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  1. Article ; Online: The Standardized Mortality Ratio and ICU Benchmarking: An Old Measure That Is Still Missing the Mark.

    Suffredini, Dante A

    Critical care medicine

    2024  Volume 52, Issue 3, Page(s) 498–501

    MeSH term(s) Benchmarking ; Intensive Care Units
    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000006109
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    Zs.A 1261: Show issues Location:
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  2. Article ; Online: The Long Road to Normalcy Following Survival From COVID-19-Associated Acute Respiratory Distress Syndrome.

    Suffredini, Dante A

    Critical care medicine

    2021  Volume 49, Issue 11, Page(s) 1996–1999

    MeSH term(s) COVID-19 ; Humans ; Respiration, Artificial ; Respiratory Distress Syndrome ; SARS-CoV-2
    Language English
    Publishing date 2021-03-08
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000005150
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A Rationale for Use of High Flow Nasal Cannula for Select Patients With Suspected or Confirmed Severe Acute Respiratory Syndrome Coronavirus-2 Infection.

    Suffredini, Dante A / Allison, Michael G

    Journal of intensive care medicine

    2020  Volume 36, Issue 1, Page(s) 9–17

    Abstract: Infection with the novel 2019 coronavirus (SARS-CoV-2) is associated with the development of a viral pneumonia with severe hypoxemia and respiratory failure. In many cases these patients will require mechanical ventilation; but in others the severity of ... ...

    Abstract Infection with the novel 2019 coronavirus (SARS-CoV-2) is associated with the development of a viral pneumonia with severe hypoxemia and respiratory failure. In many cases these patients will require mechanical ventilation; but in others the severity of disease is significantly less and may not need invasive support. High flow nasal cannula (HFNC) is a widely used modality of delivering high concentrations of oxygen and airflow to patients with hypoxemic respiratory failure, but its use in patients with SARS-CoV-2 is poorly described. Concerns with use of HFNC have arisen including aerosolization of viral particles to healthcare workers (HCW) to delaying intubation and potentially worsening of outcomes. However, use of HFNC in other coronavirus pandemics and previous experimental evidence suggest HFNC is low risk and may be effective in select patients infected with SARS-CoV-2. With the significant increase in resource utilization in care of patients with SARS-CoV-2, identification of those that may benefit from HFNC allowing allocation of ventilators to those more critically ill is of significant importance. In this manuscript, we review pertinent literature regarding the use of HFNC in the current SARS-CoV-2 pandemic and address many concerns regarding its use.
    MeSH term(s) COVID-19/complications ; COVID-19/therapy ; Humans ; Noninvasive Ventilation/methods ; Oxygen Inhalation Therapy/methods ; Patient Selection ; Respiratory Insufficiency/etiology ; Respiratory Insufficiency/therapy
    Keywords covid19
    Language English
    Publishing date 2020-09-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 632828-3
    ISSN 1525-1489 ; 0885-0666
    ISSN (online) 1525-1489
    ISSN 0885-0666
    DOI 10.1177/0885066620956630
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: A Rationale for Use of High Flow Nasal Cannula for Select Patients With Suspected or Confirmed Severe Acute Respiratory Syndrome Coronavirus-2 Infection

    Suffredini, Dante A / Allison, Michael G

    J Intensive Care Med

    Abstract: Infection with the novel 2019 coronavirus (SARS-CoV-2) is associated with the development of a viral pneumonia with severe hypoxemia and respiratory failure. In many cases these patients will require mechanical ventilation; but in others the severity of ... ...

    Abstract Infection with the novel 2019 coronavirus (SARS-CoV-2) is associated with the development of a viral pneumonia with severe hypoxemia and respiratory failure. In many cases these patients will require mechanical ventilation; but in others the severity of disease is significantly less and may not need invasive support. High flow nasal cannula (HFNC) is a widely used modality of delivering high concentrations of oxygen and airflow to patients with hypoxemic respiratory failure, but its use in patients with SARS-CoV-2 is poorly described. Concerns with use of HFNC have arisen including aerosolization of viral particles to healthcare workers (HCW) to delaying intubation and potentially worsening of outcomes. However, use of HFNC in other coronavirus pandemics and previous experimental evidence suggest HFNC is low risk and may be effective in select patients infected with SARS-CoV-2. With the significant increase in resource utilization in care of patients with SARS-CoV-2, identification of those that may benefit from HFNC allowing allocation of ventilators to those more critically ill is of significant importance. In this manuscript, we review pertinent literature regarding the use of HFNC in the current SARS-CoV-2 pandemic and address many concerns regarding its use.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32912049
    Database COVID19

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  5. Article ; Online: A Rationale for Use of High Flow Nasal Cannula for Select Patients With Suspected or Confirmed Severe Acute Respiratory Syndrome Coronavirus-2 Infection

    Suffredini, Dante A. / Allison, Michael G.

    Journal of Intensive Care Medicine

    2020  , Page(s) 88506662095663

    Abstract: Infection with the novel 2019 coronavirus (SARS-CoV-2) is associated with the development of a viral pneumonia with severe hypoxemia and respiratory failure. In many cases these patients will require mechanical ventilation; but in others the severity of ... ...

    Abstract Infection with the novel 2019 coronavirus (SARS-CoV-2) is associated with the development of a viral pneumonia with severe hypoxemia and respiratory failure. In many cases these patients will require mechanical ventilation; but in others the severity of disease is significantly less and may not need invasive support. High flow nasal cannula (HFNC) is a widely used modality of delivering high concentrations of oxygen and airflow to patients with hypoxemic respiratory failure, but its use in patients with SARS-CoV-2 is poorly described. Concerns with use of HFNC have arisen including aerosolization of viral particles to healthcare workers (HCW) to delaying intubation and potentially worsening of outcomes. However, use of HFNC in other coronavirus pandemics and previous experimental evidence suggest HFNC is low risk and may be effective in select patients infected with SARS-CoV-2. With the significant increase in resource utilization in care of patients with SARS-CoV-2, identification of those that may benefit from HFNC allowing allocation of ventilators to those more critically ill is of significant importance. In this manuscript, we review pertinent literature regarding the use of HFNC in the current SARS-CoV-2 pandemic and address many concerns regarding its use.
    Keywords Critical Care and Intensive Care Medicine ; covid19
    Language English
    Publisher SAGE Publications
    Publishing country us
    Document type Article ; Online
    ZDB-ID 632828-3
    ISSN 1525-1489 ; 0885-0666
    ISSN (online) 1525-1489
    ISSN 0885-0666
    DOI 10.1177/0885066620956630
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2158: Show issues Location:
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  6. Article ; Online: Management of Antiretrovirals in Critically Ill Patients: Great Progress But Potential Pitfalls.

    Suffredini, Dante A / George, Jomy M / Masur, Henry

    Critical care medicine

    2017  Volume 46, Issue 5, Page(s) 663–665

    MeSH term(s) Anti-HIV Agents/administration & dosage ; Anti-HIV Agents/adverse effects ; Anti-HIV Agents/therapeutic use ; Critical Illness/therapy ; Drug Interactions ; Drug Resistance, Viral ; HIV Infections/complications ; HIV Infections/drug therapy ; Humans
    Chemical Substances Anti-HIV Agents
    Language English
    Publishing date 2017-09-01
    Publishing country United States
    Document type Letter
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000003048
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1261: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: At the twisted heart of nicotine addiction.

    Suffredini, Dante A / Reed, Robert Michael

    BMJ case reports

    2012  Volume 2012

    Abstract: This case report reviews the ECG manifestations of chronic obstructive pulmonary disease (COPD). Distinct changes of the P-wave axis, QRS axis and morphology are a direct result of the pathophysiological and anatomical changes associated with COPD. These ...

    Abstract This case report reviews the ECG manifestations of chronic obstructive pulmonary disease (COPD). Distinct changes of the P-wave axis, QRS axis and morphology are a direct result of the pathophysiological and anatomical changes associated with COPD. These changes are illustrated in a patient with a history of COPD presenting with hypoxaemia and symptoms of shortness of breath.
    MeSH term(s) Diagnosis, Differential ; Electrocardiography ; Heart Diseases/diagnosis ; Heart Diseases/etiology ; Humans ; Male ; Middle Aged ; Pulmonary Disease, Chronic Obstructive/complications ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Tobacco Use Disorder/complications ; Tobacco Use Disorder/diagnosis ; Tomography, X-Ray Computed
    Language English
    Publishing date 2012-06-08
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2012-006240
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The Potential Pathogenic Contributions of Endothelial Barrier and Arterial Contractile Dysfunction to Shock Due to B. anthracis Lethal and Edema Toxins.

    Suffredini, Dante A / Cui, Xizhong / Xu, Wanying / Li, Yan / Eichacker, Peter Q

    Toxins

    2017  Volume 9, Issue 12

    Abstract: ... Shock ... ...

    Abstract Shock with
    MeSH term(s) Anthrax/complications ; Anthrax/physiopathology ; Antigens, Bacterial/toxicity ; Arteries/drug effects ; Arteries/physiopathology ; Bacillus anthracis ; Bacterial Toxins/toxicity ; Endothelium, Vascular/drug effects ; Endothelium, Vascular/physiopathology ; Humans ; Muscle Contraction/drug effects ; Muscle, Smooth, Vascular/drug effects ; Muscle, Smooth, Vascular/physiopathology ; Shock/etiology ; Shock/physiopathology
    Chemical Substances Antigens, Bacterial ; Bacterial Toxins ; anthrax toxin
    Language English
    Publishing date 2017-12-06
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, N.I.H., Intramural
    ZDB-ID 2518395-3
    ISSN 2072-6651 ; 2072-6651
    ISSN (online) 2072-6651
    ISSN 2072-6651
    DOI 10.3390/toxins9120394
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  9. Article: Impact of Adjuvant Use of Midodrine to Intravenous Vasopressors: A Systematic Review and Meta-Analysis.

    Al-Abdouh, Ahmad / Haddadin, Sadam / Matta, Atul / Jabri, Ahmad / Barbarawi, Mahmoud / Abusnina, Waiel / Radideh, Qais / Mhanna, Mohammed / Suffredini, Dante A / Michos, Erin D

    Critical care research and practice

    2021  Volume 2021, Page(s) 5588483

    Abstract: Purpose: To evaluate the efficacy and safety of midodrine use in intensive care units (ICU) to facilitate weaning off intravenous vasopressors (IVV).: Methods: We searched PubMed/MEDLINE, Cochrane library, and Google Scholar (inception through ... ...

    Abstract Purpose: To evaluate the efficacy and safety of midodrine use in intensive care units (ICU) to facilitate weaning off intravenous vasopressors (IVV).
    Methods: We searched PubMed/MEDLINE, Cochrane library, and Google Scholar (inception through October 18
    Results: A total of 6 studies were found that met inclusion criteria and had sufficient data for our quantitative analysis (1 randomized controlled trial and 5 retrospective studies). A total of 2,857 patients were included: 600 in the midodrine group and 2,257 patients in the control group. Midodrine use was not associated with a significant difference in ICU LOS (SMD 0.16 days; 95% CI -0.23 to 0.55), hospital LOS (SMD 0.03 days; 95% CI -0.33 to 0.0.39), mortality (RR 0.87; 95% CI 0.52 to 1.46), IVV reinstitution (RR 0.47; 95% CI 0.17 to 1.3), or ICU readmission (RR 1.03; 95% CI 0.71 to 1.49) when compared to using only IVV. However, there were higher trends of bradycardia with midodrine use that did not reach significance (RR 7.64; 95% CI 0.23 to 256.42).
    Conclusion: This meta-analysis suggests that midodrine was not associated with a significant decrease in ICU LOS, hospital LOS, mortality, or ICU readmissions.
    Language English
    Publishing date 2021-05-15
    Publishing country Egypt
    Document type Journal Article ; Review
    ZDB-ID 2573849-5
    ISSN 2090-1313 ; 2090-1305
    ISSN (online) 2090-1313
    ISSN 2090-1305
    DOI 10.1155/2021/5588483
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The Potential Pathogenic Contributions of Endothelial Barrier and Arterial Contractile Dysfunction to Shock Due to B. anthracis Lethal and Edema Toxins

    Dante A. Suffredini / Xizhong Cui / Wanying Xu / Yan Li / Peter Q. Eichacker

    Toxins, Vol 9, Iss 12, p

    2017  Volume 394

    Abstract: Shock with B. anthracis infection is particularly resistant to conventional cardiovascular support and its mortality rate appears higher than with more common bacterial pathogens. As opposed to many bacteria that lack exotoxins directly depressing ... ...

    Abstract Shock with B. anthracis infection is particularly resistant to conventional cardiovascular support and its mortality rate appears higher than with more common bacterial pathogens. As opposed to many bacteria that lack exotoxins directly depressing hemodynamic function, lethal and edema toxin (LT and ET respectively) both cause shock and likely contribute to the high lethality rate with B. anthracis. Selective inhibition of the toxins is protective in infection models, and administration of either toxin alone in animals produces hypotension with accompanying organ injury and lethality. Shock during infection is typically due to one of two mechanisms: (i) intravascular volume depletion related to disruption of endothelial barrier function; and (ii) extravasation of fluid and/or maladaptive dilation of peripheral resistance arteries. Although some data suggests that LT can produce myocardial dysfunction, growing evidence demonstrates that it may also interfere with endothelial integrity thereby contributing to the extravasation of fluid that helps characterize severe B. anthracis infection. Edema toxin, on the other hand, while known to produce localized tissue edema when injected subcutaneously, has potent vascular relaxant effects that could lead to pathologic arterial dilation. This review will examine recent data supporting a role for these two pathophysiologic mechanisms underlying the shock LT and ET produce. Further research and a better understanding of these mechanisms may lead to improved management of B. anthracis in patients.
    Keywords B. anthracis ; shock ; endothelial permeability ; arterial contractile dysfunction ; Medicine ; R
    Subject code 616
    Language English
    Publishing date 2017-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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