, 35 tumors (56.4%) showed ALDH1 positivity. ALDH1 expression was significantly associated with larger size, lymph node involvement, higher grade, higher stage and HER2+ or triple negative tumors.
    Conclusion: This study suggests that ALDH1 expression is associated with poor prognostic parameters and aggressive tumor behavior. Larger population-based prospective trials on Indian patients are required to validate these results.
    Language English
    Publishing date 2018-04-25
    Publishing country Romania
    Document type Journal Article
    ZDB-ID 419197-3
    ISSN 2066-8872 ; 1222-2119 ; 1224-550X
    ISSN (online) 2066-8872
    ISSN 1222-2119 ; 1224-550X
    DOI 10.15386/cjmed-925
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  10. Article ; Online: Evaluation of Long Term Effect of RV Apical Pacing on Global LV Function by Echocardiography

    Narayan Chandra Sarkar / Mahendra Tilkar / Siddhant Jain / Subrata Mondal / Piyabi Sarkar / Nitin Modi

    Journal of Clinical and Diagnostic Research, Vol 10, Iss 3, Pp OC03-OC

    2016  Volume 06

    Abstract: Introduction: We very often face pacemaker implanted patients during follow-up with shortness of breath and effort intolerance inspite of normal clinical parameters. Aim: The aim of our study is to evaluate the cause of effort intolerance and probable ... ...

    Abstract Introduction: We very often face pacemaker implanted patients during follow-up with shortness of breath and effort intolerance inspite of normal clinical parameters. Aim: The aim of our study is to evaluate the cause of effort intolerance and probable cause of sub-clinical Congestive Cardiac Failure (CCF) in a case of long term Right Ventricular (RV) apical pacing on global Left Ventricular (LV) function noninvasively by echocardiography. Materials and Methods: We studied 54 patients (Male 42, Female 12) of complete heart block (CHB) with RV apical pacing (40 VVI and 14 DCP). Mean duration of pacing was 58+4 months. All patients underwent 24 hours Holter monitoring to determine the percentage of ventricular pacing beats. 2-D Echocardiography was done to assess the regional wall motion of abnormality and global LV ejection fraction by modified Simpson’s rule. These methods were coupled with the Doppler derived Myocardial Performance Index (MPI), tissue Doppler imaging, and mechanical regional dyssynchrony with 3-D Echocardiography. Data were analysed from 54 RV- apical paced patients and compared with age and body surface area of 60 controlled subjects (Male 46, Female 14). Results: Evaluation of LV function in 54 patients demonstrated regional wall motion abnormality and Doppler study revealed both LV systolic and diastolic dysfunction compare with control subjects (regional wall motion abnormality 80±6% vs 30±3% with p-value<0.0001) which is proportional to the percentage of ventricular pacing beats (mean paced beat 78%). Global LVEF 50±4% vs 60±2% (p-valve <0.0001) and MPI 0.46 ±0.12 v/s 0.36±0.09 (p-value <0.0001). Conclusion: RV–apical pacing induces iatrogenic electrical dyssynchrony which leads to remodeling of LV and produces mechanical dyssynchrony which is responsible for LV dysfunction. Alternate site of RV pacing and/or biventricular pacing should be done to maintain biventricular electrical synchrony which will preserve the LV function.
    Keywords holter monitoring ; lvef ; wall motion abnormality ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2016-03-01T00:00:00Z
    Publisher JCDR Research and Publications Private Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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