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  1. Article ; Online: The relationship between microRNAs and Rab family GTPases in human cancers.

    Shahabi, Arman / Naghili, Behrooz / Ansarin, Khalil / Zarghami, Nosratollah

    Journal of cellular physiology

    2019  Volume 234, Issue 8, Page(s) 12341–12352

    Abstract: microRNAs (miRNAs), as a group of noncoding RNAs, posttranscriptionally control gene expression by binding to 3'-untranslated region (3'-UTR). Ras-associated binding (Rab) proteins function as molecular switches for regulating vesicular transport, which ... ...

    Abstract microRNAs (miRNAs), as a group of noncoding RNAs, posttranscriptionally control gene expression by binding to 3'-untranslated region (3'-UTR). Ras-associated binding (Rab) proteins function as molecular switches for regulating vesicular transport, which mainly have oncogenic roles in cancer development and preventing the efficacy of chemotherapies. Increased evidence supported that miRNAs/Rabs interaction have been determined as potential therapeutics for cancer therapy. Nevertheless, instability and cross-targeting of miRNAs are main limitations of using miRNA-based therapeutic. The mutual interplay between Rabs and miRNAs has been poorly understood. In the present review, we focused on the essence and activity of these molecules in cancer pathogenesis. Also, numerous hindrances and potential methods in the expansion of miRNA as an anticancer therapeutics are mentioned.
    MeSH term(s) 3' Untranslated Regions/genetics ; Gene Expression Regulation, Neoplastic/genetics ; Humans ; MicroRNAs/genetics ; Neoplasms/genetics ; Neoplasms/pathology ; Neoplasms/therapy ; Vesicular Transport Proteins/metabolism ; rab GTP-Binding Proteins/metabolism
    Chemical Substances 3' Untranslated Regions ; MicroRNAs ; Vesicular Transport Proteins ; rab GTP-Binding Proteins (EC 3.6.5.2)
    Language English
    Publishing date 2019-01-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 3116-1
    ISSN 1097-4652 ; 0021-9541
    ISSN (online) 1097-4652
    ISSN 0021-9541
    DOI 10.1002/jcp.28038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: miR-140 and miR-196a as Potential Biomarkers in Breast Cancer Patients.

    Shahabi, Arman / Naghili, Behrooz / Ansarin, Khalil / Montazeri, Vahid / Zarghami, Nosratollah

    Asian Pacific journal of cancer prevention : APJCP

    2020  Volume 21, Issue 7, Page(s) 1913–1918

    Abstract: Objective: MiR-140 and miR-196a were known to be correlated with cancer diagnosis and prognosis. The current study aimed at the analysis of miR-140 and miR-196a expression patterns and their clinical significance for breast cancer (BC) patients.: ... ...

    Abstract Objective: MiR-140 and miR-196a were known to be correlated with cancer diagnosis and prognosis. The current study aimed at the analysis of miR-140 and miR-196a expression patterns and their clinical significance for breast cancer (BC) patients.
    Methods: Differentially expressed miR-140 and miR-196a were examined via quantitative PCR in 110 cases of BC and their adjacent non-tumor (ANT) tissues.
    Results: The results indicated that miR-140 and miR-196a, respectively, notably decreased and increased expression in BC samples in comparison with ANT (p<0.001). Reduced miR-140 expression was also related to Lymph node metastasis (LNM, P= 0.023) and stage (P = 0.009). Additionally, Receiver Operating Characteristics (ROC) analysis illustrated that miR-140 had a significant diagnostic accuracy for stage and LNM of BC patients. We also discovered a strong negative correlation between miR-196a expression with histological grade (P = 0.038), LNM (P = 0.012) and stage (P = 0.001).
    Conclusion: Overall, exploring the miR-140 and miR-196a profiles not only can statistically different among BC and ANT samples, but it is also expected to become potential BC biomarkers.
    .
    MeSH term(s) Adult ; Aged ; Biomarkers, Tumor/genetics ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Case-Control Studies ; Female ; Follow-Up Studies ; Gene Expression Regulation, Neoplastic ; Humans ; MicroRNAs/genetics ; Middle Aged ; Prognosis ; Survival Rate
    Chemical Substances Biomarkers, Tumor ; MIRN196 microRNA, human ; MicroRNAs ; Mirn140 microRNA, human
    Language English
    Publishing date 2020-07-01
    Publishing country Thailand
    Document type Journal Article
    ZDB-ID 2218955-5
    ISSN 2476-762X ; 1513-7368
    ISSN (online) 2476-762X
    ISSN 1513-7368
    DOI 10.31557/APJCP.2020.21.7.1913
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Let-7d and miR-185 Impede Epithelial-Mesenchymal Transition by Downregulating Rab25 in Breast Cancer.

    Shahabi, Arman / Naghili, Behrooz / Ansarin, Khalil / Montazeri, Maryam / Dadashpour, Mehdi / Zarghami, Nosratollah

    Asian Pacific journal of cancer prevention : APJCP

    2021  Volume 22, Issue 1, Page(s) 305–313

    Abstract: Objective: MicroRNAs (miRNAs) expression has deregulated in several cancer types including breast cancer (BC). The present study aims at investigating the role, mechanism, clinical value of let-7d and miR-185 in BC, and the possible correlation these ... ...

    Abstract Objective: MicroRNAs (miRNAs) expression has deregulated in several cancer types including breast cancer (BC). The present study aims at investigating the role, mechanism, clinical value of let-7d and miR-185 in BC, and the possible correlation these miRNAs with Rab25.
    Materials and methods: Tumor samples as well adjacent normal tissues (ANT) were acquired from fresh surgical specimens from 110 patients and the expression levels of let-7d, miR-185, Rab25, and snail were evaluated using real-time PCR. The immunohistochemical (IHC) process and western blot were done to detect the level of Rab25 and Snail protein expression in BC samples.
    Results: By comparing miRNAs expression profiles in clinical tissues of 110 patients using real-time PCR, let-7d, and miR-185 expression were dramatically downregulated in BC tissues (P < 0.05). Tumor size, stage, and lymph node metastasis were significantly related to miRNAs expression. Based on qRT-PCR and bioinformatics database analyses, we also recognized Rab25 as a possible target of miR-185 and let-7d. Rab25 expression was enhanced in BC cells and associated inversely with the expression level of mentioned miRNAs. qRT-PCR, immunohistochemistry, and western blot studies verified that Rab25 upregulation increased the levels of the snail, that key transcription factor of epithelial-mesenchymal transition (EMT).
    Conclusion: These findings demonstrated that let-7d and miR-185 inhibited EMT by targeting Rab25 expression in BC. Therefore, targeting the let-7d and miR-185/Rab25 interaction may offer new therapeutic opportunities for treating BC patients.
    .
    Language English
    Publishing date 2021-01-01
    Publishing country Thailand
    Document type Journal Article
    ZDB-ID 2218955-5
    ISSN 2476-762X ; 1513-7368
    ISSN (online) 2476-762X
    ISSN 1513-7368
    DOI 10.31557/APJCP.2021.22.1.305
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  4. Article ; Online: A Report of the Telepsychiatric Evaluation of SARS-CoV-2 Patients.

    Zarghami, Arman / Farjam, Mojtaba / Fakhraei, Bahareh / Hashemzadeh, Kosar / Yazdanpanah, Mohammad Hosein

    Telemedicine journal and e-health : the official journal of the American Telemedicine Association

    2020  Volume 26, Issue 12, Page(s) 1461–1465

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Anxiety Disorders/diagnosis ; COVID-19/diagnosis ; COVID-19/psychology ; Female ; Humans ; Inpatients/statistics & numerical data ; Iran/epidemiology ; Male ; Middle Aged ; Outpatients/statistics & numerical data ; Pandemics/statistics & numerical data ; Sex Factors ; Telemedicine/methods ; Telemedicine/statistics & numerical data ; Video Recording/statistics & numerical data
    Keywords covid19
    Language English
    Publishing date 2020-06-11
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 2035659-6
    ISSN 1556-3669 ; 1530-5627
    ISSN (online) 1556-3669
    ISSN 1530-5627
    DOI 10.1089/tmj.2020.0125
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  5. Article ; Online: A Report of the Telepsychiatric Evaluation of SARS-CoV-2 Patients

    Zarghami, Arman / Farjam, Mojtaba / Fakhraei, Bahareh / Hashemzadeh, Kosar / Yazdanpanah, Mohammad Hosein

    Telemedicine and e-Health ; ISSN 1530-5627 1556-3669

    2020  

    Keywords Health Informatics ; Health Information Management ; General Medicine ; covid19
    Language English
    Publisher Mary Ann Liebert Inc
    Publishing country us
    Document type Article ; Online
    DOI 10.1089/tmj.2020.0125
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: A Report of the Telepsychiatric Evaluation of SARS-CoV-2 Patients

    Zarghami, Arman / Farjam, Mojtaba / Fakhraei, Bahareh / Hashemzadeh, Kosar / Yazdanpanah, Mohammad Hosein

    Telemed. j. e. health

    Abstract: Objective: During the current coronavirus disease 2019 (COVID-19) pandemic, telemedicine has been brought to the forefront of attention. This report aimed to assess psychiatric comorbidities in COVID-19 patients by utilizing telepsychiatry. Methods: ... ...

    Abstract Objective: During the current coronavirus disease 2019 (COVID-19) pandemic, telemedicine has been brought to the forefront of attention. This report aimed to assess psychiatric comorbidities in COVID-19 patients by utilizing telepsychiatry. Methods: COVID-19 patients admitted in Fasa University Hospital and nonhospitalized outpatients of Fasa city were interviewed by a psychiatrist through video chat for a 1-month period (March-April, 2020). Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder Assessment (GAD-7), and Perceived Stress Scale-14 (PSS 14) questionnaires were administered for all patients. Each patient's mental status was recorded, and if any psychiatric problem was diagnosed, supportive psychotherapy, pharmacotherapy, and follow-up visits based on the patient's condition were started. Result: From a total of 82 COVID-19 patients who entered the study, 32 (39.03%) and 50 (60.97%) subjects were inpatients and outpatients, respectively. Moreover, 32 (39.03%) subjects were male and 50 (60.97%) were female. Insomnia seen in 24 (29.3%) patients and adjustment disorder in 13 (15.9%) patients were the most common psychiatric disorders among a total of 33 (40.2%) patients suffering from mental illness. Female and hospitalized patients presented significantly more frequent comorbidities than males and outpatients. Conclusions: Psychiatric disorders were significantly more common in patients with hospital admission than those without and more frequent in female versus male subjects. There were no significant differences between male and female subjects with and without admission according to the PHQ-9, GAD-7, and PSS-14 scores. It was concluded that telepsychiatry in the early stages of mental problems during a catastrophic event like the coronavirus pandemic, can be an efficient instrument for the screening of psychosomatic comorbidities, so that pharmacological treatment (considering possible drug interactions with COVID-19 medications) and psychotherapeutic intervention can be optimized by psychiatrists.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #593620
    Database COVID19

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  7. Article ; Online: A Systems Biology Approach Provides Deeper Insights into Differentially Expressed Genes in Taxane-Anthracycline Chemoresistant and Non-Resistant Breast Cancers

    Sarhadi, Shamim / Sadeghi, Somayeh / Nikmanesh, Fatemeh / Pilehvar Soltanahmadi, Younes / Shahabi, Arman / Fekri Aval, Sedigheh / Zarghami, Nosratollah

    Asian Pacific journal of cancer prevention : APJCP

    2017  Volume 18, Issue 10, Page(s) 2629–2636

    Language English
    Publishing date 2017--26
    Publishing country Thailand
    Document type Journal Article
    ISSN 2476-762X
    ISSN (online) 2476-762X
    DOI 10.22034/APJCP.2017.18.10.2629
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  8. Article ; Online: Targeted cancer therapy through 17-DMAG as an Hsp90 inhibitor: Overview and current state of the art.

    Mellatyar, Hassan / Talaei, Sona / Pilehvar-Soltanahmadi, Younes / Barzegar, Abolfazl / Akbarzadeh, Abolfazl / Shahabi, Arman / Barekati-Mowahed, Mazyar / Zarghami, Nosratollah

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2018  Volume 102, Page(s) 608–617

    Abstract: Heat shock protein 90 (Hsp90) is an evolutionary preserved molecular chaperone which mediates many cellular processes such as cell transformation, proliferation, and survival in normal and stress conditions. Hsp90 plays an important role in folding, ... ...

    Abstract Heat shock protein 90 (Hsp90) is an evolutionary preserved molecular chaperone which mediates many cellular processes such as cell transformation, proliferation, and survival in normal and stress conditions. Hsp90 plays an important role in folding, maturation, stabilization and activation of Hsp90 client proteins which all contribute to the development, and proliferation of cancer as well as other inflammatory diseases. Functional inhibition of Hsp90 can have a massive effect on various oncogenic and inflammatory pathways, and will result in the degradation of their client proteins. This turns it into an interesting target in the treatment of different malignancies. 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG) as a semi-synthetic derivative of geldanamycin, has several advantages over 17-Allylamino-17-demethoxygeldanamycin (17-AAG) such as higher water solubility, good bioavailability, reduced metabolism, and greater anti-tumour capability. 17-DMAG binds to the Hsp90, and inhibits its function which eventually results in the degradation of Hsp90 client proteins. Here, we reviewed the pre-clinical data and clinical trial data on 17-DMAG as a single agent, in combination with other agents and loaded on nanomaterials in various cancers and inflammatory diseases.
    MeSH term(s) Animals ; Benzoquinones/therapeutic use ; Clinical Trials as Topic ; Drug Discovery ; HSP90 Heat-Shock Proteins/antagonists & inhibitors ; HSP90 Heat-Shock Proteins/metabolism ; Humans ; Lactams, Macrocyclic/therapeutic use ; Molecular Targeted Therapy ; Neoplasms/drug therapy
    Chemical Substances Benzoquinones ; HSP90 Heat-Shock Proteins ; Lactams, Macrocyclic ; 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (001L2FE0M3)
    Language English
    Publishing date 2018-04-05
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2018.03.102
    Database MEDical Literature Analysis and Retrieval System OnLINE

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