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  1. Article: "Pneumomediastinum: A marker of severity in Covid-19 disease".

    Khaire, Nivedita / Deshmukh, Sonali / Agarwal, Esha / Mahale, Nilesh / Khaladkar, Sanjay / Desai, Sanjay / Kulkarni, Ashwini

    Heliyon

    2023  Volume 9, Issue 1, Page(s) e12981

    Abstract: Objective: The goal of this study was to look at the incidence, risk factors, clinical characteristics, and radiological aspects of COVID-19 patients who developed pneumomediastinum and compare these features between those who died and those who ... ...

    Abstract Objective: The goal of this study was to look at the incidence, risk factors, clinical characteristics, and radiological aspects of COVID-19 patients who developed pneumomediastinum and compare these features between those who died and those who survived.
    Materials and methods: This retrospective observational study included COVID-19 patients having pneumomediastinum on CT from May 2020 to May 2021 in a COVID-19 care hospital. 1st wave patients were considered between the period of May 2020 to January 2021 and those in the second wave between February 2021 to May 2021. The clinical details were analyzed by a consultant intensivist and CT scans were read by a team of 6 resident radiologists and 5 experienced radiologists. Demographic data, co-morbidities, clinical parameters, hemodynamic markers, radiological involvement and associated complications were analyzed.
    Results: During the study period, 10,605 COVID-19 patients were admitted to our hospital of which 5689 underwent CT scan. 66 patients were detected to have pneumomediastinum on CT; 26 of them in the first wave and 40 in the second wave. Out of 66, 28 patients were admitted to ICU, 9 during the first wave and 18 during the second wave. The overall incidence of developing pneumomediastinum was 1.16%. Incidence in the 1st wave was 1.0% and in the 2nd wave was 1.29%. The overall mortality rate in admitted COVID-19 patients was 12.83% while it was 43.9% in COVID-19 patients who developed pneumomediastinum. Incidence of pneumomediastinum and pneumothorax was high in patients with extensive parenchymal involvement. 59/66 (89%) cases of pneumomediastinum had severe CT score on imaging.
    Conclusion: We conclude that pneumomediastinum is a marker of poor prognosis. Timely diagnosis of interstitial emphysema or pneumomediastinum will aid in planning early protective ventilation strategies and timely intervention of complications.
    Language English
    Publishing date 2023-01-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e12981
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: “Pneumomediastinum

    Nivedita Khaire / Sonali Deshmukh / Esha Agarwal / Nilesh Mahale / Sanjay Khaladkar / Sanjay Desai / Ashwini Kulkarni

    Heliyon, Vol 9, Iss 1, Pp e12981- (2023)

    A marker of severity in Covid-19 disease”

    2023  

    Abstract: Objective: The goal of this study was to look at the incidence, risk factors, clinical characteristics, and radiological aspects of COVID-19 patients who developed pneumomediastinum and compare these features between those who died and those who survived. ...

    Abstract Objective: The goal of this study was to look at the incidence, risk factors, clinical characteristics, and radiological aspects of COVID-19 patients who developed pneumomediastinum and compare these features between those who died and those who survived. Materials and methods: This retrospective observational study included COVID-19 patients having pneumomediastinum on CT from May 2020 to May 2021 in a COVID-19 care hospital. 1st wave patients were considered between the period of May 2020 to January 2021 and those in the second wave between February 2021 to May 2021. The clinical details were analyzed by a consultant intensivist and CT scans were read by a team of 6 resident radiologists and 5 experienced radiologists. Demographic data, co-morbidities, clinical parameters, hemodynamic markers, radiological involvement and associated complications were analyzed. Results: During the study period, 10,605 COVID-19 patients were admitted to our hospital of which 5689 underwent CT scan. 66 patients were detected to have pneumomediastinum on CT; 26 of them in the first wave and 40 in the second wave. Out of 66, 28 patients were admitted to ICU, 9 during the first wave and 18 during the second wave. The overall incidence of developing pneumomediastinum was 1.16%. Incidence in the 1st wave was 1.0% and in the 2nd wave was 1.29%. The overall mortality rate in admitted COVID-19 patients was 12.83% while it was 43.9% in COVID-19 patients who developed pneumomediastinum. Incidence of pneumomediastinum and pneumothorax was high in patients with extensive parenchymal involvement. 59/66 (89%) cases of pneumomediastinum had severe CT score on imaging. Conclusion: We conclude that pneumomediastinum is a marker of poor prognosis. Timely diagnosis of interstitial emphysema or pneumomediastinum will aid in planning early protective ventilation strategies and timely intervention of complications.
    Keywords COVID-19 ; Pneumomediastinum ; Pneumothorax ; Macklin effect ; Barotrauma ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
    Subject code 610
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: "Pneumomediastinum: A marker of severity in Covid-19 disease"

    Khaire, Nivedita / Deshmukh, Sonali / Agarwal, Esha / Mahale, Nilesh / Khaladkar, Sanjay / Desai, Sanjay / Kulkarni, Ashwini

    Heliyon. 2023 Jan., v. 9, no. 1 p.e12981-

    2023  

    Abstract: The goal of this study was to look at the incidence, risk factors, clinical characteristics, and radiological aspects of COVID-19 patients who developed pneumomediastinum and compare these features between those who died and those who survived. This ... ...

    Abstract The goal of this study was to look at the incidence, risk factors, clinical characteristics, and radiological aspects of COVID-19 patients who developed pneumomediastinum and compare these features between those who died and those who survived. This retrospective observational study included COVID-19 patients having pneumomediastinum on CT from May 2020 to May 2021 in a COVID-19 care hospital. 1st wave patients were considered between the period of May 2020 to January 2021 and those in the second wave between February 2021 to May 2021. The clinical details were analyzed by a consultant intensivist and CT scans were read by a team of 6 resident radiologists and 5 experienced radiologists. Demographic data, co-morbidities, clinical parameters, hemodynamic markers, radiological involvement and associated complications were analyzed. During the study period, 10,605 COVID-19 patients were admitted to our hospital of which 5689 underwent CT scan. 66 patients were detected to have pneumomediastinum on CT; 26 of them in the first wave and 40 in the second wave. Out of 66, 28 patients were admitted to ICU, 9 during the first wave and 18 during the second wave. The overall incidence of developing pneumomediastinum was 1.16%. Incidence in the 1st wave was 1.0% and in the 2nd wave was 1.29%. The overall mortality rate in admitted COVID-19 patients was 12.83% while it was 43.9% in COVID-19 patients who developed pneumomediastinum. Incidence of pneumomediastinum and pneumothorax was high in patients with extensive parenchymal involvement. 59/66 (89%) cases of pneumomediastinum had severe CT score on imaging. We conclude that pneumomediastinum is a marker of poor prognosis. Timely diagnosis of interstitial emphysema or pneumomediastinum will aid in planning early protective ventilation strategies and timely intervention of complications.
    Keywords COVID-19 infection ; computed tomography ; hemodynamics ; hospitals ; mortality ; observational studies ; pneumothorax ; prognosis ; pulmonary emphysema ; risk ; COVID-19 ; Pneumomediastinum ; Macklin effect ; Barotrauma
    Language English
    Dates of publication 2023-01
    Publishing place Elsevier Ltd
    Document type Article ; Online
    Note Use and reproduction
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e12981
    Database NAL-Catalogue (AGRICOLA)

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  4. Article: Mottling in Septic Shock: Ethnicity and Skin Color Matter.

    Jog, Sameer Arvind / Narasimhan, Vikram L / Rajhans, Prasad Anant / Akole, Prasad Vasant / Pawar, Balasaheb / Bhurke, Bhagyashri / Mahale, Nilesh / Chavan, Shailaja / Dalvi, Pradip / Marudwar, Prasanna / Diwane, Dnyaneshwar / Shahane, Manasi Sanjay / Gugale, Shradha / Pawar, Harshwardhan Singh

    Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine

    2023  Volume 27, Issue 12, Page(s) 902–909

    Abstract: Background: Skin mottling as a clinical perfusion marker in septic shock is significantly associated with severity and outcome in white-skinned population and its validity as a clinical sign in dark-skinned population is not known. The objectives of ... ...

    Abstract Background: Skin mottling as a clinical perfusion marker in septic shock is significantly associated with severity and outcome in white-skinned population and its validity as a clinical sign in dark-skinned population is not known. The objectives of this study were to evaluate mottling in septic shock in the Indian ethnic population who has different skin color as compared to the white-skinned population and to assess mottling as an outcome predictor with capillary refill time (CRT) and other biochemical parameters which are the established clinical markers of perfusion in septic shock.
    Materials and methods: We conducted a prospective observational study of patients with skin color categories 21-34 on the von Luschan scale or Fitzprick type IV-VI who had septic shock needing a high dose of norepinephrine ≥0.2 μg/kg/min after fluid optimization. The study was conducted in a mixed medical-surgical ICU over 12 months. Two blinded experts (a Dermatologist and a plastic surgeon) independently classified the skin type, validated the occurrence of mottling, and scored mottling in our patients. We recorded the demographics, hemodynamic variables, and mottling score and observed the incidence of mottling and its correlation with predictors of the severity of septic shock. We also compared CRT, arterial lactate, central venous oxygen saturation, and venoarterial PCO
    Results: We included 108 patients with age 61 ± 16 years. Mean Sequential Organ Failure Assessment (SOFA) and Acute Physiology and Chronic Health Evaluation (APACHE) II scores at enrolment were 10.3-21.9, respectively. Incidence of mottling was 20.3% (22/108). CRT >3 seconds was observed in 50.9% (55/108). Development of mottling was significantly associated with 90-day mortality; 20/22 (90.9%) patients died in the mottling group versus 58/86 (65.1%) in the non-mottling group (
    Conclusion: The incidence of mottling in septic shock is much less in patients of Indian ethnicity with brown skin color than in white-skinned population. Occurrence of mottling and not delayed CRT, is a better predictor of outcome in this setting.
    How to cite this article: Jog SA, Narasimhan VL, Rajhans PA, Akole PV, Pawar B, Bhurke B,
    Language English
    Publishing date 2023-03-23
    Publishing country India
    Document type Journal Article
    ZDB-ID 2121263-6
    ISSN 1998-359X ; 0972-5229
    ISSN (online) 1998-359X
    ISSN 0972-5229
    DOI 10.5005/jp-journals-10071-24586
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Electrocatalytic hydrogen evolution reaction on nano-nickel decorated graphene electrode

    Mahale, Nilesh K / Sopan T. Ingle

    Energy. 2017 Jan. 15, v. 119

    2017  

    Abstract: The quest for the replacement of noble metal electrocatalyst for the hydrogen evolution reaction (HER) with lowest overpotential and Tafel slope is still a major challenge. In the present work new concept of earth abundant material like transition metals ...

    Abstract The quest for the replacement of noble metal electrocatalyst for the hydrogen evolution reaction (HER) with lowest overpotential and Tafel slope is still a major challenge. In the present work new concept of earth abundant material like transition metals (Ni) are composed with graphene sheets as a catalyst to increase the rate of hydrogen production. The nickel nanoparticles are decorated uniformly on graphene sheets via electrophoretic deposition (EPD) method to enhance it's HER performance in alkaline solution. The composite is characterized by XRD, FTIR, XPS, SEM and TEM techniques. The composite shown improved HER performance with a low overpotential of 65 mV for 10 mA cm−2, a small Tafel slope of 54 mV dec−1 and longtime stability.
    Keywords catalysts ; electrodes ; electrophoresis ; Fourier transform infrared spectroscopy ; graphene ; hydrogen production ; nanoparticles ; nickel ; scanning electron microscopy ; transmission electron microscopy ; X-ray diffraction ; X-ray photoelectron spectroscopy
    Language English
    Dates of publication 2017-0115
    Size p. 872-878.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 2019804-8
    ISSN 0360-5442 ; 0360-5442
    ISSN (online) 0360-5442
    ISSN 0360-5442
    DOI 10.1016/j.energy.2016.11.053
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  6. Article: Intravenous Methylene Blue as a Rescue Therapy in the Management of Refractory Hypoxia in COVID-19 ARDS Patients: A Case Series.

    Mahale, Nilesh / Godavarthy, Purushotham / Marreddy, Srinath / Gokhale, Snehal D / Funde, Pradip / Rajhans, Prasad A / Akole, Prasad V / Pawar, Balasaheb / Bhurke, Bhagyashri / Dalvi, Pradip / Marudwar, Prasanna / Gugale, Shradha / Shahane, Manasi S / Kshirsagar, Sarang N / Jog, Sameer A

    Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine

    2020  Volume 25, Issue 8, Page(s) 934–938

    Abstract: Objectives: ...

    Abstract Objectives:
    Language English
    Publishing date 2020-05-21
    Publishing country India
    Document type Journal Article
    ZDB-ID 2121263-6
    ISSN 1998-359X ; 0972-5229
    ISSN (online) 1998-359X
    ISSN 0972-5229
    DOI 10.5005/jp-journals-10071-23905
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: A Retrospective Observational Study of Hypoxic COVID-19 Patients Treated with Immunomodulatory Drugs in a Tertiary Care Hospital.

    Mahale, Nilesh / Rajhans, Prasad / Godavarthy, Purushotham / Narasimhan, Vikram L / Oak, Gauri / Marreddy, Srinath / Bedekar, Amruta / Dhundi, Ujwal / Pawar, Harshwardhan S / Akole, Prasad / Pawar, Balasaheb / Bhurke, Bhagyashri / Chavan, Shailaja / Prayag, Parikshit / Purandare, Bharat / Dalvi, Pradip / Telbhare, Vishnu / Marudwar, Prasanna / Diwane, Dnyaneshwar /
    Shahane, Manasi / Prayag, Amrita / Gugale, Shradha / Bhor, Shreyas / Jog, Sameer

    Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine

    2020  Volume 24, Issue 11, Page(s) 1020–1027

    Abstract: ... of mortality.: How to cite this article: Mahale N, Rajhans P, Godavarthy P, Narasimhan VL, Oak G, Marreddy S, ...

    Abstract Objectives: To describe the demographics and evaluate the clinical outcomes of hypoxic coronavirus disease-2019 (COVID-19) patients treated with different immunomodulatory (IM) drugs in a resource-limited setting.
    Materials and methods: We conducted a retrospective cohort study of these patients admitted to our hospital between March 22 and May 31, 2020. Data were abstracted from multiple electronic data sources or patient charts to provide information on patient characteristics, clinical, laboratory variables, and outcomes.
    Results: A total of 134 patients met the inclusion criteria and were followed up till June 7, 2020. The median age of the patients was 55.6 years (range 20-89 years) and 68% were men. At least one comorbidity was seen in 72% of the patients with diabetes (44%) and hypertension (46%) being the most common. At triage, fever (82%), shortness of breath (77%), and cough (61%) were the most common presenting symptoms. A PaO
    Conclusion: Our study provides the characteristics and outcomes of hypoxic COVID-19 patients treated with IM drugs in varied combination. Five independent variables were strong predictors of mortality.
    How to cite this article: Mahale N, Rajhans P, Godavarthy P, Narasimhan VL, Oak G, Marreddy S,
    Language English
    Publishing date 2020-11-05
    Publishing country India
    Document type Journal Article
    ZDB-ID 2121263-6
    ISSN 1998-359X ; 0972-5229
    ISSN (online) 1998-359X
    ISSN 0972-5229
    DOI 10.5005/jp-journals-10071-23599
    Database MEDical Literature Analysis and Retrieval System OnLINE

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