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  1. Article: Dynamic role of personality in explaining COVID-19 vaccine hesitancy and refusal.

    Baker, Melissa N / Merkley, Eric

    Frontiers in psychology

    2023  Volume 14, Page(s) 1163570

    Abstract: Vaccine hesitancy and refusal are threats to sufficient response to the COVID-19 pandemic and public health efforts more broadly. We focus on personal characteristics, specifically personality, to explain what types of people are resistant to COVID-19 ... ...

    Abstract Vaccine hesitancy and refusal are threats to sufficient response to the COVID-19 pandemic and public health efforts more broadly. We focus on personal characteristics, specifically personality, to explain what types of people are resistant to COVID-19 vaccination and how the influence of these traits changed as circumstances surrounding the COVID-19 pandemic evolved. We use a large survey of over 40,000 Canadians between November 2020 and July 2021 to examine the relationship between personality and vaccine hesitancy and refusal. We find that all five facets of the Big-5 (openness to experience, conscientiousness, extraversion, agreeableness, and negative emotionality) are associated with COVID-19 vaccine refusal. Three facets (agreeableness, conscientiousness, and openness) tended to decline in importance as the vaccination rate and COVID-19 cases grew. Two facets (extraversion and negative emotionality) maintained or increased in their importance as pandemic circumstances changed. This study highlights the influence of personal characteristics on vaccine hesitancy and refusal and the need for additional study on foundational explanations of these behaviors. It calls for additional research on the dynamics of personal characteristics in explaining vaccine hesitancy and refusal. The influence of personality may not be immutable.
    Language English
    Publishing date 2023-06-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2023.1163570
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The correlates and dynamics of COVID-19 vaccine-specific hesitancy.

    Merkley, Eric / Loewen, Peter John

    Vaccine

    2022  Volume 40, Issue 13, Page(s) 2020–2027

    Abstract: Most work on COVID-19 vaccine hesitancy has focused on its attitudinal and demographic correlates among individuals, but the characteristics of vaccines themselves also appear to be important. People are more willing to take vaccines with higher reported ...

    Abstract Most work on COVID-19 vaccine hesitancy has focused on its attitudinal and demographic correlates among individuals, but the characteristics of vaccines themselves also appear to be important. People are more willing to take vaccines with higher reported levels of efficacy and safety. Has this dynamic sparked comparative hesitancy towards specific COVID-19 vaccines? We conduct a series of cross-sectional survey experiments to test for brand-based differences in perceived effectiveness, perceived safety, and vaccination intention. Examining more than 6,200 individuals in a series of cross-sectional surveys, we find considerably more reluctance to take the AstraZeneca and Johnson & Johnson vaccines compared to those from Pfizer and Moderna if offered, despite all vaccines being approved and deemed safe and effective by a federal regulator. Comparative hesitancy towards these vaccines grew over the course of fielding as controversy arose over their link to extremely rare, but serious side effects. Comparative vaccine-specific hesitancy is strongest among people who are usually most open to mass vaccination efforts. Its effects are substantial: most respondents reported a willingness to wait months for their preferred vaccine rather than receive either the AstraZeneca or Johnson & Johnson vaccine immediately. Our findings call for additional research on the determinants and consequences of COVID-19 vaccine-specific hesitancy and communication strategies to minimize this challenge.
    MeSH term(s) COVID-19/prevention & control ; COVID-19 Vaccines ; Cross-Sectional Studies ; Humans ; Vaccination ; Vaccines
    Chemical Substances COVID-19 Vaccines ; Vaccines
    Language English
    Publishing date 2022-02-17
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2022.02.033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: The correlates and dynamics of COVID-19 vaccine-specific hesitancy

    Merkley, Eric / Loewen, Peter John

    Vaccine. 2022 Mar. 18, v. 40, no. 13

    2022  

    Abstract: Most work on COVID-19 vaccine hesitancy has focused on its attitudinal and demographic correlates among individuals, but the characteristics of vaccines themselves also appear to be important. People are more willing to take vaccines with higher reported ...

    Abstract Most work on COVID-19 vaccine hesitancy has focused on its attitudinal and demographic correlates among individuals, but the characteristics of vaccines themselves also appear to be important. People are more willing to take vaccines with higher reported levels of efficacy and safety. Has this dynamic sparked comparative hesitancy towards specific COVID-19 vaccines? We conduct a series of cross-sectional survey experiments to test for brand-based differences in perceived effectiveness, perceived safety, and vaccination intention. Examining more than 6,200 individuals in a series of cross-sectional surveys, we find considerably more reluctance to take the AstraZeneca and Johnson & Johnson vaccines compared to those from Pfizer and Moderna if offered, despite all vaccines being approved and deemed safe and effective by a federal regulator. Comparative hesitancy towards these vaccines grew over the course of fielding as controversy arose over their link to extremely rare, but serious side effects. Comparative vaccine-specific hesitancy is strongest among people who are usually most open to mass vaccination efforts. Its effects are substantial: most respondents reported a willingness to wait months for their preferred vaccine rather than receive either the AstraZeneca or Johnson & Johnson vaccine immediately. Our findings call for additional research on the determinants and consequences of COVID-19 vaccine-specific hesitancy and communication strategies to minimize this challenge.
    Keywords COVID-19 infection ; cross-sectional studies ; people ; vaccination ; vaccines
    Language English
    Dates of publication 2022-0318
    Size p. 2020-2027.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2022.02.033
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Anti-intellectualism and the mass public's response to the COVID-19 pandemic.

    Merkley, Eric / Loewen, Peter John

    Nature human behaviour

    2021  Volume 5, Issue 6, Page(s) 706–715

    Abstract: Anti-intellectualism (the generalized distrust of experts and intellectuals) is an important concept in explaining the public's engagement with advice from scientists and experts. We ask whether it has shaped the mass public's response to coronavirus ... ...

    Abstract Anti-intellectualism (the generalized distrust of experts and intellectuals) is an important concept in explaining the public's engagement with advice from scientists and experts. We ask whether it has shaped the mass public's response to coronavirus disease 2019 (COVID-19). We provide evidence of a consistent connection between anti-intellectualism and COVID-19 risk perceptions, social distancing, mask usage, misperceptions and information acquisition using a representative survey of 27,615 Canadians conducted from March to July 2020. We exploit a panel component of our design (N = 4,910) to strongly link anti-intellectualism and within-respondent change in mask usage. Finally, we provide experimental evidence of anti-intellectualism's importance in information search behaviour with two conjoint studies (N ~ 2,500) that show that preferences for COVID-19 news and COVID-19 information from experts dissipate among respondents with higher levels of anti-intellectual sentiment. Anti-intellectualism poses a fundamental challenge in maintaining and increasing public compliance with expert-guided COVID-19 health directives.
    MeSH term(s) COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19/psychology ; Canada/epidemiology ; Communicable Disease Control/methods ; Communicable Disease Control/organization & administration ; Health Communication/methods ; Health Communication/standards ; Health Knowledge, Attitudes, Practice ; Humans ; Information Seeking Behavior/ethics ; Masks/statistics & numerical data ; Mass Behavior ; Public Health/methods ; Public Opinion ; SARS-CoV-2 ; Social Media/ethics ; Social Participation ; Social Perception/ethics ; Social Perception/psychology ; Trust
    Language English
    Publishing date 2021-04-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2397-3374
    ISSN (online) 2397-3374
    DOI 10.1038/s41562-021-01112-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Assessment of Communication Strategies for Mitigating COVID-19 Vaccine-Specific Hesitancy in Canada.

    Merkley, Eric / Loewen, Peter John

    JAMA network open

    2021  Volume 4, Issue 9, Page(s) e2126635

    Abstract: Importance: Ensuring widespread uptake of available COVID-19 vaccinations, each with different safety and efficacy profiles, is essential to combating the unfolding pandemic.: Objective: To test communication interventions that may encourage the ... ...

    Abstract Importance: Ensuring widespread uptake of available COVID-19 vaccinations, each with different safety and efficacy profiles, is essential to combating the unfolding pandemic.
    Objective: To test communication interventions that may encourage the uptake of less-preferred vaccines.
    Design, setting, and participants: This online survey was conducted from March 24 to 30, 2021, using a nonprobability convenience sample of Canadian citizens aged 18 years or older, with quota sampling to match 2016 Canadian Census benchmarks on age, gender, region, and language. Respondents completed a 2-by-2-by-2 factorial experiment with random assignment of brand (AstraZeneca or Johnson & Johnson), information about the vaccine's effectiveness against symptomatic infection (yes or no), and information about the vaccine's effectiveness at preventing death from COVID-19 (yes or no) before being asked about their willingness to receive their assigned vaccine and their beliefs about its effectiveness.
    Exposures: Respondents were randomly assigned a vaccine brand (AstraZeneca or Johnson & Johnson) and information about the vaccine's effectiveness against symptomatic COVID-19 infection (yes or no) and at preventing death from COVID-19 (yes or no).
    Main outcomes and measures: Respondents' self-reported likelihood of taking their assigned vaccine if offered (response categories: very likely, somewhat likely, not very likely, or not at all likely, scaled 0-1) and their beliefs about their assigned vaccine's effectiveness (response categories: very effective, somewhat effective, not very effective, or not at all effective, scaled 0-1) were measured.
    Results: A total of 2556 Canadian adults responded to the survey (median [IQR] age, 50 [34-63] years; 1339 women [52%]). The self-reported likelihood of taking an assigned AstraZeneca or Johnson & Johnson vaccine was higher for respondents given information about their assigned vaccine's effectiveness at preventing death from COVID-19 (b, 0.04; 95% CI, 0.01 to 0.06) and lower among those given information about its overall effectiveness at preventing symptomatic transmission (b, -0.03; 95% CI, -0.05 to 0.00), compared with those who were not given the information. Perceived effectiveness was also higher among those given information about their assigned vaccine's effectiveness at preventing death from COVID-19 (b, 0.03; 95% CI, 0.01 to 0.05) and lower among those given information about their assigned vaccine's overall efficacy at preventing symptomatic infection (b, -0.05; 95% CI, -0.08 to -0.03), compared with those who were not given this information. The interaction between these treatments was neither substantively nor statistically significant.
    Conclusions and relevance: These findings suggest that providing information on the effectiveness of less-preferred vaccines at preventing death from COVID-19 is associated with more confidence in their effectiveness and less vaccine-specific hesitancy. These results can inform public health communication strategies to reduce hesitancy toward specific COVID-19 vaccines.
    MeSH term(s) Adult ; COVID-19/prevention & control ; COVID-19/psychology ; COVID-19 Vaccines/therapeutic use ; Canada ; Female ; Health Education/methods ; Humans ; Middle Aged ; Patient Acceptance of Health Care/psychology ; Patient Acceptance of Health Care/statistics & numerical data ; Persuasive Communication ; Self Report ; Treatment Refusal/psychology ; Treatment Refusal/statistics & numerical data ; Vaccination/psychology ; Vaccination/statistics & numerical data
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2021-09-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2021.26635
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Flying blind, or just flying under the radar? The underappreciated power of de novo methods of mass spectrometric peptide identification.

    O'Bryon, Isabelle / Jenson, Sarah C / Merkley, Eric D

    Protein science : a publication of the Protein Society

    2020  Volume 29, Issue 9, Page(s) 1864–1878

    Abstract: Mass spectrometry-based proteomics is a popular and powerful method for precise and highly multiplexed protein identification. The most common method of analyzing untargeted proteomics data is called database searching, where the database is simply a ... ...

    Abstract Mass spectrometry-based proteomics is a popular and powerful method for precise and highly multiplexed protein identification. The most common method of analyzing untargeted proteomics data is called database searching, where the database is simply a collection of protein sequences from the target organism, derived from genome sequencing. Experimental peptide tandem mass spectra are compared to simplified models of theoretical spectra calculated from the translated genomic sequences. However, in several interesting application areas, such as forensics, archaeology, venomics, and others, a genome sequence may not be available, or the correct genome sequence to use is not known. In these cases, de novo peptide identification can play an important role. De novo methods infer peptide sequence directly from the tandem mass spectrum without reference to a sequence database, usually using graph-based or machine learning algorithms. In this review, we provide a basic overview of de novo peptide identification methods and applications, briefly covering de novo algorithms and tools, and focusing in more depth on recent applications from venomics, metaproteomics, forensics, and characterization of antibody drugs.
    MeSH term(s) Databases, Protein ; Peptides/analysis ; Tandem Mass Spectrometry
    Chemical Substances Peptides
    Language English
    Publishing date 2020-08-17
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 1106283-6
    ISSN 1469-896X ; 0961-8368
    ISSN (online) 1469-896X
    ISSN 0961-8368
    DOI 10.1002/pro.3919
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book ; Online: All in this together

    Bridgman, Aengus / Merkley, Eric

    deservingness of government aid during the COVID-19 pandemic

    2020  

    Abstract: The COVID-19 pandemic has placed unprecedented pressure on governments to engage in widespread cash transfers directly to citizens to help mitigate economic losses. These programs are major redistribution efforts aimed at a variety of sub-groups within ... ...

    Abstract The COVID-19 pandemic has placed unprecedented pressure on governments to engage in widespread cash transfers directly to citizens to help mitigate economic losses. These programs are major redistribution efforts aimed at a variety of sub-groups within society (the unemployed, those with children, those with pre-existing health conditions, etc.) and there has been remarkably little resistance to these government outlays. We employ a novel and pre-registered paired vignette experiment to assess support for government aid during the pandemic in a large, nationally representative sample. We evaluate whether the “normal” deservingness hierarchy and considerations of social affinity or material self-interest continue to drive preferences of Canadians regarding redistribution. We find only small deservingness considerations and little evidence that redistribution preferences are informed by similarity considerations. Instead, we find broad, generous, and non-discriminatory support for direct cash transfers during this period of crisis.
    Keywords covid19
    Publisher Center for Open Science
    Publishing country us
    Document type Book ; Online
    DOI 10.31219/osf.io/eyvhj
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Book ; Online: A Matter of Trust

    Merkley, Eric / Loewen, Peter John

    Anti-intellectualism and Public Reaction to the COVID-19 Pandemic

    2020  

    Abstract: Successful societal response to the COVID-19 pandemic requires widespread and sustained public compliance with expert-guided health directives. Understanding which citizens seek out and accept this information is thus vitally important. Anti- ... ...

    Abstract Successful societal response to the COVID-19 pandemic requires widespread and sustained public compliance with expert-guided health directives. Understanding which citizens seek out and accept this information is thus vitally important. Anti-intellectualism – the generalized distrust of experts and intellectuals – is likely to be central. We provide evidence of a consistent connection between anti-intellectualism and risk perceptions, social distancing, mask usage, misperceptions, and information search behaviour using a representative survey of 27,615 Canadians conducted from March to July 2020. We exploit a panel-component of our design (N=4,910) to mitigate the threat of endogeneity and strongly link anti-intellectualism and within-respondent change in mask usage. Finally, we provide experimental evidence of anti-intellectualism’s importance in information search behaviour with two pre-registered conjoint studies (N~2,500) that show respondents ’ preferences for 1) COVID-19 news and 2) COVID-19 information from experts both dissipate among those with higher levels of anti-intellectual sentiment.
    Keywords covid19
    Publisher Center for Open Science
    Publishing country us
    Document type Book ; Online
    DOI 10.31219/osf.io/agm57
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Framing Climate Change

    Dominik A. Stecula / Eric Merkley

    Frontiers in Communication, Vol

    Economics, Ideology, and Uncertainty in American News Media Content From 1988 to 2014

    2019  Volume 4

    Abstract: The news media play an influential role in shaping public attitudes on a wide range of issues—climate change included. As climate change has risen in salience, the average American is much more likely to be exposed to news coverage now than in the past. ... ...

    Abstract The news media play an influential role in shaping public attitudes on a wide range of issues—climate change included. As climate change has risen in salience, the average American is much more likely to be exposed to news coverage now than in the past. Yet, we don't have a clear understanding of how the content of this news coverage has changed over time, despite likely playing an important part in fostering or inhibiting public support and engagement in climate action. In this paper we use a combination of automated and manual content analysis of the most influential media sources in the U.S. -the New York Times, Wall Street Journal, the Washington Post, and the Associated Press- to illustrate the prevalence of different frames in the news coverage of climate change and their dynamics over time from the start of the climate change debate in 1988. Specifically, we focus on three types of frames, based on previous research: economic costs and benefits associated with climate mitigation, appeals to conservative and free market values and principles, and uncertainties and risk surrounding climate change. We find that many of the frames found to reduce people's propensity to support and engage in climate action have been on the decline in the mainstream media, such as frames emphasizing potential economic harms of climate mitigation policy or uncertainty. At the same time, frames conducive to such engagement by the general public have been on the rise, such as those highlighting economic benefits of climate action. News content is also more likely now than in the past to use language emphasizing risk and danger, and to use the present tense. To the extent that media framing plays an important role in fostering climate action in the public, these are welcome developments.
    Keywords climate change ; framing ; global warming ; science communication ; news media ; Communication. Mass media ; P87-96
    Subject code 070
    Language English
    Publishing date 2019-02-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Editorial

    Andrea De Angelis / Christina E. Farhart / Eric Merkley / Dominik A. Stecula

    Frontiers in Political Science, Vol

    Political Misinformation in the Digital Age During a Pandemic: Partisanship, Propaganda, and Democratic Decision-Making

    2022  Volume 4

    Keywords political misinformation ; COVID-19 ; conspiracy theories ; infodemic ; public opinion ; digital technologies (DTs) ; Political science ; J
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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